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Volumn 86, Issue 12, 2012, Pages 1809-1827

Toxicity of pristine versus functionalized fullerenes: Mechanisms of cell damage and the role of oxidative stress

Author keywords

Cytotoxicity; Fullerenes; Genotoxicity; In vitro; In vivo; Oxidative stress

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARBON; CARBON 60; DOXORUBICIN; ENVIRONMENTAL CHEMICAL; FULLERENE DERIVATIVE; FULLEROL; FUNCTIONAL GROUP; POLYMER; REACTIVE OXYGEN METABOLITE; SOLVENT; SURFACTANT; UNCLASSIFIED DRUG;

EID: 84871246370     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0859-6     Document Type: Review
Times cited : (94)

References (162)
  • 1
    • 70349895552 scopus 로고    scopus 로고
    • Safety evaluation of highly purified fullerenes (HPFs): Based on screening of eye and skin damage
    • Aoshima H, Saitoh Y, Ito S, Yamana S, Miwa N (2009) Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage. J Toxicol Sci 34:555-562.
    • (2009) J Toxicol Sci , vol.34 , pp. 555-562
    • Aoshima, H.1    Saitoh, Y.2    Ito, S.3    Yamana, S.4    Miwa, N.5
  • 2
    • 77953305211 scopus 로고    scopus 로고
    • Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity
    • Aoshima H, Yamana S, Nakamura S, Mashino T (2010) Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity. J Toxicol Sci 35:401-409.
    • (2010) J Toxicol Sci , vol.35 , pp. 401-409
    • Aoshima, H.1    Yamana, S.2    Nakamura, S.3    Mashino, T.4
  • 5
    • 0036551537 scopus 로고    scopus 로고
    • Study of mutagenetic activity of fullerene and some of its derivatives using his ? reversions of Salmonella typhimurium as an example
    • Babynin EV, Nuretdinov IA, Cubskaya VP, Barabanshchikov BI (2002) Study of mutagenetic activity of fullerene and some of its derivatives using his ? reversions of Salmonella typhimurium as an example. Russian J Genet 38:453-457.
    • (2002) Russian J Genet , vol.38 , pp. 453-457
    • Babynin, E.V.1    Nuretdinov, I.A.2    Cubskaya, V.P.3    Barabanshchikov, B.I.4
  • 11
    • 0345257786 scopus 로고    scopus 로고
    • Fullerene derivatives: An attractive tool for biological applications
    • Bosi S, Da Ros T, Spalluto G, Prato M (2003) Fullerene derivatives: an attractive tool for biological applications. Eur J Med Chem 38:913-923.
    • (2003) Eur J Med Chem , vol.38 , pp. 913-923
    • Bosi, S.1    Da, R.T.2    Spalluto, G.3    Prato, M.4
  • 13
    • 69049098778 scopus 로고    scopus 로고
    • Chronic inflammation as a manifestation of defects in immunoregulatory networks: Implications for novel therapies based on microbial products
    • Bottasso O, Docena G, Stanford JL, Grange JM (2009) Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products. Inflammopharmacology 17:193-203.
    • (2009) Inflammopharmacology , vol.17 , pp. 193-203
    • Bottasso, O.1    Docena, G.2    Stanford, J.L.3    Grange, J.M.4
  • 14
    • 0030681063 scopus 로고    scopus 로고
    • Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems
    • Briviba K, Klotz LO, Sies H (1997) Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems. Biol Chem 378:1259-1265.
    • (1997) Biol Chem , vol.378 , pp. 1259-1265
    • Briviba, K.1    Klotz, L.O.2    Sies, H.3
  • 15
    • 67449164386 scopus 로고    scopus 로고
    • Comparative photoactivity and antibacterial properties of C60 fullerenes and titanium dioxide nanoparticles
    • Brunet L, Lyon DY, Hotze EM, Alvarez PJ, Wiesner MR (2009) Comparative photoactivity and antibacterial properties of C60 fullerenes and titanium dioxide nanoparticles. Environ Sci Technol 43:4355-4360.
    • (2009) Environ Sci Technol , vol.43 , pp. 4355-4360
    • Brunet, L.1    Lyon, D.Y.2    Hotze, E.M.3    Alvarez, P.J.4    Wiesner, M.R.5
  • 17
    • 0026458996 scopus 로고
    • Fullerenes from the geologic environment
    • Buseck PR, Tsipursky SJ, Hettich R (1992) Fullerenes from the geologic environment. Science 257:215-217.
    • (1992) Science , vol.257 , pp. 215-217
    • Buseck, P.R.1    Tsipursky, S.J.2    Hettich, R.3
  • 19
    • 17844384306 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque
    • Chen F, Eriksson P, Hansson GK, Herzfeld I, Klein M, Hansson LO, Valen G (2005) Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque. Int J Mol Med 15:57-65.
    • (2005) Int J Mol Med , vol.15 , pp. 57-65
    • Chen, F.1    Eriksson, P.2    Hansson, G.K.3    Herzfeld, I.4    Klein, M.5    Hansson, L.O.6    Valen, G.7
  • 20
    • 0035028773 scopus 로고    scopus 로고
    • De novo demonstration and co-localization of free-radical production and apoptosis formation in rat kidney subjected to ischemia/reperfusion
    • Chien CT, Lee PH, Chen CF, Ma MC, Lai MK, Hsu SM (2001) De novo demonstration and co-localization of free-radical production and apoptosis formation in rat kidney subjected to ischemia/reperfusion. J Am Soc Nephrol 12:973-982.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 973-982
    • Chien, C.T.1    Lee, P.H.2    Chen, C.F.3    Ma, M.C.4    Lai, M.K.5    Hsu, S.M.6
  • 22
    • 0033590932 scopus 로고    scopus 로고
    • Medicinal chemistry with fullerenes and fullerene derivatives
    • Da Ros T, Prato M (1999) Medicinal chemistry with fullerenes and fullerene derivatives. Chem Comm 8:663-669.
    • (1999) Chem Comm , vol.8 , pp. 663-669
    • Da Ros, T.1    Prato, M.2
  • 23
    • 0037564169 scopus 로고    scopus 로고
    • Singlet oxygen-mediated damage to proteins and its consequences
    • Davies MJ (2003) Singlet oxygen-mediated damage to proteins and its consequences. Biochem Biophys Res Commun 305:761-770.
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 761-770
    • Davies, M.J.1
  • 26
    • 0030130429 scopus 로고    scopus 로고
    • Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons
    • Dugan LL, Gabrielsen JK, Yu SP, Lin TS, Choi DW (1996) Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol Dis 3:129-135.
    • (1996) Neurobiol Dis , vol.3 , pp. 129-135
    • Dugan, L.L.1    Gabrielsen, J.K.2    Yu, S.P.3    Lin, T.S.4    Choi, D.W.5
  • 28
    • 37549048626 scopus 로고    scopus 로고
    • C60 colloid formation in aqueous systems: Effects of preparation method on size, structure, and surface charge
    • Duncan LK, Jinschek JR, Vikesland PJ (2007) C60 colloid formation in aqueous systems: effects of preparation method on size, structure, and surface charge. Environ Sci Technol 42:173-178.
    • (2007) Environ Sci Technol , vol.42 , pp. 173-178
    • Duncan, L.K.1    Jinschek, J.R.2    Vikesland, P.J.3
  • 29
    • 78650523050 scopus 로고    scopus 로고
    • Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro
    • Ehrich M, Van Tassell R, Li Y, Zhou Z, Kepley CL (2011) Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro. Toxicol In Vitro 25:301-307.
    • (2011) Toxicol in Vitro , vol.25 , pp. 301-307
    • Ehrich, M.1    Van Tassell, R.2    Li, Y.3    Zhou, Z.4    Kepley, C.L.5
  • 32
    • 66349119248 scopus 로고    scopus 로고
    • Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes
    • Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Møller P (2009) Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environ Health Perspect 117:703-708.
    • (2009) Environ Health Perspect , vol.117 , pp. 703-708
    • Folkmann, J.K.1    Risom, L.2    Jacobsen, N.R.3    Wallin, H.4    Loft, S.5    Møller, P.6
  • 35
    • 57849165682 scopus 로고    scopus 로고
    • Adverse effects of fullerenes on endothelial cells: Fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro
    • Gelderman MP, Simakova O, Clogston JD, Patri AK, Siddiqui SF, Vostal AC, Simak J (2008) Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro. Int J Nanomedicine 3:59-68.
    • (2008) Int J Nanomedicine , vol.3 , pp. 59-68
    • Gelderman, M.P.1    Simakova, O.2    Clogston, J.D.3    Patri, A.K.4    Siddiqui, S.F.5    Vostal, A.C.6    Simak, J.7
  • 36
    • 30644472236 scopus 로고    scopus 로고
    • [60] Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity
    • Gharbi N, Pressac M, Hadchouel M, Szwarc H, Wilson SR, Moussa F (2005) [60] Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett 5:2578-2585.
    • (2005) Nano Lett , vol.5 , pp. 2578-2585
    • Gharbi, N.1    Pressac, M.2    Hadchouel, M.3    Szwarc, H.4    Wilson, S.R.5    Moussa, F.6
  • 37
    • 77957968431 scopus 로고    scopus 로고
    • Genotoxicity testing of nanomaterials- conclusions
    • Greim H, Norppa H (2010) Genotoxicity testing of nanomaterials- conclusions. Nanotoxicology 4:421-424.
    • (2010) Nanotoxicology , vol.4 , pp. 421-424
    • Greim, H.1    Norppa, H.2
  • 38
    • 0033790078 scopus 로고    scopus 로고
    • Excited-state properties of C60 fullerene derivatives
    • Guldi DM, Prato M (2000) Excited-state properties of C60 fullerene derivatives. Acc Chem Res 33:695-703.
    • (2000) Acc Chem Res , vol.33 , pp. 695-703
    • Guldi, D.M.1    Prato, M.2
  • 40
    • 1542503371 scopus 로고    scopus 로고
    • Singlet oxygen production from fullerene derivatives: Effect of sequential functionalization of the fullerene core
    • Hamano T, Okuda K, Mashino T, Hirobe M, Arakane K, Ryu A, Mashiko S, Nagano T (1997) Singlet oxygen production from fullerene derivatives: effect of sequential functionalization of the fullerene core. Chem Commun 1:21-22.
    • (1997) Chem Commun , vol.1 , pp. 21-22
    • Hamano, T.1    Okuda, K.2    Mashino, T.3    Hirobe, M.4    Arakane, K.5    Ryu, A.6    Mashiko, S.7    Nagano, T.8
  • 41
    • 42349090300 scopus 로고    scopus 로고
    • Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells
    • Han B, Karim MN (2008) Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells. Scanning 30:213-220.
    • (2008) Scanning , vol.30 , pp. 213-220
    • Han, B.1    Karim, M.N.2
  • 44
    • 34548267724 scopus 로고    scopus 로고
    • Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression
    • Henry TB, Menn FM, Fleming JT, Wilgus J, Compton RN, Sayler GS (2007) Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Environ Health Perspect 115:1059-1065.
    • (2007) Environ Health Perspect , vol.115 , pp. 1059-1065
    • Henry, T.B.1    Menn, F.M.2    Fleming, J.T.3    Wilgus, J.4    Compton, R.N.5    Sayler, G.S.6
  • 45
    • 79960940355 scopus 로고    scopus 로고
    • Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: A revision of previous reports
    • Henry TB, Petersen EJ, Compton RN (2011) Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reports. Curr Opin Biotechnol 22:533-537.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 533-537
    • Henry, T.B.1    Petersen, E.J.2    Compton, R.N.3
  • 46
    • 44449129554 scopus 로고    scopus 로고
    • Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water
    • Hotze EM, Labille J, Alvarez P, Wiesner MR (2008) Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water. Environ Sci Technol 42:4175-4180.
    • (2008) Environ Sci Technol , vol.42 , pp. 4175-4180
    • Hotze, E.M.1    Labille, J.2    Alvarez, P.3    Wiesner, M.R.4
  • 47
    • 0032658958 scopus 로고    scopus 로고
    • Fullerenes: Experimental evidence for a null risk of skin irritation and allergy
    • Huczko A, Lange H, Calko E (1999) Fullerenes: experimental evidence for a null risk of skin irritation and allergy. Fullerene Sci Technol 7:935-939.
    • (1999) Fullerene Sci Technol , vol.7 , pp. 935-939
    • Huczko, A.1    Lange, H.2    Calko, E.3
  • 48
    • 57749186719 scopus 로고    scopus 로고
    • Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress
    • Injac R, Boskovic M, Perse M, Koprivec-Furlan E, Cerar A, Djordjevic A, Strukelj B (2008) Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress. Pharmacol Rep 60:742-749.
    • (2008) Pharmacol, Rep , vol.60 , pp. 742-749
    • Injac, R.1    Boskovic, M.2    Perse, M.3    Koprivec-Furlan, E.4    Cerar, A.5    Djordjevic, A.6    Strukelj, B.7
  • 49
    • 57849125020 scopus 로고    scopus 로고
    • Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
    • Injac R, Perse M, Cerne M, Potocnik N, Radic N, Govedarica B, Djordjevic A, Cerar A, Strukelj B (2009) Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomaterials 30:1184-1196.
    • (2009) Biomaterials , vol.30 , pp. 1184-1196
    • Injac, R.1    Perse, M.2    Cerne, M.3    Potocnik, N.4    Radic, N.5    Govedarica, B.6    Djordjevic, A.7    Cerar, A.8    Strukelj, B.9
  • 52
    • 71849094542 scopus 로고    scopus 로고
    • The coapplication effects of fullerene and ascorbic acid on UV-B irradiated mouse skin
    • Ito S, Itoga K, Yamato M, Akamatsu H, Okano T (2010) The coapplication effects of fullerene and ascorbic acid on UV-B irradiated mouse skin. Toxicology 267:27-38.
    • (2010) Toxicology , vol.267 , pp. 27-38
    • Ito, S.1    Itoga, K.2    Yamato, M.3    Akamatsu, H.4    Okano, T.5
  • 53
    • 48249096280 scopus 로고    scopus 로고
    • Genotoxicity, cytotoxicity, and reactive oxygen species induced by singlewalled carbon nanotubes and C60 fullerenes in the FE1-MutaTM Mouse lung epithelial cells
    • Jacobsen NR, Pojana G, White P, Møller P, Cohn CA, Korsholm KS, Vogel U, Marcomini A, Loft S, Wallin H (2008) Genotoxicity, cytotoxicity, and reactive oxygen species induced by singlewalled carbon nanotubes and C60 fullerenes in the FE1-MutaTM Mouse lung epithelial cells. Environ Mol Mutagen 49:476-487.
    • (2008) Environ Mol Mutagen , vol.49 , pp. 476-487
    • Jacobsen, N.R.1    Pojana, G.2    White, P.3    Møller, P.4    Cohn, C.A.5    Korsholm, K.S.6    Vogel, U.7    Marcomini, A.8    Loft, S.9    Wallin, H.10
  • 56
    • 77957227472 scopus 로고    scopus 로고
    • Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
    • Johnson-Lyles DN, Peifley K, Lockett S, Neun BW, Hansen M, Clogston J, Stern ST, McNeil SE (2010) Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction. Toxicol Appl Pharmacol 248:249-258.
    • (2010) Toxicol Appl Pharmacol , vol.248 , pp. 249-258
    • Johnson-Lyles, D.N.1    Peifley, K.2    Lockett, S.3    Neun, B.W.4    Hansen, M.5    Clogston, J.6    Stern, S.T.7    McNeil, S.E.8
  • 57
    • 77951541621 scopus 로고    scopus 로고
    • The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity
    • Johnston HJ, Hutchison GR, Christensen FM, Aschberger K, Stone V (2010) The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity. Toxicol Sci 114:162-182.
    • (2010) Toxicol Sci , vol.114 , pp. 162-182
    • Johnston, H.J.1    Hutchison, G.R.2    Christensen, F.M.3    Aschberger, K.4    Stone, V.5
  • 59
    • 0034735909 scopus 로고    scopus 로고
    • Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications
    • Kamat JP, Devasagayam TP, Priyadarsini KI, Mohan H (2000) Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications. Toxicology 155:55-61.
    • (2000) Toxicology , vol.155 , pp. 55-61
    • Kamat, J.P.1    Devasagayam, T.P.2    Priyadarsini, K.I.3    Mohan, H.4
  • 60
    • 0342276113 scopus 로고    scopus 로고
    • Photodynamic inactivation of enveloped viruses by buckminsterfullerene
    • Käsermann F, Kempf C (1997) Photodynamic inactivation of enveloped viruses by buckminsterfullerene. Antiviral Res 34:65-70.
    • (1997) Antiviral Res , vol.34 , pp. 65-70
    • Käsermann, F.1    Kempf, C.2
  • 61
    • 65549144135 scopus 로고    scopus 로고
    • Biological safety of lipofullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue
    • Kato S, Aoshima H, Saitoh Y, Miwa N (2009a) Biological safety of lipofullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. Basic Clin Pharmacol Toxicol 104:483-487.
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , pp. 483-487
    • Kato, S.1    Aoshima, H.2    Saitoh, Y.3    Miwa, N.4
  • 62
    • 68949119598 scopus 로고    scopus 로고
    • Highly hydroxylated or c-cyclodextrin-bicapped water-soluble derivative of fullerene: The antioxidant ability assessed by electron spin resonance method and beta-carotene bleaching assay
    • Kato S, Aoshima H, Saitoh Y, Miwa N (2009b) Highly hydroxylated or c-cyclodextrin-bicapped water-soluble derivative of fullerene: the antioxidant ability assessed by electron spin resonance method and beta-carotene bleaching assay. Bioorg Med Chem Lett 19:5293-5296.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5293-5296
    • Kato, S.1    Aoshima, H.2    Saitoh, Y.3    Miwa, N.4
  • 63
    • 73249150763 scopus 로고    scopus 로고
    • Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue
    • Kato S, Aoshima H, Saitoh Y, Miwa N (2010) Fullerene-C60/liposome complex: defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue. J Photochem Photobiol B 98:99-105.
    • (2010) J Photochem Photobiol B , vol.98 , pp. 99-105
    • Kato, S.1    Aoshima, H.2    Saitoh, Y.3    Miwa, N.4
  • 64
    • 42449127134 scopus 로고    scopus 로고
    • Toxicity studies of fullerenes and derivatives
    • Kolosnjaj J, Szwarc H, Moussa F (2007) Toxicity studies of fullerenes and derivatives. Adv Exp Med Biol 620:168-180.
    • (2007) Adv Exp Med Biol , vol.620 , pp. 168-180
    • Kolosnjaj, J.1    Szwarc, H.2    Moussa, F.3
  • 69
    • 77953807180 scopus 로고    scopus 로고
    • Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
    • Leavens TL, Xia XR, Lee HA, Monteiro-Riviere NA, Brooks JD, Riviere JE (2010) Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. Toxicol Lett 197:1-6.
    • (2010) Toxicol Lett , vol.197 , pp. 1-6
    • Leavens, T.L.1    Xia, X.R.2    Lee, H.A.3    Monteiro-Riviere, N.A.4    Brooks, J.D.5    Riviere, J.E.6
  • 70
    • 0034067626 scopus 로고    scopus 로고
    • Water-soluble hexasulfobutyl[ 60]fullerene inhibit low-density lipoprotein oxidation in aqueous and lipophilic phases
    • Lee YT, Chiang LY, Chen WJ, Hsu HC (2000) Water-soluble hexasulfobutyl[ 60]fullerene inhibit low-density lipoprotein oxidation in aqueous and lipophilic phases. Proc Soc Exp Biol Med 224:69-75.
    • (2000) Proc Soc Exp Biol Med , vol.224 , pp. 69-75
    • Lee, Y.T.1    Chiang, L.Y.2    Chen, W.J.3    Hsu, H.C.4
  • 71
    • 79960579325 scopus 로고    scopus 로고
    • Recent progresses in application of fullerenes in cosmetics
    • Lens M (2011) Recent progresses in application of fullerenes in cosmetics. Recent Pat Biotechnol 5:67-73.
    • (2011) Recent Pat Biotechnol , vol.5 , pp. 67-73
    • Lens, M.1
  • 73
    • 0033198010 scopus 로고    scopus 로고
    • Surface characterization and platelet adhesion studies on polyurethane surface immobilized with C60
    • Lin JC, Wu CH (1999) Surface characterization and platelet adhesion studies on polyurethane surface immobilized with C60. Biomaterials 20:1613-1620.
    • (1999) Biomaterials , vol.20 , pp. 1613-1620
    • Lin, J.C.1    Wu, C.H.2
  • 75
    • 0031934399 scopus 로고    scopus 로고
    • The possible mechanisms of the antiproliferative effect of fullerenol, polyhydroxylated C60, on vascular smooth muscle cells
    • Lu LH, Lee YT, Chen HW, Chiang LY, Huang HC (1998) The possible mechanisms of the antiproliferative effect of fullerenol, polyhydroxylated C60, on vascular smooth muscle cells. Br J Pharmacol 123:1097-1102.
    • (1998) Br J Pharmacol , vol.123 , pp. 1097-1102
    • Lu, L.H.1    Lee, Y.T.2    Chen, H.W.3    Chiang, L.Y.4    Huang, H.C.5
  • 77
    • 46249084082 scopus 로고    scopus 로고
    • Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60)
    • Markovic Z, Trajkovic V (2008) Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60). Biomaterials 29:3561-3573.
    • (2008) Biomaterials , vol.29 , pp. 3561-3573
    • Markovic, Z.1    Trajkovic, V.2
  • 80
    • 79954574087 scopus 로고    scopus 로고
    • Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles
    • Metanawin T, Tang T, Chen R, Vernon D, Wang X (2011) Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles. Nanotechnology 22:235604.
    • (2011) Nanotechnology , vol.22 , pp. 235604
    • Metanawin, T.1    Tang, T.2    Chen, R.3    Vernon, D.4    Wang, X.5
  • 83
    • 33745742443 scopus 로고    scopus 로고
    • Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis
    • Mori T, Takada H, Ito S, Matsubayashi K, Miwa N, Sawaguchi T (2006) Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225:48-54.
    • (2006) Toxicology , vol.225 , pp. 48-54
    • Mori, T.1    Takada, H.2    Ito, S.3    Matsubayashi, K.4    Miwa, N.5    Sawaguchi, T.6
  • 86
    • 72149117673 scopus 로고    scopus 로고
    • Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHOK1 cells
    • Mrdanović J, Solajić S, Bogdanović V, Stankov K, Bogdanović G, Djordjevic A (2009) Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHOK1 cells. Mutat Res 680:25-30.
    • (2009) Mutat Res , vol.680 , pp. 25-30
    • Mrdanović, J.1    Solajić, S.2    Bogdanović, V.3    Stankov, K.4    Bogdanović, G.5    Djordjevic, A.6
  • 88
    • 80755163163 scopus 로고    scopus 로고
    • Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
    • Nakagawa Y, Suzuki T, Ishii H, Nakae D, Ogata A (2011) Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction. Arch Toxicol 85:1429-1440.
    • (2011) Arch Toxicol , vol.85 , pp. 1429-1440
    • Nakagawa, Y.1    Suzuki, T.2    Ishii, H.3    Nakae, D.4    Ogata, A.5
  • 89
    • 68649109575 scopus 로고    scopus 로고
    • Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: Possible association of diffusion and caveolae-mediated pinocytosis
    • Naota M, Shimada A, Morita T, Inoue K, Takano H (2009) Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis. Toxicol Pathol 37:456-462.
    • (2009) Toxicol Pathol , vol.37 , pp. 456-462
    • Naota, M.1    Shimada, A.2    Morita, T.3    Inoue, K.4    Takano, H.5
  • 93
    • 33751579017 scopus 로고    scopus 로고
    • Genotoxicity in cell lines induced by chronic exposure to water-soluble fullerenes using micronucleus test
    • Niwa Y, Iwai N (2006) Genotoxicity in cell lines induced by chronic exposure to water-soluble fullerenes using micronucleus test. Environ Health Prev Med 11:292-297.
    • (2006) Environ Health Prev Med , vol.11 , pp. 292-297
    • Niwa, Y.1    Iwai, N.2
  • 94
    • 33947185679 scopus 로고    scopus 로고
    • Nanomaterials induce oxidized low-density lipoprotein cellular uptake in macrophages and platelet aggregation
    • Niwa Y, Iwai N (2007) Nanomaterials induce oxidized low-density lipoprotein cellular uptake in macrophages and platelet aggregation. Circ J 71:437-444.
    • (2007) Circ J , vol.71 , pp. 437-444
    • Niwa, Y.1    Iwai, N.2
  • 95
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles
    • Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839.
    • (2005) Environ Health Perspect , vol.113 , pp. 823-839
    • Oberdörster, G.1    Oberdörster, E.2    Oberdörster, J.3
  • 97
    • 77950072894 scopus 로고    scopus 로고
    • Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice
    • Park EJ, Kim H, Kim Y, Yi J, Choi K, Park K (2010) Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice. Toxicol Appl Pharmacol 244:226-233.
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 226-233
    • Park, E.J.1    Kim, H.2    Kim, Y.3    Yi, J.4    Choi, K.5    Park, K.6
  • 98
    • 77449141909 scopus 로고    scopus 로고
    • Biomedical applications of functionalized fullerene-based nanomaterials
    • Partha R, Conyers JL (2009) Biomedical applications of functionalized fullerene-based nanomaterials. Int J Nanomedicine 4:261-275.
    • (2009) Int J Nanomedicine , vol.4 , pp. 261-275
    • Partha, R.1    Conyers, J.L.2
  • 99
    • 14744284118 scopus 로고    scopus 로고
    • Fullerol-sensitized production of reactive oxygen species in aqueous solution
    • Pickering KD, Wiesner MR (2005) Fullerol-sensitized production of reactive oxygen species in aqueous solution. Environ Sci Technol 39:1359-1365.
    • (2005) Environ Sci Technol , vol.39 , pp. 1359-1365
    • Pickering, K.D.1    Wiesner, M.R.2
  • 100
    • 0032565966 scopus 로고    scopus 로고
    • C36, a new carbon solid
    • Piskoti C, Yarger J, Zettl A (1998) C36, a new carbon solid. Nature 393:771-774.
    • (1998) Nature , vol.393 , pp. 771-774
    • Piskoti, C.1    Yarger, J.2    Zettl, A.3
  • 102
    • 33744780459 scopus 로고    scopus 로고
    • Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: Studied by high resolution electron microscopy and electron tomography
    • Porter AE, Muller K, Skepper J, Midgley P, Welland M (2006) Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: studied by high resolution electron microscopy and electron tomography. Acta Biomater 2:409-419.
    • (2006) Acta Biomater , vol.2 , pp. 409-419
    • Porter, A.E.1    Muller, K.2    Skepper, J.3    Midgley, P.4    Welland, M.5
  • 103
    • 0001273942 scopus 로고    scopus 로고
    • Triplet-state properties and singlet oxygen generation in a homologous series of functionalized fullerene derivatives
    • Prat F, Stackow R, Bernstein R, Qian W, Rubin Y, Foote CS (1999) Triplet-state properties and singlet oxygen generation in a homologous series of functionalized fullerene derivatives. J Phys Chem A 103:7230-7235.
    • (1999) J Phys Chem A , vol.103 , pp. 7230-7235
    • Prat, F.1    Stackow, R.2    Bernstein, R.3    Qian, W.4    Rubin, Y.5    Foote, C.S.6
  • 107
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Tsuji Y (2012)
    • Ray PD, Huang BW (2012) Tsuji Y (2012) Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 24:981-990.
    • (2012) Cell Signal , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.W.2
  • 109
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R (1999) Atherosclerosis: an inflammatory disease. N Engl J Med 340:115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 111
    • 33749554603 scopus 로고    scopus 로고
    • Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes
    • Rouse JG, Yang J, Barron AR, Monteiro-Riviere NA (2006) Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicol In Vitro 20:1313-1320.
    • (2006) Toxicol in Vitro , vol.20 , pp. 1313-1320
    • Rouse, J.G.1    Yang, J.2    Barron, A.R.3    Monteiro-Riviere, N.A.4
  • 112
    • 33846883504 scopus 로고    scopus 로고
    • Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin
    • Rouse JG, Yang J, Ryman-Rasmussen JP, Barron AR, Monteiro- Riviere NA (2007) Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano Lett 7:155-160.
    • (2007) Nano Lett , vol.7 , pp. 155-160
    • Rouse, J.G.1    Yang, J.2    Ryman-Rasmussen, J.P.3    Barron, A.R.4    Monteiro-, R.N.A.5
  • 114
    • 78650896209 scopus 로고    scopus 로고
    • Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages
    • Saitoh Y, Miyanishi A, Mizuno H, Kato S, Aoshima H, Kokubo K, Miwa N (2011) Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages. J Photochem Photobiol B 102:69-76.
    • (2011) J Photochem Photobiol B , vol.102 , pp. 69-76
    • Saitoh, Y.1    Miyanishi, A.2    Mizuno, H.3    Kato, S.4    Aoshima, H.5    Kokubo, K.6    Miwa, N.7
  • 115
    • 33747611256 scopus 로고    scopus 로고
    • Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives
    • Satoh M, Takayanagi I (2006) Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives. Pharmacol Sci 100:513-518.
    • (2006) Pharmacol Sci , vol.100 , pp. 513-518
    • Satoh, M.1    Takayanagi, I.2
  • 118
    • 34548164647 scopus 로고    scopus 로고
    • Comparative pulmonary toxicity assessments of C60 water suspensions in rats: Few differences in fullerene toxicity in vivo in contrast to in vitro profiles
    • Sayes CM, Marchione AA, Reed KL, Warheit DB (2007) Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Lett 7:2399-2406.
    • (2007) Nano Lett , vol.7 , pp. 2399-2406
    • Sayes, C.M.1    Marchione, A.A.2    Reed, K.L.3    Warheit, D.B.4
  • 119
    • 34548840599 scopus 로고    scopus 로고
    • Genotoxicity of poorly soluble particles
    • Schins RPF, Knaapen AM (2007) Genotoxicity of poorly soluble particles. Inhal Toxicol 19(Suppl 1):189-198.
    • (2007) Inhal Toxicol , vol.19 , Issue.SUPPL. 1 , pp. 189-198
    • Schins, R.P.F.1    Knaapen, A.M.2
  • 120
    • 0028442007 scopus 로고
    • Synthesis of 14C-labeled C60, its suspension in water, and its uptake by human keratinocytes
    • Scrivens WA, Tour JM (1994) Synthesis of 14C-labeled C60, its suspension in water, and its uptake by human keratinocytes. J Am Chem Soc 116:4517-4518.
    • (1994) J Am Chem Soc , vol.116 , pp. 4517-4518
    • Scrivens, W.A.1    Tour, J.M.2
  • 121
    • 0029661816 scopus 로고    scopus 로고
    • Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides
    • Sera N, Tokiwa H, Miyata N (1996) Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides. Carcinogenesis 17:2163-2169.
    • (1996) Carcinogenesis , vol.17 , pp. 2163-2169
    • Sera, N.1    Tokiwa, H.2    Miyata, N.3
  • 122
    • 70449519042 scopus 로고    scopus 로고
    • In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles
    • Shinohara N, Matsumoto K, Endoh S, Maru J, Nakanishi J (2009) In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol Lett 191:289-296.
    • (2009) Toxicol Lett , vol.191 , pp. 289-296
    • Shinohara, N.1    Matsumoto, K.2    Endoh, S.3    Maru, J.4    Nakanishi, J.5
  • 124
    • 70350681825 scopus 로고    scopus 로고
    • Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: Predictive tests and biomarkers
    • Simeonova PP, Erdely A (2009) Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers. Inhal Toxicol 21(Suppl 1):68-73.
    • (2009) Inhal Toxicol , vol.21 , Issue.SUPPL. 1 , pp. 68-73
    • Simeonova, P.P.1    Erdely, A.2
  • 125
    • 60949085729 scopus 로고    scopus 로고
    • C60 fullerene: A powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays
    • Spohn P, Hirsch C, Hasler F, Bruinink A, Krug HF, Wick P (2009) C60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays. Environ Pollut 157:1134-1139.
    • (2009) Environ Pollut , vol.157 , pp. 1134-1139
    • Spohn, P.1    Hirsch, C.2    Hasler, F.3    Bruinink, A.4    Krug, H.F.5    Wick, P.6
  • 127
    • 0031464118 scopus 로고    scopus 로고
    • Photodynamic effect of polyethylene glycol-modified fullerene on tumor
    • Tabata Y, Murakami Y, Ikada Y (1997) Photodynamic effect of polyethylene glycol-modified fullerene on tumor. Jpn J Cancer Res 88:1108-1116.
    • (1997) Jpn J Cancer Res , vol.88 , pp. 1108-1116
    • Tabata, Y.1    Murakami, Y.2    Ikada, Y.3
  • 128
    • 79958026454 scopus 로고    scopus 로고
    • Fullerol in human lens and retinal pigment epithelial cells: Time domain fluorescence spectroscopy and imaging
    • Taroni P, D'Andrea C, Valentini G, Cubeddu R, Hu DN, Roberts JE (2011) Fullerol in human lens and retinal pigment epithelial cells: time domain fluorescence spectroscopy and imaging. Photochem Photobiol Sci 10:904-910.
    • (2011) Photochem Photobiol Sci , vol.10 , pp. 904-910
    • Taroni, P.1    D'andrea, C.2    Valentini, G.3    Cubeddu, R.4    Hu, D.N.5    Roberts, J.E.6
  • 134
    • 77549085987 scopus 로고    scopus 로고
    • Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells
    • Tsumoto H, Kawahara S, Fujisawa Y, Suzuki T, Nakagawa H, Kohda K, Miyata N (2010) Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells. Bioorg Med Chem Lett 20:1948- 1952.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 1948-1952
    • Tsumoto, H.1    Kawahara, S.2    Fujisawa, Y.3    Suzuki, T.4    Nakagawa, H.5    Kohda, K.6    Miyata, N.7
  • 137
    • 65449144734 scopus 로고    scopus 로고
    • Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis
    • Vesterdal LK, Folkmann JK, Jacobsen NR, Sheykhzade M, Wallin H, Loft S, Møller P (2009) Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis. Part Fibre Toxicol 6:5.
    • (2009) Part Fibre Toxicol , vol.6 , pp. 5
    • Vesterdal, L.K.1    Folkmann, J.K.2    Jacobsen, N.R.3    Sheykhzade, M.4    Wallin, H.5    Loft, S.6    Møller, P.7
  • 141
    • 77953960761 scopus 로고    scopus 로고
    • 60): Lack of lethality after high dose exposure to human epidermal and bacterial cells
    • 60): lack of lethality after high dose exposure to human epidermal and bacterial cells. Toxicol Lett 197:128-134.
    • (2010) Toxicol Lett , vol.197 , pp. 128-134
    • Xia, X.R.1    Monteiro-Riviere, N.A.2    Riviere, J.E.3
  • 142
    • 70449535517 scopus 로고    scopus 로고
    • Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents
    • Xia XR, Monteiro-Riviere NA, Riviere JE (2010b) Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol 242:29-37.
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 29-37
    • Xia, X.R.1    Monteiro-Riviere, N.A.2    Riviere, J.E.3
  • 143
    • 24044454316 scopus 로고    scopus 로고
    • Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes
    • Xiao L, Takada H, Maeda K, Haramoto M, Miwa N (2005) Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes. Biomed Pharmacother 59:351-358.
    • (2005) Biomed Pharmacother , vol.59 , pp. 351-358
    • Xiao, L.1    Takada, H.2    Maeda, K.3    Haramoto, M.4    Miwa, N.5
  • 144
    • 34547673717 scopus 로고    scopus 로고
    • Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVAinduced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues
    • Xiao L, Matsubayashi K, Miwa N (2007) Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVAinduced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues. Arch Dermatol Res 299:245-257.
    • (2007) Arch Dermatol Res , vol.299 , pp. 245-257
    • Xiao, L.1    Matsubayashi, K.2    Miwa, N.3
  • 145
    • 78049257841 scopus 로고    scopus 로고
    • Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-jB
    • Xiao L, Aoshima H, Saitoh Y, Miwa N (2010) Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-jB. J Cell Biochem 111:955-966.
    • (2010) J Cell Biochem , vol.111 , pp. 955-966
    • Xiao, L.1    Aoshima, H.2    Saitoh, Y.3    Miwa, N.4
  • 146
    • 62149098871 scopus 로고    scopus 로고
    • Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
    • Xu A, Chai Y, Nohmi T, Hei TK (2009a) Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part Fibre Toxicol 20(6):3.
    • (2009) Part Fibre Toxicol , vol.20 , Issue.6 , pp. 3
    • Xu, A.1    Chai, Y.2    Nohmi, T.3    Hei, T.K.4
  • 150
    • 0142072602 scopus 로고    scopus 로고
    • Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2- versus 1O2
    • Yamakoshi Y, Umezawa N, Ryu A, Arakane K, Miyata N, Goda Y, Masumizu T, Nagano T (2003) Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2- versus 1O2. J Am Chem Soc 125:12803-12809.
    • (2003) J Am Chem Soc , vol.125 , pp. 12803-12809
    • Yamakoshi, Y.1    Umezawa, N.2    Ryu, A.3    Arakane, K.4    Miyata, N.5    Goda, Y.6    Masumizu, T.7    Nagano, T.8
  • 151
    • 33744786768 scopus 로고    scopus 로고
    • Cytotoxicity of water-soluble fullerene in vascular endothelial cells
    • Yamawaki H, Iwai N (2006) Cytotoxicity of water-soluble fullerene in vascular endothelial cells. Am J Physiol Cell Physiol 290:C1495-C1502.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Yamawaki, H.1    Iwai, N.2
  • 153
    • 35948942388 scopus 로고    scopus 로고
    • Photoinduced lipid peroxidation of erythrocyte membranes by a bis-methanophosphonate fullerene
    • Yang XL, Huang C, Qiao XG, Yao L, Zhao DX, Tan X (2007) Photoinduced lipid peroxidation of erythrocyte membranes by a bis-methanophosphonate fullerene. Toxicol In Vitro 21:1493- 1498.
    • (2007) Toxicol in Vitro , vol.21 , pp. 1493-1498
    • Yang, X.L.1    Huang, C.2    Qiao, X.G.3    Yao, L.4    Zhao, D.X.5    Tan, X.6
  • 155
    • 34248593457 scopus 로고    scopus 로고
    • Nanoparticles as a novel class of autophagy activators
    • Zabirnyk O, Yezhelyev M, Seleverstov O (2007) Nanoparticles as a novel class of autophagy activators. Autophagy 3:278-281.
    • (2007) Autophagy , vol.3 , pp. 278-281
    • Zabirnyk, O.1    Yezhelyev, M.2    Seleverstov, O.3
  • 157
    • 82355173276 scopus 로고    scopus 로고
    • Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell line
    • Zhang M, Li J, Xing G, He R, Li W, Song Y, Guo H (2011) Variation in the
    • (2011) Arch Toxicol , vol.85 , pp. 1575-1588
    • Zhang, M.1    Li, J.2    Xing, G.3    He, R.4    Li, W.5    Song, Y.6    Guo, H.7
  • 159
    • 47549083900 scopus 로고    scopus 로고
    • 24] fullerene phototoxicity towards HaCaT keratinocytes: Type I vs type II mechanisms
    • 24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms. Chem Res Toxicol 21:1056-1063.
    • (2008) Chem Res Toxicol , vol.21 , pp. 1056-1063
    • Zhao, B.1    He, Y.Y.2    Bilski, P.J.3    Chignell, C.F.4
  • 161
    • 52649138436 scopus 로고    scopus 로고
    • Oxidative stress and growth inhibition in the freshwater fish Carassius auratus induced by chronic exposure to sublethal fullerene aggregates
    • Zhu X, Zhu L, Lang Y, Chen Y (2008) Oxidative stress and growth inhibition in the freshwater fish Carassius auratus induced by chronic exposure to sublethal fullerene aggregates. Environ Toxicol Chem 27:1979-1985.
    • (2008) Environ Toxicol Chem , vol.27 , pp. 1979-1985
    • Zhu, X.1    Zhu, L.2    Lang, Y.3    Chen, Y.4


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