A computational neuroscience approach to schizophrenia and its onset

Neuroscience and Biobehavioral Reviews

Volumn 35, Issue 8, 2011, Pages 1644-1653

  Rolls, Edmund T ^a   Deco, Gustavo ^b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Adolescence; Attractor networks; Computational neuroscience; Dopamine; GABA inhibition; Grey matter volume; Neural networks; Neuronal spiking; NMDA receptors; Noise in the brain; Schizophrenia; Stochastic neurodynamics; Synaptic pruning

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ADOLESCENCE; ATTENTION; BRAIN DYSFUNCTION; BRAIN NERVE CELL; BRAIN SIZE; COGNITIVE DEFECT; COMPUTATIONAL NEUROSCIENCE; DOPAMINE BRAIN LEVEL; ENERGY METABOLISM; GRAY MATTER; HUMAN; NEGATIVE SYNDROME; NERVE CELL NETWORK; NEUROSCIENCE; NEUROTRANSMISSION; NOISE; PATHOPHYSIOLOGY; POSITIVE SYNDROME; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SHORT TERM MEMORY; SIGNAL NOISE RATIO; STATISTICAL ANALYSIS; STOCHASTIC MODEL;

ADOLESCENT; ADOLESCENT DEVELOPMENT; CEREBRAL CORTEX; COMPUTATIONAL BIOLOGY; CRITICAL PERIOD (PSYCHOLOGY); GAMMA-AMINOBUTYRIC ACID; HUMANS; MODELS, NEUROLOGICAL; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; NEUROSCIENCES; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION;

EID: 79960046671     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2010.09.001     Document Type: Review

References (108)

1. Abeles M. Corticonics-Neural Circuits of the Cerebral Cortex 1991, Cambridge University Press, New York.
2. Amit D.J. Modeling Brain Function 1989, Cambridge University Press, Cambridge.
3. Benes F.M. Amygdalocortical circuitry in schizophrenia: from circuits to molecules. Neuropsychopharmacology 2010, 35:239-257.
4. Bennett M.R. Synapse formation and regression in the cortex during adolescence and in schizophrenia. The Medical Journal of Australia 2009, 190:S14-S16.
5. Bilder R.M., Goldman R.S., Volavka J., Czobor P., Hoptman M., Sheitman B., Lindenmayer J.P., Citrome L., McEvoy J., Kunz M., Chakos M., Cooper T.B., Horowitz T.L., Lieberman J.A. Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. The American Journal of Psychiatry 2002, 159:1018-1028.
6. Borella E., Carretti B., De Beni R. Working memory and inhibition across the adult life-span. Acta Psychologica 2008, 128:33-44.
7. Braitenberg V., Schütz A. Anatomy of the Cortex 1991, Springer-Verlag, Berlin.
8. Brozoski T.J., Brown R.M., Rosvold H.E., Goldman P.S. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 1979, 205:929-932.
9. Brunel N., Wang X.J. Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. Journal of Computational Neuroscience 2001, 11:63-85.
10. Castner S.A., Williams G.V., Goldman-Rakic P.S. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science 2000, 287:2020-2022.
11. Cohen J.D., Servan-Schreiber D. Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychological Review 1992, 99:45-77.
12. Coyle J.T. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cellular and Molecular Neurobiology 2006, 26:365-384.
13. Coyle J.T., Tsai G., Goff D. Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Annals of the New York Academy of Sciences 2003, 1003:318-327.
14. De Felipe J., Marco P., Fairen A., Jones E.G. Inhibitory synaptogenesis in mouse somatosensory cortex. Cerebral Cortex 1997, 7:619-634.
15. Deco G., Rolls E.T. Attention and working memory: a dynamical model of neuronal activity in the prefrontal cortex. European Journal of Neuroscience 2003, 18:2374-2390.
16. Deco G., Rolls E.T. Attention, short-term memory, and action selection: a unifying theory. Progress in Neurobiology 2005, 76:236-256.
17. Deco G., Rolls E.T. Neurodynamics of biased competition and co-operation for attention: a model with spiking neurons. Journal of Neurophysiology 2005, 94:295-313.
18. Deco G., Rolls E.T. Decision-making and Weber's Law: a neurophysiological model. European Journal of Neuroscience 2006, 24:901-916.
19. Deco G., Rolls E.T., Romo R. Stochastic dynamics as a principle of brain function. Progress in Neurobiology 2009, 88:1-16.
20. Delawalla Z., Barch D.M., Fisher Eastep J.L., Thomason E.S., Hanewinkel M.J., Thompson P.A., Csernansky J.G. Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. Schizophrenia Bulletin 2006, 32:525-537.
21. Depue R.A., Collins P.F. Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion. The Behavioral and Brain Sciences 1999, 22:491-517. discussion 518-569.
22. Desimone R., Duncan J. Neural mechanisms of selective visual attention. Annual Review of Neuroscience 1995, 18:193-222.
23. Durstewitz D. Dopaminergic modulation of prefrontal cortex network dynamics. Monoaminergic Modulation of Cortical Excitability 2007, 217-234. Springer, New York. K.-Y. Tseng, M. Atzori (Eds.).
24. Durstewitz D., Kelc M., Gunturkun O. A neurocomputational theory of the dopaminergic modulation of working memory functions. Journal of Neuroscience 1999, 19:2807-2822.
25. Durstewitz D., Seamans J.K. The computational role of dopamine D1 receptors in working memory. Neural Networks 2002, 15:561-572.
26. Durstewitz D., Seamans J.K. The dual-state theory of prefrontal cortex dopamine function with relevance to COMT genotypes and schizophrenia. Biological Psychiatry 2008, 64:739-749.
27. Durstewitz D., Seamans J.K., Sejnowski T.J. Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex. Journal of Neurophysiology 2000, 83:1733-1750.
28. Frith C., Dolan R.J. Brain mechanisms associated with top-down processes in perception. Philosophical Transactions of the Royal Society of London 1997, 352:1221-1230.
29. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Mnemonic coding of visual space in monkey dorsolateral prefrontal cortex. Journal of Neurophysiology 1989, 61:331-349.
30. Fuster J.M. Memory in the Cerebral Cortex 1995, MIT Press, Cambridge, MA.
31. Fuster J.M. Executive frontal functions. Experimental brain research. Experimentelle Hirnforschung 2000, 133:66-70.
32. Fuster J.M., Alexander G.E. Neuron activity related to short-term memory. Science 1971, 173:652-654.
33. Garey L.J., Ong W.Y., Patel T.S., Kanani M., Davis A., Mortimer A.M., Barnes T.R., Hirsch S.R. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. Journal of Neurology, Neurosurgery, and Psychiatry 1998, 65:446-453.
34. Giedd J.N., Blumenthal J., Jeffries N.O., Castellanos F.X., Liu H., Zijdenbos A., Paus T., Evans A.C., Rapoport J.L. Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience 1999, 2:861-863.
35. Glantz L.A., Gilmore J.H., Hamer R.M., Lieberman J.A., Jarskog L.F. Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience 2007, 149:582-591.
36. Glantz L.A., Lewis D.A. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Archives of General Psychiatry 2000, 57:65-73.
37. Gogtay N., Giedd J.N., Lusk L., Hayashi K.M., Greenstein D., Vaituzis A.C., Nugent T.F., Herman D.H., Clasen L.S., Toga A.W., Rapoport J.L., Thompson P.M. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:8174-8179.
38. Gogtay N., Thompson P.M. Mapping gray matter development: implications for typical development and vulnerability to psychopathology. Brain and Cognition 2010, 72:6-15.
39. Goldman-Rakic P.S. Working memory dysfunction in schizophrenia. The Journal of Neuropsychiatry and Clinical Neurosciences 1994, 6:348-357.
40. Goldman-Rakic P.S. Cellular basis of working memory. Neuron 1995, 14:477-485.
41. Goldman-Rakic P.S. The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. Philosophical Transactions of the Royal Society B 1996, 351:1445-1453.
42. Goldman-Rakic P.S. The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biological Psychiatry 1999, 46:650-661.
43. Goldman-Rakic P.S., Brown R.M. Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Brain Research 1982, 256:339-349.
44. Goldman-Rakic P.S., Leung H.-C. Functional architecture of the dorsolateral prefrontal cortex in monkeys and humans. Principles of Frontal Lobe Function 2002, 85-95. Oxford University Press, New York. D.T. Stuss, R.T. Knight (Eds.).
45. Goldman-Rakic P.S., Muly E.C., Williams G.V. D(1) receptors in prefrontal cells and circuits. Brain Research 2000, 31:295-301.
46. Gonzalez-Burgos G., Kroener S., Zaitsev A.V., Povysheva N.V., Krimer L.S., Barrionuevo G., Lewis D.A. Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. Cerebral Cortex 2008, 18:626-637.
47. Green M.F. What are the functional consequences of neurocognitive deficits in schizophrenia?. American Journal of Psychiatry 1996, 153:321-330.
48. Hebb D.O. The Organization of Behavior: A Neuropsychological Theory 1949, Wiley, New York.
49. Hertz J., Krogh A., Palmer R.G. An Introduction to the Theory of Neural Computation 1991, Addison-Wesley, Wokingham.
50. Hopfield J.J. Neural networks and physical systems with emergent collective computational abilities. Proceedings of the National Academy of Science of the United States of America 1982, 79:2554-2558.
51. Irwin I., DeLanney L.E., McNeill T., Chan P., Forno L.S., Murphy G.M., Di Monte D.A., Sandy M.S., Langston J.W. Aging and the nigrostriatal dopamine system: a non-human primate study. Neurodegeneration 1994, 3:251-265.
52. Jacobs J., Kahana M.J., Ekstrom A.D., Fried I. Brain oscillations control timing of single-neuron activity in humans. Journal of Neuroscience 2007, 27:3839-3844.
53. Johnson W., Logie R.H., Brockmole J.R. Working memory tasks differ in factor structure across age cohorts: Implications for dedifferentiation. Intelligence 2010, 38:513-528.
54. Jucaite A., Forssberg H., Karlsson P., Halldin C., Farde L. Age-related reduction in dopamine D1 receptors in the human brain: from late childhood to adulthood, a positron emission tomography study. Neuroscience 2010, 167:104-110.
55. Kubota K., Niki H. Prefrontal cortical unit activity and delayed alternation performance in monkeys. Journal of Neurophysiology 1971, 34:337-347.
56. Lewis D.A., Cruz D., Eggan S., Erickson S. Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction in schizophrenia. Annals of the New York Academy of Sciences 2004, 1021:64-76.
57. Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nature Reviews 2005, 6:312-324.
58. Lewis D.A., Levitt P. Schizophrenia as a disorder of neurodevelopment. Annual Review of Neuroscience 2002, 25:409-432.
59. Liddle P.F. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. The British Journal of Psychiatry 1987, 151:145-151.
60. Lidow M.S., Rakic P. Scheduling of monoaminergic neurotransmitter receptor expression in the primate neocortex during postnatal development. Cerebral Cortex 1992, 2:401-416.
61. Loh M., Rolls E.T., Deco G. A dynamical systems hypothesis of schizophrenia. PLoS Computational Biology 2007, 3:e228. 210.1371/journal.pcbi.0030228.
62. Loh M., Rolls E.T., Deco G. Statistical fluctuations in attractor networks related to schizophrenia. Pharmacopsychiatry 2007, 40:S78-S84.
63. Mueser K.T., McGurk S.R. Schizophrenia. Lancet 2004, 363:2063-2072.
64. Paus T. Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nature Reviews Neuroscience 2001, 2:417-424.
65. Rakic P. Development of the cerebral cortex in human and nonhuman primates. Child and Adolescent Psychiatry 1996, 9-30. Williams and Wilkins, Baltimore, MD. M.D. Lewis (Ed.).
66. Rakic P., Bourgeois J.P., Eckenhoff M.F., Zecevic N., Goldman-Rakic P.S. Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science 1986, 232:232-235.
67. Rakic P., Bourgeois J.P., Goldman-Rakic P.S. Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness. Progress in Brain Research 1994, 102:227-243.
68. Ratcliff R., Van Zandt T., McKoon G. Connectionist and diffusion models of reaction time. Psychological Reviews 1999, 106:261-300.
69. Rolls E.T. The Brain and Emotion 1999, Oxford University Press, Oxford.
70. Rolls E.T. Emotion Explained 2005, Oxford University Press, Oxford.
71. Rolls E.T. The neurophysiology and functions of the orbitofrontal cortex. The Orbitofrontal Cortex 2006, 95-124. Oxford University Press, Oxford. D.H. Zald, S.L. Rauch (Eds.).
72. Rolls E.T. Memory, Attention, and Decision-Making: A Unifying Computational Neuroscience Approach 2008, Oxford University Press, Oxford.
73. Rolls E.T. A computational theory of episodic memory formation in the hippocampus. Behavioural Brain Research 2010, 205:180-196.
74. Rolls E.T. Noise in the brain, decision-making, determinism, free will, and consciousness. New Horizons in the Neuroscience of Consciousness 2010, John Benjamin, Amsterdam. E. Perry, D. Collerton, H. Ashton, F. Lebeau (Eds.).
75. Rolls E.T., Deco G. Computational Neuroscience of Vision 2002, Oxford University Press, Oxford.
76. Rolls E.T., Deco G. The Noisy Brain: Stochastic Dynamics as a Principle of Brain Function 2010, Oxford University Press, Oxford.
77. Rolls E.T., Grabenhorst F. The orbitofrontal cortex and beyond: from affect to decision-making. Progress in Neurobiology 2008, 86:216-244.
78. Rolls E.T., Grabenhorst F., Deco G. Choice, difficulty, and confidence in the brain. NeuroImage 2010, 53:694-706.
79. Rolls, E.T., Grabenhorst, F., Deco, G., 2010b. Decision-making, errors, and confidence in the brain. Journal of Neurophysiology. Electronic publication 1 September.
80. Rolls E.T., Loh M., Deco G. An attractor hypothesis of obsessive-compulsive disorder. European Journal of Neuroscience 2008, 28:782-793.
81. Rolls E.T., Loh M., Deco G., Winterer G. Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nature Reviews Neuroscience 2008, 9:696-709.
82. Rolls E.T., Treves A. The relative advantages of sparse versus distributed encoding for associative neuronal networks in the brain. Network (Bristol, England) 1990, 1:407-421.
83. Rolls E.T., Treves A. Neural Networks and Brain Function 1998, Oxford University Press, Oxford.
84. Rosenberg D.R., Lewis D.A. Postnatal maturation of the dopaminergic innervation of monkey prefrontal and motor cortices: a tyrosine hydroxylase immunohistochemical analysis. The Journal of Comparative Neurology 1995, 358:383-400.
85. Sawaguchi T., Goldman-Rakic P.S. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science 1991, 251:947-950.
86. Sawaguchi T., Goldman-Rakic P.S. The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task. Journal of Neurophysiology 1994, 71:515-528.
87. Sawaguchi T., Matsumura M., Kubota K. Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex. Neuroscience Research 1988, 5:465-473.
88. Sawaguchi T., Matsumura M., Kubota K. Catecholaminergic effects on neuronal activity related to a delayed response task in monkey prefrontal cortex. Journal of Neurophysiology 1990, 63:1385-1400.
89. Seamans J.K., Durstewitz D., Christie B.R., Stevens C.F., Sejnowski T.J. Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:301-306.
90. Seamans J.K., Yang C.R. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology 2004, 74:1-58.
91. Seeman P., Bzowej N.H., Guan H.C., Bergeron C., Becker L.E., Reynolds G.P., Bird E.D., Riederer P., Jellinger K., Watanabe S., et al. Human brain dopamine receptors in children and aging adults. Synapse (New York, NY) 1987, 1:399-404.
92. Seidman L.J., Yurgelun-Todd D., Kremen W.S., Woods B.T., Goldstein J.M., Faraone S.V., Tsuang M.T. Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biological Psychiatry 1994, 35:235-246.
93. Smith P.L., Ratcliff R. Psychology and neurobiology of simple decisions. Trends in Neurosciences 2004, 27:161-168.
94. Steinberg L. Cognitive and affective development in adolescence. Trends in Cognitive Sciences 2005, 9:69-74.
95. Swanson H.L. What develops in working memory? A life span perspective. Developmental Psychology 1999, 35:986-1000.
96. Treves A., Rolls E.T. What determines the capacity of autoassociative memories in the brain?. Network (Bristol, England) 1991, 2:371-397.
97. Vickers D. Decision Processes in Visual Perception 1979, Academic Press, New York.
98. Vijayraghavan S., Wang M., Birnbaum S.G., Williams G.V., Arnsten A.F. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 2007, 10:376-384.
99. Wahlstrom D., White T., Luciana M. Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neuroscience and Biobehavioral Reviews 2010, 34:631-648.
100. Wang X.J. Probabilistic decision making by slow reverberation in cortical circuits. Neuron 2002, 36:955-968.
101. Wang X.J. Toward a prefrontal microcircuit model for cognitive deficits in schizophrenia. Pharmacopsychiatry 2006, 39(Suppl. 1):S80-S87.
102. Wang X.J. Decision making in recurrent neuronal circuits. Neuron 2008, 60:215-234.
103. Weinberger D.R., Berman K.F. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London 1996, 351:1495-1503.
104. Williams G.V., Goldman-Rakic P.S. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 1995, 376:572-575.
105. Winterer G., Adams C.M., Jones D.W., Knutson B. Volition to action-an event-related fMRI study. NeuroImage 2002, 17:851-858.
106. Winterer G., Coppola R., Goldberg T.E., Egan M.F., Jones D.W., Sanchez C.E., Weinberger D.R. Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. The American Journal of Psychiatry 2004, 161:490-500.
107. Winterer G., Weinberger D.R. Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends in Neurosciences 2004, 27:683-690.
108. Winterer G., Ziller M., Dorn H., Frick K., Mulert C., Wuebben Y., Herrmann W.M., Coppola R. Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing. Clinical Neurophysiology 2000, 111:837-849.