Development of a capillary gel electrophoresis method for monitoring disulfide isomer heterogeneity in IgG2 antibodies

Electrophoresis

Volumn 31, Issue 3, 2010, Pages 448-458

  Lacher, Nathan A ^a   Wang, Qian ^a   Roberts, Rachel K ^a   Holovics, Heidi J ^a   Aykent, Serdar ^a   Schlittler, Michael R ^a   Thompson, Melissa R ^a   Demarest, Charles W ^a  

^a PFIZER INC   (United States)

Author keywords

Antibody IgG2; CE; Disulfide isomer; Protein characterization

Indexed keywords

ANTIBODIES; CAPILLARY ELECTROPHORESIS; CHROMATOGRAPHY; SULFUR COMPOUNDS; SYSTEM STABILITY;

ANTIBODY IGG2; CAPILLARY-GEL ELECTROPHORESIS; CE; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC TECHNIQUES; DISTRIBUTION CHARACTERISTICS; DISULPHIDE ISOMER; ELECTROPHORETIC METHODS; ISOMER DISTRIBUTIONS; PROTEIN CHARACTERIZATION;

ISOMERS;

DISULFIDE; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY;

ARTICLE; BIOPROCESS; CHROMATOGRAPHY; CONTROLLED STUDY; GEL ELECTROPHORESIS; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; ISOMER; MONITORING; PROTEIN STABILITY; PROTEIN SYNTHESIS;

EID: 75749143859     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200900371     Document Type: Article

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