Autonomic and hemodynamic responses to insulin in lean and obese humans

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 6, 1998, Pages 2084-2090

  Muscelli, Elza ^a,c   Emdin, Michele ^a   Natali, Andrea ^a   Pratali, Lorenza ^a   Camastra, Stefania ^a   Gastaldelli, Amalia ^a   Baldi, Simona ^a   Carpeggiani, Clara ^a   Ferrannini, Ele ^a,b  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BODY FAT; CLINICAL ARTICLE; FEMALE; HEART OUTPUT; HEART RATE VARIABILITY; HEMODYNAMIC MONITORING; HUMAN; HYPERINSULINEMIA; INSULIN METABOLISM; MALE; OBESITY; PRIORITY JOURNAL; SINUS NODE; SINUS NODE DISEASE; VASCULAR RESISTANCE;

ADULT; AUTONOMIC NERVOUS SYSTEM; BODY MASS INDEX; CARDIAC OUTPUT; CORTICOTROPIN-RELEASING HORMONE; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMIC PROCESSES; HUMAN GROWTH HORMONE; HUMANS; HYPERINSULINISM; INSULIN; KINETICS; MALE; OBESITY; STROKE VOLUME; THYROTROPIN; VASCULAR RESISTANCE;

EID: 0031765282     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.6.2084     Document Type: Article

References (56)

1. Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. 1981 Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes. 30:219-225.
2. Baron AD, Brechtel-Hook G, Johnson A, Hardin D. 1993 Skeletal muscle blood flow: a possible link between insulin resistance and blood pressure. Hypertension. 21:129-135.
3. Baron AD. 1993 Cardiovascular actions of insulin in humans. Implications for insulin sensitivity and vascular tone. Bailliere's Clin Endocrinol Metab. 7:961-987.
4. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. 1991 Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest. 87:2246-2252.
5. Berne C, Fagius J, Pollare T, Hjemdahl P. 1992 The sympatehtic response to euglycaemic hyperinsulinaemia: evidence from microelectrode nerve recordings in healthy subjects. Diabetologia. 35:873-879.
6. Fagius J, Niklasson F, Berne C. 1986 Sympathetic outflow in human muscle nerves increases during hypoglycemia. Diabetes. 35:1124-1129.
7. Landsberg L. 1986 Diet, obesity and hypertension: a hypothesis involving insulin, the sympathetic nervous system and adaptive thermogenesis. QJ Med. 236:1081-1090.
8. Davis SN, Colburn C, Robbins R, et al. 1995 Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest. 95:593-602.
9. Frohlich ED. 1991 Obesity and hypertension: hemodynamic aspects. Ann Epidemiol. 1:287-293.
10. De Haven J, Sherwin R, Hendler R, Felig P. 1980 Nitrogen and sodium balance and sympathetic nervous system activity in obese subjects treated with a low-caloric protein or mixed diet. N Engl J Med. 302:477-482.
11. Sowers JR, Whitfield LA, Catania RA, et al. 1982 Role of the sympatehtic nervous system in blood pressure maintenance in obesity. J Clin Endocrinol Metab. 54:1181-1187.
12. Scherrer U, Randin D, Tappy L, Vollenweider P, Jéquier E, Nicod P. 1994 Body fat and sympathetic nerve activity in healthy subjects. Circulation. 89:2634-2640.
13. Grassi G, Serravalle G, Cattaneo BM, Bolla GB, Lanfranchi A, Colombo M, Giannattasio C, Brunani A, Cavagnini F, Mancia G. 1995 Sympathetic activation in obese normotensive subjects. Hypertension. 25:560-563.
14. Lissner L, Odell PM, D'Agostino RB, Stokes J, Kreger BE, Belanger AJ, Brownell KD. 1991 Variability of body weight and health outcomes in the Framingham population. N Engl J Med. 315:1839-1844.
15. Burton BT, Foste WR, Hirsch J, Van Itallie TB. 1985 Health implications of obesity: an NIH consensus development conference. Int J Obes. 9:155-169.
16. Tuck ML. 1992 Obesity, the sympathetic nervous system, and essential hypertension. Hypertension. 19[Suppl I]:I67-I77.
17. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Malliani A. 1986 Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 59:178-193.
18. National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
19. Fulcher GR, Farrer M, Walker M, Rodham D, Clayton B, Alberti KGMM. 1991 A comparison of measurements of lean body mass derived by bioeletrical impedance, skinfold thickness and total body potassium. A study in obese and non-obese normal subjects. Scand J Lab Invest. 51:245-253.
20. DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E233.
21. McGuire EAH, Heldermann JH, Tobin JD, Andres R, Berman M. 1976 Effects of arterial vs. venous sampling on analysis of glucose kinetics in man. J Appl Physiol. 41:1312-1318.
22. Otterstad JE, Simonse S, Myhre E. 1984 Determination of cardiac output by Doppler echocardiography. Br Heart J. 51:54-60.
23. Taddei A, Marchesi C, Landucci L. 1984 Performance comparison of fast QRS detection algorithms. In: Marchesi C, ed. Ambulatory monitoring. The Hague: Martinus Nijhoff Publishers; 189-207.
24. Cerutti S, Baselli G, Liberati D. 1984 Autoregressive filtering in heart rate variability signal. In: Cappellini V, Constantinides AG, eds. Digital signal processing. Amsterdam: Elsevier S.P.B.V.; 679-683.
25. Durbin J. 1960 The fitting of time series models. Rev Inst Int Statist. 28:233-237.
26. Johnsen SJ, Andersen N. 1978 On power estimation in maximum entropy spectral analysis. Geophysics. 43:681-685.
27. Balocchi R, Macerata A, Carpeggiani C, Emdin M, Benassi A, L' Abbate A. 1988 A spectral approach for the heart rate fluctuations. Math Comput Mod. 10:799-805.
28. Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ. 1981 Power spectrum analysis of heart rate fluctuation: a quantitative prob of beat-to-beat cardiovascular control. Science. 213:220-223.
29. Pagani M, Lombardi F, Guzzetti S, et al. 1986 Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 59:178-193.
30. Malliani A, Pagani M, Lombardi F, Cerutti S. 1991 Cardiovascular neural regulation explored in the frequency domain Circulation. 84:481-192.
31. Task Force of the European Society of Cardiology, and the North American Society of Pacing and Electrophysiology. 1996 Heart rate variability. Standards of measurements, physiological interpretation and clinical use. Circulation. 93:1043-1065.
32. Pinciroli G, Rossi R, Vergani L. 1985 Detection of electrical axis variation for the extraction of respiratory information. Comput Cardiol. 11:499-502.
33. Perraglia F, Sawchenko PE, Rivier J, Vale W. 1987 Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature. 328:717-719.
34. Zierler KL, Rogus EM. 1980 Hyperpolarization as a mediator of insulin action: increased muscle glucose uptake induced electrically. Am J Physiol. 239:E21-E29.
35. Saum WR, Brown AM, Tuley FH. 1976 An electrogenic sodium pump and baroreceptor function in normotensive and spontaneously hypertensive rats. Circ Res. 39:497-505.
36. + pump. Am J Physiol. 247:H833-H839.
37. Wang W, Chen J-S, Zucker IH. 1990 Carotid sinus baroreceptor sensitivity in experimental heart failure. Circulation. 81:1959-1966.
38. + exchange by insulin in the human forearm. Am J Physiol. 255:E953-E958.
39. Chapleau MW, Cunningham JT, Sullivan MJ, Wachtel RE, Abboud FM. 1995 Structural vs. functional modulation of the arterial baroreflex. Hypertension. 26:341-347.
40. Shapiro E, Brown SD, Saltiel AR, Schwartz JH. 1991 Short-term action of insulin on Aplysia neurons: generation of a novel modulator of ion channels. J Neurobiol. 22:55-62.
41. Parati G, Saul JP, Di Rienzo M, Mancia G. 1995 Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal. Hypertension. 25:1276-1286.
42. Baron AD, Brechtel G. 1993 Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol. 265:E61-E67.
43. Catalano C, Muscelli E, Quiñones Galvan A, et al. 1997 Effect of insulin on systemic and renal albumin handling in nondiabetic and NIDDM subjects. Diabetes. 46:868-875.
44. Davis SN, Tarumi C, Dobbins R, Neal D, Cherrington AD. 1992 The effect of differing insulin levels on the counter-regulatory response to equivalent hypoglycemia in conscious dogs. Am J Physiol. 263:E688-E695.
45. Frizzel RT, Henrick G, Biggers D, et al. 1988 Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes. 37:749-759.
46. Chrousos GP, Gold PW. 1992 The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 267:1244-1252.
47. Orth DN. 1992 Corticotropin-releasing hormone in humans. Endocr Rev. 3:164-191.
48. Watabe T, Tanaka K, Kumagae M, et al. 1987 Hormonal responses to insulin-induced hypoglycemia in man. J Clin Endocrinol Metab. 65:1187-1193.
49. Schwartz MW, Figlewicz DP, Baskin DB, Woods SC, Porte Jr D. 1992 Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev. 13:81-113.
50. Scherrer U, Vollenweider P, Randin D, Jéquier E, Nicod P, Tappy L. 1993 Suppression of insulin-induced sympathetic activation and vasodilation by dexamethazone in humans. Circulation. 88:388-394.
51. Yamasaki Y, Kodama M, Matsuhisa M, et al. 1996 Diurnal heart rate variability in healthy subjects: effects of aging and sex difference. Am J Physiol. 271:H303-H310.
52. Vollenweider P, Randin D, Tappy L, Jéquier E, Nicod P, Scherrer U. 1994 Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest. 93:2365-2371.
53. Pagani M, Montano N, Porta A, et al. 1997 Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation. 95:1441-1448.
54. Gudbjörnsdottir S, Friberg P, Elam M, Attvall S, Lönnroth P, Wallin BG. 1994 The effect of metformin and insulin on sympathetic nerve activity, norepinephrine spillover and blood pressure in obese, insulin resistant, normoglycemic, hypertensive men. Blood Press. 3:394-403.
55. Gordon T, Kannel WB. 1976 Obesity and cardiovascular disease: the Framingham study. Clin Endocrinol Metab. 5:367-375.
56. Messerli FH, Numez BD, Ventura HO, Snyder DW. 1987 Overweight and sudden death. Arch Intern Med. 147:1725-1728.