The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men

European Journal of Endocrinology

Volumn 148, Issue 6, 2003, Pages 649-655

  Hukshorn, Chris J ^b   Menheere, Paul P C A ^a   Westerterp Plantenga, Margriet S ^b   Saris, Wim H M ^b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CORTICOTROPIN; FOLLITROPIN; GROWTH HORMONE; HYDROCORTISONE; LEPTIN; LUTEINIZING HORMONE; PLACEBO; PROLACTIN; RECOMBINANT LEPTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROID HORMONE; THYROTROPIN;

ADAPTATION; ADRENERGIC ACTIVITY; ADULT; ARTICLE; CALORIC RESTRICTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; HORMONE DETERMINATION; HORMONE INHIBITION; HUMAN; HYPOTHESIS; LOW CALORY DIET; MALE; NEUROENDOCRINOLOGY; OBESITY; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STARVATION; TREATMENT OUTCOME; URINALYSIS; WEIGHT REDUCTION;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ADULT; ENERGY INTAKE; ENERGY METABOLISM; HORMONES; HUMANS; LEPTIN; LINEAR MODELS; MALE; MIDDLE AGED; OBESITY; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; STARVATION; WEIGHT LOSS;

EID: 0038544687     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1480649     Document Type: Article

References (33)

1. Schwartz MW, Dallman MF & Woods SC. Hypothalamic response to starvation: implications for the study of wasting disorders. American Journal of Physiology 1995 269 R949-R957.
2. Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. Journal of Clinical Endocrinology and Metabolism 1998 83 1407-1413.
3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994 372 425-432.
4. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995 269 543-546.
5. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995 269 540-543.
6. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 1996 334 292-295.
7. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos Flier E et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996 382 250-252.
8. Boden G, Chen X, Mozzoli M & Ryan I. Effect of fasting on serum leptin in normal human subjects. Journal of Clinical Endocrinology and Metabolism 1996 81 3419-3423.
9. Legradi G, Emerson CH, Ahima RS, Flier JS & Lechan RM. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997 138 2569-2576.
10. Finn PD, Cunningham MJ, Pau KY, Spies HG, Clifton DK & Steiner RA. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. Endocrinology 1998 139 4652-4662.
11. Lado Abeal J, Lukyanenko YO, Swamy S, Hermida RC, Hutson JC & Norman RL. Short-term leptin infusion does not affect circulating levels of LH, testosterone or cortisol in food-restricted pubertal male rhesus macaques. Clinical Endocrinology 1999 51 41-51.
12. Lado Abeal J, Hickox JR, Cheung TL, Veldhuis JD, Hardy DM & Norman RL. Neuroendocrine consequences of fasting in adult male macaques: effects of recombinant rhesus macaque leptin infusion. Neuroendocrinology 2000 71 196-208.
13. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T et al. Recombinant leptin for weight loss in obese and lean adults-A randomized, controlled, dose-escalation trial. Journal of the American Medical Association 1999 282 1568-1575.
14. Nucci ML, Shorr R & Abuchoweski A. The therapeutic value of poly(ethylene-glycol)-modified proteins. Advanced Drug Delivery Reviews 1991 6 133-151.
15. Kahler A, Geary N, Eckel LA, Campfield LA, Smith FJ & Langhans W. Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats. American Journal of Physiology 1998 275 R180-R185.
16. Hukshorn CJ, Saris WHM, Westerterp Plantenga MS, Farid AR, Smith FJ & Campfield LA. Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men. Journal of Clinical Endocrinology and Metabolism 2000 85 4003-4009.
17. Swinkels LM, Ross HA & Benraad TJ. A symmetric dialysis method for the determination of free testosterone in human plasma. Clinica Chimica Acta 1987 165 341-349.
18. Swinkels LM, Meulenberg PM, Ross HA & Benraad TJ. Salivary and plasma free testosterone and androstenedione levels in women using oral contraceptives containing desogestrel or levonorgestrel. Annals of Clinical Biochemistry 1988 25 354-359.
19. Dunn JF, Nisula BC & Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Journal of Clinical Endocrinology and Metabolism 1981 53 58-68.
20. Hukshorn CJ, Westerterp Plantenga MS & Saris WHM. Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severe energy-restricted overweight men. American Journal of Clinical Nutrition 2003 77 771-776.
21. Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez Lopez LE & Askew EW. Endocrine markers of semi-starvation in healthy lean men in a multistressor environment. Journal of Applied Physiology 2000 88 1820-1830.
22. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE & Leibel RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. Journal of Clinical Endocrinology and Metabolism 2002 87 2391-2394.
23. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997 387 903-908.
24. Ozata M, Ozdemir IC & Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. Journal of Clinical Endocrinology and Metabolism 1999 84 3686-3695.
25. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998 392 398-401.
26. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 1999 341 879-884.
27. Oral EA, Ruiz E, Andewelt A, Sebring N, Wagner AJ, Depaoli AM et al. Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. Journal of Clinical Endocrinology and Metabolism 2002 87 3110-3117.
28. Himms Hagen J. Physiological roles of the leptin endocrine system: differences between mice and humans. Critical Reviews in Clinical Laboratory Sciences 1999 36 575-655.
29. Hileman SM, Pierroz DD & Flier JS. Leptin, nutrition, and reproduction: timing is everything. Journal of Clinical Endocrinology and Metabolism 2000 85 804-807.
30. Hamilton GD & Bronson FH. Food restriction and reproductive development: male and female mice and male rats. American Journal of Physiology 1986 250 R370-R376.
31. Lado-Abeal J, Prieto D, Lorenzo M, Lojo S, Febrero M, Camarero E et al. Differences between men and women as regards the effects of protein-energy malnutrition on the hypothalamic-pituitary-gonadal axis. Nutrition 1999 15 351-358.
32. Yu WH, Kimura M, Walczewska A, Karanth S & McCann SM. Role of leptin in hypothalamic-pituitary function. PNAS 1997 94 1023-1028.
33. Ahima RS, Kelly J, Elmquist JK & Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology 1999 140 4923-4931.