Non-enzymatic hinge region fragmentation of antibodies in solution

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 818, Issue 2, 2005, Pages 115-121

  Cordoba, Armando J ^a,b   Shyong, Bao Jen ^a   Breen, Deirdre ^a,c   Harris, Reed J ^a  

^a GENENTECH INC   (United States)

^b MS 62 ^*  (United States)

^c ELAN PHARMACEUTICALS   (United States)

Author keywords

Hinge region fragmentation; Monoclonal antibodies; Protease inhibitors; Size exclusion chromatography; Stability

Indexed keywords

CELL CULTURE; ENZYME INHIBITION; MASS SPECTROMETRY; PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY; SODIUM CHLORIDE;

ELECTROSPRAY MASS SPECTROMETRY; MONOCLONAL ANTIBODIES (MAB); PAPAIN CLEAVAGE; PROTEIN INHIBITORS;

ANTIBODIES;

MONOCLONAL ANTIBODY;

ARTICLE; CHEMICAL BOND; DNA CLEAVAGE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ANALYSIS; ENZYME DEGRADATION; GEL PERMEATION CHROMATOGRAPHY; GENE SEQUENCE; KINETICS; PEPTIDE SYNTHESIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; TEMPERATURE MEASUREMENT;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; DRUG STABILITY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN FRAGMENTS; KINETICS; PROTEASE INHIBITORS; TEMPERATURE;

EID: 14744289246     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.12.033     Document Type: Article

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