Inhalation Toxicity and Lung Toxicokinetics of C60 Fullerene Nanoparticles and Microparticles

Toxicological Sciences

Volumn 101, Issue 1, 2008, Pages 122-131

  Baker, Gregory L ^a   Gupta, Amit ^a   Clark, Mark L ^a   Valenzuela, Blandina R ^a   Staska, Lauren M ^a   HarboS J , Sam J ^a   Pierce, Judy T ^a   Dill, Jeffery A ^a  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

C60; Fullerenes; Inhalation; Microparticles; Nanoparticles; Particles

Indexed keywords

CARBON; FULLERENE DERIVATIVE; NANOPARTICLE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INHALATION; LUNG DEPOSIT; LUNG LAVAGE; LUNG TOXICITY; MALE; NONHUMAN; RAMAN SPECTROMETRY; RAT; STATISTICAL SIGNIFICANCE; TOXICITY TESTING; TOXICOKINETICS; VAPORIZATION; X RAY DIFFRACTION;

ADMINISTRATION, INHALATION; AEROSOLS; ALGORITHMS; ANIMALS; BODY BURDEN; BRONCHOALVEOLAR LAVAGE FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; FULLERENES; LUNG; MALE; NANOPARTICLES; ORGAN SIZE; PARTICLE SIZE; RATS; RATS, INBRED F344; REFERENCE STANDARDS; SOLVENTS; SPECTRUM ANALYSIS, RAMAN; WATER; X-RAY DIFFRACTION;

RATTUS;

EID: 36949034965     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm243     Document Type: Article

References (23)

1. Andrievsky, G., Klochkov, V., and Derevyanchenko, L. (2005). Is the C60 fullerene molecule toxic? Fuller. Nanotub. Carbon Nanostruct. 13, 363-376.
2. Brecher, G., and Schneiderman, M. (1950). A time-saving device for the counting of reticulocytes. Am. J. Clin. Pathol. 20, 1079-1083.
3. Cannon, W. C., Blanton, E. F., and McDonald, K. E. (1983). The flow-past chamber: An improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44, 923-928.
4. Deguchi, S., Alargova, R. G., and Tsujii, K. (2001). Stable dispersions of fullerenes, C60 and C70, in water. Preparation and characterization. Langmuir 17, 6013-6017.
5. Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., and O'Malley, K. L. (2001). Fullerene-based antioxidants and neurodegenerative disorders. Parkinsonism Relat. Disord. 7, 243-246.
6. Elder, A., Gelein, R., Finkelstein, J. N., Driscoll, K. E., Harkema, J., and Oberdorster, G. (2005). Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol. Sci. 88, 614-629.
7. Gharbi, N., Pressac, M., Hadchouel, M., Szwarc, H., Wilson, S. R., and Moussa, F. (2005). [60]Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett. 5, 2578-2585.
8. Gupta, A., Forsythe, W. C., Clark, M. L., Dill, J. A., and Baker, G. L. (2007). Generation of C60 nanoparticle aerosols in high mass concentrations. J. Aerosol Sci. 38, 592-603.
9. Hughes, L. S., Cass, G. R., Gone, J., Ames, M., and Olmez, I. (1998). Physical and chemical characterization of atmospheric ultrafine particles in the Los Angeles area. Environ. Sci. Technol. 32 1153-1161.
10. Kroto, H. W., Heath, J. R., O'Brien, S. C., Curl, R. F., and Smalley, R. E. (1985). C60: Buckminsterfullerene. Nature 318, 162-163.
11. Maynard, A. D., Baron, P. A., Foley, M., Shvedova, A. A., Kisin, E. R., and Castranova, V. (2004). Exposure to carbon nanombe material: Aerosol release during the handling of unrefined single-walled carbon nanotube material. J. Toxicol. Environ. Health A 67, 87-107.
12. Mori, T., Takada, H., Ito, S., Matsubayashi, K., Miwa, N., and Sawaguchi, T. (2006). Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225, 48-54.
13. Murr, L. E., Esquivel, E. V., Bang, J. J., de la Rosa, G., and Gardea-Torresdey, J. L. (2004). Chemistry and nanoparticulate compositions of a 10,000 year-old ice core melt water. Water Res. 38, 4282-4296.
14. Oberdorster, E. (2004). Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ. Health Perspect. 112, 1058-1062.
15. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., and Cox, C. (2002). Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health A 65, 1531-1543.
16. Peters, A., Dockery, D. W., Muller, J. E., and Mittleman, M. A. (2001). Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103, 2810-2815.
17. Ruoff, R. S., Tse, D. S., Malhotra, R., and Lorents, D. C. (1993). Solubility of fullerene (C60) in a variety of solvents. J. Phys. Chem. 97, 3379-3383.
18. Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., et al. (2004). The differential cytotoxicity of water-soluble fullerenes. Nano Lett. 4, 1881-1887.
19. Sayes, C. M., Gobin, A. M., Ausman, K. D., Mendez, J., West, J. L., and Colvin, V. L. (2005). Nano-C60 cytotoxicity is due to lipid peroxidation. Biomaterials 26, 7587-7595.
20. Scrivens, W. A., Tour, J. M., Creek, K. E., and Pirisi, L. (1994). Synthesis of 14C-tabeted C60, its suspension in water, and its uptake by human keratinocytes. J. Am. Chem. Soc. 116, 4517-4518.
21. Utsunomiya, S., Jensen, K. A., Keeler, G. J., and. Ewing, R. C. (2002). Uraninite and fullerene in atmospheric particulates. Environ. Sci. Technol. 36, 4943-4947.
22. Wang, Z. X., Li, X. P., Wang, W. M., Xu, X. J., Zi, C. T., Huang, R. B., and Zheng, L. S. (1998). Fullerenes in the fossil of dinosaur egg. Fuller. Sci. Technol. 6, 715.
23. Whalan, J. E., Foureman, G. L., and Vandenberg, J. J. (2006). Inhalation risk assessment at the enivornmental protection agency. In Inhalation Toxicology, 2nd ed. (H. Salem and S. A. Katz, Eds.), pp. 3-37. CRC Press, Boca Raton, FL.