Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4405-4409

  Siles, Rogelio ^a   Chen, Shen En ^a   Zhou, Ming ^a   Pinney, Kevin G ^a   Trawick, Mary Lynn ^a  

^a BAYLOR UNIVERSITY   (United States)

Author keywords

Chagas' Disease; Cruzain inhibitors; Drug discovery and development; Molecular recognition; Small molecule inhibitors; Thiosemicarbazone functionality

Indexed keywords

BENZOPHENONE; CARBONYL DERIVATIVE; CRUZIPAIN; ENZYME INHIBITOR; PROPIOPHENONE; TETRALIN DERIVATIVE; THIOSEMICARBAZONE;

ARTICLE; CHAGAS DISEASE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50;

CARBON; CHAGAS DISEASE; CHEMISTRY, PHARMACEUTICAL; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PROTOZOAN PROTEINS; SEMICARBAZONES;

EID: 33745772587     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.041     Document Type: Article

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