Divergent modes of enzyme inhibition in a homologous structure-activity series

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5005-5008

  Ferreira, Rafaela S ^a   Bryant, Clifford ^a   Ang, Kenny K H ^a   McKerrow, James H ^a   Shoichet, Brian K ^a   Renslo, Adam R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE INHIBITOR; OXADIAZOLE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

COLLOIDS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DATABASES, FACTUAL; GLYCOLATES; MODELS, MOLECULAR; OXADIAZOLES; PARASITIC SENSITIVITY TESTS; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 69049101145     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9009229     Document Type: Article

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