Cerebral network disorders after stroke: Evidence from imaging-based connectivity analyses of active and resting brain states in humans

Journal of Physiology

Volumn 591, Issue 1, 2013, Pages 17-31

  Rehme, Anne K ^a   Grefkes, Christian ^a,b  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BOLD SIGNAL; BRAIN DAMAGE; BRAIN REGION; CEREBROVASCULAR ACCIDENT; DEMYELINATION; DISEASE ASSOCIATION; FUNCTIONAL ANATOMY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMISPHERE; HEMODYNAMICS; HUMAN; MOTOR DYSFUNCTION; NERVE CELL NETWORK; NERVE CONDUCTION; NEUROANATOMY; NEUROIMAGING; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SENSORIMOTOR FUNCTION; STRUCTURAL EQUATION MODELING;

ANIMALS; BRAIN; HUMANS; NEURAL PATHWAYS; NEUROIMAGING; STROKE;

EID: 84872011725     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.243469     Document Type: Article

References (127)

1. Achard S & Bullmore E (2007). Efficiency and cost of economical brain functional networks. PLoS Comput Biol 3, e17.
2. Achard S, Salvador R, Whitcher B, Suckling J & Bullmore E (2006). A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci 26, 63-72.
3. Alstott J, Breakspear M, Hagmann P, Cammoun L & Sporns O (2009). Modeling the impact of lesions in the human brain. PLoS Comput Biol 5, e1000408.
4. Andrews RJ (1991). Transhemispheric diaschisis. A review and comment. Stroke 22, 943-949.
5. Beharelle AR, Kovacevic N, McIntosh AR & Levine B (2012). Brain signal variability relates to stability of behaviour after recovery from diffuse brain injury. Neuroimage 60, 1528-1537.
6. Biswal B, Yetkin FZ, Haughton VM & Hyde JS (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34, 537-541.
7. Bodegard A, Geyer S, Herath P, Grefkes C, Zilles K & Roland PE (2003). Somatosensory areas engaged during discrimination of steady pressure, spring strength, and kinesthesia. Hum Brain Mapp 20, 103-115.
8. Bonakdarpour B, Parrish TB & Thompson CK (2007). Hemodynamic response function in patients with stroke-induced aphasia: implications for fMRI data analysis. Neuroimage 36, 322-331.
9. Bradnam LV, Stinear CM, Barber PA & Byblow WD (2011). Contralesional hemisphere control of the proximal paretic upper limb following stroke. Cereb Cortex 22, 2662-2671.
10. Buch ER, Modir SA, Fourkas AD, Weber C, Birbaumer N & Cohen LG (2012). Parietofrontal integrity determines neural modulation associated with grasping imagery after stroke. Brain 135, 596-614.
11. Bullmore E & Sporns O (2009). Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10, 186-198.
12. Buxton RB, Wong EC & Frank LR (1998). Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39, 855-864.
13. Calautti C, Leroy F, Guincestre JY & Baron JC (2001). Dynamics of motor network overactivation after striatocapsular stroke: a longitudinal PET study using a fixed-performance paradigm. Stroke 32, 2534-2542.
14. Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB & Wolf PA (2006). Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA 296, 2939-2946.
15. Carmichael ST (2003). Plasticity of cortical projections after stroke. Neuroscientist 9, 64-75.
16. Carmichael ST (2006). Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 59, 735-742.
17. Carmichael ST & Chesselet MF (2002). Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult. J Neurosci 22, 6062-6070.
18. Carmichael ST, Wei L, Rovainen CM & Woolsey TA (2001). New patterns of intracortical projections after focal cortical stroke. Neurobiol Dis 8, 910-922.
19. Carter AR, Astafiev SV, Lang CE, Connor LT, Rengachary J, Strube MJ, Pope DL, Shulman GL & Corbetta M (2010). Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke. Ann Neurol 67, 365-375.
20. Carter AR, Patel KR, Astafiev SV, Snyder AZ, Rengachary J, Strube MJ, Pope A, Shimony JS, Lang CE, Shulman GL & Corbetta M (2012). Upstream dysfunction of somatomotor functional connectivity after corticospinal damage in stroke. Neurorehabil Neural Repair 26, 7-19.
21. Chollet F, DiPiero V, Wise RJ, Brooks DJ, Dolan RJ & Frackowiak RS (1991). The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol 29, 63-71.
22. Cramer SC (2008). Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery. Ann Neurol 63, 272-287.
23. Culham JC, Cavina-Pratesi C & Singhal A (2006). The role of parietal cortex in visuomotor control: what have we learned from neuroimaging Neuropsychologia 44, 2668-2684.
24. Dafotakis M, Grefkes C, Wang L, Fink GR & Nowak DA (2008). The effects of 1 Hz rTMS over the hand area of M1 on movement kinematics of the ipsilateral hand. J Neural Transm 115, 1269-1274.
25. Damoiseaux JS & Greicius MD (2009). Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct 213, 525-533.
26. Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM & Beckmann CF (2006). Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A 103, 13848-13853.
27. Dancause N, Barbay S, Frost SB, Plautz EJ, Chen D, Zoubina EV, Stowe AM & Nudo RJ (2005). Extensive cortical rewiring after brain injury. J Neurosci 25, 10167-10179.
28. Deco G, Jirsa VK & McIntosh AR (2011). Emerging concepts for the dynamical organization of resting-state activity in the brain. Nat Rev Neurosci 12, 43-56.
29. Dubovik S, Pignat JM, Ptak R, Aboulafia T, Allet L, Gillabert N, Magnin C, Albert F, Momjian-Mayor I, Nahum L, Lascano AM, Michel CM, Schnider A, Guggisberg AG (2012). The behavioral significance of coherent resting-state oscillations after stroke. Neuroimage 61, 249-257.
30. Dum RP & Strick PL (2002). Motor areas in the frontal lobe of the primate. Physiol Behav 77, 677-682.
31. Dum RP & Strick PL (2005). Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere. J Neurosci 25, 1375-1386.
32. Duncan PW, Goldstein LB, Horner RD, Landsman PB, Samsa GP & Matchar DB (1994). Similar motor recovery of upper and lower extremities after stroke. Stroke 25, 1181-1188.
33. Duque J, Hummel F, Celnik P, Murase N, Mazzocchio R & Cohen LG (2005). Transcallosal inhibition in chronic subcortical stroke. Neuroimage 28, 940-946.
34. Eickhoff SB, Grefkes C, Fink GR & Zilles K (2008). Functional lateralization of face, hand, and trunk representation in anatomically defined human somatosensory areas. Cereb Cortex 18, 2820-2830.
35. Fox MD & Raichle ME (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8, 700-711.
36. Frackowiak RS & Friston KJ (1994). Functional neuroanatomy of the human brain: positron emission tomography-a new neuroanatomical technique. J Anat 184, 211-225.
37. Fregni F, Boggio PS, Mansur CG, Wagner T, Ferreira MJ, Lima MC, Rigonatti SP, Marcolin MA, Freedman SD, Nitsche MA & Pascual-Leone A (2005). Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport 16, 1551-1555.
38. Friston K (2002). Functional integration and inference in the brain. Prog Neurobiol 68, 113-143.
39. Friston KJ (1994). Functional and effective connectivity in neuroimaging: a synthesis. Hum Brain Mapp 2, 56-78.
40. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E & Dolan RJ (1997). Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6, 218-229.
41. Friston KJ, Frith CD, Liddle PF & Frackowiak RS (1993). Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab 13, 5-14.
42. Friston KJ, Harrison L & Penny W (2003). Dynamic causal modelling. Neuroimage 19, 1273-1302.
43. Friston KJ, Mechelli A, Turner R & Price CJ (2000). Nonlinear responses in fMRI: the Balloon model, Volterra kernels, and other hemodynamics. Neuroimage 12, 466-477.
44. Gates KM, Molenaar PC, Hillary FG & Slobounov S (2011). Extended unified SEM approach for modelling event-related fMRI data. Neuroimage 54, 1151-1158.
45. Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG & Hallett M (2006). Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 129, 791-808.
46. Grefkes C, Eickhoff SB, Nowak DA, Dafotakis M & Fink GR (2008a). Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM. Neuroimage 41, 1382-1394.
47. Grefkes C & Fink GR (2005). The functional organization of the intraparietal sulcus in humans and monkeys. J Anat 207, 3-17.
48. Grefkes C & Fink GR (2011). Reorganization of cerebral networks after stroke: new insights from neuroimaging using connectivity approaches. Brain. 134, 1264-1276.
49. Grefkes C, Nowak DA, Eickhoff SB, Dafotakis M, Kust J, Karbe H & Fink GR (2008b). Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging. Ann Neurol 63, 236-246.
50. Grefkes C, Nowak DA, Wang LE, Dafotakis M, Eickhoff SB & Fink GR (2010). Modulating cortical connectivity in stroke patients by rTMS assessed with fMRI and dynamic causal modelling. Neuroimage 50, 233-242.
51. He BJ, Snyder AZ, Vincent JL, Epstein A, Shulman GL & Corbetta M (2007). Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect. Neuron 53, 905-918.
52. Heeger DJ & Ress D (2002). What does fMRI tell us about neuronal activity Nat Rev Neurosci 3, 142-151.
53. Heuschmann PU, Wiedmann S, Wellwood I, Rudd A, Di CA, Bejot Y, Ryglewicz D, Rastenyte D & Wolfe CD (2011). Three-month stroke outcome: the European Registers of Stroke (EROS) investigators. Neurology 76, 159-165.
54. Honey CJ, Kotter R, Breakspear M & Sporns O (2007). Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci USA 104, 10240-10245.
55. Honey CJ & Sporns O (2008). Dynamical consequences of lesions in cortical networks. Hum Brain Mapp 29, 802-809.
56. Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R & Hagmann P (2009). Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A 106, 2035-2040.
57. Horwitz B, Rumsey JM & Donohue BC (1998). Functional connectivity of the angular gyrus in normal reading and dyslexia. Proc Natl Acad Sci U S A 95, 8939-8944.
58. Hoshi E & Tanji J (2004). Differential roles of neuronal activity in the supplementary and presupplementary motor areas: from information retrieval to motor planning and execution. J Neurophysiol 92, 3482-3499.
59. Hoshi E & Tanji J (2007). Distinctions between dorsal and ventral premotor areas: anatomical connectivity and functional properties. Curr Opin Neurobiol 17, 234-242.
60. Inman CS, James GA, Hamann S, Rajendra JK, Pagnoni G & Butler AJ (2012). Altered resting-state effective connectivity of fronto-parietal motor control systems on the primary motor network following stroke. Neuroimage 59, 227-237.
61. James GA, Lu ZL, VanMeter JW, Sathian K, Hu XP & Butler AJ (2009). Changes in resting state effective connectivity in the motor network following rehabilitation of upper extremity poststroke paresis. Top Stroke Rehabil 16, 270-281.
62. Jenkins IH, Jahanshahi M, Jueptner M, Passingham RE & Brooks DJ (2000). Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow. Brain 123, 1216-1228.
63. Johnson PB, Ferraina S, Bianchi L & Caminiti R (1996). Cortical networks for visual reaching: physiological and anatomical organization of frontal and parietal lobe arm regions. Cereb Cortex 6, 102-119.
64. Kwakkel G, Kollen B & Lindeman E (2004). Understanding the pattern of functional recovery after stroke: facts and theories. Restor Neurol Neurosci 22, 281-299.
65. Kwakkel G, Kollen B & Twisk J (2006). Impact of time on improvement of outcome after stroke. Stroke 37, 2348-2353.
66. Lauritzen M & Gold L (2003). Brain function and neurophysiological correlates of signals used in functional neuroimaging. J Neurosci 23, 3972-3980.
67. Lemon RN (2008). Descending pathways in motor control. Annu Rev Neurosci 31, 195-218.
68. Logothetis NK (2002). The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philos Trans R Soc Lond B Biol Sci 357, 1003-1037.
69. Lotze M, Markert J, Sauseng P, Hoppe J, Plewnia C & Gerloff C (2006). The role of multiple contralesional motor areas for complex hand movements after internal capsular lesion. J Neurosci 26, 6096-6102.
70. Loubinoux I, Carel C, Pariente J, Dechaumont S, Albucher JF, Marque P, Manelfe C & Chollet F (2003). Correlation between cerebral reorganization and motor recovery after subcortical infarcts. Neuroimage 20, 2166-2180.
71. Loubinoux I, Dechaumont-Palacin S, Castel-Lacanal E, De B, X, Marque P, Pariente J, Albucher JF, Berry I & Chollet F (2007). Prognostic value of FMRI in recovery of hand function in subcortical stroke patients. Cereb Cortex 17, 2980-2987.
72. Lu J, Liu H, Zhang M, Wang D, Cao Y, Ma Q, Rong D, Wang X, Buckner RL & Li K (2011). Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways. J Neurosci 31, 15065-15071.
73. Luppino G, Matelli M, Camarda R & Rizzolatti G (1993). Corticocortical connections of area F3 (SMA-proper) and area F6 (pre-SMA) in the macaque monkey. J Comp Neurol 338, 114-140.
74. McIntosh AR & Gonzalez-Lima F (1991). Structural modelling of functional neural pathways mapped with 2-deoxyglucose: effects of acoustic startle habituation on the auditory system. Brain Res 547, 295-302.
75. McIntosh AR, Kovacevic N & Itier RJ (2008). Increased brain signal variability accompanies lower behavioral variability in development. PLoS Comput Biol 4, e1000106.
76. McIntosh A & Gonzalez-Lima F (1994). Structural equation modelling and its application in network analysis in functional brain imaging. Hum Brain Mapp 2, 2-22.
77. Marshall RS, Zarahn E, Alon L, Minzer B, Lazar RM & Krakauer JW (2009). Early imaging correlates of subsequent motor recovery after stroke. Ann Neurol 65, 596-602.
78. Mazzetto-Betti KC, Leoni RF, Pontes-Neto OM, Santos AC, Leite JP, Silva AC & de Araujo DB (2010). The stability of the blood oxygenation level-dependent functional MRI response to motor tasks is altered in patients with chronic ischemic stroke. Stroke 41, 1921-1926.
79. Middleton FA & Strick PL (2000). Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res Brain Res Rev 31, 236-250.
80. Murase N, Duque J, Mazzocchio R & Cohen LG (2004). Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol 55, 400-409.
81. Napieralski JA, Butler AK & Chesselet MF (1996). Anatomical and functional evidence for lesion-specific sprouting of corticostriatal input in the adult rat. J Comp Neurol 373, 484-497.
82. Nowak DA, Grefkes C, Dafotakis M, Eickhoff S, Kust J, Karbe H & Fink GR (2008). Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke. Arch Neurol 65, 741-747.
83. Nudo RJ (2006). Mechanisms for recovery of motor function following cortical damage. Curr Opin Neurobiol 16, 638-644.
84. Ogawa S, Lee TM, Kay AR & Tank DW (1990). Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87, 9868-9872.
85. Park CH, Chang WH, Ohn SH, Kim ST, Bang OY, Pascual-Leone A & Kim YH (2011). Longitudinal changes of resting-state functional connectivity during motor recovery after stroke. Stroke 42, 1357-1362.
86. Penny WD, Stephan KE, Mechelli A & Friston KJ (2004). Comparing dynamic causal models. Neuroimage 22, 1157-1172.
87. Phelps ME, Kuhl DE & Mazziota JC (1981). Metabolic mapping of the brain's response to visual stimulation: studies in humans. Science 211, 1445-1448.
88. Que M, Schiene K, Witte OW & Zilles K (1999). Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain. Neurosci Lett 273, 77-80.
89. A-receptor subtypes after focal cortical infarcts in rats: mediation by NMDA-dependent processes. J Cereb Blood Flow Metab 22, 1463-1475.
90. Rehme AK, Eickhoff SB, Rottschy C, Fink GR & Grefkes C (2012). Activation likelihood estimation meta-analysis of motor-related neural activity after stroke. Neuroimage 59, 2771-2782.
91. Rehme AK, Eickhoff SB, Wang LE, Fink GR & Grefkes C (2011a). Dynamic causal modelling of cortical activity from the acute to the chronic stage after stroke. Neuroimage 55, 1147-1158.
92. Rehme AK, Fink GR, von Cramon DY & Grefkes C (2011b). The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal FMRI. Cereb Cortex 21, 756-768.
93. Ridderinkhof KR, Van Den Wildenberg WP, Segalowitz SJ & Carter CS (2004). Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain Cogn 56, 129-140.
94. Roebroeck A, Formisano E & Goebel R (2005). Mapping directed influence over the brain using Granger causality and fMRI. Neuroimage 25, 230-242.
95. Rouiller EM, Babalian A, Kazennikov O, Moret V, Yu XH & Wiesendanger M (1994). Transcallosal connections of the distal forelimb representations of the primary and supplementary motor cortical areas in macaque monkeys. Exp Brain Res 102, 227-243.
96. Rubinov M & Sporns O (2010). Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52, 1059-1069.
97. Schaechter JD, Perdue KL & Wang R (2008). Structural damage to the corticospinal tract correlates with bilateral sensorimotor cortex reorganization in stroke patients. Neuroimage 39, 1370-1382.
98. A-receptor expression in the surround of cerebral photothrombosis. J Cereb Blood Flow Metab 16, 906-914.
99. Schubotz RI & von Cramon DY (2003). Functional-anatomical concepts of human premotor cortex: evidence from fMRI and PET studies. Neuroimage 20, S120-S131.
100. Schuyler B, Ollinger JM, Oakes TR, Johnstone T & Davidson RJ (2010). Dynamic Causal Modeling applied to fMRI data shows high reliability. Neuroimage 49, 603-611.
101. Shafi MM, Westover MB, Fox MD & Pascual-Leone A (2012). Exploration and modulation of brain network interactions with noninvasive brain stimulation in combination with neuroimaging. Eur J Neurosci 35, 805-825.
102. Sharma N, Baron JC & Rowe JB (2009). Motor imagery after stroke: relating outcome to motor network connectivity. Ann Neurol 66, 604-616.
103. Shehzad Z, Kelly AM, Reiss PT, Gee DG, Gotimer K, Uddin LQ, Lee SH, Margulies DS, Roy AK, Biswal BB, Petkova E, Castellanos FX & Milham MP (2009). The resting brain: unconstrained yet reliable. Cereb Cortex 19, 2209-2229.
104. Sporns O, Honey CJ & Kotter R (2007). Identification and classification of hubs in brain networks. PLoS One 2, e1049.
105. Sporns O, Tononi G & Kotter R (2005). The human connectome: A structural description of the human brain. PLoS Comput Biol 1, e42.
106. Stephan KE, Harrison LM, Kiebel SJ, David O, Penny WD & Friston KJ (2007). Dynamic causal models of neural system dynamics: current state and future extensions. J Biosci 32, 129-144.
107. Stinear CM, Barber PA, Smale PR, Coxon JP, Fleming MK & Byblow WD (2007). Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain 130, 170-180.
108. Strick PL & Kim CC (1978). Input to primate motor cortex from posterior parietal cortex (area 5). I. Demonstration by retrograde transport. Brain Res 157, 325-330.
109. Takeuchi N, Chuma T, Matsuo Y, Watanabe I & Ikoma K (2005). Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke. Stroke 36, 2681-2686.
110. Talelli P, Wallace A, Dileone M, Hoad D, Cheeran B, Oliver R, Vandenbos M, Hammerbeck U, Barratt K, Gillini C, Musumeci G, Boudrias MH, Cloud GC, Ball J, Marsden JF, Ward NS, Di L, V, Greenwood RG & Rothwell JC (2012). Theta burst stimulation in the rehabilitation of the upper limb: a semirandomized, placebo-controlled trial in chronic stroke patients. Neurorehabil Neural Repair 26, 976-987.
111. Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW & Jacobson MF (1996). Lifetime cost of stroke in the United States. Stroke 27, 1459-1466.
112. Tokuno H & Tanji J (1993). Input organization of distal and proximal forelimb areas in the monkey primary motor cortex: a retrograde double labelling study. J Comp Neurol 333, 199-209.
113. Van Dijk KR, Hedden T, Venkataraman A, Evans KC, Lazar SW & Buckner RL (2010). Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol 103, 297-321.
114. van Meer MP, Otte WM, van der Marel K, Nijboer CH, Kavelaars A, van der Sprenkel JW, Viergever MA & Dijkhuizen RM (2012). Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J Neurosci 32, 4495-4507.
115. van Meer MP, Van Der Marel K, Wang K, Otte WM, El BS, Roeling TA, Viergever MA, Berkelbach van der Sprenkel JW & Dijkhuizen RM (2010). Recovery of sensorimotor function after experimental stroke correlates with restoration of resting-state interhemispheric functional connectivity. J Neurosci 30, 3964-3972.
116. von Monakow C (1914). Die Lokalisation im Grosshirn und der Abbau der Funktion durch kortikale Herde. Wiesbaden, Germany.
117. Wang L, Yu C, Chen H, Qin W, He Y, Fan F, Zhang Y, Wang M, Li K, Zang Y, Woodward TS & Zhu C (2010). Dynamic functional reorganization of the motor execution network after stroke. Brain 133, 1224-1238.
118. Wang LE, Fink GR, Diekhoff S, Rehme AK, Eickhoff SB & Grefkes C (2011). Noradrenergic enhancement improves motor network connectivity in stroke patients. Ann Neurol 69, 375-388.
119. Wang LE, Tittgemeyer M, Imperati D, Diekhoff S, Ameli M, Fink GR & Grefkes C (2012). Degeneration of corpus callosum and recovery of motor function after stroke: A multimodal magnetic resonance imaging study. Hum Brain Mapp 33(12), 2941-2956. doi: 10.1002/hbm.21417. Epub 2011 Oct 22.
120. Ward NS, Brown MM, Thompson AJ & Frackowiak RS (2003). Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 126, 2476-2496.
121. Ward NS, Brown MM, Thompson AJ & Frackowiak RS (2004). The influence of time after stroke on brain activations during a motor task. Ann Neurol 55, 829-834.
122. Ward NS, Newton JM, Swayne OB, Lee L, Frackowiak RS, Thompson AJ, Greenwood RJ & Rothwell JC (2007). The relationship between brain activity and peak grip force is modulated by corticospinal system integrity after subcortical stroke. Eur J Neurosci 25, 1865-1873.
123. Ward NS, Newton JM, Swayne OB, Lee L, Thompson AJ, Greenwood RJ, Rothwell JC & Frackowiak RS (2006). Motor system activation after subcortical stroke depends on corticospinal system integrity. Brain 129, 809-819.
124. Warren JE, Crinion JT, Lambon Ralph MA & Wise RJ (2009). Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke. Brain 132, 3428-3442.
125. Weiller C, Chollet F, Friston KJ, Wise RJ & Frackowiak RS (1992). Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol 31, 463-472.
126. Werhahn KJ, Conforto AB, Kadom N, Hallett M & Cohen LG (2003). Contribution of the ipsilateral motor cortex to recovery after chronic stroke. Ann Neurol 54, 464-472.
127. Westlake KP, Hinkley LB, Bucci M, Guggisberg AG, Findlay AM, Henry RG, Nagarajan SS & Byl N (2012). Resting state alpha-band functional connectivity and recovery after stroke. Exp Neurol 237, 160-169.