Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia

Journal of Clinical Investigation

Volumn 120, Issue 4, 2010, Pages 1345-1354

  Mitchell, Catherine S ^a   Savage, David B ^a   Dufour, Sylvie ^b   Schoenmakers, Nadia ^a   Murgatroyd, Peter ^a   Befroy, Douglas ^b   Halsall, David ^c   Northcott, Samantha ^a   Raymond Barker, Philippa ^a   Curran, Suzanne ^a   Henning, Elana ^a   Keogh, Julia ^a   Owen, Penny ^c   Lazarus, John ^c   Rothman, Douglas L ^b   Farooqi, I Sadaf ^a   Shulman, Gerald I ^b   Chatterjee, Krishna ^a   Petersen, Kitt Falk ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; THYROID HORMONE RECEPTOR BETA;

ADULT; ARTICLE; CALORIC INTAKE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL FUNCTION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENERGY YIELD; FEMALE; GENE MUTATION; HUMAN; HYPERPHAGIA; MAJOR CLINICAL STUDY; MALE; MUSCLE MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; THYROID HORMONE RESISTANCE; VISUAL ANALOG SCALE;

ADENOSINE TRIPHOSPHATE; ADULT; CHILD; CITRIC ACID CYCLE; EATING; ENERGY METABOLISM; HUMANS; HYPERPHAGIA; INSULIN RESISTANCE; MIDDLE AGED; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; THYROID HORMONE RECEPTORS BETA; THYROID HORMONE RESISTANCE SYNDROME;

EID: 77951199380     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI38793     Document Type: Article

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