Dynamics of blood flow and oxygenation changes during brain activation: The balloon model

Magnetic Resonance in Medicine

Volumn 39, Issue 6, 1998, Pages 855-864

  Buxton, Richard B ^a,b   Wong, Eric C ^a   Frank, Lawrence R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCSD MEDICAL CENTER   (United States)

Author keywords

Cerebral blood flow; Cerebral blood volume; Cerebral oxygen metabolism; Functional magnetic resonance imaging

Indexed keywords

BALLOONS; BLOOD; CHEMICAL ACTIVATION; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; METABOLISM; OXYGENATION;

BIO-MECHANICAL MODELS; BLOOD OXYGENATION; BLOOD OXYGENATION LEVEL DEPENDENT SIGNALS; CEREBRAL BLOOD FLOW; CEREBRAL BLOOD VOLUME; FINGER TAPPING TASKS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; OXYGEN METABOLISMS;

FUNCTIONAL NEUROIMAGING;

DEOXYHEMOGLOBIN;

ARTICLE; BIOMECHANICS; BLOOD OXYGENATION; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; FINGER; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 0031809018     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910390602     Document Type: Article

References (31)

1. P. T. Fox, M. E. Raichle, Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc. Natl. Acad. Sci. USA 83, 1140-1144 (1986).
2. P. T. Fox, M. E. Raichle, M. A. Mintun, C. Dence, Nonoxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464 (1988).
3. K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, R. Turner, H.-M. Cheng, T. J. Brady, B. R. Rosen, Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc. Natl. Acad. Sci. USA 89, 5675-5679 (1992).
4. S. Ogawa, D. W. Tank, R. Menon, J. M. Ellermann, S.-G. Kim, H. Merkle, K. Ugurbil. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc. Natl. Acad. Sci. USA 89, 5951-5955 (1992).
5. P. A. Bandettini, E. C. Wong, R. S. Hinks, R. S. Tikofsky, J. S. Hyde, Time course EPI of human brain function during task activation. Magn. Reson. Med. 25, 390-397 (1992).
6. K. K. Kwong, Functional magnetic resonance imaging with echo planar imaging. Magn. Reson. Q. 11, 1-20 (1995).
7. J. W. Prichard, B. R. Rosen, Functional study of the brain by NMR. J. Cereb. Blood Flow Metab. 14, 365-372 (1994).
8. R. B. Buxton, L. R. Frank, A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J. Cereb. Blood Flow Metab. 17, 64-72 (1997).
9. D. Malonek, A. Grinvald, Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science 272, 551-554 (1996).
10. P. A. Bandettini, E. C. Wong. J. R. Binder, S. M. Rao, A. Jesmanowicz, E. A. Aaron, T. F. Lowry, H. V. Forster, R. S. Hinks. J. S. Hyde, in "Diffusion and Perfusion: Magnetic Resonance Imaging" (D. LeBihan, Ed.). pp. 335-349, Raven Press, New York, 1995.
11. T. Ernst, J. Hennig, Observation of a fast response in functional MR. Magn. Reson. Med. 146-149 (1994).
12. R. S. Menon, S. Ogawa, J. P. Strupp, P. Anderson, K. Ugurbil, BOLD based functional MRI at 4 tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn. Reson. Med. 33, 453-459 (1995).
13. X. Hu, T. H. Le. K. Ugurbil, Evaluation of the early response in fMRI in individual subjects using short stimulus duration. Magn. Reson. Med. 37, 877-884 (1997).
14. T. L. Davis, R. M. Weisskoff, K. K. Kwong, R. Savoy, B. R. Rosen, Susceptibility contrast undershoot is not matched by inflow contrast undershoot, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 435.
15. J. Frahm, G. Krüger, K.-D. Merboldt, A. Kleinschmidt, Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magn. Reson. Med. 35, 143-148 (1996).
16. G. Kruger, A. Kleinschmidt, J. Frahm. Dynamic MRI sensitized to cerebral blood oxygenation and flow during sustained activation of human visual cortex. Magn. Reson. Med. 35, 797-800 (1996).
17. T. L. Davis, R. M. Weisskoff, K. K. Kwong, J. L. Boxerman, B. R. Rosen, Temporal aspects of fMRI task activation: dynamic modeling of oxygen delivery, in "Proc., SMR, 2nd Annual Meeting, San Francisco. 1994," p. 69.
18. J. B. Mandeville, J. Marota, J. R. Keltner, B. Kosovsky, J. Burke, S. Hyman, L. LaPointe, T. Reese, K. Kwong, B. Rosen, R. Weissleder, R. Weisskoff, CBV functional imaging in rat brain using iron oxide agent at steady state concentration, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 292.
19. J. B. Mandeville, J. J. A. Marota, B. E. Kosofsky, J. R. Keltner, R. Weissleder. B. R. Rosen, R. M. Weisskoff. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn. Reson. Med. 39, 615-624 (1998).
20. R. B. Buxton, E. C. Wong, L. R. Frank, A biomechanical interpretation of the BOLD signal time course: the Balloon Model, in "Proc., ISMRM, 5th Annual Meeting, Vancouver, 1997," p. 743.
21. R. M. Weisskoff, C. S. Zuo, J. L. Boxerman, B. R. Rosen, Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn. Reson. Med. 31, 601-610 (1994).
22. C. R. Fisel, J. L. Ackerman, R. B. Buxton, L. Garrido, J. W. Belliveau, B. R. Rosen, T. J. Brady, MR contrast due to microscopically heterogeneous magnetic, susceptibility: numerical simulations and applications to cerebral physiology. Magn. Reson. Med. 17, 336-347 (1991).
23. S. Ogawa, R. S. Menon, D. W. Tank, S.-G. Kim, H. Merkle, J. M. Ellerman, K. Ugurbil, Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging: a comparison of signal characteristics with a biophysical model. Biophys. J. 64, 803-812 (1993).
24. D. A. Yablonsky, E. M. Haacke, Theory of NMR signal behavior in magnetically inhomogenous tissues: the static dephasing regime. Magn. Reson. Med. 32, 749-763 (1994).
25. J. L. Boxerman, P. A. Bandettini, K. K. Kwong, J. R. Baker, T. L. Davis, B. R. Rosen, R. M. Weisskoff, The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn. Reson. Med. 34, 4-10 (1995).
26. 2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5, 630-639 (1974).
27. E. C. Wong, L. R. Frank, R. B. Buxton, QUIPSS II: a method for improved quantitation of perfusion using pulsed arterial spin labeling, in "Proc., ISMRM, 5th Annual Meeting, Vancouver, 1997." p. 1761.
28. E. C. Wong, R. B. Buxton, L. R. Frank, Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed. 10, 237-249 (1997).
29. E. C. Wong, P. A. Bandettini, J. S. Hyde, Echo-planar imaging of the human brain using a three axis local gradient coil, in "Proc., SMRM, 11th Annual Meeting, Berlin, 1992." p. 105.
30. D. W. Lubbers, H. Baumgartl, W. Zimelka. Heterogeneity and stability of local PO2 distribution within the brain tissue. Adv. Exp. Med. Biol. 345, 567-574 (1994).
31. I. G. Kassissia, C. A. Goresky, C. P. Rose, A. J. Schwab, A. Simard, P. M. Huet, G. G. Bach, Tracer oxygen distribution is barrier-limited in the cerebral microcirculation. Circ. Res. 77, 1201-1211 (1995).