Reversed-phase liquid chromatography-mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments

Journal of Chromatography A

Volumn 1179, Issue 2, 2008, Pages 198-204

  Ren, Da ^a   Pipes, Gary ^a   Xiao, Gang ^a   Kleemann, Gerd R ^b   Bondarenko, Pavel V ^a   Treuheit, Michael J ^a   Gadgil, Himanshu S ^b  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Biotherapeutics; Covalent modifications; IgG; LC MS; RPLC

Indexed keywords

CHARACTERIZATION; CHEMICAL MODIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SEPARATION;

BIOTHERAPEUTICS; COVALENT MODIFICATIONS; IMMUNOGLOBULIN MOLECULES;

ANTIBODIES;

IMMUNOGLOBULIN; IMMUNOGLOBULIN F(AB) FRAGMENT; LYSINE; MONOCLONAL ANTIBODY;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ANIMALS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; ETHYLMALEIMIDE; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULINS; MASS SPECTROMETRY;

EID: 37649019585     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.11.088     Document Type: Article

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