Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 155-163

  Caputto, María E ^a   Ciccarelli, Alejandra ^b   Frank, Fernanda ^a   Moglioni, Albertina G ^a   Moltrasio, Graciela Y ^a   Vega, Daniel ^c   Lombardo, Elisa ^b   Finkielsztein, Liliana M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^c UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

Author keywords

Anti Trypanosoma cruzi compounds; Chagas's disease; Microwave assisted synthesis; Thiazolylhydrazones

Indexed keywords

2 [2 (4 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 P TOLYLTHIAZOLIUM CHLORIDE; 2 [2 (4 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 PHENYLTHIAZOLIUM CHLORIDE; 2 [2 (5 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 P TOLYLTHIAZOLIUM CHLORIDE; 2 [2 (5 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 PHENYLTHIAZOLIUM CHLORIDE; 2 [2 (5,6 DIMETHOXY 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 P TOLYLTHIAZOLIUM CHLORIDE; 2 [2 (5,6 DIMETHOXY 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 PHENYLTHIAZOLIUM CHLORIDE; 2 [2 (6 METHYL 2,3 DIHYDRO 1H INDEN 1 LIDENE)HYDRAZINYL] 4 PHENYLTHIAZOLIUM CHLORIDE; 2 [2 (6 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]4 P TOLYLTHIAZOLIUM CHLORIDE; 2[2 (2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINY] 4 P TOLYLTHIAZOLIUMCHLORIDE CHLORIDE; 2[2 (2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL] 4 PHENYLTHIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (4 METHOXY 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORID; 4 (4 CHLOROPHENYL) 2 [2 (4 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (4 NITRO 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (5 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (5,6 DIMETHOXY 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 (4 CHLOROPHENYL) 2 [2 (6 METHYL 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINYL]THIAZOLIUM CHLORIDE; 4 ARYLTHIAZOLYLHYDRAZONE; ANTIPROTOZOAL AGENT; BENZNIDAZOLE; ERGOSTEROL; HYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CHEMOTHERAPY; DRUG SYNTHESIS; EPIMASTIGOTE; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROWAVE IRRADIATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRYPOMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; CERCOPITHECUS AETHIOPS; CHEMISTRY TECHNIQUES, SYNTHETIC; HYDRAZONES; LIFE CYCLE STAGES; STEROLS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 84865741780     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.013     Document Type: Article

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