Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia

American Journal of Psychiatry

Volumn 168, Issue 3, 2011, Pages 276-285

  Ursu, Stefan ^a   Kring, Ann M ^a   Gard, Marja Germans ^a   Minzenberg, Michael J ^a   Yoon, Jong H ^a   Ragland, J Daniel ^a   Solomon, Marjorie ^a   Carter, Cameron S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; HALOPERIDOL; OLANZAPINE; PERPHENAZINE; QUETIAPINE; RISPERIDONE; ZIPRASIDONE;

ADULT; AMYGDALOID NUCLEUS; ANALYSIS OF VARIANCE; ANHEDONIA; ARTICLE; BASAL GANGLION; BRAIN MAPPING; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE SEVERITY; EMOTION; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMAGE ANALYSIS; MALE; NERVE STIMULATION; NEUROIMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SUBSTANCE ABUSE; VENTROMEDIAL PREFRONTAL CORTEX;

ADULT; BRAIN MAPPING; COGNITION; EMOTIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PREFRONTAL CORTEX; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 79952731896     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2010.09081215     Document Type: Article

References (36)

1. Bleuler E: Dementia Praecox or the Group of Schizophrenias (1911). Translated by Zinkin J. New York, International Universities Press, 1950
2. Blanchard JJ, Panzarella C: Affect and social functioning in schizophrenia, in Handbook of Social Functioning in Schizophrenia. Edited by Mueser K, Tarrier N. Needham Heights, Mass, Allyn & Bacon, pp 181-196
3. Blanchard JJ, Mueser KT, Bellack AS: Anhedonia, positive and negative affect, and social functioning in schizophrenia. Schizophr Bull 1998; 24:413-424 (Pubitemid 28378226)
4. Kring AM, Moran EK: Emotional response deficits in schizophrenia: insights from affective science. Schizophr Bull 2008; 34:819-834
5. Miller EK, Cohen JD: An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001; 24:167-202 (Pubitemid 32695227)
6. Davidson RJ: Affective neuroscience and psychophysiology: toward a synthesis. Psychophysiology 2003; 40:655-665
7. Ochsner KN, Gross JJ: The cognitive control of emotion. Trends Cogn Sci 2005; 9:242-249 (Pubitemid 40615112)
8. Ursu S, Clark KA, Stenger VA, Carter CS: Distinguishing expected negative outcomes from preparatory control in the human orbitofrontal cortex. Brain Res 2008; 1227:110-119
9. Barch DM, Carter CS, MacDonald AW 3rd, Braver TS, Cohen JD: Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms. J Abnorm Psychol 2003; 112:132-143 (Pubitemid 36249851)
10. Gold JM, Fuller RL, Robinson BM, McMahon RP, Braun EL, Luck SJ: Intact attentional control of working memory encoding in schizophrenia. J Abnorm Psychol 2006; 115:658-673 (Pubitemid 44747795)
11. MacDonald AW III, Carter CS, Kerns JG, Ursu S, Barch DM, Holmes AJ, Stenger VA, Cohen JD: Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am J Psychiatry 2005; 162:475-484 (Pubitemid 40343914)
12. Yoon JH, Minzenberg MJ, Ursu S, Walters R, Wendelken C, Ragland JD, Carter CS: Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function. Am J Psychiatry 2008; 165:1006-1014
13. Cannon TD, Glahn DC, Kim J, Van Erp TG, Karlsgodt K, Cohen MS, Nuechterlein KH, Bava S, Shirinyan D: Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry 2005; 62:1071-1080 (Pubitemid 41396932)
14. Burbridge JA, Barch DM: Anhedonia and the experience of emotion in individuals with schizophrenia. J Abnorm Psychol 2007; 116:30-42 (Pubitemid 46328613)
15. Taylor SF, Welsh RC, Chen AC, Velander AJ, Liberzon I: Medial frontal hyperactivity in reality distortion. Biol Psychiatry 2007; 61:1171-1178 (Pubitemid 46669469)
16. Fahim C, Stip E, Mancini-Marie A, Gendron A, Mensour B, Beauregard M: Differential hemodynamic brain activity in schizophrenia patients with blunted affect during quetiapine treatment. J Clin Psychopharmacol 2005; 25:367-371 (Pubitemid 41060258)
17. Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, Asai K, Okubo Y: An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage 2004; 22:1247-1254 (Pubitemid 38829213)
18. Lang PJ, Bradley MM, Cuthbert BN: International Affective Picture System (IAPS): Instruction Manual and Affective Ratings, in Technical Report A-4. Gainesville, University of Florida, Center for Research in Psychophysiology, 1999
19. Woods RP, Grafton ST, Watson JD, Sicotte NL, Mazziotta JC: Automated image registration, II: intersubject validation of linear and nonlinear models. J Comput Assist Tomogr 1998; 22:153-165 (Pubitemid 28087338)
20. D'Esposito M, Postle BR, Jonides J, Smith EE: The neural substrate and temporal dynamics of interference effects in working memory as revealed by event-related functional MRI. Proc Natl Acad Sci USA 1999; 96:7514-7519 (Pubitemid 29299693)
21. Friston KJ, Holmes A, Poline JB, Price CJ, Frith CD: Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 1996; 4(3, pt 1):223-235
22. Salo R, Ursu S, Buonocore MH, Leamon MH, Carter C: Impaired prefrontal cortical function and disrupted adaptive cognitive control in methamphetamine abusers: a functional magnetic resonance imaging study. Biol Psychiatry 2009; 65:706-709
23. Horan WP, Kring AM, Blanchard JJ: Anhedonia in schizophrenia: a review of assessment strategies. Schizophr Bull 2006; 32:259-273
24. Dowd EC, Barch DM: Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biol Psychiatry 2010; 67:902-911
25. Herbener ES, Song W, Khine TT, Sweeney JA: What aspects of emotional functioning are impaired in schizophrenia? Schizophr Res 2008; 98:239-246
26. Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME: Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol Psychiatry 2007; 61:198-209 (Pubitemid 46072788)
27. Kouneiher F, Charron S, Koechlin E: Motivation and cognitive control in the human prefrontal cortex. Nat Neurosci 2009; 12:939-945
28. Gold JM, Waltz JA, Prentice KJ, Morris SE, Heerey EA: Reward processing in schizophrenia: a deficit in the representation of value. Schizophr Bull 2008; 34:835-847
29. Heerey EA, Gold JM: Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior. J Abnorm Psychol 2007; 116:268-278 (Pubitemid 46800341)
30. Waltz JA, Schweitzer JB, Gold JM, Kurup PK, Ross TJ, Salmeron BJ, Rose EJ, McClure SM, Stein EA: Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. Neuropsychopharmacology 2009; 34:1567-1577
31. Kring AM, Kerr SL, Earnst KS: Schizophrenic patients show facial reactions to emotional facial expressions. Psychophysiology 1999; 36:186-192 (Pubitemid 29129994)
32. Rushworth MF, Hadland KA, Paus T, Sipila PK: Role of the human medial frontal cortex in task switching: a combined fMRI and TMS study. J Neurophysiol 2002; 87:2577-2592 (Pubitemid 34670728)
33. Horan WP, Green MF, Kring AM, Nuechterlein KH: Does anhedonia in schizophrenia reflect faulty memory for subjectively experienced emotions? J Abnorm Psychol 2006; 115:496-508
34. Kring AM, Kerr SL, Smith DA, Neale JM: Flat affect in schizophrenia does not reflect diminished subjective experience of emotion. J Abnorm Psychol 1993; 102:507-517 (Pubitemid 23333487)
35. Cohen AS, Minor KS: Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull 2010; 36:143-150
36. Kensinger EA, Corkin S: Two routes to emotional memory: distinct neural processes for valence and arousal. Proc Natl Acad Sci USA 2004; 101:3310-3315 (Pubitemid 38327777)