Glycerol as a promising substrate for Yarrowia lipolytica biotechnological applications

Biomass and Bioenergy

Volumn 48, Issue , 2013, Pages 148-166

  Rywińska, Anita ^a   Juszczyk, Piotr ^a   Wojtatowicz, Maria ^a   Robak, Malgorzata ^a   Lazar, Zbigniew ^a   Tomaszewska, Ludwika ^a   Rymowicz, Waldemar ^a  

^a WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

ketoglutaric acid; Citric acid; Erythritol; Glycerol; Pyruvic acid; Yarrowia lipolytica

Indexed keywords

BIODIESEL INDUSTRY; BIODIESEL PRODUCTION; BIOLOGICAL METHODS; BIOTECHNOLOGICAL APPLICATIONS; CRUDE GLYCEROL; ERYTHRITOL; FEED ADDITIVES; MANUFACTURING PROCESS; NEW PRODUCT; PYRUVIC ACID; RENEWABLE RESOURCE; RESEARCH CENTER; SCIENTIFIC RESEARCHES; VALUE ADDED PRODUCTS; Y. LIPOLYTICA; YARROWIA LIPOLYTICA;

BIOCHEMISTRY; BIODIESEL; CITRIC ACID; OILS AND FATS; YEAST;

GLYCEROL;

ALCOHOL; BIOFUEL; BIOMASS; BIOTECHNOLOGY; CITRIC ACID; FATTY ACID; FEASIBILITY STUDY; FERMENTATION; INDUSTRIAL PRODUCTION; INDUSTRIAL TECHNOLOGY; MICROBIAL ACTIVITY; RENEWABLE RESOURCE; SUBSTRATE; YEAST;

YARROWIA LIPOLYTICA;

EID: 84871565719     PISSN: 09619534     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biombioe.2012.11.021     Document Type: Review

References (202)

1. The yeast: a taxonomic study 2000, Elsevier Science BV, Amsterdam. 4th ed. C.P. Kurtzman, J.W. Fell (Eds.).
2. Barth G., Gaillardin C. Yarrowia lipolytica. Nonconventional yeasts in biotechnology. A handbook 1996, 313-388. Springer Verlag, Berlin-Heidelberg. K. Wolf (Ed.).
3. Barth G., Gaillardin C. Physiology and genetics of the dimorphic fungus Yarrowia lipolytica. FEMS Microbiol Rev 1997, 19(4):219-237.
4. Kurtzman C.P. New species and new combinations in the Hyphopichia and Yarrowia yeast clades. Anton Leeuw 2005, 88:121-130.
5. Knutsen A.K., Robert V., Poot G.A., Epping W., Figge M., Holst-Jensen A., et al. Polyphasic re-examination of Yarrowia lipolytica strains and the description of three novel Candida species: Candida oslonensis sp. nov., Candida alimentaria sp. nov. and Candida hollandica sp. nov. Int J Syst Evol Microbiol 2007, 57:2426-2435.
6. Naumova E.S., Serpova E.V., Naumov G.I. Genome variability of the yeast Yarrowia lipolytica. Microbiol 2010, 79(2):229-236.
7. Casaregola S., Neuveglise C., Lepingle A., Bon E., Feynerol C., Artiguenave F., et al. Genomic exploration of the hemiascomycetous yeasts: Yarrowia lipolytica. FEBS Lett 2000, 487:95-100.
8. Sherman D., Durrens P., Beyne E., Nikolski M., Souciet J.-L., for the Genolevures Consortium Génolevures: comparative genomics and molecular evolution of hemiascomycetous yeasts. Nucl Acids Res 2004, 32:D315-D318.
9. Mekour M., Blanc-Lenfle I., Ozanne C., Da Silva C., Cruad C., Wincker P., et al. Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structure constrains facilitating nonsense-mediated decay of intron-retaining transcripts. Genome Biol 2010, 11:R65.
10. Acker J.I., Ozann C., Kachouri-Lafond R., Gaillardin C., Neuveglise C., Marck C. Dicistronic tRNA-5S rRNA genes in Yarrowia lipolytica: an alternative TFIIIA-independent way for expression of 5S rRNA genes. Nucl Acids Res 2008, 36(18):5832-5844.
11. Thevenieau F., Nicaud J.-M., Gailardin C. Application of the non-conventional yeast Yarrowia lipolytica. Yeast biotechnology: diversity and applications 2009, 589-613. Springer Science, New Delhi. T. Satyanarayana, G. Kunze (Eds.).
12. Desfougeres T., Haddouche R., Fudalej F., Neuveglise C., Nicaud J.-M. SOA genes encode proteins controlling lipase expression in response to triacylglycerol utilisation in the yeast Yarrowia lipolytica. FEMS Yeast Res 2010, 10:93-103.
13. Beopoulos A., Haddouche R., Kabran P., Dulermo T., Chardot T., Nicaud J.-M. Identification and characterization of DGA2 an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts. Appl Microbiol Biotechnol 2012, 93(4):1523-1537.
14. Blazek J., Liu L., Redden H., Alper H. Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach. Appl Environ Microbiol 2011, 77(22):7905-7914.
15. Neuveglise C., Chalvet F., Wincker P., Gaillardin C., Casaregola S. Mutator-like element in the yeast Yarrowia lipolytica displays multiple alternative splicings. Eukaryot Cell 2005, 4(3):615-624.
16. Barnett J.A., Payne R.W., Yarrow D. Yeasts: characteristics and identification 2000, Cambridge University Press, Cambridge. 3rd ed.
17. Fickers P., Benetti P.H., Wache Y., Marty A., Mauersberger S., Smit M.S., et al. Hydrophobic substrate utilization by the yeast Yarrowia lipolytica and its potential applications. FEMS Yeast Res 2005, 5:527-543.
18. Andrighetto C., Psomas E., Tzanetakis N., Suzzi G., Lombardi A. Randomly amplified polymorphic DNA (RAPD) PCR for the identification of yeasts isolated from dairy products. Lett Appl Microbiol 2000, 30:5-9.
19. Perez-Campo F., Dominguez A. Factors affecting the morphogenic switch in Yarrowia lipolytica. Curr Microbiol 2001, 43:429-433.
20. Rodriguez C., Dominguez A. The growth characteristic of Saccharomycopsis lipolytica: morphology and induction of mycelial formation. Can J Microbiol 1984, 30:605-612.
21. Ruiz-Herrera J., Sentandreu R. Different effectors of dimorphism in Yarrowia lipolytica. Arch Microbiol 2002, 178:477-483.
22. Zinjarde S.S., Kale B.V., Vishwasrao P.V., Kumar A.R. Morphogenetic behavior of tropical marine yeast Yarrowia lipolytica in response to hydrophobic substrates. J Microbiol Biotechnol 2008, 18(9):1522-1528.
23. Cervantes-Chavez J.A., Ruiz-Herrera J. STEII disruption reveals the central role of MAPK pathway in dimorphism and mating in Yarrowia lipolytica. FEMS Yeast Res 2006, 6:801-815.
24. Cervantes-Chavez J.A., Kronberg F., Passeron S., Ruiz-Herrera J. Regulatory role of the PKA pathway in dimorphism and mating in Yarrowia lipolytica. Fungal Genet Biol 2009, 46:390-399.
25. Klug M.J., Markovetz A.J. Degradation of hydrocarbons by members of the genus Candida II. Oxidation of n-alkanes and 1-alkenes by Candida lipolytica. J Bacteriol 1967, 93:1847-1852.
26. Tsugawa R., Nakase T., Koyabashi T., Yamashita K., Okamura S. Fermentation of n-paraffins by yeast. Part III. α - ketoglutarate productivity of various yeasts. Agr Biol Chem 1969, 33:929-938.
27. Furukawa T., Ogina T., Matsuyoshi Y. Fermentative production of citric acid from n-paraffins by Saccharomycopsis lipolytica. J Ferment Technol 1982, 60:281-286.
28. Mattey M. The production of organic acids. Crit Rev Biotechnol 1992, 12:87-132.
29. Wojtatowicz M., Kuźniarz M., Sobieszczański J., Rutkowski M. Synthetic hydrocarbons obtained by means of coal processing as a raw material for the microbial industry. Part III. Assimilation of individual hydrocarbons from kogasin by selected yeast strains of the genus Candida. Acta Microbiol Polon 1981, 30(2):165-171.
30. Wojtatowicz M., Rymowicz W., Kautola H. Comparison of different strains of the yeast Yarrowia lipolytica for citric acid production from glucose hydrol. Appl Biochem Biotechnol 1991, 31(2):165-174.
31. Wojtatowicz M., Marchin G.L., Erickson L.E. Attempts to improve the strain A-101 of Yarrowia lipolytica for citric acid production from n-paraffins. Process Biochem 1993, 28:453-460.
32. Rymowicz W., Kautola H., Wojtatowicz M., Linko Y.Y., Linko P. Studies of citric acid production with immobilized Yarrowia lipolytica in repeated batch and continuous air-lift bioreactors. Appl Microbiol Biotechnol 1993, 39:1-4.
33. Abdelal A.T.H., Kennedy E.H., Ahearn D.G. Purification of a neutral protease from Saccharomycopsis lipolytica. J Bacteriol 1977, 130:1125-1129.
34. Yamada T., Ogrydziak D.M. Extracellular acid proteases produced by Saccharomycopsis lipolytica. J Bacteriol 1983, 154:23-31.
35. Ogrydziak D.M. Production of alkaline extracellular protease produced by Yarrowia lipolytica. Crit Rev Biotechnol 1988, 8:177-187.
36. Madzak C., Gaillardin C., Beckerich J.-M. Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review. J Biotechnol 2004, 109:63-81.
37. Madzak C., Nicaud J.-M., Gaillardin C. Yarrowia lipolytica. Production of recombinant proteins. Novel microbial and eukaryotic expression system 2005, 163-190. WILEY-VCH VerlagGmbH & Co. KgaA, Weinheim. G. Gellissen (Ed.).
38. Rao A., Pimprikar P., Bendigiri C., Kumar A.R., Zinjarde S. Cloning and expression of a tyrosinase from Aspergillus oryzae in Yarrowia lipolytica: application in L-DOPA biotransformation. Appl Microbiol Biotechnol 2011, 92(5):951-959.
39. Huang Y.-C., Chen Y.-F., Chen C.-Y., Chen W.-I., Ciou Y.-P., Liu W.-H., et al. Production of ferulic acid from lignocellulolytic agricultural biomass by Thermobifida fusca thermostable esterase produced in Yarrowia lipolytica transformant. Bioresour Technol 2011, 102:8117-8122.
40. Lazar Z., Walczak E., Robak M. Simultaneous production of citric acid and invertase by Yarrowia lipolytica SUC+ transformants. Bioresour Technol 2011, 102(13):6982-6989.
41. Cambon E., Piamtongkam R., Bordes F., Duquesne S., Laguerre S., Nicaud J.-M., et al. A new Yarrowia lipolytica expression system: an efficient tool for rapid and reliable kinetic analysis of improved enzymes. Enzyme Microb Technol 2010, 47:91-96.
42. Bordes F., Fudalej F., Dossat V., Nicaud J.M., Marty A. A new recombinant protein expression system for high-throughput screening in the yeast Yarrowia lipolytica. J Microbiol Methods 2007, 70(3):493-502.
43. Pignede G., Wang H.J., Fudalej F., Seman M., Gaillardin C., Nicaud J.M. Autocloning and amplification of LIP2 in Yarrowia lipolytica. Appl Environ Microbiol 2000, 66(8):3283-3289.
44. Gasmi N., Fudalej F., Kallel H., Nicaud J.-M. A molecular approach to optimize hINFα2b expression and secretion in Yarrowia lipolytica. Appl Microbiol Biotechnol 2011, 89:109-119.
45. Gasmi N., Ayed A., Nicaud J.-M., Kallel H. Design of an efficient medium for heterologous protein production in Yarrowia lipolytica: case of human interferon alpha 2b. Microb Cell Factories 2011, 10(38):13.
46. Fickers P., Marty A., Nicaud J.-M. The lipases from Yarrowia lipolytica: genetics, production, regulation, biochemical characterization and biotechnological applications. Biotechnol Adv 2011, 29:632-644.
47. Coelho M.A.Z., Amaral P.F.F., Belo I. Yarrowia lipolytica: an industrial workhorse. Current research, technology and education topics in applied microbiology and microbial biotechnology 2010, 930-944. Badajoz: Formatex Research Center. A. Mendez-Vilas (Ed.).
48. Bankar A.V., Kumar A.R., Zinjarde S.S. Environmental and industrial applications of Yarrowia lipolytica. Appl Microbiol Biotechnol 2009, 84:847-865.
49. Beopoulos A., Cescut J., Haddouche R., Uribelarrea J.-L., Molina-Jouve C., Nicaud J.-M. Yarrowia lipolytica as a model for bio-oil production. Prog Lipid Res 2009, 48:375-387.
50. Finogenova T.V., Morgunov I.G., Kamzolova S.V., Chernyavskaya O.G. Organic acid production by the yeast Yarrowia lipolytica: a review of prospects. Appl Biochem Microbiol 2005, 41(5):418-425.
51. Yusuf C. Biodiesel from microalgae. Biotechnol Adv 2007, 25:294-306.
52. Anwar F., Rashid U., Ashraf M., Nadeem M. Okra (Hibiscus esculentus) seed oil for biodiesel production. Appl Energy 2010, 87(3):779-785.
53. Montefrio M.J., Xinwen T., Obbard J.P. Recovery and pre-treatment of fats, oil and grease from grease interceptors for biodiesel production. Appl Energy 2010, 87:3155-3161.
54. Lin L., Cunshan Z., Vittayapadung S., Xiangqian S., Mingdong D. Opportunities and challenges for biodiesel fuel. Appl Energy 2011, 88(4):1020-1031.
55. Meher L.C., Vidya Sagar D., Naik S.N. Technical aspects of biodiesel production by transesterification - a review. Renew Sustain Energy Rev 2006, 10:248-268.
56. Hoydoncx H.E., De Vos D.E., Chavan S.A., Jacobs P.A. Esterification and transesterification of renewable chemicals. Top Catal 2004, 27(1-4):83-96.
57. Johnson D.T., Taconi K.A. The glycerin glut: options for the value-added conversion of crude glycerol resulting from biodiesel production. Environ Prog 2007, 26(4):338-348.
58. Terpen J.V. Biodiesel processing and production. Fuel Proc Technol 2005, 86:1097-1107.
59. Willke T., Vorlop K.D. Industrial bioconversion of renewable resources as an alternative to conventional chemistry. Appl Microbiol Biotechnol 2004, 66(2):131-142.
60. Thompson J.C., He B.B. Characterization of crude glycerol from biodiesel production from multiple feed stocks. Appl Eng Agric 2004, 22(2):261-265.
61. Jegannathan R.K., Eng-Seng C., Ravindra P. Economic assessment of biodiesel production: comparison of alkali and biocatalyst processes. Renew Sustain Energy Rev 2011, 15:745-751.
62. Bisen P.S., Sanodiya B.S., Thakur G.S., Baghel R.K., Prasad G.B. Biodiesel production with special emphasis on lipase-catalyzed transesterification. Biotechnol Lett 2010, 32:1019-1030.
63. Bournay L., Casanave D., Delfort B., Hillion G., Chodorge J.A. New heterogeneous process for biodiesel production: a way to improve the quality and the value of the crude glycerin produced by biodiesel plants. Catal Today 2005, 106:190-192.
64. Musiał I., Cibis E., Rymowicz W. Designing a process of kaolin bleaching in an oxalic acid enriched medium by Aspergillus niger cultivated on biodiesel-derived waste composed of glycerol and fatty acids. Appl Clay Sci 2011, 52:277-284.
65. Abad S., Turon X. Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: focus on polyunsaturated fatty acids. Biotechnol Adv 2012, 30(3):733-741.
66. Amaral P.F.F., Ferreira T.F., Fontes G.C., Coehlo M.A.Z. Glycerol valorization: new biotechnological routes. Food Bioprod Process 2009, 87:179-186.
67. Chatzifragkou A., Makri A., Belka A., Bellou S., Mavrou M., Mastoridou M., et al. Biotechnological conversions of biodiesel derived waste glycerol by yeast and fungal species. Energy 2011, 36(2):1097-1108.
68. Dobson R., Gray V., Rumbold K. Microbial utilization of crude glycerol for the production of value-added products. J Ind Microbiol Biotechnol 2012, 39:217-226.
69. Koutinas A., Wang R., Webb C. The biochemurgist-Bioconversion of agricultural raw materials for chemical production. Biotechnol Biofuels 2007, 1:24-38.
70. Mantzouridou F., Naziri E., Tsimidou M.Z. Industrial glycerol as a supplementary carbon source in the production of β-carotene by Blakeslea trispora. J Agric Food Chem 2008, 56:2668-2675.
71. Ethier S., Woisard K., Vaughan D., Wen Z. Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. Bioresour Technol 2011, 102:88-93.
72. Anand P., Saxena R.K. Comparative study of solvent-assisted pretreatment of biodiesel derived crude glycerol on growth and 1,3-propanediol production from Citrobacter freundii. New Biotechnol 2012, 29(2):199-205.
73. Jun S.A., Moon C., Kang C.H., Kong S.W., Sang B.I., Um Y. Microbial fed-batch production of 1,3-propanediol using raw glycerol with suspended and immobilized Klebsiella pneumoniae. Appl Biochem Biotechnol 2010, 161:491-501.
74. Wilkens E., Ringel A.K., Hortig D., Willke T., Vorlop K.D. High-level production of 1,3-propanediol from crude glycerol by Clostridium butyricum AKR102a. Appl Microbiol Biotechnol 2012, 93:1057-1063.
75. Sattayasamitsathit S., Prasertsan P., Methacanon P. Statistical optimization for simultaneous production of 1,3-propanediol and 2,3-butanediol using crude glycerol by newly bacterial isolate. Process Biochem 2011, 46(2):608-614.
76. Metsoviti M., Paramithiotis S., Drosinos E.H., Galiotou-Panayotou M., Nychas G.J.E., Zeng A.P., et al. Screening of bacterial strains capable of converting biodiesel-derived raw glycerol into 1,3-propanediol, 2,3-butanediol and ethanol. Eng Life Sci 2012, 12:57-68.
77. Lee S., Kim B., Park K., Um Y., Lee J. Synthesis of pure meso-2,3-butanediol from crude glycerol using an engineered metabolic pathway in Escherichia coli. Appl Biochem Biotechnol 2012, 166:1801-1813.
78. Liu X., Jensen P.R., Workman M. Bioconversion of crude glycerol feedstocks into ethanol by Pachysolen tannophilus. Bioresour Technol 2012, 104:579-586.
79. Choi W.J., Hartono M.R., Chan W.H., Yeo S.S. Ethanol production from biodiesel-derived crude glycerol by newly isolated Kluyvera cryocrescens. Appl Microbiol Biotechnol 2011, 98:1255-1264.
80. 12 production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii: optimization of medium composition through statistical experimental designs. Bioresour Technol 2012, 105:128-133.
81. Liu Y., Koh C.M.J., Ji L. Bioconversion of crude glycerol to glycolipids in Ustilago maydis. Bioresour Technol 2011, 102(4):3927-3933.
82. Saenge C., Cheirsilp B., Suksaroge T.T., Bourtoom T. Potential use of oleaginous red yeast Rhodotorula glutinis for the bioconversion of crude glycerol from biodiesel plant to lipids and carotenoids. Process Biochem 2011, 46(1):210-218.
83. Hu Z.C., Zheng Y.G., Shen Y.C. Use of glycerol for producing 1,3-dihydroxyacetone by Gluconobacter oxydans in an airlift bioreactor. Bioresour Technol 2011, 102(14):7177-7182.
84. Mothes G., Schnorpfeil C., Ackermann J.U. Production of PHB from crude glycerol. Eng Life Sci 2007, 7:475-479.
85. Ruhal B., Choudhury B. Use of an osmotically sensitive mutant of Propionibacterium freudenreichii sub spp. shermanii for the simultaneous productions of organic acids and trehalose from biodiesel waste based crude glycerol. Bioresour Technol 2012, 109:131-139.
86. Sabourin-Provost G., Hallenbeck P.C. High yield conversion of a crude glycerol fraction from biodiesel production to hydrogen by photofermentation. Bioresour Technol 2009, 100(14):3513-3517.
87. Tang S., Boehme L., Lam H., Zhang Z. Pichia pastoris fermentation for phytase production using crude glycerol from biodiesel production as the sole carbon source. Biochem Eng J 2009, 43(2):157-162.
88. Volpato G., Rodrigues R.C., Heck J.X., Ayub M.A.Z. Production of organic solvent tolerant lipase by Staphylococcus caseolyticus EX17 using raw glycerol as substrate. J Chem Technol Biotechnol 2008, 83:821-828.
89. Yu Z., Du G., Zhou J., Chen J. Enhanced α-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by an improved integrated fed-batch strategy. Bioresour Technol 2012, 10.1016/j.biortech.2012.03.021.
90. Morgunov I.G., Kamzolova S.V., Perevoznikova O.A., Shishkanova N.V., Finogenova T.V. Pyruvic acid production by a thiamine auxotroph of Yarrowia lipolytica. Process Biochem 2004, 39(11):1469-1474.
91. Yuzbashev T.V., Yuzbasheva E.Y., Sobolevskaya T.I., Laptev I.A., Vybornaya T.V., Larina A.S., et al. Production of succinic acid at low pH by a recombinant strain of the aerobic yeast Yarrowia lipolytica. Biotechnol Bioeng 2010, 107(4):673-682.
92. Chang C.C., Ryu D.D.Y., Park C.S., Kim J.Y. Enhancement of rice α-amylase production in recombinant Yarrowia lipolytica. J Ferment Bioeng 1997, 84(5):421-442.
93. Lee G.H., Bae J.H., Suh M.J., Kim I.H., Hou C.T., Kim H.R. New finding and optimal production of a novel extracellular alkaline lipase from Yarrowia lipolytica NRRL Y-2178. J Microbiol Biotechnol 2007, 17(6):1054-1057.
94. Fontes G.C., Amaral P.F.F., Nele H., Coelho M.A.Z. Factorial design to optimize biosurfactant production by Yarrowia lipolytica. J Biomed Biotechnol 2010, [art. no. 821306].
95. Rywińska A., Rymowicz W., Marcinkiewicz M. Valorization of raw glycerol for citric acid production by Yarrowia lipolytica yeast. Electron J Biotechnol 2010, 13(4).
96. Rymowicz W., Rywińska A., Gładkowski W. Simultaneous production of citric acid and erythritol from crude glycerol by Yarrowia lipolytica Wratislavia K1. Chem Pap 2008, 62(3):239-246.
97. Rymowicz W., Rywińska A., Marcinkiewicz M. High yield production of erythritol from raw glycerol in fed-batch cultures of Yarrowia lipolytica. Biotechnol Lett 2009, 31:377-380.
98. Tomaszewska L., Rywińska A., Gładkowski W. Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol. J Ind Microbiol Biotechnol 2012, 39:1333-1343.
99. Scott S.D., Armenta R.E., Berryman K.T., Norman A.W. Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. Enzyme Microb Technol 2011, 48(3):267-272.
100. Papanikolaou S., Aggelis G. Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture. Bioresour Technol 2002, 82(1):43-49.
101. Papanikolaou S., Muniglia L., Chevalot I., Aggelis G., Marc I. Accumulation of a cocoa-butter-like lipid by Yarrowia lipolytica cultivated on agro-industrial residues. Curr Microbiol 2003, 46(2):124-130.
102. Taccari M., Canonico L., Comitini F., Mannazzu I., Ciani M. Screening of yeasts for growth on crude glycerol and optimization of biomass production. Bioresour Technol 2012, 110:488-495.
103. Puniya A.K., Singh S., Kumar C.G., Singh K. Single cell protein: a promising dietary substitute. Indian J Exp Biol 1995, 33:545-551.
104. Stone C.W. Yeast products in the feed industry: a practical guide for feed professionals 1998, Diamond V Mills, Inc, Cedar Rapids, IA.
105. Gao Y., Li D., Liu Y. Production of single cell protein from soy molasses using Candida tropicalis. Ann Microbiol 2011, 62(3):1165-1172.
106. Adedayo M.R., Ajiboye E.A., Akintunde J.K., Odaibo A. Single cell proteins: as nutritional enhancer. Adv Appl Sci Res 2011, 2:2396-2409.
107. Boze H., Moulin G., Galzy P. Production of food and fodder yeasts. Crit Rev Biotechnol 1992, 12(1/2):65-86.
108. Coelho M.A.Z., Amaral P.F.F., Belo I. Yarrowia lipolytica: an industrial workhorse. Microbiology book series 2010, 233-245. Formatex. A. Mendez-Vilas (Ed.).
109. Imandi S.B., Karanam S.K., Darsipudi S., Garapati H.R. Growth rate data fitting of Yarrowia lipolytica NCIM 3589 using logistic equation and artificial neural networks. Adv Biosci Biotechnol 2010, 1:47-50.
110. Yoshida M., Hashimoto K. Assessment of the pathogenicity of yeasts used in the production of single cell protein. Agr Biol Chem 1986, 50(8):2117-2118.
111. Musiał I., Rymowicz W., Cibis E. Optimization of single-cell-biomass production by Yarrowia lipolytica using response surface methodology and pulse method. EJPAU 2004, 7(1):02.
112. Montet D., Ratomahenina R., Ba A., Pina M., Graille J., Galzy P. Production of single cell protein from vegetable oils. J Ferment Technol 1983, 61(4):417-420.
113. Makri A., Fakas S., Aggelis G. Metabolic activities of biotechnological interest in Yarrowia lipolytica grown on glycerol in repeated batch cultures. Bioresour Technol 2010, 101:2351-2358.
114. Galvagno M.A., Iannone L.J., Bianchi J., Kronberg F., Rost E., Carstens M.R., et al. Optimization of biomass production of a mutant of Yarrowia lipolytica with an increased lipase activity using raw glycerol. Rev Argent Microbiol 2011, 43(3):218-225.
115. Nasseri A.T., Rasoul-Amini S., Moromvat M.H., Ghasemi Y. Single cell protein: production and process. Am J Food Technol 2011, 6(2):103-116.
116. Rajoka M.I., Khan S.H., Jabbar M.A., Awan M.S., Hashmi A.S. Kinetics of batch single cell protein production from rice polishings with Candida utilis in continuously aerated tank reactors. Bioresour Technol 2006, 97:1934-1941.
117. Ugalde U.O., Castrillo J.I. Single cell proteins from fungi and yeasts. Agriculture and food production 2002, 360-391. Elsevier Science, Amsterdam. D.K. Arora, G.G. Khachatourians (Eds.).
118. Chatzifragkou A., Petrou I., Gardeli C.H., Komaitis M., Papanikolaou S. Effect of Origanum vulgare L. essential oil on growth and lipid profile of Yarrowia lipolytica cultivated on glycerol-based media. J Am Oil Chem Soc 2011, 88:1955-1964.
119. André A., Chatzifragkou A., Diamantopoulou P., Sarris D., Philippoussis A., Galiotou-Panayotou M., et al. Biotechnological conversions of biodiesel derived crude glycerol by Yarrowia lipolytica strains. Eng Life Sci 2009, 9:468-478.
120. Juszczyk P., Musiał I., Rymowicz W. Selection of yeast strains for biomass production from raw glycerol. Acta Sci Pol Biotechnol 2005, 4(1-2):65-76.
121. Juszczyk P., Rymowicz W. Microbial bioconversions of raw glycerol. Microbial conversions of raw glycerol 2009, 125-135. Nova Science Publishers, Inc, New York. G. Aggelis (Ed.).
122. Papanikolaou S., Fakas S., Fick M., Chevalot I., Galiotou-Panayotou M., Komaitis M., et al. Biotechnological valorisation of raw glycerol discharged after bio-diesel (fatty acid methyl esters) manufacturing process: production of 1,3-propanediol, citric acid and single cell oil. Biomass Bioenergy 2008, 32:60-71.
123. Kamzolova S.V., Fatykhova A.R., Dedyukhina E.G., Anastassiadis S.G., Golovchenko N.P., Morgunov I.G. Citric acid production by yeast grown on glycerol-containing waste from biodiesel industry. Food Technol Biotechnol 2011, 49:65-74.
124. Rymowicz W., Rywińska A., zarowska B., Juszczyk P. Citric acid production from crude glycerol by acetate mutants of Yarrowia lipolytica. Chem Pap 2006, 60:391-394.
125. Rywińska A., Juszczyk P., Wojtatowicz M., Rymowicz W. Chemostat study of citric acid production from glycerol by Yarrowia lipolytica. J Biotechnol 2011, 152:54-57.
126. Anupama, Ravindra P. Value - added food: single cell protein. Biotechnol Adv 2000, 18:459-479.
127. Giec A., Skupin J. Single cell protein as food and feed. Die Nahrung 1988, 32:219-229.
128. Boze H., Moulin G., Galzy P. Production of microbial biomass. Biotechnology 1995, 167-175. VCH Publishers, Weinheim. 2nd ed. H.J. Rehm, G. Reed (Eds.).
129. Rymowicz W., Fatykhova A.R., Kamzolova S.V., Rywińska A., Morgunov I.G. Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl Microbiol Biotechnol 2010, 87:971-979.
130. Papanikolaou S., Chevalot I., Komaitis M., Aggelis G., Marc I. Kinetic profile of the cellular lipid composition in an oleaginous Yarrowia lipolytica capable of producing a cocoa-butter substitute from industrial fats. Anton Leeuw 2001, 80:215-224.
131. Araujo A., D'souza A. Enzymatic saccharification of pretreated rice straw and biomass production. Biotechnol Bioeng 1986, 28:15-39.
132. Parajo J.C., Santos V., Dominguez H., Vázquez M. Protein concentrates from yeast cultured in wood hydrolysates. Food Chem 1995, 53:157-163.
133. Paul D., Mukhopadhyay R., Chatterjee B.P., Guha A.K. Nutritional profile of food yeast Kluyveromyces fragilis biomass grown on whey. Appl Biochem Biotechnol 2002, 97:209-218.
134. Nicol R.W., Marchand K., Lubitz W.D. Bioconversion of crude glycerol by fungi. Appl Microbiol Biotechnol 2012, 93:1865-1875.
135. Meng X., Yang J., Xu X., Zhang L., Nie Q., Xian M. Biodiesel production from oleaginous microorganisms. Renewable Energy 2009, 34:1-5.
136. Ratledge C., Cohen Z. Microbial and algal oils: do they have a future for biodiesel or as commodity oils?. Lipid Technol 2008, 20:155-160.
137. Papanikolaou S., Aggelis G. Lipids of oleaginous yeasts-part I: biochemistry of single cell oil production. Eur J Lipid Sci Technol 2011, 113:1031-1051.
138. Papanikolaou S., Aggelis G. Lipids of oleaginous yeasts-part II: technology and potential applications. Eur J Lipid Sci Technol 2011, 113:1052-1073.
139. Fadaly H.A.E., Naggar N.E.A.E., Marwan E.S.M. Single cell oil production by an oleaginous yeast strain in a low cost cultivation medium. Res J Microbiol 2009, 4:301-313.
140. Beopoulos A., Desfougéres T., Sabirova J., Nicaud J.M. Yarrowia lipolytica as a cell factory for oleochemical biotechnology. Handbook of hydrocarbon and lipid microbiology 2010, 3003-3010. Springer-Verlag, Berlin/Heidelberg. K.N. Timmis (Ed.).
141. Ratledge C., Wynn J. The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms. Adv Appl Microbiol 2002, 51:1-51.
142. Fakas S., Papanikolaou S., Galiotou-Panayotou M., Komaitis M., Aggelis G. Biochemistry and biotechnology of single cell oil. New horizons in biotechnology 2009, 53-75. Asiatech Publishers, Inc. A. Pandey, C. Larroche (Eds.).
143. Beopoulos A., Mrozova Z., Thevenieau F., Le Dall M.T., Hapala I., Papanikolaou S., et al. Control of lipid accumulation in the yeast Yarrowia lipolytica. Appl Environ Microbiol 2008, 74:7779-7789.
144. Li Q., Du W., Liu D. Perspectives of microbial oils for biodiesel production. Appl Microbiol Biot 2008, 80:749-756.
145. Bati N., Hammond E.G., Glatz B.A. Biomodification of fats and oils: trials with Candida lipolytica. J Am Oil Chem Soc 1984, 61:1743-1746.
146. Papanikolaou S., Chevalot J., Komaitis M., Marc I. Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures. Appl Microbiol Biotechnol 2002, 553:308-312.
147. Berovic M., Legisa M. Citric acid production. Biotechnol Annu Rev 2007, 13:303-343.
148. Soccol C.R., Vandenberghe L.P.S., Rodrigues C., Pandey A. New perspectives for citric acid production and application. Food Technol Biotechnol 2006, 44:141-149.
149. Akiyama S., Suzuki T., Sumino Y., Nakao Y., Fukudi H. Induction and citric acid productivity of fluoroacetate-sensitive mutant strains of Candida lipolytica. Agr Biol Chem 1973, 37(4):879-884.
150. Anastassiadis S., Morgunov I.G., Kamzolova S.V., Finogenova T.V. Citric acid production patent review. Recent Pat Biotechnol 2008, 2:1-17.
151. Rane K., Sims K. Production of citric acid by Candida lipolytica Y 1095: effect of glucose concentration on yield and productivity. Enzyme Microb Technol 1993, 15:646-651.
152. Arzumanov T.E., Shishkanova N.V., Finogenova T.V. Biosynthesis of citric acid by Yarrowia lipolytica repeat-batch on culture on ethanol. Appl Microbiol Biotechnol 2000, 53:525-529.
153. Aurich A., Förster A., Mauersberger S., Barth G., Stottmeister U. Citric acid production from renewable resources by Yarrowia lipolytica. Biotechnol Adv 2003, 21:454-455.
154. Förster A., Aurich A., Mauersberger S., Barth G. Citric acid production from sucrose using a recombinant strain of the yeast Yarrowia lipolytica. Appl Microbiol Biotechnol 2007, 75:1409-1417.
155. Förster A., Jacobs K., Juretzek T., Mauersberger S., Barth G. Overexpression of the ICL1 gene changes the product ratio of citric acid production by Yarrowia lipolytica. Appl Microbiol Biotechnol 2007, 77:861-869.
156. Kamzolova S.V., Morgunov I.G., Aurich A., Perevoznikova O.A., Shishkanova N.V., Stottmeister U., et al. Lipase secretion and citric acid production in Yarrowia lipolytica yeast grown on animal and vegetable fat. Food Technol Biotechnol 2005, 43:113-122.
157. Kamzolova S.V., Finogenova T.V., Morgunov I.G. Microbiological production of citric and isocitric acids from sunflower oil. Food Technol Biotechnol 2008, 46:51-59.
158. Venter T., Kock J.L.F., Botes P.J., Smit M.S., Hugo A., Joseph M. Acetate enhances citric acid production by Yarrowia lipolytica when grown on sunflower oil. Syst Appl Microbiol 2004, 27:135-138.
159. Papanikolaou S., Muniglia L., Chevalot I., Aggelis A., Marc I. Yarrowia lipolytica as a potential producer of citric acid from crude glycerol. J Appl Microbiol 2002, 92:737-744.
160. Ermakova I.T., Morgunov I.G. Pathways of glycerol metabolism in Yarrowia (Candida) lipolytica yeasts. Mikrobiologiya 1987, 57:533-537.
161. Rywińska A., Rymowicz W., zarowska B., Skrzypiński A. Comparison of citric acid production from glycerol and glucose by different strains of Yarrowia lipolytica. World J Microbiol Biotechnol 2010, 26:1217-1224.
162. Papanikolaou S., Aggelis G. Modelling aspects of the biotechnological valorization of raw glycerol: production of citric acid by Yarrowia lipolytica and 1,3-propanediol by Clostridium butyricum. J Chem Technol Biotechnol 2003, 78:542-547.
163. Rywińska A., Rymowicz W. High-yield production of citric acid by Yarrowia lipolytica on glycerol in repeated-batch bioreactors. J Ind Microbiol Biotechnol 2010, 37:431-435.
164. Rywińska A., Musiał I., Rymowicz W., zarowska B., Boruczkowski T. Effect of agitation and aeration on the citric acid production by Yarrowia lipolytica grown on glycerol. Prep Biochem Biotechnol 2012, 42:279-291.
165. Rywińska A., Rymowicz W. Citric acid production from raw glycerol by Yarrowia lipolytica Wratislavia 1.31. Microbial conversions of raw glycerol 1999, 19-30. Nova Science Publishers Inc, New York. G. Aggelis (Ed.).
166. Levinson W.E., Kurtzman C.P., Kuo T.M. Characterization of Yarrowia lipolytica and related species for citric acid production from glycerol. Enzyme Microb Technol 2007, 41:292-295.
167. Imandi S.B., Bandaru V.V.R., Somalanka S.R., Garapati H.R. Optimization of medium constituents for the production of citric acid from byproduct glycerol using Doehlert experimental design. Enzyme Microb Technol 2007, 40:1367-1372.
168. Kim Y.-H., Kang S.W., Lee J.H., Chang H.-I., Yun Ch-W., Paik H.-D., et al. High cell density fermentation of Saccharomyces cerevisiae JUL3 in fed-batch culture for the production of β-glucan. J Ind Eng Chem 2007, 13(1):153-158.
169. Rywińska A., Rymowicz W., zarowska B., Wojtatowicz M. Biosynthesis of citric acid from glycerol by acetate mutants of Yarrowia lipolytica in fed-batch fermentation. Food Technol Biotechnol 2009, 47:1-6.
170. Rywińska A., Rymowicz W. Continuous production of citric acid from raw glycerol by Yarrowia lipolytica in cell recycle cultivation. Chem Pap 2011, 65:119-123.
171. Nicaud J.M., Fabre E., Gaillardin C. Expression of invertase activity in Yarrowia lipolytica and its use as a selective marker. Curr Genet 1989, 16(4):253-260.
172. Hong S.P., Seip J., Walters-Pollak D., Rupert R., Jackson R., Xue Z., et al. Engineering Yarrowia lipolytica to express secretory invertase with strong FBA1IN promoter. Yeast 2012, 29:59-72.
173. Li Y., Chen J., Lun S.-Y. Biotechnological production of pyruvic acid. Appl Microbiol Biotechnol 2001, 57:451-459.
174. Xu P., Qiu J., Ch Gao, Ma C. Biotechnological router to pyruvate production. J Biosci Bioeng 2008, 105(3):169-175.
175. Otto Ch, Yovkova V., Barth G. Overproduction and secretion of ketoglutaric acid by microorganisms. Appl Microbiol Biotechnol 2011, 92:689-695.
176. Tsugawa R., Nakase T., Kobayash T., Yamashita K., Okumura S. Fermentation of n-paraffins by yeast. III. A-Ketoglutarate productivity of various yeast. Agr Biol Chem 1969, 33:929-941.
177. Chernyavskaya O.G., Shishkanova N.V., Ilchenko A.P., Finogenova T.V. Synthesis of alpha-ketglutaric acid by Yarrowia lipolytica yeast grown on ethanol. Appl Microbiol Biotechnol 2000, 53:152-158.
178. Ilchenko A.P., Chernyavskaya O.G., Shishkanova N.V., Finogenova T.V. Biochemical characterization of the yeast Yarrowia lipolytica overproducing carboxylic acids from ethanol: nitrogen metabolism enzymes. Microbiol 2003, 72:470-475.
179. Ilchenko A.P., Chernyavskaya O.G., Shishkanova N.V., Finogenova T.V. Metabolism of Yarrowia lipolytica grown on ethanol under conditions promoting the production of α-ketoglutaric and citric acids: a comparative study of the central metabolism enzymes. Microbiol 2002, 71:315-322.
180. Kamzolova S.V., Chiglintseva M.N., Lunina J.N., Morgunov I.G. α-ketoglutaric acid production by Yarrowia lipolytica and its regulation. Appl Microbiol Biotechnol 2012, 10.1007/s00253-012-4222x.
181. Aurich A, Stottmeister U. Verbunvorhaben: Biotechnologische Gewinnung von Carbosäuren, Teilvorhaben 1: Biotechnologische Gewinnung von Oxocarbonsäuren als Synthesebausteine. Präambel, Endbericht; Projekt der Fachagentur für nachwachsende Rohstoffe e.V., FZ: 220011071.
182. Zhou J., Zhou H., Du G., Liu L., Chen J. Screening of thiamine-auxotrophic yeast for α-ketoglutaric acid overproduction. Lett Appl Microbiol 2010, 51:264-271.
183. 2] on yeast respiration and acidogenesis. Microbiol 2001, 70:189-195.
184. Holz M., Otto Ch, Kretzschmar A., Yovkova V., Aurich A., Pötter M., et al. Overexpression of alpha-ketoglutarate dehydrogenase in Yarrowia lipolytica and its effect on production of organic acids. Appl Microbiol Biotechnol 2011, 89:1519-1526.
185. Yin X., Madzak C., Du G., Zhou J., Chen J. Enhanced alpha-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by regulation of the pyruvate carboxylation pathway. Appl Microbiol Biotechnol 2012, 10.1007/s00253-012-4192-z.
186. Zhou J., Yin X., Madzak C., Du G., Chen J. Enhanced α-ketoglutarate production in Yarrowia lipolytica WSH-Z06 by alteration of the acetyl-CoA metabolism. J Biotechnol 2012, 161:257-264.
187. Lee S.Y., Hong S.H., Lee S.H., Park S.J. Fermentative production of chemicals that can be used for polymer synthesis. Macromol Biosci 2004, 4:157-164.
188. Papanikolaou S., Chatzifragkou A., Fakas S., Galiotou-Panayotou M., Komaitis M., Nicaud J.M., et al. Biosynthesis of lipids and organic acids by Yarrowia lipolytica strains cultivated on glucose. Eur J Lipid Sci Technol 2009, 111:1221-1232.
189. Tomaszewska L., Rywińska A., Musiał I., Utecht M., Juszczyk P., Rymowicz W., et al. Screening of Yarrowia lipolytica yeast strains for erythritol production from glycerol (in polish). Acta Sci Pol 2011, 10:15-28.
190. Tomaszewska L., Rywińska A., Musiał I., Rymowicz W., Juszczyk P. Effect of vitamins on erythritol biosynthesis by Yarrowia lipolytica Wratislavia K1. Curr Opin Biotech 2011, 22(Suppl. 1):S94-S95.
191. Moon H.J., Jeya M., Kim I.W., Lee J.K. Biotechnological production of erythritol and its applications. Appl Microbiol Biotechnol 2010, 86:1017-1025.
192. Saha B.C., Racine F.M. Biotechnological production of mannitol and its applications. Appl Microbiol Biotechnol 2011, 89:879-891.
193. Ueda M, Yamagishi K. Method for producing erythritol. European Patent Application EP0770683; 1997.
194. Musiał I., Wojtatowicz M., Juszczyk P., Rywińska A. Erythritol production by Yarrowia lipolytica DN I W 2a and its UV mutants on media containing glycerol. Curr Opin Biotech 2011, 22(Suppl. 1):S95.
195. Musiał I., Marcinkiewicz M., Cibis E., Rywińska A., Juszczyk P., Rymowicz W. Optimization of erythritol production from glycerol by Yarrowia lipolytica Wratislavia K1. Curr Opin Biotech 2011, 22(Suppl. 1):S95.
196. Lin S.J., Wen C.Y., Liau J.C., Chu W.S. Screening and production of erythritol by newly isolated osmophilic yeast-like fungi. Process Biochem 2001, 36:1249-1258.
197. Kim S.Y., Lee K.H., Kim J.H., Oh D.K. Erythritol production by controlling osmotic pressure in Trigonopsis variabilis. Biotechnol Lett 1997, 19(8):727-729.
198. Kim J.W., Park T.J., Ryu D.D.Y., Kim J.Y. High cell density culture of Yarrowia lipolytica using a one-step feeding process. Biotechnol Prog 2000, 16:657-660.
199. Alba-Lois L., Segal C., Rodarte B., Valdes-Lopez V., DeLuna A., Cardenas R. NADP-glutamate dehydrogenase activity is increased under hyperosmotic conditions in the halotolerant yeast Debaryomyces hansenii. Curr Microbiol 2004, 48:68-72.
200. Kayingo G., Kilian S.G., Prior B.A. Conservation and release of osmolytes by yeast during hypo-osmotic stress. Arch Microbiol 2001, 177:29-35.
201. Lucca M.E., Spencer J.F.T., de Figueroa L.I.C. Glycerol and arabitol production by an intergeneric hybrid, PB2, obtained by protoplast fusion between Saccharomyces cerevisiae and Torulaspora delbrueckii. Appl Microbiol Biotechnol 2002, 59:472-476.
202. van Eck J.H., Prior B.A., Brandt E.V. The water relations of growth and polyhydroxy alcohol production by ascomycetous yeasts. J Gen Microbiol 1993, 139:1047-1054.