The way forward, enhanced characterization of therapeutic antibody glycosylation: Comparison of three level mass spectrometry-based strategies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 872, Issue 1-2, 2008, Pages 23-37

  Wagner Rousset, Elsa ^a   Bednarczyk, Audrey ^b   Bussat, Marie Claire ^a   Colas, Olivier ^a   Corvaïa, Nathalie ^a   Schaeffer, Christine ^b   Van Dorsselaer, Alain ^b   Beck, Alain ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b INSTITUT DE RECHERCHES SUBATOMIQUES   (France)

Author keywords

Glycopeptides; Glycosylation; Graphitized carbon; LC ESI TOF; LC MS; Mass spectrometry; N glycans; NanoLC Chip; NS0 and CHO cell lines; Oligosaccharides; RP HPLC; Tandem mass spectrometry; Therapeutic monoclonal antibodies

Indexed keywords

AMINES; AMINO ACIDS; ANTIBODIES; CELL CULTURE; CHEMICAL REACTIONS; CHROMATOGRAPHIC ANALYSIS; COLUMNS (STRUCTURAL); ELECTROSPRAY IONIZATION; ESTERIFICATION; FOOD ADDITIVES; GLYCOSYLATION; INDUSTRIAL ENGINEERING; IONIZATION; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; PLANTS (BOTANY); POPULATION STATISTICS; PRODUCTION ENGINEERING; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

AMINO-ACID SEQUENCES; ANALYTICAL METHODS; BOTTOM-UP APPROACH; CELL LINES; CHINESE-HAMSTER OVARY; CLONAL POPULATIONS; DERIVATIZATION; ELECTRO SPRAYING; ESI-MS/MS; GLYCOFORMS; GLYCOPEPTIDES; GLYCOSYLATION PATTERNS; GRAPHITIZED CARBON; GRAPHITIZED CARBON COLUMN; ION TRAPPING; LC-ESI-TOF; LC-MS; MANUFACTURING PROCESSES; N-GLYCANS; N-GLYCOSIDASE; N-GLYCOSYLATION; N-LINKED GLYCANS; NANOLC-CHIP; NS0 AND CHO CELL LINES; OLIGOSACCHARIDE STRUCTURE; OLIGOSACCHARIDES; PEPTIDE MOIETY; PHARMACOLOGICAL PROPERTIES; PNGASE F; PRODUCTION SYSTEMS; REVERSED-PHASE COLUMNS; RP-HPLC; TANDEM MASS SPECTROMETRY; THERAPEUTIC MONOCLONAL ANTIBODIES; THREE-LEVEL; TIME OF FLIGHT-MASS SPECTROMETERS; TOP DOWN APPROACHES;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

GLYCOSIDASE; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CHO CELL; ELECTROSPRAY; FEMALE; GLYCOSYLATION; MASS SPECTROMETRY; MOUSE; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; GLYCOSYLATION; MASS SPECTROMETRY; PEPTIDE MAPPING;

CRICETULUS GRISEUS; MURINAE;

EID: 50049122941     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.03.032     Document Type: Article

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