Pulmonary responses to polyhydroxylated fullerenols, C60(OH) x

Journal of Applied Toxicology

Volumn 29, Issue 7, 2009, Pages 578-584

  Xu, Jing Ying ^a,b   Kaiyu, Han ^c   Li, Shu Xia ^a   Cheng, Jin Sheng ^d   Xu, Guo Tong ^a   Lib, Wen Xin ^b   Li, Qing Nuan ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

C60(OH)x; Inflammation; Nanotoxicology; Oxidative stress; Polyhydroxylated fullerenol; Pulmonary response

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; FULLERENE DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 6; POLYHYDROXYLATED FULLERENOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CHEMICAL ANALYSIS; CONTROLLED STUDY; HISTOPATHOLOGIC SKIN REACTION; HYDROXYLATION; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NEUTROPHIL; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FULLERENES; HYDROXYLATION; INFLAMMATION; LUNG; MALE; OXIDATIVE STRESS; PARTICLE SIZE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 70350212954     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1442     Document Type: Article

References (16)

1. Baughman RP, Gunther KL, Rashkin MC, Keeton DA, Pattishall EN. 1996. Changes in the inflammatory response of lung during acute respiratory distress syndrome: prognostic indicators. Am. J. Respir. Crit. Care Med. 154: 76-81.
2. 22 on doxorubicin-induced cytotoxicity. Toxicol. in Vitro 18: 629-637.
3. +-induced cellular model of Parkinson's disease. J. Neurosci. Res. 86: 3622-3634.
4. Cao Q, Zhang S, Dong C, Song W. 2007. Pulmonary responses to fine particles: differences between the spontaneously hypertensive rats and wistar kyoto rats. Toxicol. Lett. 171: 126-137.
5. Chiang LY, Lu FJ, Lin JT. 1995. Free-radical scavenging activity of water-soluble fullerenols. J. Chem. Soc., Chem. Commun. 12: 1283-1284.
6. Gonda I. 2006. Systemic delivery of drugs to humans via inhalation. J. Aerosol Med. 19: 47-53.
7. n. Chem. Commun. 4: 30-32 [in Chinese].
8. 24. Nitric Oxide 11: 201-207.
9. Montravers P, Chollet-Martin S, Marmuse JP, Cougerot-Pocidalo MA, Desmonts JM. 1995. Lymphatic release of cytokines during acute lung injury complicating severe pancreatitis. Am. J. Respir. Crit. Care Med. 152: 1527-1533.
10. Nemmar A, Vanbilloen H, Hoylaerts MF, Hoet PH, Verbruggen A, Nemery B. 2001. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care. Med. 164: 1665-1668.
11. Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105: 411-414. (Pubitemid 34141694)
12. Sayes CM, Reed KL, Warheit DB. 2007. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol. Sci. 97: 163-180.
13. Smaldone GC. 2006. Advances in aerosols: adult respiratory disease. J. Aerosol. Med. 19: 36-46.
14. 2 particulates substantially encapsulated with pyrogenically deposited, amorphous silica. Part. Fibre Toxicol. 3: 3.
15. x in Sprague-Dawley rats after intratracheal instillation. Carbon 45: 1865-1870.
16. Zhao Q, Li Y, Xu J, Liu R, Li WX. 2005. Radioprotection by fullerenols of Stylonychia mytilus exposed to γ-rays. Int. J. Radoat. Biol. 81: 169-175.