Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stability

Journal of Chromatography A

Volumn 1120, Issue 1-2, 2006, Pages 112-120

  Dillon, Thomas M ^a   Bondarenko, Pavel V ^a   Rehder, Douglas S ^a   Pipes, Gary D ^a   Kleemann, Gerd R ^a   Ricci, Margaret Speed ^a  

^a AMGEN INC   (United States)

Author keywords

Antibody; Glycosylation; Heterogeneity; IgG; LC MS; Reversed phase HPLC

Indexed keywords

ANTIBODIES; GLUCOSE; GLYCOLS; IONIZATION; MASS SPECTROMETRY; ORGANIC SOLVENTS;

GLYCOSYLATION; HETEROGENEITY; IGG; LC/MS; REVERSED-PHASE HPLC;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

FUCOSE; GALACTOSE; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY;

ACCURACY; ANIMAL CELL; ARTICLE; FEMALE; GENETIC HETEROGENEITY; GLYCOSYLATION; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; GLYCOSYLATION; IMMUNOGLOBULIN G; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33744995253     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.01.016     Document Type: Article

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