Enhanced α-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by an improved integrated fed-batch strategy

Bioresource Technology

Volumn 114, Issue , 2012, Pages 597-602

  Yu, Zongzhong ^a   Du, Guocheng ^a   Zhou, Jingwen ^a   Chen, Jian ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Ketoglutaric acid; Fed batch; Overproduction; PH control strategy; Yarrowia lipolytica

Indexed keywords

ACID PRODUCTION; BATCH CULTURE; BATCH FERMENTATION; FED BATCHES; GROWTH PHASE; INDUSTRIAL PRODUCTION; OVERPRODUCTION; PH CONTROL; PRODUCTION PHASE; YARROWIA LIPOLYTICA;

BATCH CELL CULTURE; CALCIUM CARBONATE; GLYCEROL; PRODUCTIVITY;

PH EFFECTS;

2 OXOGLUTARIC ACID; CALCIUM CARBONATE; GLYCEROL;

BIOREACTOR; CONTROL SYSTEM; FERMENTATION; PH; YEAST;

ARTICLE; BATCH FERMENTATION; FUNGUS CULTURE; NONHUMAN; PH; PRIORITY JOURNAL; SYNTHESIS; YARROWIA LIPOLYTICA;

BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; KETOGLUTARIC ACIDS; SYSTEMS INTEGRATION; YARROWIA;

YARROWIA LIPOLYTICA;

EID: 84860481547     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2012.03.021     Document Type: Article

References (26)

1. Akerberg C., Zacchi G. An economic evaluation of the fermentative production of lactic acid from wheat flour. Bioresour. Technol. 2000, 75:119-126.
2. Barrett D.G., Yousaf M.N. Poly (triol α-ketoglutarate) as biodegradable, chemoselective, and mechanically tunable elastomers. Macromolecules 2008, 41:6347-6352.
3. Barth G., Gaillardin C. Physiology and genetics of the dimorphic fungus Yarrowia lipolytica. FEMS Microbiol. Rev. 1997, 19:219-237.
4. Campbell B., Roberts M., Kerksick C., Wilborn C., Marcello B., Taylor L., Nassar E., Leutholtz B., Bowden R., Rasmussen C., Greenwood M., Kreider R. Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men. Nutrition 2006, 22:872-881.
5. Chernyavskaya O.G., Shishkanova N.V., Il'chenko A.P., Finogenova T.V. Synthesis of alpha-ketoglutaric acid by Yarrowia lipolytica yeast grown on ethanol. Appl. Microbiol. Biotechnol. 2000, 53:152-158.
6. Cynober L.A. The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care. Curr. Opin. Clin. Nutr. 1999, 2:33-37.
7. De Bandt J.P., Coudray-Lucas C., Lioret N., Lim S.K., Saizy R., Giboudeau J., Cynober L. A randomized controlled trial of the influence of the mode of enteral ornithine α-ketoglutarate administration in burn patients. J. Nutr. 1998, 128:563-569.
8. Finogenova T.V., Morgunov I.G., Kamzolova S.V., Chernyavskaya O.G. Organic acid production by the yeast Yarrowia lipolytica: a review of prospects. Appl. Biochem. Microbiol. 2005, 41:418-425.
9. Hama S., Tamalampudi S., Yoshida A., Tamadani N., Kuratani N., Noda H., Fukuda H., Kondo A. Process engineering and optimization of glycerol separation in a packed-bed reactor for enzymatic biodiesel production. Bioresour. Technol. 2011, 102:10419-10424.
10. Holz M., Otto C., Kretzschmar A., Yovkova V., Aurich A., Pötter M., Marx A., Barth G. Overexpression of alpha-ketoglutarate dehydrogenase in Yarrowia lipolytica and its effect on production of organic acids. Appl. Microbiol. Biotechnol. 2010, 89:1519-1526.
11. Huang H.J., Liu L.M., Li Y., Du G.C., Chen J. Redirecting carbon flux in Torulopsis glabrata from pyruvate to α-ketoglutaric acid by changing metabolic co-factors. Biotechnol. Lett. 2006, 28:95-98.
12. Kim Y.B., Yun H.S., Kim E.K. Enhanced sophorolipid production by feeding-rate-controlled fed-batch culture. Bioresour. Technol. 2009, 100:6028-6032.
13. Li Y., Jiang H., Du X., Huang X., Zhang X., Xu Y. Enhancement of phenazine-1-carboxylic acid production using batch and fed-batch culture of gacA inactivated Pseudomonas sp. M18G. Bioresour. Technol. 2010, 101:3649-3656.
14. Liu L., Li Y., Zhu Y., Du G., Chen J. Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metab. Eng. 2007, 9:21-29.
15. Madzak C., Gaillardin C., Beckerich J.M. Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review. J. Biotechnol. 2004, 109:63-81.
16. Matzi V., Lindenmann J., Muench A., Greilberger J., Juan H., Wintersteiger R., Maier A., Smolle-Juettner F.M. The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural. Eur. J. Cardio-thorac. 2007, 32:776-782.
17. Mirbagheri M., Nahvi I., Emtiazi G., Darvishi F. Enhanced Production of Citric Acid in Yarrowia lipolytica by Triton X-100. Appl. Biochem. Biotechnol. 2011, 165:1068-1074.
18. Otto C., Yovkova V., Barth G. Overproduction and secretion of alpha-ketoglutaric acid by microorganisms. Appl. Microbiol. Biotechnol. 2011, 92:689-695.
19. Rymowicz W., Fatykhova A.R., Kamzolova S.V., Rywinska A., Morgunov I.G. Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl. Microbiol. Biotechnol. 2010, 87:971-979.
20. Tang Y.J., Zhang W., Zhong J.J. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresour. Technol. 2009, 100:1852-1859.
21. van Duuren J.B.J.H., Wijte D., Karge B., Santos V.A.P.M.d., Yang Y., Mars A.E., Eggink G. pH-stat fed-batch process to enhance the production of Cis, Cis-muconate from benzoate by Pseudomonas putida KT2440-JD1. Biotechnol. Progr. 2011, 1002:792-801.
22. Walajtys-Rhode E., Zapatero J., Moehren G., Hoek J. The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment. J. Biol. Chem. 1992, 267:370-379.
23. Zhang D., Liang N., Shi Z., Liu L., Chen J., Du G. Enhancement of α-ketoglutarate production in Torulopsis glabrata: Redistribution of carbon flux from pyruvate to α-ketoglutarate. Biotechnol. Bioproc. E. 2009, 14:134-139.
24. Zhou J.W., Dong Z.Y., Liu L.M., Du G.C., Chen J. A reusable method for construction of non-marker large fragment deletion yeast auxotroph strains: a practice in Torulopsis glabrata. J. Microbiol. Methods 2009, 76:70-74.
25. Zhou J.W., Zhou H.Y., Du G.C., Liu L.M., Chen J. Screening of a thiamine-auxotrophic yeast for alpha-ketoglutaric acid overproduction. Lett. Appl. Microbiol. 2010, 51:264-271.
26. Zhu Y., Li J., Tan M., Liu L., Jiang L., Sun J., Lee P., Du G., Chen J. Optimization and scale-up of propionic acid production by propionic acid-tolerant Propionibacterium acidipropionici with glycerol as the carbon source. Bioresour. Technol. 2010, 101:8902-8906.