Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice

Basic and Clinical Pharmacology and Toxicology

Volumn 103, Issue 4, 2008, Pages 386-388

  Roursgaard, Martin ^a   Poulsen, Steen S ^b   Kepley, Christopher L ^c   Hammer, Maria ^a   Nielsen, Gunnar D ^a   Larsen, Søren T ^a  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Luna Innovations   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; FULLERENE DERIVATIVE; FULLERENOL; MACROPHAGE INFLAMMATORY PROTEIN 2; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; CXCL2 CHEMOKINE; FULLEROL C60(OH)22; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; INFLAMMATION; LUNG LAVAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; SILICOSIS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; IMMUNOLOGY; METABOLISM; NEUTROPHIL; PATHOLOGY; PNEUMONIA;

MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FULLERENES; MICE; MICE, INBRED BALB C; NEUTROPHIL INFILTRATION; NEUTROPHILS; PNEUMONIA; QUARTZ;

EID: 52049125241     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2008.00315.x     Document Type: Article

References (25)

1. Groneberg DA, Chung KF. Models of chronic obstructive pulmonary disease. Respir Res 2004 5 : 18.
2. Huaux F. New developments in the understanding of immunology in silicosis. Curr Opin Allergy Clin Immunol 2007 7 : 168 73.
3. Parr DG, White AJ, Bayley DL, Guest PJ, Stockley RA. Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study. Respir Res 2006 7 : 136.
4. Zeidler P, Hubbs A, Battelli L, Castranova V. Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis. J Toxicol Environ Health A 2004 67 : 1001 26.
5. Gulumian M, Borm PJ, Vallyathan V, Castranova V, Donaldson K, Nelson G et al. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. J Toxicol Environ Health B Crit Rev 2006 9 : 357 95.
6. Kuempel ED, Attfield MD, Vallyathan V, Lapp NL, Hale JM, Smith RJ et al. Pulmonary inflammation and crystalline silica in respirable coal mine dust: dose-response. J Biosci 2003 28 : 61 9.
7. Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med 2005 11 : 169 73.
8. Fubini B, Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 2003 34 : 1507 16.
9. Porter DW, Millecchia L, Robinson VA, Hubbs A, Willard P, Pack D et al. Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica. Am J Physiol Lung Cell Mol Physiol 2002 283 : L485 93.
10. Warheit DB, Webb TR, Colvin VL, Reed KL, Sayes CM. Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci 2007 95 : 270 80.
11. 60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Lett 2007 7 : 2399 406.
12. Albrecht C, Hohr D, Haberzettl P, Becker A, Borm PJ, Schins RP. Surface-dependent quartz uptake by macrophages: potential role in pulmonary inflammation and lung clearance. Inhal Toxicol 2007 19 (Suppl 1 39 48.
13. Barbarin V, Nihoul A, Misson P, Arras M, Delos M, Leclercq I et al. The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis. Respir Res 2005 6 : 112.
14. Kaewamatawong T, Shimada A, Okajima M, Inoue H, Morita T, Inoue K et al. Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol 2006 34 : 958 65.
15. Kajiwara T, Ogami A, Yamato H, Oyabu T, Morimoto Y, Tanaka I. Effect of particle size of intratracheally instilled crystalline silica on pulmonary inflammation. J Occup Health 2007 49 : 88 94.
16. Driscoll KE, Howard BW, Carter JM, Asquith T, Johnston C, Detilleux P et al. Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure. Am J Pathol 1996 149 : 1627 37.
17. Sadowska AM, Verbraecken J, Darquennes K, De Backer WA. Role of N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis 2006 1 : 425 34.
18. Zhu X, Su B, Wang X, Smith MA, Perry G. Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci 2007 64 : 2202 10.
19. 60: buckminsterfullerene. Letters to Nature 1985 318 : 162 3.
20. Nielsen GD, Roursgaard M, Jensen KA, Poulsen SS, Larsen ST. In vivo biology and toxicology of fullerenes and their derivatives. Basic Clin Pharmacol Toxicol 2008 in press.
21. 60), a novel carbon allotrope, and its derivatives. J Pharmacol Sci 2006 100 : 513 8.
22. Isakovic A, Markovic Z, Todorovic-Markovic B, Nikolic N, Vranjes-Djuric S, Mirkovic M et al. Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene. Toxicol Sci 2006 91 : 173 83.
23. Dugan LL, Gabrielsen JK, Yu SP, Lin TS, Choi DW. Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol Dis 1996 3 : 129 35.
24. Larsen ST, Hansen JS, Hansen EW, Clausen PA, Nielsen GD. Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice. Toxicology 2007 235 : 119 29.
25. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006 160 : 1 40.