Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: A converging pathway leading to chagasic vasculopathy

British Journal of Pharmacology

Volumn 165, Issue 5, 2012, Pages 1333-1347

  Andrade, Daniele ^a   Serra, Rafaela ^a   Svensjö, Erik ^a   Lima, Ana Paula C ^a   Ramos Junior, Erivan S ^a   Fortes, Fabio S ^b   Morandini, Ana Carolina F ^c   Morandi, Verônica ^d   Soeiro, Maria De N ^e   Tanowitz, Herbert B ^f   Scharfstein, Julio ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Centro Universitario Estadual da Zona Oeste   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e INSTITUTO OSWALDO CRUZ   (Brazil)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

bradykinin; cardiomyopathy; Chagas disease; cruzipain; endothelin; GPCRs; invasion; kininogens; microcirculation; oedema; Trypanosoma cruzi

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; CHOLESTEROL; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; ICATIBANT; IMMUNOGLOBULIN G ANTIBODY; METHYL BETA CYCLODEXTRIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; RHODAMINE; SMALL INTERFERING RNA; THAPSIGARGIN; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHAGAS DISEASE; CHEEK POUCH; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; EDEMA; ENDOTHELIUM; FOOT EDEMA; HEART MUSCLE CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LEUKOCYTE; MALE; MICROSCOPY; MONOTHERAPY; MOUSE; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CALCIUM; CELLS, CULTURED; CHAGAS DISEASE; CHO CELLS; CRICETINAE; EDEMA; ENDOTHELIN-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; KININS; MICE; MICE, INBRED BALB C; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; RECEPTOR, BRADYKININ B2; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; TRYPANOSOMA CRUZI;

EID: 84857089753     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01609.x     Document Type: Article

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