Cognition-emotion dysinteraction in schizophrenia

Frontiers in Psychology

Volumn 3, Issue OCT, 2012, Pages

  Anticevic, Alan ^a   Corlett, Philip R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; Cognition; Cortical disinhibition; Delusions; Emotion; Fronto striatal circuits; Schizophrenia; Working memory

Indexed keywords

EID: 84871012293     PISSN: None     EISSN: 16641078     Source Type: Journal    
DOI: 10.3389/fpsyg.2012.00392     Document Type: Article

References (234)

1. Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., et al. (2002). Prefrontal dopamine D1 receptors and working memory in schizophrenia. J. Neurosci. 22, 3708-3719.
2. Adams, C. A., and Dickinson, A. (1981). Actions and habits: variations in associative representations during instrumental learning, in Information Processing in Animals: Memory Mechanisms, eds N. E. Spear and R. R. Miller (Hillsdale: Lawrence Erlbaum).
3. Aleman, A., and Kahn, R. S. (2005). Strange feelings:do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog. Neurobiol. 77, 283-298.
4. Anand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., et al. (2000). Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of Nmethyl-D-aspartate receptor antagonists. Arch. Gen. Psychiatry 57, 270-276.
5. Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N. R., Ennis, D. J., et al. (2012a). NMDA receptor function in large-scale anti-correlated neural systems with implications for cognition and schizophrenia. Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/ pnas.1208494109
6. Anticevic, A., Repovs, G., and Barch, D. M. (2012b). Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia. Schizophr. Bull. 38, 967-980.
7. Anticevic, A., Van Snellenberg, J. X., Cohen, R. E., Repovs, G., Dowd, E. C., and Barch, D. M. (2012c). Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophr. Bull. 38, 608-621.
8. Anticevic, A., Repovs, G., and Barch, D. M. (2011a). Working memory encoding and maintenance deficits in schizophrenia:neural evidence for activation and deactivation abnormalities. Schizophr. Bull. [Epub ahead of print].
9. Anticevic, A., Repovs, G., Corlett, P. R., and Barch, D. M. (2011b). Negative and non-emotional interference with visual working memory in schizophrenia. Biol. Psychiatry 70, 1159-1168.
10. Arnsten, A. F. (2011). Catecholamine influences on dorsolateral prefrontal cortical networks. Biol. Psychiatry 69, 89-99.
11. Arnsten, A. F., and Rubia, K. (2012). Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatricdisorders. J. Am. Acad. Child Adolesc. Psychiatry 51, 356-367.
12. Barbas, H. (2007). Flow of information for emotions through temporal and orbitofrontal pathways. J. Anat. 237-249.
13. Barch, D. M. (2005). "The cognitive neuroscience of schizophrenia, " in Annual Review of Clinical Psychology, eds T. Cannon and S. Mineka (Washington: American Psychological Association), 321-353.
14. Barch, D. M., Carter, C. S., and Cohen, J. D. (2003). Context processing deficit in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms. J. Abnorm. Psychol. 112, 132-143.
15. Barch, D. M., and Ceaser, A. (2012). Cognition in schizophrenia: core psychological and neural mechanisms. Trends Cogn. Sci. 16, 27-34.
16. Barch, D. M., and Dowd, E. C. (2010). Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions. Schizophr. Bull. 36, 919-934.
17. Barch, D. M., and Keefe, R. S. E. (2010). Anticipating DSM-V: opportunities and challenges for cognition and psychosis. Schizophr. Bull. 36, 43-47.
18. Bartlett, F. C. (1932). Remembering. Cambridge: Cambridge University Press.
19. Benes, F. M., McSparren, J., Bird, E. D., SanGiovanni, J. P., and Vincent, S. L. (1991). Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch. Gen. Psychiatry 48, 996-1001.
20. Beninger, R. J. (1983). The role of dopamine in locomotor activity and learning. Brain Res. 287, 173-196.
21. Bentall, R. P., Corcoran, R., Howard, R., Blackwood, N., and Kinderman, P. (2001). Persecutory delusions: a review and theoretical integration. Clin. Psychol. Rev. 21, 1143-1192.
22. Bentall, R. P., and Swarbrick, R. (2003). The best laid schemas of paranoid patients: autonomy, sociotropy and need for closure. Psychol. Psychother. 76(PART 2), 163-171.
23. Berenbaum, H., and Oltmanns, T. F. (1992). Emotional experience and expression in schizophrenia and depression. J. Abnorm. Psychol. 101, 37-44.
24. Berkes, P., Orbán, G., Lengyel, M., and Fiser, J. (2011). Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment. Science 331, 83-87.
25. Berridge, K. C. (2003). Pleasures of the brain. Brain Cogn. 52, 106-128.
26. Berridge, K. C. (2004). Motivation concepts in behavioral neuroscience. Physiol. Behav. 81, 179-209.
27. Bleuler, E. (1911). Dementia Praecox, or The Group of Schizophrenias. New York: International Universities Press.
28. Bradley, M. M., Sabatinelli, D., Lang, P. J., Fitzsimmons, J. R., King, W., and Desai, P. (2003). Activation of the visual cortex in motivated attention. Behav. Neurosci. 117, 369-380.
29. Braun, J., and Mattia, M. (2010). Attractors and noise: twin drivers of decisions and multistability. Neuroimage 52, 740-751.
30. Braver, T. S. (2012). The variable nature of cognitive control: a dual mechanisms framework. Trends Cogn. Sci. (Regul. Ed.) 16, 106-113.
31. Braver, T. S., Barch, D. M., and Cohen, J. D. (1999). Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function. Biol. Psychiatry 46, 312-328.
32. Burbridge, J. A., and Barch, D. M. (2002). Emotional valence and reference disturbance in schizophrenia. J. Abnorm. Psychol. 111, 186-191.
33. Butts, C. (1998). A Bayesian model of panic in belief. Comput. Math. Organ. Theory 4, 373-404.
34. Carlsson, A., Waters, N., Holm-Waters, S., Tedroff, J., Nilsson, M., and Carlsson, M. L. (2001). Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence.Annu. Rev. Pharmacol. Toxicol. 41, 237-260.
35. Carlsson, M., and Carlsson, A. (1990). Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13, 272-276.
36. Cedro, A., Kokoszka, A., Popiel, A., and Narkiewicz-Jodko, W. (2001). Alexithymia in schizophrenia: an exploratory study. Psychol. Rep. 89, 95-98.
37. Chen, L. S., Rice, T. K., Thompson, P. A., Barch, D. M., and Csernansky, J. G. (2009). Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia. Schizophr. Res. 111, 159-166.
38. Chouinard, G., and Miller, R. (1999). A rating scale for psychotic symptoms (RSPS) part I: theoretical principles and subscale 1: perception symptoms (illusions and hallucinations). Schizophr. Res. 38, 101-122.
39. Cole, S., and McNally, G. P. (2007). Temporal-difference prediction errors and Pavlovian fear conditioning: role of NMDA and opioid receptors. Behav. Neurosci. 121, 1043-1052.
40. Cole, S., and McNally, G. P. (2009). Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning. Learn. Mem. 16, 1-7.
41. Coltheart, M. (2010). The neuropsychology of delusions. Ann. N. Y. Acad. Sci. 1191, 16-26.
42. Coltheart, M., Langdon, R., and McKay, R. (2011). Delusional belief. Annu. Rev. Psychol. 62, 271-298.
43. Conrad, K. (1958). Die BeginnendeSchizophrenie. Stuttgart: G.
44. Thieme Corlett, P. R., Frith, C. D., and Fletcher, P. C. (2009a). From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology (Berl.) 206, 515-530.
45. Corlett, P. R., Krystal, J. H., Taylor, J. R., and Fletcher, P. C. (2009b). Why do delusions persist? Front. Hum. Neurosci. 3:12. doi:10.3389/neuro.09.012.2009
46. Corlett, P. R., Honey, G. D., Aitken, M. R., Dickinson, A., Shanks, D. R., Absalom, A. R., et al. (2006). Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Arch. Gen. Psychiatry 63, 611-621.
47. Corlett, P. R., Honey, G. D., Krystal, J. H., and Fletcher, P. C. (2011). Glutamatergic model psychoses: prediction error, learning, and inference. Neuropsychopharmacology 36, 294-315.
48. Corlett, P. R., Murray, G. K., Honey, G. D., Aitken, M. R., Shanks, D. R., Robbins, T. W., et al. (2007a). Disrupted prediction-error signal in psychosis:evidence for anassociative account of delusions. Brain 130(PART 9), 2387-2400.
49. Corlett, P. R., Honey, G. D., and Fletcher, P. C. (2007b). From prediction error to psychosis: ketamine as a pharmacological model of delusions. J. Psychopharmacol. (Oxford) 21, 238-252.
50. Corlett, P. R., Taylor, J. R., Wang, X. J., Fletcher, P. C., and Krystal, J. H. (2010a). Toward a neurobiology of delusions. Prog. Neurobiol. 92, 345-369.
51. Corlett, P. R., D'Souza, D. C., and Krystal, J. H. (2010b). Capgras syndrome induced by ketamine in a healthy subject. Biol. Psychiatry 68, e1-e2.
52. Cornblatt, B., Obuchowski, M., Roberts, S., Pollack, S., and ErlenmeyerKimling, L. (1999). Cognitive and behavioral precursors of schizophrenia. Dev. Psychopathol. 11, 487-508.
53. Coyle, J. T. (2006). Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell. Mol. Neurobiol. 26, 365-384.
54. Csernansky, J. G., Gillespie, S. K., Dierker, D. L., Anticevic, A., Wang, L., Barch, D. M., et al. (2008). Symmetric abnormalities in sulcal patterning in schizophrenia. Neuroimage 43, 440-446.
55. Csernansky, J. G., Joshi, S., Wang, L., Haller, J. W., Gado, M., Miller, J. P., et al. (1998). Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc. Natl. Acad. Sci. U.S.A. 95, 11406-11411.
56. Csernansky, J. G., Schindler, M. K., Splinter, N. R., Wang, L., Gado, M., Selemon, L. D., et al. (2004). Abnormalities of thalamic volume and shape in schizophrenia. Am. J. Psychiatry 161, 896-902.
57. Daw, N. D., Niv, Y., and Dayan, P. (2005). Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control. Nat. Neurosci. 8, 1704-1711.
58. Delawalla, Z., Barch, D. M., Fisher Eastep, J. L., Thomason, E. S., Hanewinkel, M. J., Thompson, P. A., et al. (2006). Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophr. Bull. 32, 525-537.
59. Dickinson, A. (2001). The 28th Bartlett memorial lecture. Causal learning: an associative analysis. Q. J. Exp. Psychol. B 54, 3-25.
60. Dickinson, A., and Balleine, B. (1990). Motivational control of instrumental performance following a shift from thirst to hunger. Q. J. Exp. Psychol. B. 42, 413-431.
61. Dickinson, A., Smith, J., and Mirenowicz, J. (2000). Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists. Behav. Neurosci. 114, 468-483.
62. Dolcos, F., LaBar, K. S., and Cabeza, R. (2004). Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events. Neuron 42, 855-863.
63. Dowd, E. C., and Barch, D. M. (2010). Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biol. Psychiatry 67, 902-911.
64. Dutta, R., Greene, T., Addington, J., McKenzie, K., Phillips, M., and Murray, R. M. (2007). Biological, life course, and cross-cultural studies all point toward the value of dimensional and developmental ratings in the classification of psychosis. Schizophr. Bull. 33, 868-876.
65. Edwards, J., Jackson, H. J., and Pattison, P. E. (2002). Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin. Psychol. Rev. 22, 789-832.
66. Eichenbaum, H., and Bodkin, J. A. (2000)."Belief and knowledge as distinct forms of memory, " in Memory Brain and Belief, eds D. L. Schacter and E. Scarry (Cambridge, MA: Harvard University Press), 176-207.
67. Eisenhardt, D., and Menzel, R. (2007). Extinction learning, reconsolidation and the internal reinforcement hypothesis. Neurobiol. Learn. Mem. 87, 167-173.
68. Ellis, H. D., and Young, A. W. (1990). Accounting for delusional misidentifications. Br. J. Psychiatry 157, 239-248.
69. Fletcher, P. C., and Frith, C. D. (2009). Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat. Rev. Neurosci. 10, 48-58.
70. Fotopoulou, A. (2010). The affective neuropsychology of confabulation and delusion. Cogn. Neuropsychiatry 15, 38-63.
71. Gard, D. E., Kring, A. M., Gard, M. G., Horan, W. P., and Green, M. F. (2007). Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr. Res. 93, 253-260.
72. Garety, P. (1991). Reasoning and delusions. Br. J. Psychiatry Suppl. 14, 14-18.
73. Glahn, D. C., Ragland, J. D., Abramoff, A., Barrett, J., Laird, A. R., Bearden, C. E., et al. (2005). Beyond hypofrontality: a quantitative metaanalysis of functional neuroimaging studies of working memory in schizophrenia. Hum. Brain Mapp. 25, 60-69.
74. Goldman-Rakic, P. S., Castner, S. A., Svensson, T. H., Siever, L. J., and Williams, G. V. (2004). Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology (Berl.) 174, 3-16.
75. Gonzalez-Burgos, G., and Lewis, D. A. (2012). NMDA receptor hypofunction, parvalbumin-positive neurons and cortical gamma oscillations in schizophrenia. Schizophr. Bull. doi: 10.1093/schbul/sbs010. [Epub ahead of print].
76. Gray, J. A. (1995). Dopamine release in the nucleus accumbens: the perspective from aberrations of consciousness in schizophrenia. Neuropsychologia 33, 1143-1153.
77. Gray, J. A. (1998). Integrating schizophrenia. Schizophr. Bull. 24, 249-266.
78. Gray, J. A., Feldon, J., Rawlins, J. N. P., Hemsley, D., and Smith, A. D. (1991). The neuropsychology of schizophrenia. Behav. Brain Sci. 14, 1-84.
79. Gray, J. A., Joseph, M. H., Hemsley, D. R., Young, A. M., Warburton, E. C., Boulenguez, P., et al. (1995). The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behav. Brain Res. 71, 19-31.
80. Green, M. F. (2006). Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J. Clin. Psychiatry 67, e12.
81. Greenwald, A. G., and Farnham, S. D. (2000). Using the implicit association test to measure self-esteem and self-concept. J. Pers. Soc. Psychol. 79, 1022-1038.
82. Greenwald, A. G., McGhee, D. E., and Schwartz, J. L. (1998). Measuring individual differences in implicit cognition: the implicit association test. J. Pers. Soc. Psychol. 74, 1464-1480.
83. Gruzelier, J. H. (1976). Clinical attributes of schizophrenic skin conductance responders and non-responders. Psychol. Med. 6, 254-249.
84. Habel, U., Gur, R. C., Mandal, M. K., Salloum, J. B., Gur, R. E., and Schneider, F. (2000). Emotional processing in schizophrenia across cultures: standardized measures of discrimination and experience. Schizophr. Res. 42, 57-66.
85. Hagen, E. (2008). "Non-bizarre delusions as strategic deception, " in Medicine and Evolution: Current Applications, Future Prospect, eds S. Elton and P. O'Higgins (New York: Taylor and Francis).
86. Harms, M. P., Wang, L., Campanella, C., Aldridge, K., Moffitt, A. J., Kuelper, J., et al. (2010). Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings. Br. J. Psychiatry 196, 150-157.
87. Harms, M. P., Wang, L., Csernansky, J. G., and Barch, D. M. (2012). Structure-function relationship of working memory activity with hippocampal and prefrontal cortex volumes. Brain Struct. Funct. doi: 10.1007/s00429-012-0391-8. [Epub ahead of print].
88. Harms, M. P., Wang, L., Mamah, D., Barch, D. M., Thompson, P. A., and Csernansky, J. G. (2007). Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings. J. Neurosci. 27, 13835-13842.
89. Harvey, P. O., Zaki, J., Lee, J., Ochsner, K., and Green, M. F. (2012). Neural substrates of empathic accuracy in people with schizophrenia. Schizophr. Bull. doi: 10.1093/schbul/sbs042. [Epub ahead of print].
90. Heaton, R., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D., Jeste, D. V. (2001). Stability and course of neuropsychological deficits in schizophrenia. Arch. Gen. Psychiatry 58, 24-32.
91. Heckers, S., and Konradi, C. (2010). Hippocampal pathology in schizophrenia. Curr. Top. Behav. Neurosci. 4, 529-553.
92. Heerey, E. A., and Gold, J. M. (2007). Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior. J. Abnorm. Psychol. 116, 268-278.
93. Herbener, E. S., Song, W., Khine, T. T., and Sweeney, J. A. (2008). What aspects of emotional functioning are impaired in schizophrenia? Schizophr. Res. 98, 239-246.
94. Hitchcott, P. K., Quinn, J. J., and Taylor, J. R. (2007). Bidirectional modulation of goal-directed actions by prefrontal cortical dopamine. Cereb. Cortex 17, 2820-2827.
95. Holt, D. J., Lebron-Milad, K., Milad, M. R., Rauch, S. L., Pitman, R. K., Orr, S. P., et al. (2009). Extinction memory is impaired in schizophrenia. Biol. Psychiatry 65, 455-463.
96. Honey, G., and Bullmore, E. (2004). Human pharmacological MRI. Trends Pharmacol. Sci. 25, 366-374.
97. Hopfield, J. J. (1982). Neural networks and physical systems with emergent collective computational abilities. Proc. Natl. Acad. Sci. U.S.A. 79, 2554-2558.
98. Houran, J., and Houran, J. (1998). Preliminary study of tolerance of ambiguity of individuals reporting paranormal experiences. Psychol. Rep. 82, 183.
99. Howes, O. D., Kambeitz, J., Kim, E., Stahl, D., Slifstein, M., Abi-Dargham, A., et al. (2012). The nature of dopamine dysfunction in schizophrenia and what this means for treatment: meta-analysis of imaging studies. Arch. Gen. Psychiatry 69, 776-786.
100. Howes, O. D., and Kapur, S. (2009). The dopamine hypothesis of schizophrenia: version III - the final common pathway. Schizophr. Bull. 35, 549-562.
101. Howes, O. D., Montgomery, A. J., Asselin, M. C., Murray, R. M., Valli, I., Tabraham, P., et al. (2009). Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch. Gen. Psychiatry 66, 13-20.
102. Insel, T. R. (2010). Rethinking schizophrenia. Nature 468, 187-193.
103. Insel, T. R., and Cuthbert, B. N. (2009). Endophenotypes: bridging genomic complexity and disorder heterogeneity. Biol. Psychiatry 66, 988-989.
104. Irani, F., Kalkstein, S., Moberg, E. A., and Moberg, P. J. (2011). Neuropsychological performance in older patients with schizophrenia: a metaanalysis of cross-sectional and longitudinal studies. Schizophr. Bull. 37, 1318-1326.
105. Iwase, M., Yamashita, K., Takahashi, K., Kajimoto, O., Shimizu, A., Nishikawa, T., et al. (1999). Diminished facial expression despite the existence of pleasant emotional experience in schizophrenia. Methods Find Exp. Clin. Pharmacol. 21, 189-194.
106. Jaspers, K. (1963). General Psychopathology. Manchester: Manchester University Press.
107. Jensen, J., Willeit, M., Zipursky, R. B., Savina, I., Smith, A. J., Menon, M., et al. (2008). The formation of abnormal associations in schizophrenia: neural and behavioral evidence. Neuropsychopharmacology 33, 473-479.
108. Johnson, M. R., Kawasawa, Y. I., Mason, C. E., Krsnik, Z., Coppola, G., Bogdanovic, D., et al. (2009). Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 62, 494-509.
109. Jonides, J., Lewis, R. L., Nee, D. E., Lustig, C. A., Berman, M. G., and Moore, K. S. (2008). The mind and brain of short-term memory. Annu. Rev. Psychol. 59, 193-224.
110. Juckel, G., Schlagenhauf, F., Koslowski, M., Wüstenberg, T., Villringer, A., Knutson, B., et al. (2006a). Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 29, 409-416.
111. Juckel, G., Schlagenhauf, F., Koslowski, M., Filonov, D., Wüstenberg, T., Villringer, A., et al. (2006b). Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl.) 187, 222-228.
112. Kaney, S., and Bentall, R. P. (1989). Persecutory delusions and attributional style. Br. J. Med. Psychol. 62(PART 2), 191-198.
113. Kaney, S., and Bentall, R. P. (1992). Persecutory delusions and the selfserving bias. Evidence from a contingency judgment task. J. Nerv. Ment. Dis. 180, 773-780.
114. Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., et al. (2011). Spatio-temporal transcriptome of the human brain. Nature 478, 483-489.
115. Kapur, S. (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.Am. J. Psychiatry 160, 13-23.
116. Kapur, S., Mizrahi, R., and Li, M. (2005). From dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis. Schizophr. Res. 79, 59-68.
117. Kee, K. S., Green, M. F., Mintz, J., and Brekke, J. S. (2003). Is emotion processing a predictor of functional outcome in schizophrenia? Schizophr. Bull. 29, 487-497.
118. Kegeles, L. S., Abi-Dargham, A., Frankle, W. G., Gil, R., Cooper, T. B., Slifstein, M., et al. (2010). Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch. Gen. Psychiatry 67, 231-239.
119. Kegeles, L. S., Abi-Dargham, A., Zea-Ponce, Y., Rodenhiser-Hill, J., Mann, J. J., Van Heertum, R. L., et al. (2000). Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol. Psychiatry 48, 627-640.
120. Kiebel, S. J., Daunizeau, J., and Friston, K. J. (2009). Perception and hierarchical dynamics. Front. Neuroinformatics 3:20. doi:10.3389/neuro.11.020.2009
121. Kinderman, P. (1994). Attentional bias, persecutory delusions and the selfconcept. Br. J. Med. Psychol. 67(PART 1), 53-66.
122. Kinderman, P., and Bentall, R. P. (1996). Self-discrepancies and persecutory delusions: evidence for a model of paranoid ideation. J. Abnorm. Psychol. 105, 106-113.
123. Knutson, B., Westdorp, A., Kaiser, E., and Hommer, D. (2000). FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12, 20-27.
124. Kober, H., Barrett, L. F., Joseph, J., BlissMoreau, E., Lindquist, K., andWager, T. D. (2008). Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage 42, 998-1031.
125. Kohler, C. G., Turner, T. H., Bilker, W. B., Brensinger, C. M., Siegel, S. J., Kanes, S. J., et al. (2003). Facial emotion recognition in schizophrenia: intensity effects and error pattern. Am. J. Psychiatry 160, 1768-1774.
126. Kraeplin, E. (1950). Dementia Praecox and Paraphrenia. New York: International Universities Press, Inc.
127. Krause, R., Steimer, E., Sänger-Alt, C., and Wagner, G. (1989). Facial expression of schizophrenic patients and their interaction partners. Psychiatry 52, 1-12.
128. Kring, A. M. (2011). The future of emotion research in the study of psychopathology. Emot. Rev. 2, 225-228.
129. Kring, A. M., Alpert, M., Neale, J. M., and Harvey, P. D. (1994). A multimethod, multichannel assessment of affective flattening in schizophrenia. Psychiatry Res. 54, 211-222.
130. Kring, A. M., Kerr, S. L., Smith, D. A., and Neale, J. M. (1993). Flat affect in schizophrenia does not reflect diminished subjective experience of emotion. J. Abnorm. Psychol. 102, 507-517.
131. Kring, A. M., and Moran, E. K. (2008). Emotional response deficits in schizophrenia: insights from affective science. Schizophr. Bull. 34, 819-834.
132. Kruglanski, A. W., and Webster, D. M. (1996). Motivated closing of the mind: "seizing" and "freezing." Psychol. Rev. 103, 263-283.
133. Kruglanski, A. W., Webster, D. M., and Klem, A. (1993). Motivated resistance and openness to persuasion in the presence or absence of prior information. J. Pers. Soc. Psychol. 65, 861-876.
134. Krystal, J. H., D'Souza, D. C., Karper, L. P., Bennett, A., Abi-Dargham, A., Abi-Saab, D., et al. (1999). Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology (Berl.) 145, 193-204.
135. Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., and Hoffman, R. (2003). NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berl.) 169, 215-233.
136. Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., et al. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51, 199-214.
137. Krystal, J. H., Perry, E. B. Jr., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., et al. (2005). Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch. Gen. Psychiatry 62, 985-994.
138. Lang, P. (2010). Emotion and motivation: toward consensus definitions and a common research purpose. Emot. Rev. 2, 229-233.
139. Lang, P. J., and Bradley, M. M. (2010). Emotion and the motivational brain. Biol. Psychol. 84, 437-450.
140. Lang, P. J., and Davis, M. (2006). Emotion, motivation, and the brain: reflex foundations in animal and human research. Prog. Brain Res. 156, 3-29.
141. Laruelle, M., Abi-Dargham, A., Gil, R., Kegeles, L., and Innis, R. (1999). Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol. Psychiatry 46, 56-72.
142. Laruelle, M., Kegeles, L. S., and Abi Dargham, A. (2003). Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. Ann. N. Y. Acad. Sci. 1003, 138-158.
143. Laruelle, M., VanDyck, C., and AbiDargham, A. (1995). SPECT imaging of dopamine release following amphetamine challenge in healthy subjects and in patients with schizophrenia. J. Nucl. Med. 36, 10P.
144. Laviolette, S. R., and Grace, A. A. (2006). The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. Cell. Mol. Life Sci. 63, 1597-1613.
145. LeDoux, J. E. (2000). Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184.
146. Lee, J., and Park, S. (2005). Working memory impairments in schizophrenia: a meta-analysis. J. Abnorm. Psychol. 114, 599-611.
147. Lee, J. L. (2008). Memory reconsolidation mediates the strengthening of memories by additional learning. Nat. Neurosci. 11, 1264-1266.
148. Lewis, D. A., Curley, A. A., Glausier, J. R., and Volk, D. W. (2012). Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci. 35, 57-67.
149. Lewis, D. A., and Hashimoto, T. (2007). Deciphering the disease process of schizophrenia: the contribution of cortical GABA neurons. Int. Rev. Neurobiol. 78, 109-131.
150. Lewis, D. A., Hashimoto, T., andVolk, D. W. (2005). Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 6, 312-324.
151. Lewis, D. A., and Moghaddam, B. (2006). Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch. Neurol. 63, 1372-1376.
152. Lewis, D. A., Volk, D. W., and Hashimoto, T. (2004). Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl.) 174, 143-150.
153. Lisman, J. (2012). Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia? Curr. Opin. Neurobiol. 22, 537-544.
154. Loh, M., Rolls, E. T., and Deco, G. (2007). A dynamical systems hypothesis of schizophrenia. PLoS Comput. Biol. 3, e228. doi:10.1371/journal.pcbi.0030228
155. Mamah, D., Conturo, T. E., Harms, M. P., Akbudak, E., Wang, L., McMichael, A. R., et al. (2010). Anteriorthalamicradiationintegrity in schizophrenia: a diffusion-tensor imaging study. Psychiatry Res. 183, 144-150.
156. Mandal, M. K., Pandey, R., and Prasad, A. B. (1998). Facial expressions of emotions and schizophrenia: a review. Schizophr. Bull. 24, 399-412.
157. Marin, O. (2012). Interneuron dysfunction in psychiatric disorders. Nat. Rev. Neurosci. 13, 107-120.
158. Mathews, J. R., and Barch, D. M. (2004). Episodic memory for emotional and nonemotional words in schizophrenia. Cogn. Emot. 18, 721-740.
159. Mattes, R. M., Schneider, F., Heimann, H., and Birbaumer, N. (1995). Reduced emotional response of schizophrenic patients in remission during social interaction. Schizophr. Res. 17, 249-255.
160. McKay, R., Langdon, R., and Coltheart, M. (2007a). Jumping to delusions? Paranoia, probabilistic reasoning, and need for closure. Cogn. Neuropsychiatry 12, 362-376.
161. McKay, R., Langdon, R., and Coltheart, M. (2007b). Models of misbelief: integrating motivational and deficit theories of delusions. Conscious. Cogn. 16, 932-941.
162. McKay, R., Langdon, R., and Coltheart, M. (2007c). The defensive function of persecutory delusions: an investigation using the implicit association test. Cogn. Neuropsychiatry 12, 1-24.
163. McKay, R. T., and Dennett, D. C. (2009). The evolution of misbelief. Behav. Brain Sci. 32, 493-510; discussion 510-561.
164. McNally, G. P., Johansen, J. P., and Blair, H. T. (2011). Placing prediction into the fear circuit. Trends Neurosci. 34, 283-292.
165. McNally, G. P., and Westbrook, R. F. (2006). Predicting danger: the nature, consequences, and neural mechanisms of predictive fear learning. Learn. Mem. 13, 245-253.
166. Mijovic-Prelec, D., and Prelec, D. (2010). Self-deception as selfsignalling:a model andexperimental evidence. Philos. Trans. R. Soc. Lond. B Biol. Sci. 365, 227-240.
167. Miller, B. T., and D'Esposito, M. (2005). Searching for "the top" in top-down control. Neuron 48, 535-538.
168. Miller, E. K., and Cohen, J. D. (2001). An integrative theory of prefrontal cortex function.Annu. Rev. Neurosci. 24, 167-202.
169. Milton, F., Patwa, V. K., and Hafner, R. J. (1978). Confrontation vs. belief modification in persistently deluded patients. Br. J. Med. Psychol. 51, 127-130.
170. Mishara, A. L., and Corlett, P. R. (2009). Are delusions biologically adaptive? Salvaging the doxastic shear pin. Behav. Brain Sci. 32, 530-531.
171. Montague, P. R., Dolan, R. J., Friston, K. J., and Dayan, P. (2012). Computational psychiatry. Trends Cogn. Sci. (Regul. Ed.) 16, 72-80.
172. Morita, K., Morishima, M., Sakai, K., and Kawaguchi, Y. (2012). Reinforcement learning: computing the temporal difference of values via distinct corticostriatal pathways. Trends Neurosci. 35, 457-467.
173. Moritz, S., Kother, U., Woodward, T. S., Veckenstedt, R., Dechene, A., and Stahl, C. (2012). Repetition is good? An internet trial on the illusory truth effect in schizophrenia and nonclinical participants. J. Behav. Ther. Exp. Psychiatry 43, 1058-1063.
174. Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., et al. (2008). Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol. Psychiatry 13, 239, 267-276.
175. Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., et al. (2012). GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology 62, 1574-1583.
176. Niedenthal, P. M., and Brauer, M. (2012). Social functionality of human emotion. Annu. Rev. Psychol. 63, 259-285.
177. Nielsen, M. O., Rostrup, E., Wulff, S., Bak, N., Lublin, H., Kapur, S., et al. (2012). Alterations of the brain reward system in antipsychotic naïve schizophrenia patients. Biol. Psychiatry 71, 898-905.
178. Niendam, T. A., Bearden, C. E., Rosso, I. M., Sanchez, L. E., Hadley, T., Nuechterlein, K. H., et al. (2003). A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am. J. Psychiatry 160, 2060-2062.
179. Ochsner, K. N. (2008). The socialemotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol. Psychiatry 64, 48-61.
180. O'Doherty, J. P., Deichmann, R., Critchley, H. D., and Dolan, R. J. (2002). Neural responses during anticipation of a primary taste reward. Neuron 33, 815-826.
181. O'Tuathaigh, C. M., Salum, C., Young, A. M., Pickering, A. D., Joseph, M. H., and Moran, P. M. (2003). The effect of amphetamine on Kamin blocking and overshadowing. Behav. Pharmacol. 14, 315-322.
182. Owen, A. M., McMillan, K. M., Laird, A. R., and Bullmore, E. (2005). Nback working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp. 25, 46-59.
183. Padmala, S., and Pessoa, L. (2008). Affective learning enhances visual detection and responses in primary visual cortex. J. Neurosci. 28, 6202-6210.
184. Pally, R. (2005). Non-conscious prediction and a role for consciousness in correcting prediction errors. Cortex 41, 643-662; discussion 731-734.
185. Pally, R. (2007). The predicting brain: unconscious repetition, conscious reflection and therapeutic change. Int. J. Psychoanal. 88(PART 4), 861-881.
186. Pearce, J. M., and Hall, G. (1980). A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli. Psychol. Rev. 87, 532-552.
187. Pedreira, M. E., Perez-Cuesta, L. M., and Maldonado, H. (2004). Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction. Learn. Mem. 11, 579-585.
188. Peralta, V., and Cuesta, M. J. (2001). How many and which are the psychopathological dimensions in schizophrenia? Issues influencing their ascertainment. Schizophr. Res. 49, 269-285.
189. Pessoa, L. (2008). On the relationship between emotion and cognition. Nat. Rev. Neurosci. 9, 148-158.
190. Pessoa, L., and Adolphs, R. (2010). Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat. Rev. Neurosci. 11, 773-783.
191. Petersen, S. E., Snyder, A. Z., and Raichle, M. E. (1990). Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science 249, 1041-1044.
192. Phillips, M. L. (2003). Understanding the neurobiology of emotion perception: implications for psychiatry. Br. J. Psychiatry 182, 190-192.
193. Phillips, M. L., Drevets, W. C., Rauch, S. L., and Lane, R. (2003). Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol. Psychiatry 54, 515-528.
194. Posner, M. I., and Petersen, S. E. (1990). The attention system of the human brain. Annu. Rev. Neurosci. 13, 25-42.
195. Postle, B. R. (2005). Delay-period activity in the prefrontal cortex: one function is sensory gating. J. Cogn. Neurosci. 17, 1679-1690.
196. Ramachandran, V., and Blakeslee, S. (1998). Phantoms in the Brain: Probing the Mysteries of the Human Mind. New York: William Morrow.
197. Rao, S. G., Williams, G. V., and Goldman-Rakic, P. S. (2000). Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory. J. Neurosci. 20, 485-494.
198. Reichenberg, A., and Harvey, P. D. (2007). Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychol. Bull. 133, 833-858.
199. Rescorla, R. A., and Wagner, A. R. (1972). "A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement, " in Classical Conditioning II: Current Research and Theory, eds A. H. Black and W. F. Prokasy (New York: AppletonCentury-Crofts), 64-99.
200. Robinson, T. E., and Berridge, K. C. (2001). Incentive-sensitization and addiction. Addiction 96, 103-114.
201. Rolls, E. T., and Deco, G. (2011). A computational neuroscience approach to schizophrenia and its onset. Neurosci. Biobehav. Rev. 35, 1644-1653.
202. Rolls, E. T., and Stringer, S. M. (2001). A model of the interaction between mood and memory. Network 12, 89-109.
203. Romaniuk, L., Honey, G. D., King, J. R., Whalley, H. C., McIntosh, A. M., Levita, L., et al. (2010). Midbrain activation during pavlovian conditioning and delusional symptoms in schizophrenia. Arch. Gen. Psychiatry 67, 1246-1254.
204. Ross, C. A., Margolis, R. L., Reading, S. A., Pletnikov, M., and Coyle, J. T. (2006). Neurobiology of schizophrenia. Neuron 52, 139-153.
205. Rubin, R. D. (1976). Clinical use of retrograde amnesia produced by electroconvulsive shock. A conditioning hypothesis. Can. Psychiatr. Assoc. J. 21, 87-90.
206. Salzman, C. D., and Fusi, S. (2010). Emotion, cognition, and mental state representation in amygdala and prefrontal cortex. Annu. Rev. Neurosci. 33, 173-202.
207. Schiller, D., Levy, I., Niv, Y., LeDoux, J. E., and Phelps, E. A. (2008). From fear to safety and back: reversal of fear in the human brain. J. Neurosci. 28, 11517-11525.
208. Schlagenhauf, F., Juckel, G., Koslowski, M., Kahnt, T., Knutson, B., Dembler, T., et al. (2008). Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology (Berl.) 196, 673-684.
209. Scholten, M. R., Aleman, A., Montagne, B., and Kahn, R. S. (2005). Schizophrenia and processing of facial emotions: sex matters. Schizophr. Res. 78, 61-67.
210. Shadlen, M. N., and Newsome, W. T. (1994). Noise, neural codes and cortical organization. Curr. Opin. Neurobiol. 4, 569-579.
211. Simen, A. A., DiLeone, R., and Arnsten, A. F. (2009). Primate models of schizophrenia: future possibilities. Prog. Brain Res. 179, 117-125.
212. Sison, C. E., Alpert, M., Fudge, R., and Stern, R. M. (1996). Constricted expressiveness and psychophysiological reactivity in schizophrenia. J. Nerv. Ment. Dis. 184, 589-597.
213. Stanton, B., and David, A. (2000). Firstperson accounts of delusions. Psychiatr. Bull. R. Coll. Psychiatr. 24, 333-336.
214. Stephan, K. E., Baldeweg, T., and Friston, K. J. (2006). Synaptic plasticity and dysconnection in schizophrenia. Biol. Psychiatry 59, 929-939.
215. Stickgold, R., and Walker, M. P. (2007). Sleep-dependent memory consolidation and reconsolidation. Sleep Med. 8, 331-343.
216. Sutton, R. S., and Barto, A. G. (1998). Reinforcement Learning: An Introduction. Cambridge: MIT Press.
217. Taylor, S., Kang, J., Brege, I. S., Tso, I. F., Hosanagar, A., and Johnson, T. D. (2011). Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia. Biol. Psychiatry 71, 136-145.
218. Trémeau, F. (2006). A review of emotion deficits in schizophrenia. Dialogues Clin. Neurosci. 8, 59-70.
219. Trémeau, F., Malaspina, D., Duval, F., Corrêa, H., Hager-Budny, M., CoinBariou, L., et al. (2005). Facial expressiveness in patients with schizophrenia compared to depressed patients and nonpatient comparison subjects. Am. J. Psychiatry 162, 92-101.
220. Tricomi, E., Balleine, B. W., and O'Doherty, J. P. (2009). A specific role for posterior dorsolateral striatum in human habit learning. Eur. J. Neurosci. 29, 2225-2232.
221. Trivers, R. (1985). Social Evolution. Menlo Park, CA: Benjamin/Cummins Publishing Co.
222. Tulving, E. (1972). "Episodic and semantic memory, " in Organization of Memory, eds E. Tulving and W. Donaldson (New York: Academic Press), 381-403.
223. Tye, K. M., and Diesseroth, K. (2012). Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat. Rev. Neurosci. 13, 251-266.
224. Ursu, S., Kring, A. M., Gard, M. G., Minzenberg, M. J., Yoon, J. H., Ragland, J. D., et al. (2011). Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia. Am. J. Psychiatry 168, 276-285.
225. Van Snellenberg, J. X., Torres, I. J., and Thornton, A. E. (2006). Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable. Neuropsychology 20, 497-510.
226. Wager, T. D., and Smith, E. E. (2003). Neuroimaging studies of working memory: a meta-analysis. Cogn. Affect. Behav. Neurosci. 3, 255-274.
227. Walker, E., Kestler, L., Bollini, A., and Hochman, K. M. (2004). Schizophrenia: etiology and course. Annu. Rev. Psychol. 55, 401-430.
228. Wang, X. J. (1999). Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. J. Neurosci. 19, 9587-9603.
229. Wang, X.-J. (2006). Toward a prefrontal microcircuit model for cognitive deficits in schizophrenia. Pharmacopsychiatry 39(Suppl. 1), S80-S87.
230. Wang, X.-J. (2008). Decision making in recurrent neuronal circuits. Neuron 60, 215-234.
231. Wang, X.-J. (2010). Neurophysiological and computational principles of cortical rhythms in cognition. Physiol. Rev. 90, 1195-1268.
232. Whitson, J. A., and Galinsky, A. D. (2008). Lacking control increases illusory pattern perception. Science 322, 115-117.
233. Yamashita, Y., and Tani, J. (2012). Spontaneous prediction error generation in schizophrenia. PLoS ONE 7, e37843. doi:10.1371/journal.pone.0037843
234. Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O'Shea, D. J., et al. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477, 171-178.