Charge heterogeneity of a therapeutic monoclonal antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin

Journal of Chromatography A

Volumn 1217, Issue 45, 2010, Pages 7164-7171

  Maeda, Eiki ^a   Urakami, Koji ^a   Shimura, Kiyohito ^b   Kinoshita, Mitsuhiro ^c   Kakehi, Kazuaki ^c  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

Capillary isoelectric focusing; Charge heterogeneity; Charge variant; Monoclonal antibody

Indexed keywords

ANALYTICAL PARAMETERS; ANTITUMOR ANTIBIOTICS; ANTITUMOR COMPOUNDS; CALICHEAMICIN; CAPILLARY ISOELECTRIC FOCUSING; CHARGE HETEROGENEITY; CHARGE VARIANT; COATED CAPILLARIES; COVALENTLY BOUND; CYTOTOXIC; HIGH RESOLUTION; MONOCLONAL ANTIBODIES (MAB); NON-LINEAR; PH GRADIENTS; PHARMACEUTICAL INDUSTRY; PI VALUES; QUALITY TESTING; RELATIVE STANDARD DEVIATIONS; THERAPEUTIC MONOCLONAL ANTIBODIES;

ANTIBIOTICS; BLOOD VESSELS; DRUG PRODUCTS PLANTS; FOCUSING; MONOCLONAL ANTIBODIES; NANOINDENTATION; OPTIMIZATION; PH EFFECTS; SILICONES; SURFACE PLASMON RESONANCE;

ELECTROPHORESIS;

DIMETICONE; GEMTUZUMAB OZOGAMICIN; IMMUNOGLOBULIN G4;

ACCURACY; ARTICLE; CONTROLLED STUDY; ISOELECTRIC FOCUSING; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUALITY CONTROL; REPRODUCIBILITY;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; ELECTROPHORESIS, CAPILLARY; GLYCOSYLATION; IMMUNOELECTROPHORESIS; IMMUNOTOXINS; ISOELECTRIC POINT; MODELS, CHEMICAL; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 77957883559     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.09.022     Document Type: Article

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