NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 41, 2012, Pages 16720-16725

  Anticevic, Alan ^a,b   Gancsos, Mark ^a,b   Murray, John D ^a,c   Repovs, Grega ^d   Driesen, Naomi R ^a,b   Ennis, Debra J ^e   Niciu, Mark J ^a,b   Morgan, Peter T ^a,b   Surti, Toral S ^a,b   Bloch, Michael H ^a,b   Ramani, Ramachandran ^a   Smith, Mark A ^e   Wang, Xiao Jing ^a   Krystal, John H ^a,b,f,g   Corlett, Philip R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale University School of Medicine   (United States)

^c Yale University   (United States)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e ASTRAZENECA   (United Kingdom)

^f YALE NEW HAVEN HOSPITAL   (United States)

^g VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Default mode network; fMRI; Pharmacological manipulation; Task based activation; Task based deactivation

Indexed keywords

KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; ARTICLE; BIOPHYSICS; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; MALE; MATHEMATICAL MODEL; NERVE CELL INHIBITION; NERVE CELL STIMULATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHIZOPHRENIA; SYMPTOM; WORKING MEMORY;

ADULT; ALGORITHMS; BRAIN; COGNITION; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; KETAMINE; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MODELS, NEUROLOGICAL; PATTERN RECOGNITION, VISUAL; PSYCHOMOTOR PERFORMANCE; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION; YOUNG ADULT;

EID: 84867393672     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208494109     Document Type: Article

References (51)

1. Kapur S, Remington G (1996) Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 153:466-476. (Pubitemid 26113309)
2. Wang X-J (2008) Decision making in recurrent neuronal circuits. Neuron 60:215-234.
3. Krystal JH, et al. (2003) NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: Toward a paradigm shift in medication development. Psychopharmacology (Berl) 169:215-233. (Pubitemid 37264943)
4. Marín O (2012) Interneuron dysfunction in psychiatric disorders. Nat Rev Neurosci 13:107-120.
5. Yizhar O, et al. (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477:171-178.
6. Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17:2921-2927. (Pubitemid 27155025)
7. Moghaddam B, Adams BW (1998) Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281:1349-1352. (Pubitemid 28406826)
8. Fox MD, et al. (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102:9673-9678. (Pubitemid 40981739)
9. Raichle ME, Snyder AZ (2007) A default mode of brain function: A brief history of an evolving idea. Neuroimage 37:1083-1090. (Pubitemid 47385262)
10. Shulman GL, et al. (1997) Common blood flow changes across visual tasks: I. Increases in subcortical structures and cerebellum but not in nonvisual cortex. J Cogn Neurosci 9:624-647. (Pubitemid 27455555)
11. Whitfield-Gabrieli S, et al. (2009) Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci USA 106:1279-1284.
12. Biswal BB, et al. (2010) Toward discovery science of human brain function. Proc Natl Acad Sci USA 107:4734-4739.
13. Honey G, Bullmore E (2004) Human pharmacological MRI. Trends Pharmacol Sci 25:366-374. (Pubitemid 38829490)
14. Krystal JH, et al. (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51:199-214. (Pubitemid 24081509)
15. Honey GD, et al. (2008) Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo. J Neurosci 28:6295-6303.
16. Stephan KE, Baldeweg T, Friston KJ (2006) Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry 59:929-939. (Pubitemid 44288017)
17. Corlett PR, et al. (2006) Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: Linking cognition, brain activity, and psychosis. Arch Gen Psychiatry 63:611-621. (Pubitemid 43848292)
18. Honey RA, et al. (2004) Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: An FMRI study. Neuropsychopharmacology 29:1203-1214. (Pubitemid 38670056)
19. Jonides J, et al. (2008) The mind and brain of short-term memory. Annu Rev Psychol 59:193-224.
20. Lee J, Park S (2005) Working memory impairments in schizophrenia: A meta-analysis. J Abnorm Psychol 114:599-611. (Pubitemid 41746997)
21. Anticevic A, Repovs G, Shulman GL, Barch DM (2010) When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage 49:2638-2648.
22. Daselaar SM, Prince SE, Cabeza R (2004) When less means more: Deactivations during encoding that predict subsequent memory. Neuroimage 23:921-927. (Pubitemid 39446526)
23. Fox MD, Greicius M (2010) Clinical applications of resting state functional connectivity. Front Syst Neurosci 4:19.
24. Compte A, Brunel N, Goldman-Rakic PS, Wang XJ (2000) Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. Cereb Cortex 10:910-923.
25. Montague PR, Dolan RJ, Friston KJ, Dayan P (2012) Computational psychiatry. Trends Cogn Sci 16:72-80.
26. Neill JC, et al. (2010) Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism. Pharmacol Ther 128:419-432.
27. Morgan CJ, Curran HV (2006) Acute and chronic effects of ketamine upon human memory: A review. Psychopharmacology (Berl) 188:408-424. (Pubitemid 46758974)
28. Owen AM, McMillan KM, Laird AR, Bullmore E (2005) N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 25:46-59. (Pubitemid 40656192)
29. Nichols TE, Brett M, Andersson J, Wager TD, Poline JB (2005) Valid conjunction inference with the minimum statistic. Neuroimage 25:653-660. (Pubitemid 40461704)
30. Kotermanski SE, Johnson JW (2009) Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J Neurosci 29:2774-2779.
31. Hayden BY, Smith DV, Platt ML (2009) Electrophysiological correlates of default-mode processing in macaque posterior cingulate cortex. Proc Natl Acad Sci USA 106:5948-5953.
32. Brunel N, Wang XJ (2001) Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. J Comput Neurosci 11:63-85. (Pubitemid 32926844)
33. Dosenbach NU, et al. (2007) Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci USA 104:11073-11078. (Pubitemid 47175228)
34. Satterthwaite TD, et al. (2012) Impact of in-scanner head motion on multiple measures of functional connectivity: Relevance for studies of neurodevelopment in youth. Neuroimage 60:623-632.
35. Van Dijk KRA, Sabuncu MR, Buckner RL (2012) The influence of head motion on intrinsic functional connectivity MRI. Neuroimage 59:431-438.
36. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142-2154.
37. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Steps toward optimizing motion artifact removal in functional connectivity MRI; a reply to Carp. Neuroimage, 10.1016/j.neuroimage.2012.03.017.
38. Pessoa L, Gutierrez E, Bandettini P, Ungerleider L (2002) Neural correlates of visual working memory: fMRI amplitude predicts task performance. Neuron 35:975-987.
39. Minzenberg MJ, Yoon JH, Carter CS (2011) Modafinil modulation of the default mode network. Psychopharmacology (Berl) 215:23-31.
40. Greene R (2001) Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. Hippocampus 11:569-577.
41. Eldaief MC, Halko MA, Buckner RL, Pascual-Leone A (2011) Transcranial magnetic stimulation modulates the brain's intrinsic activity in a frequency-dependent manner. Proc Natl Acad Sci USA 108:21229-21234.
42. Buckner RL (2011) The serendipitous discovery of the brain's default network. Neuroimage 62:1137-1145.
43. Barch DM, Dowd EC (2010) Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions. Schizophr Bull 36:919-934.
44. Meyer-Lindenberg A, et al. (2001) Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am J Psychiatry 158:1809-1817. (Pubitemid 33054773)
45. Buchanan RW, et al. (2007) The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry 164:1593-1602. (Pubitemid 350069740)
46. Driesen NR, et al. (2008) Impairment of working memory maintenance and response in schizophrenia: Functional magnetic resonance imaging evidence. Biol Psychiatry 64:1026-1034.
47. Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-349. (Pubitemid 19063448)
48. Ollinger JM, Corbetta M, Shulman GL (2001) Separating processes within a trial in event-related functional MRI. Neuroimage 13:218-229. (Pubitemid 34188259)
49. Anticevic A, Repovs G, Barch DM (2010) Resisting emotional interference: Brain regions facilitating working memory performance during negative distraction. Cogn Affect Behav Neurosci 10:159-173.
50. Anticevic A, Repovs G, Barch DM (2011) Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia. Schizophr Bull, 10.1093/schbul/sbq168.
51. Repovs G, Csernansky JG, Barch DM (2011) Brain network connectivity in individuals with schizophrenia and their siblings. Biol Psychiatry 69:967-973.