Structurally simple inhibitors of lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease

Journal of Medicinal Chemistry

Volumn 52, Issue 12, 2009, Pages 3703-3715

  Suryadevara, Praveen Kumar ^a   Olepu, Srinivas ^a   Lockman, Jeffrey W ^c   Ohkanda, Junko ^c   Karimi, Mandana ^a   Verlinde, Christophe L M J ^b   Kraus, James M ^a   Schoepe, Jan ^a,b   Van Voorhis, Wesley C ^a   Hamilton, Andrew D ^c   Buckner, Frederick S ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(6 CHLOROBIPHENYL 3 YL)[3 (3 AMINOBIPHENYL 4 YLMETHYL) 3H IMIDAZOL 4 YLMETHYL]AMINE; ALKYL GROUP; IMIDAZOLE DERIVATIVE; POSACONAZOLE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CHAGAS DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MOUSE; NONHUMAN; PARASITEMIA; POLYMERASE CHAIN REACTION; RODENT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ACUTE DISEASE; ANIMALS; CHAGAS DISEASE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; IMIDAZOLES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

EID: 67549086262     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900030h     Document Type: Article

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