STE11 disruption reveals the central role of a MAPK pathway in dimorphism and mating in Yarrowia lipolytica

FEMS Yeast Research

Volumn 6, Issue 5, 2006, Pages 801-815

  Cervantes Chávez, José A ^a   Ruiz Herrera, José ^a  

^a DEPARTAMENTO DE INGENIERÍA GENÉTICA   (Mexico)

Author keywords

MAPK pathway; Mating; Morphogenesis; STE11 gene; Yarrowia lipolytica

Indexed keywords

AMINO ACID; FUNGAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; REGULATOR PROTEIN; SCAFFOLD PROTEIN;

ARTICLE; DELETION MUTANT; FUNGAL GENE; FUNGAL GENETICS; GENE; GENE DISRUPTION; GENE ISOLATION; GENETIC TRANSCRIPTION; GROWTH RATE; HYPOTHESIS; INTRON; LEAF DIMORPHISM; MATING; MORPHOGENESIS; MYCELIAL GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC STRESS; PROMOTER REGION; REVERTANT; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STE11; USTILAGO MAYDIS; WILD TYPE; YARROWIA LIPOLYTICA;

AMINO ACID SEQUENCE; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; OPEN READING FRAMES; PHENOTYPE; REPRODUCTION; TRANSCRIPTION, GENETIC; TRANSFORMATION, GENETIC; YARROWIA;

FUNGI; SACCHAROMYCES CEREVISIAE; USTILAGO MAYDIS; YARROWIA LIPOLYTICA;

EID: 33745910845     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00084.x     Document Type: Article

References (57)

1. Banuett F (1998) Signalling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol Mol Biol Rev 62: 249-274.
2. Bardwell L (2005) A walk-through of the yeast mating pheromone response pathway. Peptides 26: 339-350.
3. Barth G & Gaillardin C (1996) Yarrowia lipolytica. Nonconventional Yeasts in Biotechnology (Wolf K, ed.), pp. 313-388. Springer, Berlin.
4. Boeke J, Trueheart DJ, Natsoulis G & Fink GR (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol 154: 164-174.
5. Braun BR & Johnson AD (2000) TUP1, CPH1, EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155: 57-67.
6. Butler G, Kenny C, Fagan A, Kurischko C, Gaillardin C & Wolfe KH (2004) Evolution of the MAT locus and its Ho endonuclease in yeast species. Proc Natl Acad Sci USA 101: 1632-1637.
7. Cairns BR, Ramer SW & Kornberg RG (1992) Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev 6: 1305-1318.
8. Chaleff DT & Tatchell K (1985) Molecular cloning and characterization of the STE7 and STE11 genes of Saccharomyces cerevisiae. Mol Cell Biol 5: 1878-1886.
9. Clarke DL, Woodlee GL, McClelland CM, Seymour TS & Wickes BL (2001) The Cryptococcus neoformans STE11α gene is similar to other fungal mitogen-activated protein kinase kinase kinase (MAPKKK) genes but is mating type specific. Mol Microbiol 40: 200-213.
10. Davis DA, Bruno VM, Loza L, Filler SG & Mitchell AP (2002) Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 162: 1573-1581.
11. Dhillon NK, Sharma S & Khuller GK (2003) Signaling through protein kinases and transcriptional regulators in Candida albicans. Crit Rev Microbiol 29: 259-275.
12. Domínguez A, Fermiñán E & Gaillardin C (2000) Yarrowia lipolytica: an organism amenable to genetic manipulation as a model for analyzing dimorphism in fungi. Dimorphism in Human Pathogenic and Apathogenic Yeasts (Ernst JF & Schmidt A, eds), pp. 151-172. Karger, Basel.
13. Elion EA (2000) Pheromone response, mating and cell biology. Curr Opin Microbiol 3: 573-581.
14. Fickers P, Benetti PH, Waché Y, Marty A, Mauersberger S, Smit MS & Nicaud JM (2005) Hydrophobic substrate utilisation by the yeast Yarrowia lipolytica and its potential applications. FEMS Yeast Res 5: 527-543.
15. Gold SE, Duncan G, Barret K & Kronstad JM (1994) cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis. Genes Dev 8: 2805-2816.
16. González-López CI, Ortiz-Castellanos L & Ruiz-Herrera J (2006) The PacC homologue from the basidiomycete Ustilago maydis is functional in multiple pH-sensitive phenomena in Yarrowia lipolytica. Curr Microbiol. in press.
17. Guevara-Olvera L, Calvo-Mendez C & Ruiz-Herrera J (1993) The role of polyamine metabolism in dimorphism of Yarrowia lipolytica. J Gen Microbiol 193: 485-493.
18. Hanks SK, Quinn AM & Hunter T (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241: 42-52.
19. Heinisch JJ, Lorberg A, Schmitz HP & Jacoby JJ (1999) The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol 32: 671-680.
20. Hoffman CS & Winston F (1987) A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57: 267-272.
21. Ito H, Fukuda Y, Murata K & Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168.
22. Jones JDG, Dunsmuir P & Bedbrook J (1985) High-level expression of introduced chimeric genes in regenerated transformed plants. EMBO J 4: 2411-2418.
23. Jouannic S, Hamal A, Leprince A, Tregear SJW, Kreis M & Henry Y (1999) Plant MAP kinase kinase kinase structure, classification and evolution. Gene 233: 1-11.
24. Kim J, Cheon SA, Park S, Song Y & Kim JY (2000) Serum-induced hypha formation in the dimorphic yeast Yarrowia lipolytica. FEMS Microbiol Lett 190: 9-12.
25. Kurischko C, Schilhabel MB, Kunze I & Franzl E (1999) The MATA locus of the dimorphic yeast Yarrowia lipolytica consists of two divergently oriented genes. Mol Gen Genet 262: 180-188.
26. Lamson RE, Winters MJ & Pryciak PM (2002) Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20. Mol Cell Biol 22: 2939-2951.
27. León M, Sentandreu R & Zueco J (2002) A single FKS homologue in Yarrowia lipolytica is essential for viability. Yeast 19: 1003-1014.
28. Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, Ziegelbauer K, Schmidt A, Gow NAR, Brown AJP & Thomas DY (1996) Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 93: 13217-13222.
29. Lee BN & Elion EA (1999) The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signalling components. Proc Natl Acad Sci USA 96: 12679-12684.
30. Lengeler KB, Davidson RC, D'Souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M & Heitman J (2000) Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 64: 746-785.
31. Liu H (2001) Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4: 728-735.
32. Liu H (2002) Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen. Int J Med Microbiol 292: 299-311.
33. Madzak C, Blanchin-Roland S, Cordero-Otero RR & Gaillardin C (1999) Functional analysis of upstream regulating regions from the Yarrowia lipolytica XPR2 promoter. Microbiology 145: 75-87.
34. Martínez-Espinoza AD, García-Pedrajas MD & Gold SE (2002) The Ustilaginales as plant pests and model systems. Fungal Genet Biol 35: 1-20.
35. Martínez-Espinoza AD, Ruiz-Herrera J, León-Ramírez CG & Gold SE (2004) MAP Kinase and cAMP signaling pathways modulate the pH-induced yeast-to-mycelium dimorphic transition in the corn smut fungus Ustilago maydis. Curr Microbiol 49: 274-281.
36. Müller P, Weinzierl G, Brachmann A, Feldbrügge M & Kahmann R (2003) Mating and pathogenic development of the smut fungus Ustilago maydis are regulated by one mitogen-activated protein kinase cascade. Eukaryot Cell 2: 1187-1199.
37. Pan X, Harashima T & Heitman J (2000) Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol 3: 567-572.
38. Ramon AM, Porta A & Fonzi WA (1999) Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2. J Bacteriol 181: 7524-7530.
39. Richard M, Rosas-Quijano R, Bezzate S, Bordon-Pallier F & Gaillardin C (2001) Tagging morphogenetic genes by insertional mutagenesis in the yeast Yarrowia lipolytica. J Bacteriol 183: 3098-3107.
40. Rodríguez C & Domínguez A (1984) The growth characteristics of Saccharomycopsis lipolytica: morphology and induction of mycelial formation. Can J Microbiol 30: 605-612.
41. Ruiz-Herrera J, León CG, Guevara-Olvera L & Cárabez-Trejo A (1995) Yeast-mycelium dimorphism of haploid and diploid strains of Ustilago maydis. Microbiology 141: 695-703.
42. Ruiz-Herrera J & Sentandreu R (2002) Different effectors of dimorphism in Yarrowia lipolytica. Arch Microbiol 178: 477-483.
43. Saito H & Tatebayashi K (2004) Regulation of the osmoregulatory HOG MAPK cascade in yeast. J Biochem (Tokyo) 136: 267-272.
44. Sambrook J & Russell DW (1999) Molecular Cloning: a Laboratory Manual 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
45. Sánchez-Martínez C & Pérez-Martín J (2001) Dimorphism in fungal pathogens: Candida albicans and Ustilago maydis - similar inputs, different outputs. Curr Opin Microbiol 4: 214-221.
46. Schultz J, Ponting CP, Hofmann K & Bork P (1997) SAM as a protein interaction domain involved in developmental regulation. Protein Sci 6: 249-253.
47. Stevenson BJ, Rhodes N, Errede B & Sprague GF Jr (1992) Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev 6: 1293-1304.
48. Styrkársdóttir U, Egel R & Nielsen O (1992) Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction. Mol Gen Genet 235: 122-130.
49. Szabo R & Stofaníková V (2002) Presence of organic sources of nitrogen is critical for filament formation and pH-dependent morphogenesis in Yarrowia lipolytica. FEMS Microbiol Lett 206: 45-50.
50. Tu H, Barr M, Dong DL & Wigler M (1997) Multiple regulatory domains on the Byr2 protein kinase. Mol Cell Biol 17: 5876-5887.
51. Vanden Bossche H, Odds F & Kerridge CD, eds, (1993) Dimorphic Fungi in Biology and Medicine. Plenum Press, N.Y.
52. Wei H, Requena N & Fisher R (2003) The MAPKK kinase SteC regulates conidiophore morphology and is essential for heterokaryon formation and sexual development in the homothallic fungus Aspergillus nidulans. Mol Microbiol 47: 1577-1588.
53. Whiteway M & Oberholzer U (2004) Candida morphogenesis and host-pathogen interactions. Curr Opin Microbiol 7: 350-357.
54. Widmann C, Gibson S, Jarpe MB & Johnson GL (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79: 143-180.
55. Wu C, Leberer E, Thomas DY & Whiteway M (1999) Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae. Mol Biol Cell 10: 2425-2440.
56. Xuan JW, Fournier P, Declerck N, Chasles M & Gaillardin C (1990) Overlapping reading frames at the lys5 locus in the yeast Yarrowia lipolytica. Mol Cell Biol 10: 4795-4806.
57. Zaret KS & Sherman F (1982) DNA sequence required for efficient transcription termination in yeast. Cell 28: 563-573.