Separation of oxidized variants of a monoclonal antibody by anion-exchange

Journal of Chromatography A

Volumn 1218, Issue 15, 2011, Pages 2091-2097

  Teshima, Glen ^a   Li, Ming Xiang ^a   Danishmand, Rahima ^a   Obi, Chidi ^a   To, Robert ^a   Huang, Carol ^a   Kung, Jacob ^a   Lahidji, Vafa ^a   Freeberg, Joel ^a   Thorner, Lauren ^a   Tomic, Milan ^a  

^a XOMA Corporation   (United States)

Author keywords

AEX of antibodies; Anion exchange of antibodies; Characterization of monoclonal antibodies; Ion exchange HPLC; LC MS; Methionyl oxidation in antibodies; Monoclonal antibodies; Oxidation; Peptide mapping; Post translational modifications

Indexed keywords

AEX OF ANTIBODIES; ANION EXCHANGE; LC/MS; METHIONYL OXIDATION IN ANTIBODIES; PEPTIDE MAPPING; POST-TRANSLATIONAL MODIFICATIONS;

ALLERGIES; CHROMATOGRAPHY; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG PRODUCTS; IONS; MAPPING; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; OXIDATION; PEPTIDES; QUALITY CONTROL; SURFACE PLASMON RESONANCE;

ION EXCHANGE;

MONOCLONAL ANTIBODY;

ANION EXCHANGE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CATION EXCHANGE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MELTING POINT; OXIDATION; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; PROTEIN MODIFICATION; SEPARATION TECHNIQUE; SURFACE CHARGE;

ANIONS; ANTIBODIES, MONOCLONAL; BOTULINUM TOXINS, TYPE A; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; COMPLEMENTARITY DETERMINING REGIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; TRYPSIN;

EID: 79952817000     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.10.107     Document Type: Article

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