Working memory impairments in schizophrenia: A meta-analysis

Journal of Abnormal Psychology

Volumn 114, Issue 4, 2005, Pages 599-611

  Lee, Junghee ^a   Park, Sohee ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Frontal lobe; Schizophrenia; Spatial; Verbal; Working memory

Indexed keywords

DATA ANALYSIS; DEPTH PERCEPTION; DISTRACTIBILITY; HEMISPHERIC DOMINANCE; HUMAN; MEDLINE; MEMORY DISORDER; META ANALYSIS; PERSEVERATION; PREFRONTAL CORTEX; PSYCINFO; RESPONSE TIME; REVIEW; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; VERBAL MEMORY; WISCONSIN CARD SORTING TEST; WORKING MEMORY;

EID: 28544436939     PISSN: 0021843X     EISSN: None     Source Type: Journal    
DOI: 10.1037/0021-843X.114.4.599     Document Type: Review

References (161)

1. Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D. R., Keilp, J., Kochan, L., Van Heertum, R., Gorman, J. M., & Laruelle, M. (2002). Prefrontal dopamine D1 receptors and working memory in schizophrenia. Journal of Neuroscience, 22, 3708-3719.
2. Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., & Freedman, R. (1998). Schizophrenia, sensory gating, and nicotinic receptors. Schizophrenia Bulletin, 24, 189-202.
3. American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: Author.
4. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
5. Anil, A. E., Kivircik, B. B., Batur, S., Kabakci, E., Kitis, A., Giiven, E., Basar, K., Turgut, T. I., & Arkar, H. (2003). The Turkish version of the Auditory Consonant Trigram Test as a measure of working memory: A normative study. Clinical Neuropsychologist, 17, 159-169.
6. Baddeley, A. (1986). Working memory. New York: Oxford University Press.
7. Bagner, D. M., Melinder, M. R., & Barch, D. M. (2003). Language comprehension and working memory language comprehension and working memory deficits in patients with schizophrenia. Schizophrenia Research, 60, 299-309.
8. Barch, D. M., Carter, C. S., Braver, T. S., Sabb, F. W., MacDonald, A., III, Noll, D. C., & Cohen, J. D. (2001). Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry, 58, 280-288.
9. Barch, D. M., Carter, C. S., MacDonald, A. W., III, Braver, T. S., & Cohen, J. D. (2003). Context-processing deficits in schizophrenia: Diagnostic specificity, 4-week course, and relationship to clinical symptoms. Journal of Abnormal Psychology, 112, 132-143.
10. Barch, D. M., Csernansky, J. G., Conturo, T., & Snyder, A. Z. (2002). Working and long-term memory deficits in schizophrenia: Is there a common prefrontal mechanism? Journal of Abnormal Psychology, 111, 478-494.
11. Barch, D. M., Sheline, Y. I., Csernansky, J. G., & Snyder, A. Z. (2003). Working memory and prefrontal cortex dysfunction: Specificity to schizophrenia compared with major depression. Biological Psychiatry, 53, 376-384.
12. Bertolino, A., Esposito, G., Callicott, J. H., Mattay, V. S., Van Horn, J. D., Frank, J. A., Berman, K. F., & Weinberger, D. R. (2000). Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia. American Journal of Psychiatry, 157, 26-33.
13. Bertolino, A., Sciota, D., Brudaglio, F., Altamura, M., Blasi, G., Bellomo, A., Antonucci, N., Callicott, J. H., Goldberg, T. E., Scarabino, T., Weinberger, D. R., & Nardini, M. (2003). Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder. American Journal of Psychiatry, 160, 483-489.
14. Bollini, A. M., Arnold, M. C., & Keefe, R. S. (2000). Test-retest reliability of the dot test of visuospatial working memory in patients with schizophrenia and controls. Schizophrenia Research, 45, 169-173.
15. Braver, T. S., Barch, D. M., & Cohen, J. D. (1999). Cognition and control in schizophrenia: A computational model of dopamine and prefrontal function. Biological Psychiatry, 46, 312-328.
16. Brebion, G., Amador, X., Smith, M. J., & Gorman, J. M. (1998). Memory impairment and schizophrenia: The role of processing speed. Schizophrenia Research, 30, 31-39.
17. Bruder, G. E., Wexler, B. E., Sage, M. M., Gil, R. B., & Gorman, J. M. (2004). Verbal memory in schizophrenia: Additional evidence of subtypes having different cognitive deficits. Schizophrenia Research, 68, 137-147.
18. Burglen, F., Marczewski, P., Mitchell, K. J., van der Linden, M., Johnson, M. K., Danion, J. M., & Salame, P. (2004). Impaired performance in a working memory binding task in patients with schizophrenia. Psychiatry Research, 125, 247-255.
19. Cadenhead, K. S., Perry, W., Shafer, K., & Braff, D. L. (1999). Cognitive functions in schizotypal personality disorder. Schizophrenia Research, 37, 123-132.
20. Callicott, J. H., Bertolino, A., Mattay, V. S., Langheim, F. J., Duyn, J., Coppola, R., Goldberg, T. E., & Weinberger, D. R. (2000). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex, 10, 1078-1092.
21. Callicott, J. H., Mattay, V. S., Verchinski, B. A., Marenco, S., Egan, M. F., & Weinberger, D. R. (2003). Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down. American Journal of Psychiatry, 160, 2209-2215.
22. Callicott, J. H., Ramsey, N. F., Tallent, K., Bertolino, A., Knable, M. B., Coppola, R., Goldberg, T., van Gelderen, P., Mattay, V. S., Frank, J. A., Moonen, C. T., & Weinberger, D. R. (1998). Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology, 18, 186-196.
23. Cameron, A. M., Geffen, G. M., Kavanagh, D. J., Wright, M. J., McGrath, J. J., & Geffen, L. B. (2003). Event-related potential correlates of impaired visuospatial working memory in schizophrenia. Psychophysiology, 40, 702-715.
24. Carter, C., Robertson, L., Nordahl, T., Chaderjian, M., Kraft, L., & O'Shora-Celaya, L. (1996). Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients. Biological Psychiatry, 40, 930-932.
25. Carter, C. S., MacDonald, A. W., III, Ross, L. L., & Stenger, V. A. (2001). Anterior cingulated cortex activity and impaired self-monitoring of performance in patients with schizophrenia: An event-related fMRI study. American Journal of Psychiatry, 158, 1423-1428.
26. Carter, C. S., Perlstein, W., Ganguli, R., Brar, J., Mintun, M., & Cohen, J. D. (1998). Functional hypofrontality and working memory dysfunction in schizophrenia. American Journal of Psychiatry, 155, 1285-1287.
27. Chen, Y. L., Chen, Y. H., & Lieh-Mak, F. (2000). Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Research, 95, 133-148.
28. Chey, J., Lee, J., Kim, Y. S., Kwon, S. M., & Shin, Y. M. (2002). Spatial working memory span, delayed response and executive function in schizophrenia. Psychiatry Research, 110, 259-271.
29. Cohen, J. D., Barch, D. M., Carter, C. S., & Servan-Schreiber, D. (1999). Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. Journal of Abnormal Psychology, 108, 120-133.
30. Cohen, J. D., & Servan-Schreiber, D. (1992). Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia. Psychological Review, 99, 45-77.
31. Coleman, M. J., Cook, S., Matthysse, S., Barnard, J., Lo, Y., Levy, D. L., Rubin, D. B., & Holzman, P. S. (2002). Spatial and object working memory impairments in schizophrenia patients: A Bayesian item-response theory analysis. Journal of Abnormal Psychology, 111, 425-435.
32. *Condray, R., Steinhauer, S. R., van Kämmen, D. P., & Kasparek, A. (1996). Working memory capacity predicts language comprehension in schizophrenic patients. Schizophrenia Research, 20, 1-13.
33. Conklin, H. M., Curtis, C. E., Katsanis, J., & Iacono, W. G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the digit span task. American Journal of Psychiatry, 157, 275-277.
34. Cooper, H., & Hedges, L. V. (1994). The handbook of research synthesis. New York: Russell Sage Foundation.
35. Cowan, N. (1988). Evolving conceptions of memory storage, selective attention, and their mutual constraints within the human information-processing system. Psychological Bulletin, 104, 163-191.
36. Danion, J. M., Meulemans, T., Kauffmann-Muller, F., & Vermaat, H. (2001). Intact implicit learning in schizophrenia. American Journal of Psychiatry, 158, 944-948.
37. D'Esposito, M., Aguirre, G. K., Zarahn, E., Ballard, D., Shin, R. K., & Lease, J. (1998). Functional MRI studies of spatial and nonspatial working memory. Brain Research: Cognitive Brain Research, 7, 1-13.
38. Dolan, S. L., Sacco, K. A., Termine, A., Seyal, A. A., Dudas, M. M., Vessicchio, J. C., Wexler, B. E., & George, T. P. (2004). Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia. Schizophrenia Research, 70, 263-275.
39. Dreher, J. C., Banquet, J. P., Allilaire, J. F., Paillere-Martinot, M. L., Dubois, B., & Burnod, Y. (2001). Temporal order and spatial memory in schizophrenia: A parametric study. Schizophrenia Research, 51, 137-147.
40. Egeland, J., Sundet, K., Rund, B. R., Asbjornsen, A., Hugdahl, K., Landro, N. I., Lund, A., Roness, A., & Stordal, K. I. (2003). Sensitivity and specificity of memory dysfunction in schizophrenia: A comparison with major depression. Journal of Clinical and Experimental Neuropsychology, 25, 79-93.
41. Elliott, R., McKenna, P. J., Robbins, T. W., & Sahakian, B. I. (1998). Specific neuropsychological deficits in schizophrenia patients with preserved intellectual function. Cognitive Neuropsychiatry, 3, 45-70.
42. Engle, R. W., Kane, M. J., & Tuholski, S. W. (1999). Individual differences in working memory capacity and what they tell us about controlled attention, general fluid intelligence, and functions of the prefrontal cortex. In A. Miyake & P. Shah (Eds.), Models of working memory: Mechanisms of active maintenance and executive control. New York: Cambridge University Press.
43. Engle, R. W., Tuholski, S. W., Laughlin, J. E., & Conway, A. R. A. (1999). Working memory, short-term memory, and general fluid intelligence: A latent-variable approach. Journal of Experimental Psychology: General, 128, 309-331.
44. Ericsson, K. A., & Delaney, P. F. (1999). Long-term working memory as an alternative to capacity models of working memory in everyday skilled performance. In A. Miyake, & P. Shah (Eds.), Models of working memory: Mechanisms of active maintenance and executive control. New York: Cambridge University Press.
45. Fallgatter, A. J., Bartsch, A. J., Zielasek, J., & Herrmann, M. J. (2003). Brain electrical dysfunction of the anterior cingulate in schizophrenic patients. Psychiatry Research, 124, 37-48.
46. Fleming, K., Goldberg, T. E., Binks, S., Randolph, C., Gold, J. M., & Weinberger, D. R. (1997). Visuospatial working memory in patients with schizophrenia. Biological Psychiatry, 41, 43-49.
47. Fleming, K., Goldberg, T. E., Gold, J. M., & Weinberger, D. R. (1995). Verbal working memory dysfunction in schizophrenia: Use of a Brown-Peterson paradigm. Psychiatry Research, 56, 155-161.
48. Fossati, P., Amar, G., Raoux, N., Ergis, A. M., & Allilaire, J. F. (1999). Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia. Psychiatry Research, 89, 171-187.
49. Fraser, D., Park, S., Clark, G., Yohanna, D., & Houk, J. C. (2004). Spatial serial order processing in schizophrenia. Schizophrenia Research, 70, 203-213.
50. George, T. P., Vessicchio, J. C., Termine, A., Sahady, D. M., Head, C. A., Pepper, W. T., Kosten, T. R., & Wexler, B. E. (2002). Effects of smoking abstinence on visuospatial working memory function in schizophrenia. Neuropsychopharmacology, 26, 75-85.
51. Glahn, D. C., Cannon, T. D., Gur, R. E., Ragland, J. D., & Gur, R. C. (2000). Working memory constrains abstraction in schizophrenia. Biological Psychiatry, 47, 34-42.
52. Glahn, D. C., Therman, S., Manninen, M., Huttunen, M., Kaprio, J., Loennqvist, J., & Cannon, T. D. (2003). Spatial working memory as an endophenotype for schizophrenia. Biological Psychiatry, 53, 624-626.
53. Gleser, L. J., & Olkin, I. (1994). Stochastically dependent effect sizes. In H. Cooper & L.-V. Hedges (Eds.), The handbook of research synthesis (pp. 339-356). New York: Russell Sage Foundation.
54. Gold, J. M., Carpenter, C., Randolph, C., Goldberg, T. E., & Weinberger, D. R. (1997). Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives of General Psychiatry, 54, 159-165.
55. Gold, J. M., Wilk, C. M., McMahon, R. P., Buchanan, R. W., & Luck, S. J. (2003). Working memory for visual features and conjunctions in schizophrenia. Journal of Abnormal Psychology, 112, 61-71.
56. Goldberg, T. E., Aloia, M. S., Gourovitch, M. L., Missar, D., Pickar, D., & Weinberger, D. R. (1998). Cognitive substrates of thought disorder: I. The semantic system. American Journal of Psychiatry, 155, 1671-1676.
57. Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T., Kolachana, B. S., Goldman, D., & Weinberger, D. R. (2003). Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Vall58Met genotype and schizophrenia. Archives of General Psychiatry, 60, 889-896.
58. Goldberg, T. E., Patterson, K. J., Taqqu, Y., & Wilder, K. (1998). Capacity limitations in short-term memory in schizophrenia: Tests of competing hypotheses. Psychological Medicine, 28, 665-673.
59. Goldman-Rakic, P. S. (1991). Prefrontal cortical dysfunction in schizophrenia: The relevance of working memory. In B. Carroll (Ed.), Psychopathology and the brain (pp. 1-23). New York: Raven Press.
60. Goldman-Rakic, P. S. (1994). Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience, 6, 348-357.
61. Goldman-Rakic, P. S. (1999). The physiological approach: Functional architecture of working memory and disordered cognition in schizophrenia. Biological Psychiatry, 46, 650-661.
62. Gooding, D. C., & Tallent, K. A. (2001). The association between antisaccade task and working memory task performance in schizophrenia and bipolar disorder. Journal of Nervous and Mental Disorders, 189, 8-16.
63. Gooding, D. C., & Tallent, K. A. (2002). Spatial working memory performance in patients with schizoaffective psychosis versus schizophrenia: A tale of two disorders? Schizophrenia Research, 53, 209-218.
64. Gooding, D. C., & Tallent, K. A. (2004). Nonverbal working memory deficits in schizophrenia patients: Evidence of a supramodal executive processing deficit. Schizophrenia Research, 68, 189-201.
65. Granholm, E., Morris, S. K., Sarkin, A. J., Asarnow, R. F., & Jeste, D. V. (1997). Pupillary responses index overload of working memory resources in schizophrenia. Journal of Abnormal Psychology, 106, 458-467.
66. Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry, 153, 321-330.
67. Green, M. F., Marshall, B. D., Jr., Wirshing, W. C., Ames, D., Marder, S. R., McGurk, S., Kern, R. S., & Mintz, J. (1997). Does risperidone improve verbal working memory in treatment-resistant schizophrenia? American Journal of Psychiatry, 154, 799-804.
68. Hartman, M., Steketee, M. C., Silva, S., Lanning, K., & McCann, H. (2002). Working memory and schizophrenia: Evidence for slowed encoding. Schizophrenia Research, 59, 99-113.
69. Heaton, R. K. (1981). A manual for the Wisconsin Card Sorting Test. Odessa, FL: Psychological Assessment Resources.
70. Heinrichs, R. W. (2001). In search of madness: Schizophrenia and neuroscience. New York: Oxford University Press.
71. Honey, G. D., Bullmore, E. T., & Sharma, T. (2002). De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophrenia Research, 53, 45-56.
72. Honey, G. D., Bullmore, E. T., Soni, W., Varatheesan, M., Williams, S. C., & Sharma, T. (1999). Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proceedings of National Academic Sciences, USA, 96, 13432-13437.
73. Honey, G. D., Sharma, T., Suckling, J., Giampietro, V., Soni, W., Williams, S. C., & Bullmore, E. T. (2003). The functional neuroanatomy of schizophrenic subsyndromes. Psychological Medicine, 33, 1007-1018.
74. Huguelet, P., Zanello, A., & Nicastro, R. (2000). A study of visual and auditory verbal working memory in schizophrenic patients compared to healthy subjects. European Archives of Psychiatry and Clinical Neuroscience, 250, 79-85.
75. Hutton, S. B., Huddy, V., Barnes, T. R., Robbins, T. W., Crawford, T. J., Kennard, C., & Joyce, E. M. (2004). The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry, 56, 553-559.
76. Hutton, S. B., Puri, B. K., Duncan, L. J., Robbins, T. W., Barnes, T. R., & Joyce, E. M. (1998). Executive function in first-episode schizophrenia. Psychological Medicine, 28, 463-473.
77. Jacobsen, L. K., D'Souza, D. C., Mencl, W. E., Pugh, K. R., Skudlarski, P., & Krystal, J. H. (2004). Nicotine effects on brain function and functional connectivity in schizophrenia. Biological Psychiatry, 55, 850-858.
78. Jansma, J. M., Ramsey, N. F., van der Wee, N. J., & Kahn, R. S. (2004). Working memory capacity in schizophrenia: A parametric fMRI study. Schizophrenia Research, 68, 159-171.
79. Javitt, D. C., Strous, R. D., Grochowski, S., Ritter, W., & Cowan, N. (1997). Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia. Journal of Abnormal Psychology, 106, 315-324.
80. Joyce, E., Hutton, S., Mutsatsa, S., Gibbins, H., Webb, E., Paul, S., Robbins, T., & Barnes, T. (2002). Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: The West London study. British Journal of Psychiatry, 43(Suppl.), S38-S44.
81. Keefe, R. S., Lees-Roitman, S. E., & Dupre, R. L. (1997). Performance of patients with schizophrenia on a pen and paper visuospatial working memory task with short delay. Schizophrenia Research, 26, 9-14.
82. Keefe, R. S., Roitman, S. E., Harvey, P. D., Blum, C. S., DuPre, R. L., Prieto, D. M., Davidson, M., & Davis, K. L. (1995). A pen-and-paper human analogue of a monkey prefrontal cortex activation task: Spatial working memory in patients with schizophrenia. Schizophrenia Research, 17, 25-33.
83. Kiefer, M., Apel, A., & Weisbrod, M. (2002). Arithmetic fact retrieval and working memory in schizophrenia. Schizophrenia Research, 53, 219-227.
84. Kieras, D. E., Meyer, D. E., Mueller, S., & Seymour, T. (1999). Insights into working memory from the perspective of the EPIC architecture for modeling skilled perceptual-motor and cognitive human performance. In A. Miyake, & P. Shah (Eds.), Models of working memory: Mechanisms of active maintenance and executive control (pp. 183-223). New York: Cambridge University Press.
85. Kim, J., Glahn, D. C., Nuechterlein, K. H., & Cannon, T. D. (2004). Maintenance and manipulation of information in schizophrenia: Further evidence for impairment in the central executive component of working memory. Schizophrenia Research, 68, 173-187.
86. Kim, J. J., Kwon, J. S., Park, H. J., Youn, T., Rang, D. H., Kim, M. S., Lee, D. S., & Lee, M. C. (2003). Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: A [-sup-1-sup-5O]H-sub-2O PET study. American Journal of Psychiatry, 160, 919-923.
87. Kindermann, S. S., Brown, G. G., Zorrilla, L. E., Olsen, R. K., & Jeste, D. V. (2004). Spatial working memory among middle-aged and older patients with schizophrenia and volunteers using fMRI. Schizophrenia Research, 68, 203-216.
88. Kravariti, E., Morris, R. G., Rabe-Hesketh, S., Murray, R. M., & Frangou, S. (2003). The Maudsley Early-Onset Schizophrenia Study: Cognitive function in adolescent-onset schizophrenia. Schizophrenia Research, 65, 95-103.
89. Landro, N. I., Pape-Ellefsen, E., Hagland, K. O., & Odland, T. (2001). Memory deficits in young schizophrenics with normal general intellectual function. Scandinavian Journal of Psychology, 42, 459-466.
90. Lee, J., & Park, S. (2002). The role of stimulus-driven attention in spatial working memory in schizophrenia. Schizophrenia Research, 55(Suppl. 1), 131.
91. Leiderman, E. A., & Strejilevich, S. A. (2004). Visuospatial deficits in schizophrenia: Central executive and memory subsystems impairments. Schizophrenia Research, 68, 217-223.
92. Lencz, T., Bilder, R. M., Turkel, E., Goldman, R. S., Robinson, D., Kane, J. M., Lieberman, J. A. (2003). Impairments in perceptual competency and maintenance on a visual delayed match-to-sample test in first-episode schizophrenia. Archives of General Psychiatry, 60, 238-243.
93. Leudar, I., Thomas, P., & Johnston, M. (1992). Self-repair in dialogues of schizophrenics: Effects of hallucinations and negative symptoms. Brain and Language, 43, 487-511.
94. Low, A., Rockstroh, B., Harsch, S., Berg, P., & Cohen, R. (2000). Event-related potentials in a working-memory task in schizophrenics and controls. Schizophrenia Research, 46, 175-186.
95. Manoach, D. S., Gollub, R. L., Benson, E. S., Searl, M. M., Goff, D. C., Halpern, E., Saper, C. B., & Rauch, S. L. (2000). Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry, 48, 99-109.
96. Manoach, D. S., Press, D. Z., Thangaraj, V., Searl, M. M., Goff, D. C., Halpern, E., Saper, C. B., & Warach, S. (1999). Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry, 45, 1128-1137.
97. McGrath, J., Chapple, B., & Wright, M. (2001). Working memory in schizophrenia and mania: Correlation with symptoms during the acute and subacute phases. Acta Psychiatrica Scandinaviaca, 103, 181-188.
98. Mendrek, A., Laurens, K. R., Kiehl, K. A., Ngan, E. T., Slip, E., & Liddle, P. F. (2004). Changes in distributed neural circuitry function in patients with first-episode schizophrenia. British Journal of Psychiatry, 185, 205-214.
99. Menon, V., Anagnoson, R. T., Mathalon, D. H., Glover, G. H., & Pfefferbaum, A. (2001). Functional neuroanatomy of auditory working memory in schizophrenia: Relation to positive and negative symptoms. Neuroimage, 13, 433-446.
100. Meyer-Lindenberg, A., Poline, J. B., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2001). Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American Journal of Psychiatry, 158, 1809-1817.
101. Miyake, A., & Shah, P. (Eds.). (1999). Models of working memory: Mechanisms of active maintenance and executive control. New York: Cambridge University Press.
102. Morice, R., & Delahunty, A. (1996). Frontal/executive impairments in schizophrenia. Schizophrenia Bulletin, 22, 125-137.
103. Moritz, S., Birkner, C., Kloss, M., Jahn, H., Hand, I., Haasen, C., & Krausz, M. (2002). Executive functioning in obsessive-compulsive disorder, unipolar depression, and schizophrenia. Archives of Clinical Neuropsychology, 17, 477-483.
104. Morris, S. K., Granholm, E., Sarkin, A. J., & Jeste, D. V. (1997). Effects of schizophrenia and aging on pupillographic measures of working memory. Schizophrenia Research, 27, 119-128.
105. Myles-Worsley, M., & Park, ,S. (2002). Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, Micronesia. American Journal of Medical Genetics, 114, 609-615.
106. Nienow, T. M., & Docherty, N. M. (2004). Internal source monitoring and thought disorder in schizophrenia. Journal of Nervous and Mental Disease, 192, 696-700.
107. Oie, M., Sunde, K., & Rund, B. R. (1999). Contrasts in memory functions between adolescents with schizophrenia or ADHD. Neuropsychologia, 37, 1351-1358.
108. Okada, A. (2002). Deficits of spatial working memory in chronic schizophrenia. Schizophrenia Research, 53, 75-82.
109. Pantelis, C., Barnes, T. R., Nelson, H. E., Tanner, S., Weatherley, L., Owen, A. M., & Robbins, T. W. (1997). Frontal-striatal cognitive deficits in patients with chronic schizophrenia. Brain, 120(Pt. 10), 1823-1843.
110. Park, S. (1997). Association of an oculomotor delayed response task and the Wisconsin Card Sort Test in schizophrenic patients. International Journal of Psychophysiology, 27, 147-151.
111. Park, S. (1999). Hemispheric asymmetry of spatial working memory deficit in schizophrenia. International Journal of Psychophysiology, 34, 313-322.
112. Park, S., & Holzman, P. S. (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry, 49, 975-982.
113. Park, S., & Holzman, P. S. (1993). Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophrenia Research, 11, 55-61,
114. Park, S., Holzman, P. S., & Goldman-Rakic, P. S. (1995). Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry, 52, 821-828.
115. Park, S., Holzman, P. S., & Lenzenweger, M. F. (1995). Individual differences in spatial working memory in relation to schizotypy. Journal of Abnormal Psychology, 104, 355-363.
116. Park, S., & Lee, J. (2002). Spatial working memory function in schizophrenia. In M. F. Lenzenweger & J. M. Hooley (Eds.), Principles of experimental psychopathology: Essays in honor of Brendan A. Maher (pp. 83-106). Washington, DC: American Psychological Association.
117. Park, S., & McTigue, K. (1997). Working memory and the syndromes of schizotypal personality. Schizophrenia Research, 26, 213-220.
118. Park, S., Puschel, J., Sauter, B. H., Rentsch, M., & Hell, D. (1999). Spatial working memory deficits and clinical symptoms in schizophrenia: A 4-month follow-up study. Biological Psychiatry, 46, 392-400.
119. Park, S., Puschel, J., Sauter, B. H., Rentsch, M., & Hell, D. (2003). Visual object working memory function and clinical symptoms in schizophrenia. Schizophrenia Research, 59, 261-268.
120. Park, S., Swisher, T., & Knurek, E. (2001). Affect facilitates prefrontal function in schizophrenia: "What" modulates working memory for "where." Schizophrenia Research, 49, 118.
121. Perlstein, W. M., Carter, C. S., Noll, D. C., & Cohen, I. D. (2001). Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry, 158, 1105-1113.
122. Perlstein, W. M., Dixit, N. K., Carter, C. S., Noll, D. C., & Cohen, J. D. (2003). Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biological Psychiatry, 53, 25-38.
123. Perry, W., Heaton, R. K., Potterat, E., Roebuck, T., Minassian, A., & Braff, D. L. (2001). Working memory in schizophrenia: Transient "online" storage versus executive functioning. Schizophrenia Bulletin, 27, 157-176.
124. Pukrop, R., Matuschek, E., Ruhrmann, S., Brockhaus Dumke, A., Tendolkar, I., Bertsch, A., & Klosterkoetter, J. (2003). Dimensions of working memory dysfunction in schizophrenia. Schizophrenia Research, 62, 259-268.
125. Quintana, J., Davidson, T., Kovalik, E., Marder, S. R., & Mazziotta, J. C. (2001). A compensatory mirror cortical mechanism for facial affect processing in schizophrenia. Neuropsychopharmacology, 25, 915-924.
126. Quintana, J., Wong, T., Ortiz-Portillo, E., Kovalik, E., Davidson, T., Marder, S. R., & Mazziotta, J. C. (2003). Prefrontal-posterior parietal networks in schizophrenia: Primary dysfunctions and secondary compensations. Biological Psychiatry, 53, 12-24.
127. Rosenthal, R. (1991). Meta-analytic procedures for social research. Thousand Oaks, CA: Sage.
128. Rosenthal, R. (1995). Writing meta-analytic reviews. Psychological Bulletin, 118, 183-192.
129. Ross, R. G., Harris, J. G., Olincy, A., & Radant, A. (2000). Eye movement task measures inhibition and spatial working memory in adults with schizophrenia, ADHD, and a normal comparison group. Psychiatry Research, 95, 35-42.
130. Sabri, O., Owega, A., Schreckenberger, M., Sturz, L., Fimm, B., Kunert, P., Meyer, P. T., Sander, D., & Klingelhofer, J. (2003). A truly simultaneous combination of functional transcranial Doppler sonography and H(2)(15)O PET adds fundamental new information on differences in cognitive activation between schizophrenics and healthy control subjects. Journal of Nuclear Medicine, 44, 671-681.
131. Sahakian, B. J., & Owen, A. M. (1992). Computerized assessment in neuropsychiatry using CANTAB: Discussion paper. Journal of the Royal Society of Medicine, 85, 399-402.
132. Salgado-Pineda, P., Junque, C., Vendrell, P., Baeza, I., Bargallo, N., Falcon, C., & Bernardo, M. (2004). Decreased cerebral activation during CPT performance; Structural and functional deficits in schizophrenic patients. Neuroimage, 21, 840-847.
133. Schlösser, R., Gesierich, T., Kaufmann, B., Vucurevic, G., Hunsche, S., Gawehn, J., & Stoeter, P. (2003). Altered effective connectivity during working memory performance in schizophrenia: A study with fMRI and structural equation modeling. Neuroimage, 19, 751-763.
134. Schroder, J., Tittel, A., Stocken, A., & Karr, M. (1996). Memory deficits in subsyndromes of chronic schizophrenia. Schizophrenia Research, 21, 19-26.
135. Schwartz, B. L., Howard, D. V., Howard, J. H., Jr., Hovaguimian, A., & Deutsch, S. I. (2003). Implicit learning of visuospatial sequences in schizophrenia. Neuropsychology, 17, 517-533.
136. Servan-Schreiber, D., Cohen, J. D., & Steingard, S. (1996). Schizophrenic deficits in the processing, of context: A test of a theoretical model. Archives of General Psychiatry, 53, 1105-1112.
137. Shadish, W. S., & Haddock, C. K. (1994). Combining estimates of effect size. In H. Cooper & L. V. Hedger (Eds.), The handbook of research synthesis (pp. 261-281). New York: Russell Sage Foundation.
138. Shelley, A. M., Grochowski, S., Lieberman, J. A., & Javitt, D. C. (1996). Premature disinhibition of P3 generation in schizophrenia. Biological Psychiatry, 39, 714-719.
139. Silver, H., Feldman, P., Bilker, W., & Gur, R. C. (2003). Working memory deficit as a core neuropsychological dysfunction in schizophrenia. American Journal of Psychiatry, 160, 1809-1816.
140. Smith, E. E., & Jonides, J. (1999, March 12). Storage and executive processes in the frontal lobes. Science, 283, 1657-1661.
141. Snitz, B. E., Curtis, C. E., Zald, D. H., Katsanis, J., & Iacono, W. G. (1999). Neuropsychological and oculomotor correlates of spatial working memory performance in schizophrenia patients and controls. Schizophrenia Research, 38, 37-50.
142. Spindler, K. A., Sullivan, E. V., Menon, V., Lim, K. O., & Pfefferbaum, A. (1997). Deficits in multiple systems of working memory in schizophrenia. Schizophrenia Research, 27, 1-10.
143. Spitzer, M. (1993). The psychopathology, neuropsychology, and neurobiology of associative and working memory in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 243, 57-70.
144. Stevens, A. A., Goldman-Rakic, P. S., Gore, J. C., Fulbright, R. K., & Wexler, B. E. (1998). Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Archives of General Psychiatry, 55, 1097-1103.
145. Stone, M., Gabrieli, J. D., Stebbins, G. T., & Sullivan, E. V. (1998). Working and strategic memory deficits in schizophrenia. Neuropsychology, 12, 278-288.
146. Stratta, P., Daneluzzo, E., Prosperini, P., Bustini, M., Marinangeli, M. G., & Rossi, A. (1999). Spatial working memory assessment by a visual-manual delayed response task: A controlled study in schizophrenia. Neuroscience Letter, 275, 9-12.
147. Stratta, P., Daneluzzo, E., Prosperini, P., Bustini, M., Mattel, P., & Rossi, A. (1997). Is Wisconsin Card Sorting Test performance related to 'working memory' capacity? Schizophrenia Research, 27, 11-19.
148. Stratta, P., Prosperini, P., Daneluzzo, E., Bustini, M., & Rossi, A. (2001). Educational level and age influence spatial working memory and Wisconsin Card Sorting Test performance differently: A controlled study in schizophrenic patients. Psychiatry Research, 102, 39-48.
149. Straube, E. R., Bischoff, N., Misch, C., Sauer, H., & Volz, H. P. (2002). Input dysfunction and beyond-An evaluation of CPT components. Schizophrenia Research, 54, 131-139.
150. Strauss, M. E. (2001). Demonstrating specific cognitive deficits: A psychometric perspective. Journal of Abnormal Psychology, 110, 6-14.
151. Suwa, H., Matsushima, E., Ohta, K., & Mori, K. (2004). Attention disorders in schizophrenia. Psychiatry and Clinical Neuroscience, 58, 249-256.
152. Tallent, K. A., & Gooding, D. C. (1999). Working memory and Wisconsin Card Sorting Test performance in schizotypic individuals: A replication and extension. Psychiatry Research, 89, 161-170.
153. Tek, C., Gold, J., Blaxton, T., Wilk, C., McMahon, R. P., & Buchanan, R. W. (2002). Visual perceptual and working memory impairments in schizophrenia. Archives of General Psychiatry, 59, 146-153.
154. Thoma, R. J., Hanlon, F. M., Moses, S. N., Edgar, J. C., Huang, M., Weisend, M. P., Irwin, J., Sherwood, A., Paulson, K., Bustillo, J., Adler, L. E., Miller, G. A., & Canive, J. M. (2003). Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia. American Journal of Psychiatry, 160, 1595-1605.
155. Toulopoulou, T., Morris, R. G., Rabe-Hesketh, S., & Murray, R. M. (2003). Selectivity of verbal memory deficit in schizophrenic patients and their relatives. American Journal of Medicine and Genetics, 116B, 1-7.
156. Ueland, T., Oie, M., Inge Landro, N., & Rund, B. R. (2004). Cognitive functioning in adolescents with schizophrenia spectrum disorders. Psychiatry Research, 126, 229-239.
157. Vogel, E. K., Woodman, G. F., & Luck, S. J. (in press). The time
158. Woodman, G. F., & Vogel, E. K. (2005). Fractionating working memory. Psychological Science, 16, 106-113.
159. World Health Organization. (1978). Mental disorders glossary and guide to their classification in accordance with ninth revision of the International Classification of Diseases. Geneva, Switzerland: World Health Organization.
160. World Health Organization. (1992). The ICD-10 classification of mental and behavioral disorders: Clinical descriptions and diagnostic guidelines (10th rev.). Geneva, Switzerland: World Health Organization.
161. Zuffante, P., Leonard, C. M., Kuldau, J. M., Bauer, R. M., Doty, E. G., & Bilder, R. M. (2001). Working memory deficits in schizophrenia are not necessarily specific or associated with MRI-based estimates of area 46 volumes. Psychiatry Research, 108, 187-209.