Structural investigation of anti-trypanosoma cruzi 2-iminothiazolidin-4- ones allows the identification of agents with efficacy in infected mice

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 10918-10936

  Moreira, Diogo Rodrigo Magalhaes ^a   Costa, Salvana Priscylla Manso ^a   Hernandes, Marcelo Zaldini ^a   Rabello, Marcelo Montenegro ^a   De Oliveira Filho, Gevanio Bezerra ^a   De Melo, Cristiane Moutinho Lagos ^b   Da Rocha, Lucas Ferreira ^b   De Simone, Carlos Alberto ^c   Ferreira, Rafaela Salgado ^d   Fradico, Jordana Rodrigues Barbosa ^d   Meira, Cássio Santana ^b   Guimarães, Elisalva Teixeira ^b,e   Srivastava, Rajendra Mohan ^a   Pereira, Valéria Reîgo Alves ^b   Soares, Milena Botelho Pereira ^b,f   Leite, Ana Cristina Lima ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e UNIVERSIDADE DO ESTADO DA BAHIA   (Brazil)

^f HOSPITAL SÃO RAFAEL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL)] 4 (4 BROMOPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 3 METHYL 4 PHENYL 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 3,4 DIPHENYL 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (2 FURANYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (2 NAPHTHALENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (2 THIOPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (2,3,4 TRICHLOROPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (2,4 DICHLOROPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (3 NITROPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (3 PYRIDINYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (4 ANISYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (4 CHLOROPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (4 FLUOROPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (4 PYRIDINYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (4 TOLYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 (TERT BUTYLPHENYL) 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZINYL] 4 PHENYL 1,3 THIAZOLE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 (4 ANISYL) 5 ETHYLTHIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 (4 TOLYL) 5 ETHYLTHIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 PHENYL 5 ETHYLTHIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 PHENYL 5 ISOPROPYLTHIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 PHENYL 5 METHYL THIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 PHENYLTHIAZOLIDIN 4 ONE; 2 [(1 PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3,5 DIPHENYLTHIAZOLIDIN 4 ONE; 2 [(1PHENOXYPROPAN 2 YLIDENE)HYDRAZONO] 3 (CYCLOHEXYL) 5 ETHYLTHIAZOLIDIN 4 ONE; 2 IMINOTHIAZOLIDIN 4 ONE; 2 MINOTHIAZOLIDIN 4 ONE; ANTITRYPANOSOMAL AGENT; CRUZIPAIN; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CHAGAS DISEASE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMASTIGOTE; FEMALE; IC 50; MOUSE; NONHUMAN; PARASITE; SPLEEN CELL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CELL PROLIFERATION; CHAGAS DISEASE; COMPUTER SIMULATION; CYSTEINE ENDOPEPTIDASES; FEMALE; IMINES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PROTEIN BINDING; PROTOZOAN PROTEINS; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84871671001     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301518v     Document Type: Article

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