The defence of body weight: A physiological basis: For weight regain after weight loss

Clinical Science

Volumn 124, Issue 4, 2013, Pages 231-241

  Sumithran, Priya ^a   Proietto, Joseph ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Appetite; Diet; Hypothalamus; Obesity; Weight gain; Weight loss

Indexed keywords

AGOUTI RELATED PROTEIN; AMYLIN; BOMBESIN; CANNABINOID 1 RECEPTOR; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; GHRELIN; GLUCAGON LIKE PEPTIDE 1; LEPTIN; NEUROPEPTIDE Y; OXYTOCIN; PEPTIDE YY; PROOPIOMELANOCORTIN; PROTIRELIN; SEROTONIN; UROCORTIN; UROGUANYLIN;

ADIPOCYTE; APPETITE; ARCUATE NUCLEUS; BODY WEIGHT; BRAIN BLOOD FLOW; CALORIC INTAKE; COGNITION; DIET; DIET RESTRICTION; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; GASTRIC BANDING; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VISUAL CORTEX; WEIGHT GAIN; WEIGHT REDUCTION; ENERGY METABOLISM; LOW CALORY DIET; PATHOPHYSIOLOGY; PHYSIOLOGY;

APPETITE; DIET, REDUCING; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; OBESITY; WEIGHT GAIN; WEIGHT LOSS;

EID: 84872120798     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120223     Document Type: Review

References (155)

1. Anderson, J. W., Konz, E. C., Frederich, R. C. and Wood, C. L. (2001) Long-term weight-loss maintenance: a meta-analysis of US studies. Am. J. Clin. Nutr. 74, 579-584
2. Kramer, F. M., Jeffery, R. W., Forster, J. L. and Snell, M. K. (1989) Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int. J. Obes. 13, 123-136
3. Christiansen, T., Bruun, J. M., Madsen, E. L. and Richelsen, B. (2007) Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up. Obesity 15, 413-420
4. Wing, R. R. and Hill, J. O (2001) Successful weight loss maintenance. Annu. Rev. Nutr. 21, 323-341
5. Maclean, P. S., Bergouignan, A., Cornier, M-A. and Jackman, M. R. (2011) Biology's response to dieting: the impetus for weight regain. Am. J. Physiol. Regul. Integ. Comp. Physiol. 301, R581-R600
6. Sainsbury, A. and Zhang, L. (2009) Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Mol. Cell. Endocrinol. 316, 109-119
7. Bernstein, I. L, Lotter, E. C., Kulkosky, P. J., Porte, Jr, D. and Woods, S. C. (1975) Effect of force-feeding upon basal insulin levels of rats. Proc. Soc. Exp. Biol. Med. 150, 546-548
8. Pasquet, P. and Apfelbaum, M. (1994) Recovery of initial body weight and composition after long-term massive overfeeding in men. Am. J. Clin. Nutr. 60, 861-863
9. Schwartz, M. W., Woods, S. C., Seeley, R. J., Barsh, G. S., Baskin, D. G and Leibel, R. L. (2003) Is the energy homeostasis system inherently biased toward weight gain? Diabetes 52, 232-238
10. Siervo, M., Fruhbeck, G., Dixon, A., Goldberg, G. R., Coward, W. A., Murgatroyd, P. R., Prentice, A. M. and Jebb, S. A. (2008) Efficiency of autoregulatory homeostatic responses to imposed caloric excess in lean men. Am. J. Physiol. Endocrinol. Metab. 294, E416-E424
11. Schwartz, M. W., Woods, S. C., Porte, Jr, D., Seeley, R. J. and Baskin, D. G. (2000) Central nervous system control of food intake. Nature 404, 661-671
12. Proietto, J. (2011) Why is treating obesity so difficult? Justification for the role of bariatric surgery. Med. J. Aust. 195, 144-146
13. Krude, H., Biebermann, H. and Gruters, A. (2003) Mutations in the human proopiomelanocortin gene. Ann. N.Y. Acad. Sci. 994, 233-239
14. Billington, C. J., Briggs, J. E., Grace, M. and Levine, A. S. (1991) Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260, R321-R327
15. Oh-I, S., Shimizu, H., Satoh, T., Okada, S., Adachi, S., Inoue, K., Eguchi, H., Yamamoto, M., Imaki, T., Hashimoto, K. et al. (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443, 709-712
16. Rossi, M., Kim, M. S., Morgan, D. G., Small, C. J., Edwards, C. M., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A. et al. (1998) A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology 139, 4428-4431
17. Vijayan, E. and McCann, S. M. (1977) Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH). Endocrinology 100, 1727-1730
18. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S. et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585
19. Britton, D. R., Koob, G. F., Rivier, J. and Vale, W. (1982) Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci. 31, 363-367
20. Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S. and Maratos-Flier, E. (1998) Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-674
21. Arletti, R., Benelli, A. and Bertolini, A. (1989) Influence of oxytocin on feeding behavior in the rat. Peptides 10, 89-93
22. Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Batkai, S., Jarai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T. and Kunos, G. (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410, 822-825
23. Blundell, J. E. (1977) Is there a role for serotonin (5-hydroxytryptamine) in feeding? Int. J. Obes. 1, 15-42
24. Jalowiec, J. E., Panksepp, J., Zolovick, A. J., Najam, N. and Herman, B. H. (1981) Opioid modulation of ingestive behavior. Pharmacol. Biochem. Behav. 15, 477-484
25. Sakata, T., Fukagawa, K., Ookuma, K., Fujimoto, K., Yoshimatsu, H., Yamatodani, A. and Wada, H. (1988) Modulation of neuronal histamine in control of food intake. Physiol. Behav. 44, 539-543
26. Spina, M., Merlo-Pich, E., Chan, R. K., Basso, A. M., Rivier, J., Vale, W. and Koob, G. F. (1996) Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 273, 1561-1564
27. Muurahainen, N., Kissileff, H. R., Derogatis, A. J. and Pi-Sunyer, F. X. (1988) Effects of cholecystokinin-octapeptide (CCK-8) on food intake and gastric emptying in man. Physiol. Behav. 44, 645-649
28. Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A. and Bloom, S. R. (2001) Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 5992-5995
29. Flint, A., Raben, A., Astrup, A. and Holst, J. J. (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J. Clin. Invest. 101, 515-520
30. Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A. et al. (2002) Gut hormone PYY3-36 physiologically inhibits food intake. Nature 418, 650-654
31. Cohen, M. A., Ellis, S. M., le Roux, C. W., Batterham, R. L., Park, A. J., Patterson, M., Frost, G. S., Ghatei, M. A. and Bloom, S. R. (2003) Oxyntomodulin suppresses appetite and reduces food intake in humans. J. Clin. Endocrinol. Metab. 88, 4696-4701
32. Erlanson-Albertsson, C. and York, D. (1997) Enterostatin-a peptide regulating fat intake. Obes. Res. 5, 360-372
33. Muurahainen, N. E., Kissileff, H. R. and Pi-Sunyer, F. X. (1993) Intravenous infusion of bombesin reduces food intake in humans. Am. J. Physiol. 264, R350-R354
34. Valentino, M. A., Lin, J. E., Snook, A. E., Li, P., Kim, G. W., Marszalowicz, G., Magee, M. S., Hyslop, T., Schulz, S. and Waldman, S. A. (2011) A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. J. Clin. Invest. 121, 3578-3588
35. Chapman, I., Parker, B., Doran, S., Feinle-Bisset, C., Wishart, J., Lush, C. W., Chen, K., Lacerte, C., Burns, C., McKay, R. et al. (2007) Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects. Obesity 15, 1179-1186
36. Porte, Jr, D. and Woods, S. C. (1981) Regulation of food intake and body weight in insulin. Diabetologia 20 (Suppl), 274-280
37. Batterham, R. L., le Roux, C. W., Cohen, M. A., Park, A. J., Ellis, S. M., Patterson, M., Frost, G. S., Ghatei, M. A. and Bloom, S. R. (2003) Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 88, 3989-3992
38. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432
39. Fulton, S., Woodside, B. and Shizgal, P. (2000) Modulation of brain reward circuitry by leptin. Science 287, 125-128
40. Kawai, K., Sugimoto, K., Nakashima, K., Miura, H. and Ninomiya, Y. (2000) Leptin as a modulator of sweet taste sensitivities in mice. Proc. Natl. Acad. Sci. U.S.A. 97, 11044-11049
41. Shalev, U., Yap, J. and Shaham, Y. (2001) Leptin attenuates acute food deprivation-induced relapse to heroin seeking. J. Neurosci. 21, RC129
42. Naleid, A. M., Grace, M. K., Cummings, D. E. and Levine, A. S. (2005) Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 26, 2274-2279
43. Disse, E., Bussier, A-L., Veyrat-Durebex, C., Deblon, N., Pfluger, P. T., Tschop, M. H., Laville, M. and Rohner-Jeanrenaud, F. (2010) Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. Physiol. Behav. 101, 277-281
44. Jelsing, J., Larsen, P. J. and Vrang, N. (2008) Identification of cannabinoid type 1 receptor expressing cocaine amphetamine-regulated transcript neurons in the rat hypothalamus and brainstem using in situ hybridization and immunohistochemistry. Neuroscience 154, 641-652
45. Koch, J. E. and Matthews, S. M. (2001) Delta9-tetrahydrocannabinol stimulates palatable food intake in Lewis rats: effects of peripheral and central administration. Nutr. Neurosci. 4, 179-187
46. Leibel, R. L., Rosenbaum, M. and Hirsch, J. (1995) Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. 332, 621-628
47. Flatt, J. P. (2007) Exaggerated claim about adaptive thermogenesis. Int. J. Obes. 31, 1626
48. Doucet, E., St-Pierre, S., Almeras, N., Despres, J. P., Bouchard, C. and Tremblay, A. (2001) Evidence for the existence of adaptive thermogenesis during weight loss. Br. J. Nutr. 85, 715-723
49. Schwartz, A., Kuk, J. L., Lamothe, G. and Doucet, E (2012) Greater than predicted decrease in resting energy expenditure and weight loss: results from a systematic review. Obesity, doi: 10.1038/oby.2012.34
50. Rosenbaum, M., Vandenborne, K., Goldsmith, R., Simoneau, J-A., Heymsfield, S., Joanisse, D. R., Hirsch, J., Murphy, E., Matthews, D., Segal, K. R. and Leibel, R. L. (2003) Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R183-R192
51. Doucet, E., Imbeault, P., St-Pierre, S., Almeras, N., Mauriege, P., Despres, J-P., Bouchard, C. and Tremblay, A. (2003) Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin. Sci. 105, 89-95
52. Rosenbaum, M., Hirsch, J., Gallagher, D. A. and Leibel, R. L. (2008) Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am. J. Clin. Nutr. 88, 906-912
53. Melanson, E. L., Gozansky, W. S., Barry, D. W., Maclean, P. S., Grunwald, G. K. and Hill, J. O. (2009) When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. J. Appl. Physiol. 107, 1847-1856
54. Bergouignan, A., Gozansky, W. S., Barry, D. W., Leitner, W., MacLean, P. S., Hill, J. O., Draznin, B. and Melanson, E. L. (2012) Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS ONE 7, e30164
55. MacLean, P. S., Higgins, J. A., Johnson, G. C., Fleming-Elder, B. K., Peters, J. C. and Hill, J. O. (2004) Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R288-R297
56. Ballor, D. L., Harvey-Berino, J. R., Ades, P. A., Cryan, J. and Calles-Escandon, J. (1996) Decrease in fat oxidation following a meal in weight-reduced individuals: a possible mechanism for weight recidivism. Metab., Clin. Exp. 45, 174-178
57. Astrup, A., Buemann, B., Christensen, N. J. and Toubro, S. (1994) Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. Am. J. Physiol. 266, E592-E599
58. Buemann, B., Toubro, S. and Astrup, A. (1998) Substrate oxidation and thyroid hormone response to the introduction of a high fat diet in formerly obese women. Int. J. Obes. 22, 869-877
59. Raben, A., Andersen, H. B., Christensen, N. J., Madsen, J., Holst, J. J. and Astrup, A. (1994) Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity. Am. J. Physiol. 267, E549-E559
60. Larson, D. E., Ferraro, R. T., Robertson, D. S. and Ravussin, E. (1995) Energy metabolism in weight-stable postobese individuals. Am. J. Clin. Nutr. 62, 735-739
61. Filozof, C. M., Murua, C., Sanchez, M. P., Brailovsky, C., Perman, M., Gonzalez, C. D. and Ravussin, E. (2000) Low plasma leptin concentration and low rates of fat oxidation in weight-stable post-obese subjects. Obes. Res. 8, 205-210
62. Flatt, J. P. (1987) The difference in the storage capacities for carbohydrate and for fat, and its implications in the regulation of body weight. Ann. N.Y. Acad. Sci. 499, 104-123
63. Seidell, J. C., Muller, D. C., Sorkin, J. D. and Andres, R. (1992) Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int. J. Obes. 16, 667-674
64. Zurlo, F., Lillioja, S., Esposito-Del Puente, A., Nyomba, B. L., Raz, I., Saad, M. F., Swinburn, B. A., Knowler, W. C., Bogardus, C. and Ravussin, E. (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am. J. Physiol. 259, E650-E657
65. Marra, M., Scalfi, L., Covino, A., Esposito-Del Puente, A. and Contaldo, F. (1998) Fasting respiratory quotient as a predictor of weight changes in non-obese women. Int. J. Obes. 22, 601-603
66. Muscelli, E., Emdin, M., Natali, A., Pratali, L., Camastra, S., Gastaldelli, A., Baldi, S., Carpeggiani, C. and Ferrannini, E. (1998) Autonomic and hemodynamic responses to insulin in lean and obese humans. J. Clin. Endocrinol. Metab. 83, 2084-2090
67. Goldsmith, R., Joanisse, D. R., Gallagher, D., Pavlovich, K., Shamoon, E., Leibel, R. L. and Rosenbaum, M. (2010) Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R79-R88
68. Eikelis, N. and Esler, M. (2005) The neurobiology of human obesity. Exp. Physiol. 90, 673-682
69. Grassi, G., DellOro, R., Quarti-Trevano, F., Scopelliti, F., Seravalle, G., Paleari, F., Gamba, P. L. and Mancia, G. (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48, 1359-1365
70. Eikelis, N., Schlaich, M., Aggarwal, A., Kaye, D. and Esler, M. (2003) Interactions between leptin and the human sympathetic nervous system. Hypertension 41, 1072-1079
71. Paolisso, G., Manzella, D., Tagliamonte, M. R., Rizzo, M. R., Gambardella, A. and Varricchio, M. (1999) Effects of different insulin infusion rates on heart rate variability in lean and obese subjects. Metab., Clin. Exp. 48, 755-762
72. Rosenbaum, M., Goldsmith, R., Bloomfield, D., Magnano, A., Weimer, L., Heymsfield, S., Gallagher, D., Mayer, L., Murphy, E. and Leibel, R. L. (2005) Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J. Clin. Invest. 115, 3579-3586
73. Straznicky, N. E., Lambert, E. A., Lambert, G. W., Masuo, K., Esler, M. D. and Nestel, P. J. (2005) Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome. J. Clin. Endocrinol. Metab. 90, 5998-6005
74. Masuo, K., Kawaguchi, H., Mikami, H., Ogihara, T. and Tuck, M. L. (2003) Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 42, 474-480
75. Masuo, K., Mikami, H., Ogihara, T. and Tuck, M. L. (1997) Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population. Am. J. Hypertens. 10, 77-83
76. Scheidegger, K., O'Connell, M., Robbins, D. C. and Danforth, E. Jr (1984) Effects of chronic β-receptor stimulation on sympathetic nervous system activity, energy expenditure, and thyroid hormones. J. Clin. Endocrinol. Metab. 58, 895-903
77. Greenfield, J. R. and Campbell, L. V. (2008) Role of the autonomic nervous system and neuropeptides in the development of obesity in humans: targets for therapy? Curr. Pharm. Des. 14, 1815-1820
78. Julius, S., Valentini, M. and Palatini, P. (2000) Overweight and hypertension: a 2-way street? Hypertension 35, 807-813
79. Arone, L. J., Mackintosh, R., Rosenbaum, M., Leibel, R. L. and Hirsch, J. (1995) Autonomic nervous system activity in weight gain and weight loss. Am. J. Physiol. 269, R222-R225
80. Grassi, G., Seravalle, G., Colombo, M., Bolla, G., Cattaneo, B. M., Cavagnini, F. and Mancia, G. (1998) Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans. Circulation 97, 2037-2042
81. Rissanen, P., Franssila-Kallunki, A. and Rissanen, A. (2001) Cardiac parasympathetic activity is increased by weight loss in healthy obese women. Obes. Res. 9, 637-643
82. Laaksonen, D. E., Laitinen, T., Schonberg, J., Rissanen, A. and Niskanen, L. K (2003) Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome. J. Hypertens. 21, 371-378
83. Straznicky, N. E., Grima, M. T., Eikelis, N., Nestel, P. J., Dawood, T., Schlaich, M. P., Chopra, R., Masuo, K., Esler, M. D., Sari, C. I. et al. (2011) The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components. J. Clin. Endocrinol. Metab. 96, E503-508
84. al-Adsani, H., Hoffer, L. J. and Silva, J. E. (1997) Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J. Clin. Endocrinol. Metab. 82, 1118-1125
85. Bianco, A. C., Maia, A. L., da Silva, W. S. and Christoffolete, M. A. (2005) Adaptive activation of thyroid hormone and energy expenditure. Biosci. Rep. 25, 191-208
86. Mitchell, C. S., Savage, D. B., Dufour, S., Schoenmakers, N., Murgatroyd, P., Befroy, D., Halsall, D., Northcott, S., Raymond-Barker, P., Curran, S. et al. (2010) Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. J. Clin. Invest. 120, 1345-1354
87. Bianco, A. C. and Silva, J. E. (1987) Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J. Clin. Invest. 79, 295-300
88. Marine, N., Hershman, J. M., Maxwell, M. H., Dornfeld, L. P. and Schroth, P. (1991) Dietary restriction on serum thyroid hormone levels. Am. J. Med. Sci. 301, 310-313
89. Romijn, J. A., Adriaanse, R., Brabant, G., Prank, K., Endert, E. and Wiersinga, W. M. (1990) Pulsatile secretion of thyrotropin during fasting: a decrease of thyrotropin pulse amplitude. J. Clin. Endocrinol. Metab. 70, 1631-1636
90. Wadden, T. A., Mason, G., Foster, G. D., Stunkard, A. J and Prange, A. J. (1990) Effects of a very low calorie diet on weight, thyroid hormones and mood. Int. J. Obes. 14, 249-258
91. Torgerson, J. S., Carlsson, B., Stenlof, K., Carlsson, L. M., Bringman, E. and Sjostrom, L. (1999) A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans. J. Clin. Endocrinol. Metab. 84, 4197-4203
92. Kozlowska, L. and Rosolowska-Huszcz, D. (2004) Leptin, thyrotropin, and thyroid hormones in obese/overweight women before and after two levels of energy deficit. Endocrine 24, 147-153
93. O'Brian, J. T., Bybee, D. E., Burman, K. D., Osburne, R. C., Ksiazek, M. R., Wartofsky, L. and Georges, L. P. (1980) Thyroid hormone homeostasis in states of relative caloric deprivation. Metab., Clin. Exp. 29, 721-727
94. Weinsier, R. L., Nagy, T. R., Hunter, G. R., Darnell, B. E., Hensrud, D. D. and Weiss, H. L. (2000) Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Am. J. Clin. Nutr. 72, 1088-1094
95. Hukshorn, C. J., Menheere, P. P. C. A., Westerterp-Plantenga, M. S. and Saris, W. H. M. (2003) The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men. Eur. J. Endocrinol. 148, 649-655
96. Naslund, E., Andersson, I., Degerblad, M., Kogner, P., Kral, J. G., Rossner, S. and Hellstrom, P. M. (2000) Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men. J. Intern. Med. 248, 299-308
97. Doucet, E., Imbeault, P., St-Pierre, S., Almeras, N., Mauriege, P., Richard, D. and Tremblay, A. (2000) Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int. J. Obes. Relat. Metab. Disord. 24, 906-914
98. Zakrzewska, K. E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F. and Jeanrenaud, B. (1997) Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance. Diabetes 46, 717-719
99. Johnstone, A. M., Faber, P., Andrew, R., Gibney, E. R., Elia, M., Lobley, G., Stubbs, R. J. and Walker, B. R. (2004) Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men. Eur. J. Endocrinol. 150, 185-194
100. Tomiyama, A. J., Mann, T., Vinas, D., Hunger, J. M., Dejager, J. and Taylor, S. E. (2010) Low calorie dieting increases cortisol. Psychosom. Med. 72, 357-364
101. Galvao-Teles, A., Graves, L., Burke, C. W., Fotherby, K. and Fraser, R. (1976) Free cortisol in obesity; effect of fasting. Acta Endocrinol. 81, 321-329
102. Edelstein, C. K., Roy-Byrne, P., Fawzy, F. I. and Dornfeld, L. (1983) Effects of weight loss on the dexamethasone suppression test. Am. J. Psychiatry 140, 338-341
103. Ho, J. T., Keogh, J. B., Bornstein, S. R., Ehrhart-Bornstein, M., Lewis, J. G., Clifton, P. M. and Torpy, D. J. (2007) Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis function. Horm. Metab. Res. 39, 694-699
104. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T. and Collins, F. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543
105. Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P. and Baskin, D. G. (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2123
106. Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M. and Kriauciunas, A. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532
107. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J. and Bauer, T. L. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295
108. Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. and Flier, J. S. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252
109. Havel, P. J., Kasim-Karakas, S., Mueller, W., Johnson, P. R., Gingerich, R. L. and Stern, J. S. (1996) Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J. Clin. Endocrinol. Metab. 81, 4406-4413
110. Keim, N. L., Stern, J. S. and Havel, P. J. (1988) Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women. Am. J. Clin. Nutr. 68, 794-801
111. Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A. and Proietto, J. (2011) Long-term persistence of hormonal adaptations to weight loss. N. Engl. J. Med. 365, 1597-1604
112. Rosenbaum, M., Nicolson, M., Hirsch, J., Murphy, E., Chu, F. and Leibel, R. L. (1997) Effects of weight change on plasma leptin concentrations and energy expenditure. J. Clin. Endocrinol. Metab. 82, 3647-3654
113. Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P. and McCamish, M. (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA, J. Am. Med. Assoc. 282, 1568-1575
114. Westerterp-Plantenga, M. S., Saris, W. H., Hukshorn, C. J. and Campfield, L. A. (2001) Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men. Am. J. Clin. Nutr. 74, 426-434
115. Kissileff, H. R., Thornton, J. C., Torres, M. I., Pavlovich, K., Mayer, L. S., Kalari, V., Leibel, R. L. and Rosenbaum, M. (2012) Leptin reverses declines in satiation in weight-reduced obese humans. Am. J. Clin. Nutr. 95, 309-317
116. Rosenbaum, M., Sy, M., Pavlovich, K., Leibel, R. L. and Hirsch, J. (2008) Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J. Clin. Invest. 118, 2583-2591
117. Chearskul, S., Delbridge, E., Shulkes, A., Proietto, J. and Kriketos, A. (2008) Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. Am. J. Clin. Nutr. 87, 1238-1246
118. Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E. P. and Purnell, J. Q. (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346, 1623-1630
119. Essah, P. A., Levy, J. R., Sistrun, S. N., Kelly, S. M. and Nestler, J. E. (2010) Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels. Int. J. Obes. 34, 1239-1242
120. Pfluger, P. T., Kampe, J., Castaneda, T. R., Vahl, T., D'Alessio, D. A., Kruthaupt, T., Benoit, S. C., Cuntz, U., Rochlitz, H. J., Moehlig, M. et al. (2007) Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J. Clin. Endocrinol. Metab. 92, 583-588
121. Reinehr, T., de Sousa, G., Niklowitz, P. and Roth, C. L. (2007) Amylin and its relation to insulin and lipids in obese children before and after weight loss. Obesity 15, 2006-2011
122. Reinehr, T., Enriori, P. J., Harz, K., Cowley, M. A. and Roth, C. L. (2006) Pancreatic polypeptide in obese children before and after weight loss. Int. J. Obes. 30, 1476-1481
123. Adam, T. C. M., Lejeune, M. P. G. M. and Westerterp-Plantenga, M. S. (2006) Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjects. Br. J. Nutr. 95, 160-167
124. Verdich, C., Toubro, S., Buemann, B., Lysgard Madsen, J., Holst, J. J. and Astrup, A. (2001) The role of postprandial releases of insulin and incretin hormones in meal-induced satiety-effect of obesity and weight reduction. Int. J. Obes. 25, 1206-1214
125. Hauner, H., Glatting, G., Kaminska, D. and Pfeiffer, E. F. (1988) Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes. Ann. Nutr. Metab. 32, 282-288
126. Cameron, J. D., Goldfield, G. S., Cyr, M-J. and Doucet, E. (2008) The effects of prolonged caloric restriction leading to weight-loss on food hedonics and reinforcement. Physiol. Behav. 94, 474-80
127. Drewnowski, A., Brunzell, J. D., Sande, K., Iverius, P. H. and Greenwood, M. R. (1985) Sweet tooth reconsidered: taste responsiveness in human obesity. Physiol. Behav. 35, 617-622
128. Heini, A. F., Lara-Castro, C., Kirk, K. A., Considine, R. V., Caro, J. F. and Weinsier, R. L. (1998) Association of leptin and hunger-satiety ratings in obese women. Int. J. Obes. 22, 1084-1087
129. Cornier, M.-A., Salzberg, A. K., Endly, D. C., Bessesen, D. H., Rojas, D. C. and Tregellas, J. R. (2009) The effects of overfeeding on the neuronal response to visual food cues in thin and reduced-obese individuals. PLoS ONE 4, e6310
130. DelParigi, A., Chen, K., Salbe, A. D., Hill, J. O., Wing, R. R., Reiman, E. M. and Tataranni, P. A. (2004) Persistence of abnormal neural responses to a meal in postobese individuals. Int. J. Obes. 28, 370-377
131. Gordon, C. M., Dougherty, D. D., Rauch, S. L., Emans, S. J., Grace, E., Lamm, R., Alpert, N. M., Majzoub, J. A. and Fischman, A. J. (2000) Neuroanatomy of human appetitive function: A positron emission tomography investigation. Int. J. Eat. Disord. 27, 163-171
132. Malik, S., McGlone, F., Bedrossian, D. and Dagher, A. (2008) Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab. 7, 400-409
133. Baicy, K., London, E. D., Monterosso, J., Wong, M-L., Delibasi, T., Sharma, A. and Licinio, J. (2007) Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc. Nat. Acad. Sci. U.S.A. 104, 18276-18279
134. DelParigi, A., Chen, K., Salbe, A. D., Hill, J. O., Wing, R. R., Reiman, E. M. and Tataranni, P. A. (2007) Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int. J. Obes. 31, 440-448
135. Klem, M. L., Wing, R. R., McGuire, M. T., Seagle, H. M. and Hill, J. O. (1997) A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am. J. Clin. Nutr. 66, 239-246
136. Wyatt, H. R., Phelan, S., Wing, R. R. and Hill, J. O. (2005) Lessons from patients who have successfully maintained weight loss. Obesity Management 1, 56-61
137. Shick, S. M., Wing, R. R., Klem, M. L., McGuire, M. T., Hill, J. O. and Seagle, H. (1998) Persons successful at long-term weight loss and maintenance continue to consume a low-energy, low-fat diet. J. Am. Diet. Assoc. 98, 408-413
138. Gorin, A. A., Phelan, S., Wing, R. R. and Hill, J. O. (2004) Promoting long-term weight control: does dieting consistency matter? Int. J. Obes. 28, 278-281
139. Raynor, H. A., Jeffery, R. W., Phelan, S., Hill, J. O. and Wing, R. R. (2005) Amount of food group variety consumed in the diet and long-term weight loss maintenance. Obes. Res. 13, 883-890
140. Phelan, S., Roberts, M., Lang, W. and Wing, R. R. (2007) Empirical evaluation of physical activity recommendations for weight control in women. Med. Sci. Sports Exercise 39, 1832-1836
141. Raynor, D. A., Phelan, S, Hill, J. O. and Wing, R. R. (2006) Television viewing and long-term weight maintenance: results from the National Weight Control Registry. Obesity 14, 1816-1824
142. Phelan, S., Hill, J. O., Lang, W., Dibello, J. R. and Wing, R. R. (2003) Recovery from relapse among successful weight maintainers. Am. J. Clin. Nutr. 78, 1079-1084
143. Borg, C. M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G. and Aylwin, S. J. B. (2006) Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br. J. Surg. 93, 210-215
144. Dixon, A. F. R., Dixon, J. B. and O'Brien, P. E. (2005) Laparoscopic adjustable gastric banding induces prolonged satiety: a randomized blind crossover study. J. Clin. Endocrinol. Metab. 90, 813-819
145. Burton, P. R. and Brown, W. A. (2011) The mechanism of weight loss with laparoscopic adjustable gastric banding: induction of satiety not restriction. Int. J. Obes. 35 (Suppl. 3), S26-S30
146. Korner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L. and Wardlaw, S. L. (2005) Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J. Clin. Endocrinol. Metab. 90, 359-365
147. Morinigo, R., Moize, V., Musri, M., Lacy, A. M., Navarro, S., Marin, J. L., Delgado, S., Casamitjana, R. and Vidal, J. (2006) Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J. Clin. Endocrinol. Metab. 91, 1735-1740
148. Backhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F. and Gordon, J. I. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc. Nat. Acad. Sci. U.S.A. 101, 15718-15723
149. Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P. and Flint, H. J. (2008) Human colonic microbiota associated with diet, obesity and weight loss. Int. J. Obes. 32, 1720-1724
150. Ley, R. E., Turnbaugh, P. J., Klein, S. and Gordon, J. I. (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023
151. Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R. and Gordon, J. I. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031
152. Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D. and Mantzoros, C. S. (2003) The role of falling leptin levels in the neuroendocrine and metabolic adaptation to shortterm starvation in healthy men. J. Clin. Invest. 111, 1409-1421
153. Ravussin, E., Smith, S. R., Mitchell, J. A., Shringarpure, R., Shan, K., Maier, H., Koda, J. E. and Weyer, C. (2009) Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 17, 1736-1743
154. Astrup, A., Rossner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F. and Lean, M. E. J. (2009) Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374, 1606-1616
155. Greenway, F. L., Dunayevich, E., Tollefson, G., Erickson, J., Guttadauria, M., Fujioka, K. and Cowley, M. A. (2009) Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo. J. Clin. Endocrinol. Metab. 94, 4898-4906