Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4189-4204

  Keenan, Martine ^a   Abbott, Michael J ^a   Alexander, Paul W ^a   Armstrong, Tanya ^b   Best, Wayne M ^a   Berven, Bradley ^a   Botero, Adriana ^b   Chaplin, Jason H ^a   Charman, Susan A ^c   Chatelain, Eric ^d   Von Geldern, Thomas W ^d   Kerfoot, Maria ^b   Khong, Andrea ^b   Nguyen, Tien ^c   McManus, Joshua D ^a   Morizzi, Julia ^c   Ryan, Eileen ^c   Scandale, Ivan ^d   Thompson, R Andrew ^b   Wang, Sen Z ^a   White, Karen L ^c   more..

^a Murdoch University Campus   (Australia)

^b MURDOCH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

(2 CHLOROPHENYL)(4 CHLOROPHENYL)(PYRIDIN 3 YL)ACETONITRILE; (2 CHLOROPHENYL)(4 CHLOROPHENYL)(PYRIMIDIN 4 YL)METHANOL; (2 CHLOROPHENYL)(4 CHLOROPHENYL)PYRIDIN 2 YL METHANOL; (2 CHLOROPHENYL)(4 CHLOROPHENYL)PYRIMIDIN 2 YL METHANOL; (2 CHLOROPHENYL)(4' CHLOROPHENYL)PYRIDIN 3 YL METHANOL; (4 BROMOPHENYL)(4 CHLOROPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(2 CHLOROPHENYL)PYRIMIDIN 5 YL N OXIDE METHANOL; (4 CHLOROPHENYL)(2 FLUOROPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(2 FLUOROPHENYL)PYRIMIDIN 5 YL METHANOL; (4 CHLOROPHENYL)(2 METHYLPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(3 FLUOROPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(3 FLUOROPHENYL)PYRIMIDIN 5 YL METHANOL; (4 CHLOROPHENYL)(3 METHOXYPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(4 BROMOPHENYL)PYRIMIDIN 5 YL METHANOL; (4 CHLOROPHENYL)(4 METHOXYPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(4 METHYLPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)(4 METHYLPHENYL)PYRIMIDIN 5 YL METHANOL; (4 CHLOROPHENYL)(4 TRIFLUOROMETHYLPHENYL)PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)[2 (PROPAN 2 YLOXY)PHENYL]PYRIDIN 3 YL METHANOL; (4 CHLOROPHENYL)[3 (PROPAN 2 YLOXY)PHENYL]PYRIDIN 3 YL METHANOL; (4 TRIFLUOROMETHYLPHENYL)(4 CHLOROPHENYL)PYRIMIDIN 5 YL METHANOL; 3 [(4 CHLOROPHENYL)(HYDROXY)PYRIDIN 3 YLMETHYL]BENZAMIDE; 3 [BIS(4 CHLOROPHENYL)METHYL]PYRIDINE; 3 [METHOXY(2 CHLOROPHENYL)(4 CHLOROPHENYL)METHYL]PYRIDINE; 4 [(4 TRIFLUOROMETHYLPHENYL)(HYDROXY)PYRIDIN 3 YLMETHYL]BENZONITRILE; 5 [(2 CHLOROPHENYL)(4 CHLOROPHENYL)METHYL]PYRIMIDINE; BIS(4 CHLOROPHENYL)(PYRIDIN 3 YL)METHANOL; BIS(4 CHLOROPHENYL)(PYRIMIDIN 5 YL)METHANOL; FENARIMOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ASSAY; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PARASITEMIA; RAT; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; WHOLE CELL;

ANIMALS; CELL LINE; CHAGAS DISEASE; DISEASE MODELS, ANIMAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INHIBITORY CONCENTRATION 50; MALE; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84861021112     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2015809     Document Type: Article

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