The possible mechanisms of the antiproliferative effect of fullerenol, polyhydroxylated C60, on vascular smooth muscle cells

British Journal of Pharmacology

Volumn 123, Issue 6, 1998, Pages 1097-1102

  Lu, Liang Huei ^a   Lee, Yuan Teh ^b   Chen, Huei Wen ^a   Chiang, Long Y ^a   Huang, Huei Chen ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antioxidant; Antiproliferative effect; Ascorbic acid; Fullerenol; Protein kinase C; Protein tyrosine kinase; Smooth muscle cells (vascular)

Indexed keywords

ALLOXAN; ANTIMITOTIC AGENT; ASCORBIC ACID; FREE RADICAL; FULLERENE DERIVATIVE; FULLERENOL; HYDROXYL RADICAL; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ASCORBIC ACID; CARBON; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; FULLERENES; HUMANS; MUSCLE, SMOOTH, VASCULAR; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RATS; SUPEROXIDES;

EID: 0031934399     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701722     Document Type: Article

References (24)

1. BERLINER, J.A., NAVAB, M., FOGELMAN, A.M., FRANK, J.S., DEMER, L.L., EDWARDS, P.A., WATSON, A.D. & LUSIS, A.J. (1995). Atherosclerosis: basic mechanisms, oxidation, inflammation, and genetics. Circulation, 91, 2488-2496.
2. BISHOP, J.M. (1983). Cellular oncogenes and retroviruses. Ann. Rev. Biochem., 52, 301-354.
3. CAREW, T., SCHWENKE, D.C. & STEINBERG, D. (1987). Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit. Proc. Natl. Acad. Sci. U.S.A., 84, 7725-7729.
4. CHIANG, L.Y., LU, F.J. & LIN, J.T. (1995). Free radical scavenging activity of water-soluble fullerenol. J. Chem. Soc. Chem. Commun., 1283-1284.
5. 60 fullerene functionalization. J. Am. Chem. Soc., 114, 10154-10157.
6. COHEN. G. & HEIKKILA, R.E. (1974). The generation of hydrogen peroxide, Superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem., 249, 2447-2452.
7. GEY, K.F., BRUBACHER, G.B. & STAHELIN, H.B. (1987). Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am. J. Clin. Nutr., 45, 1368-1377.
8. CLASSER, S.P., SELWYN, A.P. & GANZ, P. (1996). Atherosclerosis: risk factors and the vascular endothelium. Am. Heart, J. 131, 379-384.
9. GRANKVIST, K. (1981). Alloxan-induced luminol luminescence as a tool for investigating mechanisms of radical-mediated diabetogenicity. Biochem. J. 200, 685-690.
10. GRYGLEWSKI, R.J., PALMER, R.M.J. & MONCADA, S. (1986). Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factors. Nature, 320, 454-456.
11. HANNUN, Y.A., LOOMIS, C.R. & ROBERT, M.B. (1985). Activation of protein kinase C by Triton X-100 mixed micelles containing diacyglycerol and phosphatidylserine. J. Biol. Chem., 260, 10039-10043.
12. HEIM, K.F., THOMAS, G. & RAMWELL, P.W. (1991). Superoxide production in the isolated rabbit aorta and effect of alloxan, indomethacin and nitrovasodilators. J. Pharmacol. Exp. Ther., 256, 537-541.
13. HUANG, H.C., HSIEH, L.M., CHEN, H.W., LIN, Y.S. & CHEN, J.S. (1994a). Effects of baicalein and esculetin on transduction signais and growth factors expression in T-lymphoid leukemia cells. Eur. J. Pharmacol. Mol. Pharmacol., 268, 73-78.
14. HUANG, H.C., HUANG, Y.L., CHANG, J.H., CHEN, C.C. & LEE, Y.T. (1992a). Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin). Eur. J. Pharmacol., 217, 143-148.
15. HUANG, H.C., JAN, T.R. & YEH, S.F. (1992b). Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur. J. Pharmacol., 221, 381-384.
16. HUANG, H.C., LAI, M.W., WANG, H.R., CHUNG, Y.L., HSIEH, L.M. & CHEN, C.C, (1993). Antiproliferative effect of esculetin on vascular smooth muscle cell: Possible roles of signal transduction pathways. Eur. J. Pharmacol., 237, 39-44.
17. HUANG, H.C., LEE, C.R., WENG, Y.I., LEE, M.C. & LEE, Y.T. (1992c). Vasodilator effect of scoparone (6,7-dimethoxycoumarin) from a Chinese herb. Eur. J. Pharmacol., 218, 123-128.
18. HUANG, H.C., WANG, H.R. & HSIEH, L.M. (1994b). Antiproliferative effect of baicalein, a flavonoid from Chinese herb, on vascular smooth muscle cells. Eur. J. Pharmacol., 251, 91-93.
19. LEVINE, M. (1986). New concepts in the biology and biochemistry of ascorbic acid. N. Engl. J. Med., 314, 892-902.
20. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
21. LUNDERGAN, C.F., FOEGH, M.L. & RAMWELL, P.W. (1991). Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J. Am. Coll. Cardiol., 17, 132B-136B.
22. POWIS, G. & KOZIKOWSKI, A. (1991). Growth factor and oncogene signalling pathways as targets for rational anticancer drug development. Clin. Biochem., 24, 385-397.
23. ROSS, R. (1993). The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature, 362, 801-809.
24. WATABE, S., SENDO, F., KIMURA, S. & ARAI, S. (1984). Activation of cytotoxic polymorphonucleuar leukocytes by in vivo administration of a streptoccal preparation, OK432. J. Natl. Cancer Inst., 72, 1365-1370.