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Volumn 13, Issue 1, 2012, Pages

Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions

Author keywords

Gene sets analysis; Hepatic zonation; Hepatocellular carcinoma; Pdms microfluidic biochips; Petri plates; Ubiquitination system

Indexed keywords

CYTOCHROME P450; PHOSPHOTRANSFERASE; BETA CATENIN; GLUTAMINE; PROTEIN KINASE; PROTEOME; UBIQUITIN;

EID: 84856376823     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-13-54     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 0032898916 scopus 로고    scopus 로고
    • A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver
    • Christoffels VM, Sassi H, Ruijter JM, Moorman AF, Grange T, Lamers WH. A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver. Hepatology 1999, 29(4):1180-1192.
    • (1999) Hepatology , vol.29 , Issue.4 , pp. 1180-1192
    • Christoffels, V.M.1    Sassi, H.2    Ruijter, J.M.3    Moorman, A.F.4    Grange, T.5    Lamers, W.H.6
  • 2
    • 0026766117 scopus 로고
    • Metabolic zonation of the liver: regulation and implications for liver function
    • Gebhardt R. Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol Ther 1992, 53(3):275-354.
    • (1992) Pharmacol Ther , vol.53 , Issue.3 , pp. 275-354
    • Gebhardt, R.1
  • 3
    • 0024336445 scopus 로고
    • Functional specialization of different hepatocyte populations
    • Jungermann K, Katz N. Functional specialization of different hepatocyte populations. Physiol Rev 1989, 69(3):708-764.
    • (1989) Physiol Rev , vol.69 , Issue.3 , pp. 708-764
    • Jungermann, K.1    Katz, N.2
  • 4
    • 0029800090 scopus 로고    scopus 로고
    • Zonation of parenchymal and nonparenchymal metabolism in liver
    • Jungermann K, Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr 1996, 16:179-203.
    • (1996) Annu Rev Nutr , vol.16 , pp. 179-203
    • Jungermann, K.1    Kietzmann, T.2
  • 5
    • 77749336635 scopus 로고    scopus 로고
    • β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver
    • Braeuning A, Schwarz M. β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver. Biological Chemistry 2009, 391(2/3):139-148.
    • (2009) Biological Chemistry , vol.391 , Issue.2-3 , pp. 139-148
    • Braeuning, A.1    Schwarz, M.2
  • 6
    • 77954484528 scopus 로고    scopus 로고
    • Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity
    • Sheikh-Bahaei S, Maher JJ, Anthony Hunt C. Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity. J Theor Biol 2010, 265(4):718-733.
    • (2010) J Theor Biol , vol.265 , Issue.4 , pp. 718-733
    • Sheikh-Bahaei, S.1    Maher, J.J.2    Anthony Hunt, C.3
  • 7
    • 77953400851 scopus 로고    scopus 로고
    • Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research
    • Ierapetritou MG, Georgopoulos PG, Roth CM, Androulakis LP. Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clin Transl Sci 2009, 2(3):228-237.
    • (2009) Clin Transl Sci , vol.2 , Issue.3 , pp. 228-237
    • Ierapetritou, M.G.1    Georgopoulos, P.G.2    Roth, C.M.3    Androulakis, L.P.4
  • 8
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002, 31(4):339-346.
    • (2002) Nat Genet , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 9
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: molecular pathways and new therapeutic targets
    • Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005, 25(2):212-225.
    • (2005) Semin Liver Dis , vol.25 , Issue.2 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 12
    • 0036083396 scopus 로고    scopus 로고
    • The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
    • Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002, 82(2):373-428.
    • (2002) Physiol Rev , vol.82 , Issue.2 , pp. 373-428
    • Glickman, M.H.1    Ciechanover, A.2
  • 13
    • 0033536637 scopus 로고    scopus 로고
    • The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
    • Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 1999, 286(5438):309-312.
    • (1999) Science , vol.286 , Issue.5438 , pp. 309-312
    • Joazeiro, C.A.1    Wing, S.S.2    Huang, H.3    Leverson, J.D.4    Hunter, T.5    Liu, Y.C.6
  • 14
    • 79251544654 scopus 로고    scopus 로고
    • Ubiquitination-Dependent Regulation of Signaling Receptors in Cancer
    • HuangFu W-C, Fuchs SY. Ubiquitination-Dependent Regulation of Signaling Receptors in Cancer. Genes & Cancer 2010, 1(7):725-734.
    • (2010) Genes & Cancer , vol.1 , Issue.7 , pp. 725-734
    • HuangFu, W.-C.1    Fuchs, S.Y.2
  • 15
    • 5344234076 scopus 로고    scopus 로고
    • The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications
    • Burger AM, Seth AK. The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications. Eur J Cancer 2004, 40:2217-2229.
    • (2004) Eur J Cancer , vol.40 , pp. 2217-2229
    • Burger, A.M.1    Seth, A.K.2
  • 18
    • 65649128767 scopus 로고    scopus 로고
    • Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure
    • Thomas R, Gohlke JM, Stopper GF, Parham FM, Portier CJ. Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. Genome Biol 2009, 10(4):R44.
    • (2009) Genome Biol , vol.10 , Issue.4
    • Thomas, R.1    Gohlke, J.M.2    Stopper, G.F.3    Parham, F.M.4    Portier, C.J.5
  • 19
    • 78049375674 scopus 로고    scopus 로고
    • General review on in vitro hepatocyte models and their applications
    • Guguen-Guillouzo C, Guillouzo A. General review on in vitro hepatocyte models and their applications. Methods Mol Biol 2010, 640:1-40.
    • (2010) Methods Mol Biol , vol.640 , pp. 1-40
    • Guguen-Guillouzo, C.1    Guillouzo, A.2
  • 20
    • 33745119474 scopus 로고    scopus 로고
    • Hepatocyte cultures in drug metabolism and toxicological research and testing
    • Vanhaecke T, Rogiers V. Hepatocyte cultures in drug metabolism and toxicological research and testing. Methods Mol Biol 2006, 320:209-227.
    • (2006) Methods Mol Biol , vol.320 , pp. 209-227
    • Vanhaecke, T.1    Rogiers, V.2
  • 21
    • 18244366662 scopus 로고    scopus 로고
    • Tissue engineering--current challenges and expanding opportunities
    • Griffith LG, Naughton G. Tissue engineering--current challenges and expanding opportunities. Science 2002, 295(5557):1009-1014.
    • (2002) Science , vol.295 , Issue.5557 , pp. 1009-1014
    • Griffith, L.G.1    Naughton, G.2
  • 22
    • 34147108130 scopus 로고    scopus 로고
    • Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity
    • Baudoin R, Corlu A, Griscom L, Legallais C, Leclerc E. Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity. Toxicology in Vitro 2007, 21(4):535-544.
    • (2007) Toxicology in Vitro , vol.21 , Issue.4 , pp. 535-544
    • Baudoin, R.1    Corlu, A.2    Griscom, L.3    Legallais, C.4    Leclerc, E.5
  • 24
    • 32244434299 scopus 로고    scopus 로고
    • Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen
    • Huang R, Wallqvist A, Covell DG. Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen. Genomics 2006, 87(3):315-328.
    • (2006) Genomics , vol.87 , Issue.3 , pp. 315-328
    • Huang, R.1    Wallqvist, A.2    Covell, D.G.3
  • 26
    • 78651429899 scopus 로고    scopus 로고
    • Transcription dynamics in a physiological process: beta-catenin signaling directs liver metabolic zonation
    • Torre C, Perret C, Colnot S. Transcription dynamics in a physiological process: beta-catenin signaling directs liver metabolic zonation. Int J Biochem Cell Biol 2011, 43(2):271-278.
    • (2011) Int J Biochem Cell Biol , vol.43 , Issue.2 , pp. 271-278
    • Torre, C.1    Perret, C.2    Colnot, S.3
  • 27
    • 0035960122 scopus 로고    scopus 로고
    • Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young
    • Fajans SS, Bell GI, Polonsky KS. Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young. New England Journal of Medicine 2001, 345(13):971-980.
    • (2001) New England Journal of Medicine , vol.345 , Issue.13 , pp. 971-980
    • Fajans, S.S.1    Bell, G.I.2    Polonsky, K.S.3
  • 28
    • 0027506948 scopus 로고
    • The expression of cytochrome P-450, epoxide hydrolase, and glutathione s-transferase in hepatocellular carcinoma
    • Murray GI, Paterson PJ, Weaver RJ, Ewen SWB, Melvin WT, Burke MD. The expression of cytochrome P-450, epoxide hydrolase, and glutathione s-transferase in hepatocellular carcinoma. Cancer 1993, 71(1):36-43.
    • (1993) Cancer , vol.71 , Issue.1 , pp. 36-43
    • Murray, G.I.1    Paterson, P.J.2    Weaver, R.J.3    Ewen, S.W.B.4    Melvin, W.T.5    Burke, M.D.6
  • 29
    • 77950842489 scopus 로고    scopus 로고
    • Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters
    • Rendic S, Guengerich FP. Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters. Curr Drug Metab 2010, 11(1):4-84.
    • (2010) Curr Drug Metab , vol.11 , Issue.1 , pp. 4-84
    • Rendic, S.1    Guengerich, F.P.2
  • 31
    • 66449102968 scopus 로고    scopus 로고
    • Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1
    • Braeuning A, Sanna R, Huelsken J, Schwarz M. Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab Dispos 2009, 37(5):1138-1145.
    • (2009) Drug Metab Dispos , vol.37 , Issue.5 , pp. 1138-1145
    • Braeuning, A.1    Sanna, R.2    Huelsken, J.3    Schwarz, M.4
  • 32
    • 0025733909 scopus 로고
    • Dose-dependent acinar induction of cytochromes P450 in rat liver. Evidence for a differential mechanism of induction of P450IA1 by beta-naphthoflavone and dioxin
    • Bars RG, Elcombe CR. Dose-dependent acinar induction of cytochromes P450 in rat liver. Evidence for a differential mechanism of induction of P450IA1 by beta-naphthoflavone and dioxin. Biochem J 1991, 277(Pt 2):577-580.
    • (1991) Biochem J , vol.277 , Issue.PART 2 , pp. 577-580
    • Bars, R.G.1    Elcombe, C.R.2
  • 33
    • 0028104347 scopus 로고
    • Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones
    • Oinonen T, Saarikoski S, Husgafvel-Pursiainen K, Hirvonen A, Lindros KO. Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones. Biochem Pharmacol 1994, 48(12):2189-2197.
    • (1994) Biochem Pharmacol , vol.48 , Issue.12 , pp. 2189-2197
    • Oinonen, T.1    Saarikoski, S.2    Husgafvel-Pursiainen, K.3    Hirvonen, A.4    Lindros, K.O.5
  • 34
    • 0027236953 scopus 로고
    • Differential expression of drug metabolizing enzymes in primary and secondary liver neoplasm: immunohistochemical characterization of cytochrome P4503A and glutathione-S-transferase
    • Fritz P, Behrle E, Beaune P, Eichelbaum M, Kroemer HK. Differential expression of drug metabolizing enzymes in primary and secondary liver neoplasm: immunohistochemical characterization of cytochrome P4503A and glutathione-S-transferase. Histochemistry 1993, 99(6):443-451.
    • (1993) Histochemistry , vol.99 , Issue.6 , pp. 443-451
    • Fritz, P.1    Behrle, E.2    Beaune, P.3    Eichelbaum, M.4    Kroemer, H.K.5
  • 35
    • 78650572031 scopus 로고    scopus 로고
    • Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data
    • Garcia-Alcalde F, Garcia-Lopez F, Dopazo J, Conesa A. Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data. Bioinformatics 2011, 27(1):137-139.
    • (2011) Bioinformatics , vol.27 , Issue.1 , pp. 137-139
    • Garcia-Alcalde, F.1    Garcia-Lopez, F.2    Dopazo, J.3    Conesa, A.4
  • 37
    • 65549136561 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling
    • Braeuning A. Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling. Curr Drug Metab 2009, 10(2):138-158.
    • (2009) Curr Drug Metab , vol.10 , Issue.2 , pp. 138-158
    • Braeuning, A.1
  • 40
    • 0034282097 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    • Henderson BR. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover. Nat Cell Biol 2000, 2(9):653-660.
    • (2000) Nat Cell Biol , vol.2 , Issue.9 , pp. 653-660
    • Henderson, B.R.1
  • 41
    • 0034661466 scopus 로고    scopus 로고
    • CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90
    • Goasduff T, Cederbaum AI. CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90. Arch Biochem Biophys 2000, 379(2):321-330.
    • (2000) Arch Biochem Biophys , vol.379 , Issue.2 , pp. 321-330
    • Goasduff, T.1    Cederbaum, A.I.2
  • 42
    • 77953289239 scopus 로고    scopus 로고
    • HCCNet: an integrated network database of hepatocellular carcinoma
    • He B, Qiu X, Li P, Wang L, Lv Q, Shi T. HCCNet: an integrated network database of hepatocellular carcinoma. Cell Res 2010, 20(6):732-734.
    • (2010) Cell Res , vol.20 , Issue.6 , pp. 732-734
    • He, B.1    Qiu, X.2    Li, P.3    Wang, L.4    Lv, Q.5    Shi, T.6
  • 44
    • 70149117469 scopus 로고    scopus 로고
    • Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations
    • Dixit A, Verkhivker GM. Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations. PLoS Comput Biol 2009, 5(8):e1000487.
    • (2009) PLoS Comput Biol , vol.5 , Issue.8
    • Dixit, A.1    Verkhivker, G.M.2
  • 45
    • 77957241496 scopus 로고    scopus 로고
    • Molecular dynamics simulations and elastic network analysis of protein kinase B (Akt/PKB) inactivation
    • Cheng S, Niv MY. Molecular dynamics simulations and elastic network analysis of protein kinase B (Akt/PKB) inactivation. J Chem Inf Model 2010, 50(9):1602-1610.
    • (2010) J Chem Inf Model , vol.50 , Issue.9 , pp. 1602-1610
    • Cheng, S.1    Niv, M.Y.2
  • 46
    • 0032493444 scopus 로고    scopus 로고
    • The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha
    • Miyake S, Lupher ML, Druker B, Band H. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci USA 1998, 95(14):7927-7932.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.14 , pp. 7927-7932
    • Miyake, S.1    Lupher, M.L.2    Druker, B.3    Band, H.4
  • 47
    • 0037204990 scopus 로고    scopus 로고
    • Signal Transduction by the TGF-β Superfamily
    • Attisano L, Wrana JL. Signal Transduction by the TGF-β Superfamily. Science 2002, 296(5573):1646-1647.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 48
    • 73949116718 scopus 로고    scopus 로고
    • Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond
    • Gebhardt R, Hovhannisyan A. Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond. Dev Dyn 2010, 239(1):45-55.
    • (2010) Dev Dyn , vol.239 , Issue.1 , pp. 45-55
    • Gebhardt, R.1    Hovhannisyan, A.2
  • 49
    • 33846200819 scopus 로고    scopus 로고
    • Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2
    • Mavri-Damelin D, Eaton S, Damelin LH, Rees M, Hodgson HJ, Selden C. Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. Int J Biochem Cell Biol 2007, 39(3):555-564.
    • (2007) Int J Biochem Cell Biol , vol.39 , Issue.3 , pp. 555-564
    • Mavri-Damelin, D.1    Eaton, S.2    Damelin, L.H.3    Rees, M.4    Hodgson, H.J.5    Selden, C.6
  • 50
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009, 9(1):28-39.
    • (2009) Nat Rev Cancer , vol.9 , Issue.1 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3


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