Theta burst stimulation in the rehabilitation of the upper limb: A semirandomized, placebo-controlled trial in chronic stroke patients

Neurorehabilitation and Neural Repair

Volumn 26, Issue 8, 2012, Pages 976-987

  Talelli, PenelopE ^a   Wallace, Amanda ^a   Dileone, Michelle ^b   Hoad, Damon ^a   Cheeran, Binith ^a   Oliver, Rupert ^a   Vandenbos, Mehdi ^a   Hammerbeck, Ulrike ^a   Barratt, Karen ^a   Gillini, Cecilia ^b   Musumeci, Gabriella ^b   Boudrias, Marie Hélène ^a   Cloud, Geoffrey C ^c   Ball, Joanna ^d   Marsden, Jonathan F ^e   Ward, Nicholas S ^a   Di Lazzaro, Vincenzo ^b   Greenwood, Richard G ^f   Rothwell, John C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CATHOLIC UNIVERSITY   (Italy)

^c ST GEORGE S HOSPITAL   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF PLYMOUTH   (United Kingdom)

^f NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

motor control; stroke rehabilitation; theta burst stimulation; transcranial magnetic stimulation; upper extremity

Indexed keywords

ADULT; ARM; ARTICLE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EFFECT SIZE; FEMALE; HAND; HAND GRIP; HUMAN; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; STROKE; THETA BURST STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

ADULT; AGED; ANALYSIS OF VARIANCE; FEMALE; HAND STRENGTH; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUSCLE STRENGTH DYNAMOMETER; PAIN MEASUREMENT; STROKE; TIME FACTORS; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; UPPER EXTREMITY;

EID: 84866303576     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968312437940     Document Type: Article

References (47)

1. Hess G, Donoghue JP. Long-term potentiation and long-term depression of horizontal connections in rat motor cortex. Acta Neurobiol Exp (Wars). 1996 ; 56: 397-405
2. Talelli P, Rothwell J. Does brain stimulation after stroke have a future?. Curr Opin Neurol. 2006 ; 19: 543-550
3. Reis J, Robertson EM, Krakauer JW, et al. Consensus: can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation?. Brain Stimul. 2008 ; 1: 363-369
4. Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol. 2004 ; 55: 400-409
5. Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain. 2003 ; 126 (pt 11). 2476-2496
6. Gerloff C, Bushara K, Sailer A, et al. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain. 2006 ; 129 (pt 3). 791-808
7. Ackerley SJ, Stinear CM, Barber PA, Byblow WD. Combining theta burst stimulation with training after subcortical stroke. Stroke. 2010 ; 41: 1568-1572
8. Fregni F, Boggio PS, Mansur CG, et al. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport. 2005 ; 16: 1551-1555
9. Hummel F, Celnik P, Giraux P, et al. Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain. 2005 ; 128 (pt 3). 490-499
10. Mansur CG, Fregni F, Boggio PS, et al. A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients. Neurology. 2005 ; 64: 1802-1804
11. Takeuchi N, Chuma T, Matsuo Y, Watanabe I, Ikoma K. Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke. Stroke. 2005 ; 36: 2681-2686
12. Talelli P, Greenwood RJ, Rothwell JC. Exploring theta burst stimulation as an intervention to improve motor recovery in chronic stroke. Clin Neurophysiol. 2007 ; 118: 333-342
13. Kim YH, You SH, Ko MH, et al. Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke. Stroke. 2006 ; 37: 1471-1476
14. Khedr EM, Ahmed MA, Fathy N, Rothwell JC. Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke. Neurology. 2005 ; 65: 466-468
15. Chang WH, Kim YH, Bang OY, Kim ST, Park YH, Lee PK. Long-term effects of rTMS on motor recovery in patients after subacute stroke. J Rehabil Med. 2010 ; 42: 758-764
16. Kim DY, Lim JY, Kang EK, et al. Effect of transcranial direct current stimulation on motor recovery in patients with subacute stroke. Am J Phys Med Rehabil. 2010 ; 89: 879-886
17. Fregni F, Boggio PS, Valle AC, et al. A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients. Stroke. 2006 ; 37: 2115-2122
18. Malcolm MP, Triggs WJ, Light KE, et al. Repetitive transcranial magnetic stimulation as an adjunct to constraint-induced therapy: an exploratory randomized controlled trial. Am J Phys Med Rehabil. 2007 ; 86: 707-715
19. Lindenberg R, Renga V, Zhu LL, Nair D, Schlaug G. Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients. Neurology. 2010 ; 75: 2176-2184
20. Emara TH, Moustafa RR, Elnahas NM, et al. Repetitive transcranial magnetic stimulation at 1Hz and 5Hz produces sustained improvement in motor function and disability after ischaemic stroke. Eur J Neurol. 2010 ; 17: 1203-1209
21. Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005 ; 45: 201-206
22. Huang YZ, Chen RS, Rothwell JC, Wen HY. The after-effect of human theta burst stimulation is NMDA receptor dependent. Clin Neurophysiol. 2007 ; 118: 1028-1032
23. Stagg CJ, Wylezinska M, Matthews PM, et al. Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy. J Neurophysiol. 2009 ; 101: 2872-2877
24. Di Lazzaro V, Pilato F, Dileone M, et al. Modulating cortical excitability in acute stroke: a repetitive TMS study. Clin Neurophysiol. 2008 ; 119: 715-723
25. Lisanby SH, Gutman D, Luber B, Schroeder C, Sackeim HA. Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials. Biol Psychiatry. 2001 ; 49: 460-463
26. Huang YZ, Rothwell JC, Edwards MJ, Chen RS. Effect of physiological activity on an NMDA-dependent form of cortical plasticity in human. Cereb Cortex. 2008 ; 18: 563-570
27. Wallace AC, Talelli P, Dileone M, et al. Standardizing the intensity of upper limb treatment in rehabilitation medicine. Clin Rehabil. 2010 ; 24: 471-478
28. Van der Lee JH, De Groot V, Beckerman H, Wagenaar RC, Lankhorst GJ, Bouter LM. The intra- and interrater reliability of the Action Research Arm Test: a practical test of upper extremity function in patients with stroke. Arch Phys Med Rehabil. 2001 ; 82: 14-19
29. Winward CE, Halligan PW, Wade DT. The Rivermead Assessment of Somatosensory Performance (RASP): standardization and reliability data. Clin Rehabil. 2002 ; 16: 523-533
30. Heller A, Wade DT, Wood VA, Sunderland A, Hewer RL, Ward E. Arm function after stroke: measurement and recovery over the first three months. J Neurol Neurosurg Psychiatry. 1987 ; 50: 714-719
31. Jebsen RH, Taylor N, Trieschmann RB, Trotter MJ, Howard LA. An objective and standardized test of hand function. Arch Phys Med Rehabil. 1969 ; 50: 311-319
32. Boissy P, Bourbonnais D, Carlotti MM, Gravel D, Arsenault BA. Maximal grip force in chronic stroke subjects and its relationship to global upper extremity function. Clin Rehabil. 1999 ; 13: 354-362
33. Turner-Stokes L, Williams H. Goal attainment scaling: a direct comparison of alternative rating methods. Clin Rehabil. 2010 ; 24: 66-73
34. Price CI, Curless RH, Rodgers H. Can stroke patients use visual analogue scales?. Stroke. 1999 ; 30: 1357-1361
35. Taves DR. Minimization: a new method of assigning patients to treatment and control groups. Clin Pharmacol Ther. 1974 ; 15: 443-453
36. van der Lee JH, Wagenaar RC, Lankhorst GJ, Vogelaar TW, Deville WL, Bouter LM. Forced use of the upper extremity in chronic stroke patients: results from a single-blind randomized clinical trial. Stroke. 1999 ; 30: 2369-2375
37. Pocock SJ, Geller NL, Tsiatis AA. The analysis of multiple endpoints in clinical trials. Biometrics. 1987 ; 43: 487-498
38. Cheeran B, Talelli P, Mori F, et al. A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol. 2008 ; 586 (pt 23). 5717-5725
39. Rothkegel H, Sommer M, Rammsayer T, Trenkwalder C, Paulus W. Training effects outweigh effects of single-session conventional rTMS and theta burst stimulation in PD patients. Neurorehabil Neural Repair. 2009 ; 23: 373-381
40. Hesse S, Waldner A, Mehrholz J, Tomelleri C, Pohl M, Werner C. Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: an exploratory, randomized multicenter trial. Neurorehabil Neural Repair. 2011 ; 25: 838-846
41. Buetefisch C, Heger R, Schicks W, Seitz R, Netz J. Hebbian-type stimulation during robot-assisted training in patients with stroke. Neurorehabil Neural Repair. 2011 ; 25: 645-655
42. Castel-Lacanal E, Marque P, Tardy J, et al. Induction of cortical plastic changes in wrist muscles by paired associative stimulation in the recovery phase of stroke patients. Neurorehabil Neural Repair. 2009 ; 23: 366-372
43. Dimyan MA, Cohen LG. Contribution of transcranial magnetic stimulation to the understanding of functional recovery mechanisms after stroke. Neurorehabil Neural Repair. 2010 ; 24: 125-135
44. Wang RY, Tseng HY, Liao KK, Wang CJ, Lai KL, Yang YR. rTMS combined with task-oriented training to improve symmetry of interhemispheric corticomotor excitability and gait performance after stroke: a randomized trial [published online ahead of print October 5, 2011]. Neurorehabil Neural Repair. :
45. Dobkin BH. Progressive staging of pilot studies to improve phase III trials for motor interventions. Neurorehabil Neural Repair. 2009 ; 23: 197-206
46. Ward NS. Getting lost in translation. Curr Opin Neurol. 2008 ; 21: 625-627
47. Ameli M, Grefkes C, Kemper F, et al. Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke. Ann Neurol. 2009 ; 66: 298-309