Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways

Journal of Neuroscience

Volumn 31, Issue 42, 2011, Pages 15065-15071

  Lu, Jie ^a   Liu, Hesheng ^b   Zhang, Miao ^a   Wang, Danhong ^b   Cao, Yanxiang ^a   Ma, Qingfeng ^a   Rong, Dongdong ^a   Wang, Xiaoyi ^a   Buckner, Randy L ^b,c,d   Li, Kuncheng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN DAMAGE; BRAIN FUNCTION; CEREBELLUM; CEREBROPONTOCEREBELLAR PATHWAY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INTRINSIC FUNCTIONAL CONNECTIVITY; MALE; MOTOR CORTEX; NERVE TRACT; PONS; PRIORITY JOURNAL; STROKE; SYNAPSE;

ADULT; AGED; BRAIN MAPPING; CEREBELLUM; FEMALE; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURAL PATHWAYS; OXYGEN; PONS; STROKE; TIME FACTORS;

EID: 80054766191     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2364-11.2011     Document Type: Article

References (35)

1. Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537-541.
2. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V (1989) Measurements of acute cerebral infarction: a clinical examination scale. Stroke 20:864-870.
3. Buckner RL (2010) Human functional connectivity: new tools, unresolved questions. Proc Natl Acad Sci U S A 107:10769-10770.
4. Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BT (2011) The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol. Advance online publication. Retrieved September 12, 2011. doi:10.1152/jn.00339.2011.
5. Cole DM, Smith SM, Beckmann CF (2010) Advances and pitfalls in the analysis and interpretation of resting-state fMRI data. Front Syst Neurosci 4:8.
6. Evarts EV, Thach WT (1969) Motor mechanisms of the CNS: cerebrocerebellar interrelations. Annu Rev Physiol 31:451-498.
7. Fornito A, Bullmore ET (2010) What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders? Curr Opin Psychiatry 23:239-249.
8. Fox MD, Greicius M (2010) Clinical applications of resting state functional connectivity. Front Syst Neurosci 4:19.
9. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711.
10. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A 102:9673-9678.
11. Fugl-Meyer AR, Jääskö L, Leyman I, Olsson S, Steglind S (1975) The poststroke hemiplegic patient. 1. A method for evaluation of physical performance. Scand J Rehabil Med 7:13-31.
12. Gladstone DJ, Danells CJ, Black SE (2002) The Fugl-Meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair 16:232-240.
13. Granger CV, Dewis LS, Peters NC, Sherwood CC, Barrett JE (1979) Stroke rehabilitation: analysis of repeated Barthel Index measures. Arch Phys Med Rehabil 60:14-17.
14. Greicius M (2008) Resting-state functional connectivity in neuropsychiatric disorders. Curr Opin Neurol 21:424-430.
15. Greicius MD, Supekar K, Menon V, Dougherty RF (2009) Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 19:72-78.
16. Habas C, Kamdar N, Nguyen D, Prater K, Beckmann CF, Menon V, Greicius MD (2009) Distinct cerebellar contributions to intrinsic connectivity networks. J Neurosci 29:8586-8594.
17. Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R, Hagmann P (2009) Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A 106:2035-2040.
18. Johnston JM, Vaishnavi SN, Smyth MD, Zhang D, He BJ, Zempel JM, Shimony JS, Snyder AZ, Raichle ME (2008) Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci 28:6453-6458.
19. Kemp JM, Powell TP (1971) The connexions of the striatum and globus pallidus: synthesis and speculation. Philos Trans R Soc Lond B Biol Sci 262:441-457.
20. Krienen FM, Buckner RL (2009) Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity. Cereb Cortex 19:2485-2497.
21. Margulies DS, Vincent JL, Kelly C, Lohmann G, Uddin LQ, Biswal BB, Villringer A, Castellanos FX, Milham MP, Petrides M (2009) Precuneus shares intrinsic functional architecture in humans and monkeys. Proc Natl Acad Sci U S A 106:20069-20074.
22. Middleton FA, Strick PL (2001) Cerebellar projections to the prefrontal cortex of the primate. J Neurosci 21:700-712
23. Moeller S, Nallasamy N, Tsao DY, Freiwald WA (2009) Functional connectivity of the macaque brain across stimulus and arousal states. J Neurosci 29:5897-5909.
24. O'Reilly JX, Beckmann CF, Tomassini V, Ramnani N, Johansen-Berg H (2010) Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity. Cereb Cortex 20:953-965.
25. Schmahmann JD, Pandya DN (1997) Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. J Neurosci 17:438-458.
26. Schmahmann JD, Rosene DL, Pandya DN (2004a) Ataxia after pontine stroke: insights from pontocerebellar fibers in monkey. Ann Neurol 55:585-589.
27. Schmahmann JD, Ko R, MacMore J (2004b) The human basis pontis: motor syndromes and topographic organization. Brain 127:1269-1291.
28. Strick PL (1985) How do the basal ganglia and cerebellum gain access to the cortical motor areas? Behav Brain Res 18:107-123.
29. Van Dijk KR, Hedden T, Venkataraman A, Evans KC, Lazar SW, Buckner RL (2010) Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol 103:297-321.
30. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604-607.
31. Vincent JL, Snyder AZ, Fox MD, Shannon BJ, Andrews JR, Raichle ME, Buckner RL (2006) Coherent spontaneous activity identifies a hippocampalparietal memory network. J Neurophysiol 96:3517-3531.
32. Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83-86.
33. Vogel AC, Power JD, Petersen SE, Schlaggar BL (2010) Development of the brain's functional network architecture. Neuropsychol Rev 20:362-375.
34. Yeo BTT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL (2011) The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 106:1125-1165.
35. Zhang D, Raichle ME (2010) Disease and the brain's dark energy. Nat Rev Neurol 6:15-28.