Analytical strategies for the characterization of therapeutic monoclonal antibodies

TrAC - Trends in Analytical Chemistry

Volumn 42, Issue , 2013, Pages 74-83

  Fekete, Szabolcs ^a   Gassner, Anne Laure ^a   Rudaz, Serge ^a   Schappler, Julie ^a   Guillarme, Davy ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Adsorption; Analytical strategy; Capillary electrophoresis (CE); Characterization; Liquid chromatography (LC); Mass spectrometry; Monoclonal antibody (mAb); Recombinant; Separation; Therapeutic monoclonal antibody

Indexed keywords

ADSORPTION; CAPILLARY ELECTROPHORESIS; DISEASES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; SEPARATION; SURFACE PLASMON RESONANCE;

ANALYTICAL METHOD; ANALYTICAL STRATEGY; AUTOIMMUNE DISEASE; INHERENT COMPLEXITY; MONOCLONAL ANTIBODIES (MAB); RECOMBINANT; RECOMBINANT MONOCLONAL ANTIBODY; SEPARATION SCIENCE; SEPARATION TECHNIQUES; THERAPEUTIC MONOCLONAL ANTIBODIES;

CHARACTERIZATION;

MONOCLONAL ANTIBODY;

ANALYTIC METHOD; ANTIBODY STRUCTURE; CAPILLARY ISOELECTRIC FOCUSING; CAPILLARY ZONE ELECTROPHORESIS; DRUG STRUCTURE; ELECTROSPRAY; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84871512666     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2012.09.012     Document Type: Review

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