Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: Disruptions in neurodevelopmental psychiatric disorders

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 51, Issue 4, 2012, Pages 356-367

  Arnsten, Amy F T ^a   Rubia, Katya ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

arousal; MDD; OCD; prefrontal cortex ADHD

Indexed keywords

NEUROTRANSMITTER;

ATTENTION; ATTENTION DEFICIT DISORDER; BRAIN FUNCTION; BRAIN REGION; CEREBELLUM; COGNITION; CONDUCT DISORDER; CORPUS STRIATUM; EMOTION; HUMAN; LEFT HEMISPHERE; MAJOR DEPRESSION; MENTAL DISEASE; MOTIVATION; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROIMAGING; OBSESSIVE COMPULSIVE DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; VENTROMEDIAL PREFRONTAL CORTEX;

ADOLESCENT; ATTENTION; BRAIN; BRAIN DISEASES; BRAIN MAPPING; CEREBRAL CORTEX; CHILD; COGNITION; DOMINANCE, CEREBRAL; EMOTIONS; HUMANS; INHIBITION (PSYCHOLOGY); INTERNAL-EXTERNAL CONTROL; MENTAL DISORDERS; MOTIVATION; NERVE NET; NEUROTRANSMITTER AGENTS;

EID: 84859108120     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2012.01.008     Document Type: Review

References (92)

1. F.A. Middleton, P.L. Strick Basal ganglia and cerebellar loops: motor and cognitive circuits Brain Res Brain Res Rev 31 2000 236 250 (Pubitemid 30136179)
2. A.F.T. Arnsten, F.X. Castellanos Neurobiology of attention regulation and its disorders A. Martin, L. Scahill, D.S. Charney, J.F. Leckman, Pediatric Psychopharmacology: Principles and Practice 2003 Oxford University Press New York, NY
3. A.F.T. Arnsten The emerging neurobiology of attention deficit hyperactivity disorder: the key role of the prefrontal association cortex J Pediatr 154 5 Suppl 1 2009 S22 S31
4. C.D. Chambers, H. Garavan, M.A. Bellgrove Insights into the neural basis of response inhibition from cognitive and clinical neuroscience Neurosci Biobehav Rev 33 2009 631 646
5. J. Derrfuss, M. Brass, J. Neumann, D.Y. von Cramon Involvement of the inferior frontal junction in cognitive control: meta-analyses of switching and Stroop studies Hum Brain Mapp 25 2005 22 34 (Pubitemid 40656190)
6. J.L. Price, S.T. Carmichael, W.C. Drevets Networks related to the orbital and medial prefrontal cortex; a substrate for emotional behavior? Prog Brain Res 107 1996 523 536 (Pubitemid 26401686)
7. M. Best, J.M. Williams, E.F. Coccaro Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder Proc Natl Acad Sci USA 99 2002 8448 8453 (Pubitemid 34651072)
8. S.D. Iversen, M. Mishkin Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity Exp Brain Res 11 1970 376 386
9. R. Dias, T.W. Robbins, A.C. Roberts Dissociation in prefrontal cortex of affective and attentional shifts Nature 380 1996 69 72 (Pubitemid 26076238)
10. S.W. Anderson, A. Bechara, H. Damasio, D. Tranel, A.R. Damasio Impairment of social and moral behavior related to early damage in human prefrontal cortex Nat Neurosci 2 1999 1032 1037 (Pubitemid 30599569)
11. T.W. Robbins, A.F. Arnsten The neuropsychopharmacology of fronto-executive function: monoaminergic modulation Annu Rev Neurosci 32 2009 267 287
12. P.S. Goldman-Rakic Cellular basis of working memory Neuron 14 1995 477 485
13. A.F. Arnsten Stress signalling pathways that impair prefrontal cortex structure and function Nat Rev Neurosci 10 2009 410 422
14. S.R. Chamberlain, N. Del Campo, J. Dowson Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder Biol Psychiatry 62 2007 977 984 (Pubitemid 47562368)
15. H.F. Clarke, S.C. Walker, J.W. Dalley, T.W. Robbins, A.C. Roberts Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific Cereb Cortex 17 2007 18 27 (Pubitemid 44973891)
16. K. Rubia, F. Lee, A.J. Cleare Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI Psychopharmacology (Berl) 179 2005 791 803 (Pubitemid 40767899)
17. R. Lee, E. Coccaro The neuropsychopharmacology of criminality and aggression Can J Psychiatry 46 2001 35 44 (Pubitemid 32209343)
18. M. Sarter, M.E. Hasselmo, J.P. Bruno, B. Givens Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection Brain Res Brain Res Rev 48 2005 98 111 (Pubitemid 40215784)
19. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders DSM-IV 1994 American Psychiatric Association Washington, DC
20. K. Langley, T. Fowler, T. Ford Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder Br J Psychiatry 196 2010 235 240
21. N. Easton, Y.B. Shah, F.H. Marshall, K.C. Fone, C.A. Marsden Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast Psychopharmacology (Berl) 189 2006 369 385 (Pubitemid 44773700)
22. K. Rubia "Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a review Biol Psychiatry 69 2011 e69 e87
23. A. Cubillo, R. Halari, E. Taylor, K. Rubia A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with attention deficit hyperactivity disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention Cortex 48 2012 194 215
24. S.G. Dickstein, K. Bannon, F.X. Castellanos, M.P. Milham The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis J Child Psychol Psychiatry 47 2006 1051 1062 (Pubitemid 44642434)
25. A.L. Krain, F.X. Castellanos Brain development and ADHD Clin Psychol Rev 26 2006 433 444
26. T. Nakao, J. Radua Gray matter volume abnormalities in ADHD and the effects of stimulant medication: voxel-based meta-analysis Am J Psychiatry 168 2011 1154 1163
27. E.M. Valera, S.V. Faraone, K.E. Murray, L.J. Seidman Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder Biol Psychiatry 61 2007 1361 1369 (Pubitemid 46855763)
28. K. Rubia, R. Halari, A. Christakou, E. Taylor Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate Philos Trans R Soc Lond B Biol Sci 364 2009 1919 1931
29. P. Shaw, K. Eckstrand, W. Sharp Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation Proc Natl Acad Sci U S A 104 2007 19649 19654
30. K. Rubia, R. Halari, A.B. Smith, M. Mohammad, S. Scott, M.J. Brammer Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation J Child Psychol Psychiatry 50 2009 669 678
31. K. Rubia, A.B. Smith, R. Halari Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention Am J Psychiatry 166 2009 83 94
32. K. Rubia, R. Halari, A. Cubillo, A.M. Mohammad, S. Scott, M. Brammer Disorder-specific inferior prefrontal hypofunction in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure conduct disorder during cognitive flexibility Hum Brain Mapp 31 2010 1823 1833
33. K. Rubia, R. Halari, A.B. Smith Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder Am J Psychiatry 165 2008 889 897 (Pubitemid 351948721)
34. K. Rubia, A. Cubillo, A.B. Smith, J. Woolley, I. Heyman, M.J. Brammer Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive-compulsive disorder Hum Brain Mapp 31 2009 287 299
35. A.M. Passarotti, J.A. Sweeney, M.N. Pavuluri Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder Psychiatry Res 181 2010 36 43
36. N.J. Gamo, A.F. Arnsten Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders Behav Neurosci 125 2011 282 296
37. A.F. Arnsten, A.G. Dudley Methylphenidate improves prefrontal cortical cognitive function through a2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder Behav Brain Funct 1 2005 2
38. C.W. Berridge, D.M. Devilbiss, M.E. Andrzejewski Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function Biol Psychiatry 60 2006 1111 1120 (Pubitemid 44647216)
39. J.M. Swanson, N.D. Volkow Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD Behav Brain Res 130 2002 73 78 (Pubitemid 34201784)
40. G. Bush, T.J. Spencer, J. Holmes Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task Arch Gen Psychiatry 65 2008 102 114
41. K. Rubia, R. Halari, A. Cubillo, A.M. Mohammad, M. Brammer, E. Taylor Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naive children with ADHD during a rewarded continuous performance task Neuropharmacology 57 2009 640 652
42. K. Rubia, R. Halari, A. Cubillo Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naive boys with attention-deficit hyperactivity disorder Neuropsychopharmacology 36 2011 1575 1586
43. C.J. Vaidya, G. Austin, G. Kirkorian Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study Proc Natl Acad Sci U S A 95 1998 14494 14499 (Pubitemid 28549395)
44. C. Hobson, S. Scott, K. Rubia Investigation of cool and hot executive function in ODD/CD independently of ADHD J Child Psychol Psychiatry 52 2011 1035 1043
45. S.A. De Brito, A. Mechelli, M. Wilke Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits Brain 132 2009 843 852
46. J. Decety, K.J. Michalska, Y. Akitsuki, B.B. Lahey Atypical empathic responses in adolescents with aggressive conduct disorder: a functional MRI investigation Biol Psychol 80 2009 203 211
47. E.C. Finger, A.A. Marsh, D.G. Mitchell Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning Arch Gen Psychiatry 65 2008 586 594 (Pubitemid 351645054)
48. A.A. Marsh, E.C. Finger, D.G. Mitchell Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders Am J Psychiatry 165 2008 712 720 (Pubitemid 351810540)
49. D.F. Connor, R.L. Findling, S.H. Kollins Effects of guanfacine extended release on oppositional symptoms in children aged 6-12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trial CNS Drugs 24 2010 755 768
50. J.C. Steere, A.F. Arnsten The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys Behav Neurosci 111 1997 883 891 (Pubitemid 27469093)
51. S.C. Caetano, M. Fonseca, J.P. Hatch Medial temporal lobe abnormalities in pediatric unipolar depression Neurosci Lett 427 2007 142 147 (Pubitemid 47633794)
52. V. Gabbay, D.A. Hess, S. Liu, J.S. Babb, R.G. Klein, O. Gonen Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study Am J Psychiatry 164 2007 1881 1889 (Pubitemid 351739242)
53. F.P. MacMaster, A. Russell, Y. Mirza Pituitary volume in treatment-naive pediatric major depressive disorder Biol Psychiatry 60 2006 862 866 (Pubitemid 44527892)
54. F.P. MacMaster, Y. Mirza, P.R. Szeszko Amygdala and hippocampal volumes in familial early onset major depressive disorder Biol Psychiatry 63 2008 385 390
55. S. MacMillan, P.R. Szeszko, G.J. Moore Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression J Child Adolesc Psychopharmacol 13 2003 65 73 (Pubitemid 36570189)
56. I.M. Rosso, C.M. Cintron, R.J. Steingard, P.F. Renshaw, A.D. Young, D.A. Yurgelun-Todd Amygdala and hippocampus volumes in pediatric major depression Biol Psychiatry 57 2005 21 26 (Pubitemid 39647587)
57. C.L. Nolan, G.J. Moore, R. Madden Prefrontal cortical volume in childhood-onset major depression: preliminary findings Arch Gen Psychiatry 59 2002 173 179 (Pubitemid 34137388)
58. T.D. Wager, K.L. Phan, I. Liberzon, S.F. Taylor Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging Neuroimage 19 2003 513 531 (Pubitemid 36926274)
59. E. Harmon-Jones, P.A. Gable Neural activity underlying the effect of approach-motivated positive affect on narrowed attention Psychol Sci 20 2009 406 409
60. R.J. Davidson, W. Irwin The functional neuroanatomy of emotion and affective style Trends Cogn Sci 3 1999 11 21 (Pubitemid 29045582)
61. E.J. Thomas, R. Elliott Brain imaging correlates of cognitive impairment in depression Front Hum Neurosci 3 2009 30
62. R. Halari, M. Simic, C.M. Pariante Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naive adolescents with depression compared to controls J Child Psychol Psychiatry 50 2009 307 316
63. K. Chantiluke, R. Halari, M. Simic Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attention Biol Psychiatry 71 2011 59 67
64. M.P. Austin, M. Ross, C. Murray, R.E. O'Carroll, K.P. Ebmeier, G.M. Goodwin Cognitive function in major depression J Affect Disord 25 1992 21 29
65. L. Menzies, S.R. Chamberlain, A.R. Laird, S.M. Thelen, B.J. Sahakian, E.T. Bullmore Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited Neurosci Biobehav Rev 32 2008 525 549 (Pubitemid 351173336)
66. J. Radua, D. Mataix-Cols Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder Br J Psychiatry 195 2009 393 402
67. J. Radua, O.A. van den Heuvel, S. Surguladze, D. Mataix-Cols Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders Arch Gen Psychiatry 67 2010 701 711
68. J.Y. Rotge, N. Langbour, D. Guehl Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis Neuropsychopharmacology 35 2010 686 691
69. C. Huyser, D.J. Veltman, E. de Haan, F. Boer Paediatric obsessive-compulsive disorder, a neurodevelopmental disorder? Evidence from neuroimaging Neurosci Biobehav Rev 33 2009 818 830
70. J.C. Britton, S.L. Rauch, I.M. Rosso Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder J Am Acad Child Adolesc Psychiatry 49 2010 944 953
71. C. Huyser, D.J. Veltman, L.H. Wolters, E. de Haan, F. Boer Functional magnetic resonance imaging during planning before and after cognitive-behavioral therapy in pediatric obsessive-compulsive disorder J Am Acad Child Adolesc Psychiatry 49 2010 1238 1248
72. J. Woolley, I. Heyman, M. Brammer, I. Frampton, P.K. McGuire, K. Rubia Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control Br J Psychiatry 192 2008 25 31 (Pubitemid 351183157)
73. K. Rubia, A. Cubillo, J. Woolley, M.J. Brammer, A. Smith Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocation Hum Brain Mapp 32 2011 601 611
74. J. Krause SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder Expert Rev Neurother 8 2008 611 625 (Pubitemid 351551013)
75. N.D. Volkow, G.J. Wang, J. Newcorn Brain dopamine transporter levels in treatment and drug naive adults with ADHD Neuroimage 34 2007 1182 1190 (Pubitemid 46394475)
76. N.D. Volkow, G.J. Wang, S.H. Kollins Evaluating dopamine reward pathway in ADHD: clinical implications JAMA 302 2009 1084 1091
77. D. Denys, W.N. van der, J. Janssen, G.F. De, H.G. Westenberg Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder Biol Psychiatry 55 2004 1041 1045 (Pubitemid 38581920)
78. C.H. Kim, M.S. Koo, K.A. Cheon, Y.H. Ryu, J.D. Lee, H.S. Lee Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder Eur J Nucl Med Mol Imaging 30 2003 1637 1643
79. C.H. Kim, K.A. Cheon, M.S. Koo Dopamine transporter density in the basal ganglia in obsessive-compulsive disorder, measured with [123I]IPT SPECT before and after treatment with serotonin reuptake inhibitors Neuropsychobiology 55 2007 156 162 (Pubitemid 47525234)
80. S. Hesse, U. Muller, T. Lincke Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder Psychiatry Res 140 2005 63 72 (Pubitemid 41443497)
81. A.C. Roberts The importance of serotonin for orbitofrontal function Biol Psychiatry 69 2011 1185 1191
82. K.Q. Tanis, S.S. Newton, R.S. Duman Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development CNS Neurol Disord Drug Targets 6 2007 151 160 (Pubitemid 46681775)
83. J.N. Giedd, J.L. Rapoport Structural MRI of pediatric brain development: what have we learned and where are we going? Neuron 67 2010 728 734
84. P.B. Fitzgerald, A.R. Laird, J. Maller, Z.J. Daskalakis A meta-analytic study of changes in brain activation in depression Hum Brain Mapp 29 2008 683 695 (Pubitemid 351794123)
85. S.E. Murphy Using functional neuroimaging to investigate the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs) Curr Pharm Des 16 2010 1990 1997
86. A.R. Gilbert, G.J. Moore, M.S. Keshavan Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine Arch Gen Psychiatry 57 2000 449 456 (Pubitemid 30257259)
87. P.R. Szeszko, S. MacMillan, M. McMeniman Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder Am J Psychiatry 161 2004 1049 1056 (Pubitemid 38735991)
88. L. Lazaro, N. Bargallo, J. Castro-Fornieles Brain changes in children and adolescents with obsessive-compulsive disorder before and after treatment: a voxel-based morphometric MRI study Psychiatry Res 172 2009 140 146
89. L. Lazaro, X. Caldu, C. Junque Cerebral activation in children and adolescents with obsessive-compulsive disorder before and after treatment: a functional MRI study J Psychiatr Res 42 2008 1051 1059
90. D.R. Rosenberg, F.P. MacMaster, M.S. Keshavan, K.D. Fitzgerald, C.M. Stewart, G.J. Moore Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine J Am Acad Child Adolesc Psychiatry 39 2000 1096 1103
91. E.R. Sowell, P.M. Thompson, A.W. Toga Mapping changes in the human cortex throughout the span of life Neuroscientist 10 2004 372 392 (Pubitemid 38971216)
92. J.D. Power, D.A. Fair, B.L. Schlaggar, S.E. Petersen The development of human functional brain networks Neuron 67 2010 735 748