Rapid analysis of charge variants of monoclonal antibodies with capillary zone electrophoresis in dynamically coated fused-silica capillary

Journal of Separation Science

Volumn 34, Issue 5, 2011, Pages 548-555

  He, Yan ^a   Isele, Colleen ^a   Hou, Weiying ^a   Ruesch, Margaret ^a  

^a PFIZER INC   (United States)

Author keywords

Charge variants; CZE; mAbs

Indexed keywords

ACCURACY AND PRECISION; CAPILLARY ZONE ELECTROPHORESIS; CAPROIC ACID; CHARGE HETEROGENEITY; CHARGE VARIANTS; CZE; DYNAMIC COATING; EXISTING METHOD; FIELD STRENGTHS; FUSED-SILICA CAPILLARIES; HIGH ELECTRIC FIELDS; IMMUNOGLOBULIN G; INTERNAL DIAMETERS; MABS; MONOCLONAL ANTIBODIES (MABS); OPTIMIZED CONDITIONS; RAPID ANALYSIS; RAPID SEPARATION; RUNTIMES; SAMPLE PREPARATION; SEPARATION BUFFERS; SEPARATION CONDITION; SEPARATION PARAMETERS; TRIETHYLENETETRAMINE;

CAPILLARY ELECTROPHORESIS; ELECTRIC FIELDS; ELECTROCHEMISTRY; MONOCLONAL ANTIBODIES; OPTIMIZATION; SILICA; SURFACE PLASMON RESONANCE;

FUSED SILICA;

AMINOCAPROIC ACID; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; SILICON DIOXIDE; TRIENTINE;

ACCURACY; ANALYTIC METHOD; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CONCENTRATION RESPONSE; PH; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADSORPTION; ANTIBODIES, MONOCLONAL; ELECTROPHORESIS, CAPILLARY; SILICON DIOXIDE;

EID: 79952020816     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000719     Document Type: Article

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