Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 3212-3219

  Greenbaum, Doron C ^a,d   Mackey, Zachary ^a   Hansell, Elizabeth ^a   Doyle, Patricia ^a   Gut, Jiri ^b   Caffrey, Conor R ^a   Lehrman, Julia ^b   Rosenthal, Philip J ^b   McKerrow, James H ^a   Chibale, Kelly ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; CRUZIPAIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; RHODESAIN; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; ANTIMALARIALS; CYSTEINE PROTEINASE INHIBITORS; MICE; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; TOXICITY TESTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 2542533103     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030549j     Document Type: Article

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