Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: Fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5

Journal of Virology

Volumn 81, Issue 17, 2007, Pages 9568-9571

  Waddington, Simon N ^a   Parker, Alan L ^b   Havenga, Menzo ^c   Nicklin, Stuart A ^b   Buckley, Suzanne M K ^a   McVey, John H ^d   Baker, Andrew H ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c CRUCELL HOLLAND BV   (Netherlands)

^d MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; WARFARIN;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TARGETING; IN VIVO STUDY; KUPFFER CELL; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PSEUDOTYPING; VIRAL GENE DELIVERY SYSTEM; VIRUS EXPRESSION; VIRUS TYPING;

ADENOVIRIDAE; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION FACTORS; CAPSID PROTEINS; GENES, REPORTER; GENETIC VECTORS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIVER; LUCIFERASES; MICE; MODELS, ANIMAL; RECEPTORS, VIRUS; TRANSDUCTION, GENETIC; VIRUS ATTACHMENT; WARFARIN;

ADENOVIRIDAE;

EID: 34548164748     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00663-07     Document Type: Article

References (23)

1. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
2. Cichon, G., S. Boeckh-Herwig, D. Kuemin, C. Hoffmann, H. H. Schmidt, E. Wehnes, W. Haensch, U. Schneider, U. Eckhardt, R. Burger, and P. Pring- Akerblom. 2003. Titer determination of Ad5 in blood: a cautionary note. Gene Ther. 10:1012-1017.
3. Cohen, C. J., J. T. C. Shieh, R. J. Pickles, T. Okegawa, J.-T. Hsieh, and J. M. Bergelson. 2001. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc. Natl. Acad. Sci. USA 98:15191-15196.
4. Einfeld, D. A., R. Schroeder, P. W. Roelvink, A. Lizonova, C. R. King, I. Kovesdi, and T. J. Wickham. 2001. Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. J. Virol. 75:11284-11291.
5. Gaggar, A., D. M. Shayakhmetov, and A. Lieber. 2003. CD46 is a cellular receptor for group B adenoviruses. Nat. Med. 9:1408-1412.
6. Havenga, M. J. E., A. A. C. Lemckert, O. J. A. E. Ophorst, M. V. Meijer, W. T. V. Germeraad, J. Grimbergen, M. A. V. D. Doel, R. Vogels, J. V. Duetekom, A. A. M. Janson, J. D. D. Bruijn, F. Uytdehaag, P. H. A. Quax, T. Logtenberg, M. Mehtali, and A. Bout. 2002. Exploiting the natural diversity in adenovirus tropism for therapy and prevention of disease. J. Virol. 76:4612-4620.
7. Huard, J., H. Lochmuller, G. Ascadi, A. Jani, B. Massie, and G. Karpati. 1995. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther. 107:107-115.
8. Lieber, A., C. Y. He, L. Meuse, D. Schowalter, I. Kirillova, B. Winther, and M. A. Kay. 1997. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J. Virol. 71:8798-8807.
9. Lyons, M., D. Onion, N. K. Green, K. Aslan, R. Rajaratnam, M. Bazan-Peregrino, S. Phipps, S. Hale, V. Mautner, L. W. Seymour, and K. D. Fisher. 2006. Adenovirus type 5 interactions with human blood cells may compromise systemic delivery. Mol. Ther. 14:118-128.
10. Manickan, E., J. S. Smith, J. Tian, T. L. Eggerman, J. N. Lozier, J. Muller, and A. P. Byrnes. 2005. Rapid Kupffer cell death after intravenous injection of adenovirus vectors. Mol. Ther. 13:108-117.
11. Nicklin, S., E. Wu, G. Nemerow, and A. Baker. 2005. The influence of adenovirus fiber structure and function on vector development for gene therapy. Mol. Ther. 12:384-393.
12. Nicol, C., D. Graham, W. Miller, S. White, T. Smith, S. Nicklin, S. Stevenson, and A. Baker. 2004. Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Mol. Ther. 10:343-353.
13. Oka, K., L. Pastore, I. Kim, A. Merched, S. Nomura, H. Lee, M. Merched-Sauvage, C. Arden-Riley, B. Lee, M. Finegold, A. Beaudet, and L. Chan. 2001. Long term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor. Circulation 103:1274-1281.
14. Parker, A. L., J. H. McVey, J. H. Doctor, O. Lopez-Franco, S. N. Waddington, M. J. E. Havenga, S. A. Nicklin, and A. H. Baker. 2007. Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D. J. Virol. 81:3627-3631.
15. Parker, A. L., S. N. Waddington, C. G. Nicol, D. M. Shayakhmetov, S. M. Buckley, L. Denby, G. Kemball-Cook, S. Ni, A. Lieber, J. H. McVey, S. A. Nicklin, and A. H. Baker. 2006. Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes Blood. 108:2554-2561.
16. Reynolds, P. N., S. A. Nicklin, L. Kaliberova, B. G. Boatman, W. E. Grizzle, I. V. Balyasnikova, A. H. Baker, S. M. Danilov, and D. T. Curiel. 2001. Combined transductional and transcriptional targeting improves the specificty of transgene expression in vivo. Nat. Biotechnol. 19:838-842.
17. Reynolds, P. N., K. R. Zinn, V. D. Gavrilyuk, I. V. Balyasnikova, B. E. Rogers, D. J. Buchsbaum, M. H. Wang, D. J. Miletich, W. E. Grizzle, J. T. Douglas, S. M. Danilov, and D. T. Curiel. 2000. A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol. Ther. 2:562-578.
18. Shayakhmetov, D., A. Gaggar, S. Ni, Z.-Y. Li, and A. Lieber. 2005. Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J. Virol. 79:7478-7491.
19. Shayakhmetov, D., Z. Li, S. Ni, and A. Lieber. 2002. Targeting of adenovirus vectors to tumor cells does not enable efficient transduction of breast cancer metastases. Cancer Res. 62:1063-1068.
20. Tao, N., G. P. Gao, M. Parr, J. Johnston, T. Baradet, J. M. Wilson, J. Barsoum, and S. E. Fawell. 2001. Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver. Mol. Ther. 3:28-35.
21. Tomko, R. P., R. Xu, and L. Philipson. 1997. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc. Natl. Acad. Sci. USA 94:3352-3356.
22. 5, promote adenovirus internalization but not virus attachment. Cell 73:309-319.
23. Zinn, K. R., A. Szalai, A. Stargel, V. Krasnykh, and T. R. Chaudhuri. 2004. Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus. Gene Ther. 11:1482-1486.