The liver as a target organ for gene therapy: State of the art, challenges, and future perspectives

Pharmaceuticals

Volumn 5, Issue 12, 2012, Pages 1372-1392

  Jacobs, Frank ^a   Gordts, Stephanie C ^a   Muthuramu, Ilayaraja ^a   De Geest, Bart ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

AAV; Fenestrae; Gene transfer; Hepatocytes; Liver

Indexed keywords

ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 9; CAPSID PROTEIN; CLODRONIC ACID; INTRALIPID; LENTIVIRUS VECTOR; LIPOSOME; NAKED DNA; NEUTRALIZING ANTIBODY;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ANTIBODY TITER; ANTIGEN BINDING; ANTIGEN PRESENTATION; CELL PROLIFERATION; COMPLEX FORMATION; DNA TRANSFER; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; GENE DOSAGE; HEMOPHILIA B; HUMAN; HYDRODYNAMICS BASED TRANSFECTION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; KUPFFER CELL; LIVER PARENCHYMA; LIVER SINUSOID; NONHUMAN; PARTICLE SIZE; PROTEIN EXPRESSION; REVIEW; TARGET ORGAN; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS ATTACHMENT; VIRUS GENOME; VIRUS NEUTRALIZATION; VIRUS RELEASE;

EID: 84871049753     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5121372     Document Type: Review

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