Substantia nigra/ventral tegmental reward prediction error disruption in psychosis

Molecular Psychiatry

Volumn 13, Issue 3, 2008, Pages 267-276

  Murray, G K ^a,b,c,e   Corlett, P R ^a,c   Clark, L ^c   Pessiglione, M ^d   Blackwell, A D ^a   Honey, G ^a,c   Jones, P B ^a,b   Bullmore, E T ^a,b,c   Robbins, T W ^c   Fletcher, P C ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dopamine; fMRI; Incentive salience; Reinforcement learning; Reward; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONDITIONING; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEARNING; LIMBIC CORTEX; MALE; MESENCEPHALON; MOTIVATION; NEUROPSYCHIATRY; PREDICTION; PRIORITY JOURNAL; PSYCHOSIS; REINFORCEMENT; REWARD; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM; ADOLESCENT; ANALYSIS OF VARIANCE; BLOOD; DECISION MAKING; IMAGE PROCESSING; METHODOLOGY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PSYCHOLOGICAL MODEL; PSYCHOLOGICAL RATING SCALE; VASCULARIZATION;

OXYGEN;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHOICE BEHAVIOR; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MODELS, PSYCHOLOGICAL; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PHOTIC STIMULATION; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REWARD; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 39449124914     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4002058     Document Type: Article

References (46)

1. Crow TJ. Positive and negative schizophrenia symptoms and the role of dopamine. Br J Psychiatry 1981; 139: 251-254.
2. Laruelle M, Kegeles LS, Abi-Dargham A. Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. Ann N Y Acad Sci 2003; 1003: 138-158.
3. Angrist B, Sathananthan G, Wilk S, Gershon S. Amphetamine psychosis: behavioral and biochemical aspects. J Psychiatr Res 1974; 11: 13-23.
4. Krystal JH, Perry Jr EB, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A et al. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch Gen Psychiatry 2005; 62: 985-994.
5. Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 1996; 93: 9235-9240.
6. Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci USA 1997; 94: 2569-2574.
7. Kapur S, Remington G. Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient. Biol Psychiatry 2001; 50: 873-883.
8. Gray JA. Integrating schizophrenia. Schizophr Bull 1998; 24: 249-266.
9. Crow TJ. Catecholamine reward pathways and schizophrenia: the mechanism of the antipsychotic effect and the site of the primary disturbance. Fed Proc 1979; 38: 2462-2467.
10. Miller R. Schizophrenic psychology, associative learning and the role of forebrain dopamine. Med Hypotheses 1976; 2: 203-211.
11. Gray JA, Feldon J, Rawlins JNP, Smith AD. The neuropsychology of schizophrenia. Behav Brain Sci 1991; 14: 1-19.
12. Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward. Science 1997; 275: 1593-1599.
13. Schultz W, Dickinson A. Neuronal coding of prediction errors. Annu Rev Neurosci 2000; 23: 473-500.
14. Crow TJ. Catecholamine-containing neurones and electrical self-stimulation. 2. A theoretical interpretation and some psychiatric implications. Psychol Med 1973; 3: 66-73.
15. Berridge KC. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) 2007; 191: 391-431.
16. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 1998; 28: 309-369.
17. Robbins TW, Everitt BJ. A role for mesencephalic dopamine in activation: commentary on Berridge (2006). Psychopharmacology (Berl) 2006.
18. Bleuler E. Dementia Praecox or the Group of Schizophrenias. International University Press: New York, 1911/1950.
19. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160: 13-23.
20. Beninger RJ. The slow therapeutic action of antipsychotic drugs. A possible mechanism involving the role of dopamine in incentive learning. In: Simon P, Soubrie P, Widlocher D (eds). Selected Models of Anxiety, Depression and Psychosis. Basel: Karger, 1988, pp 36-51.
21. O'Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 2004; 304: 452-454.
22. Sutton RS, Barto AG. Reinforcement Learning. MIT Press: Cambridge, MA, 1998.
23. Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 2006; 442: 1042-1045.
24. Nelson HE. The National Adult Reading Test (NART). NFER-Nelson: Windsor, 1982.
25. Woods SW. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 2003; 64: 663-667.
26. Ventura J, Green MF, Shaner A, Lieberman RP. Training and quality assurance with the Brief Psychiatric Rating Scale: 'The Drift Buster'. Int J Methods Psychiatric Res 1993; 3: 221-224.
27. Cools R, Blackwell A, Clark L, Menzies L, Cox S, Robbins TW. Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology 2005; 30: 1362-1373.
28. Henson R. Analysis of fMRI timeseries: Linear Time-Invariant models, event-related fMRI and optimal experimental design. In: Frackowiak R, Friston K, Frith C, Dolan R, Price C (eds). Human Brain Function. Elsevier: London, 2004, pp 793-822.
29. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002; 15: 870-878.
30. Aron AR, Shohamy D, Clark J, Myers C, Gluck MA, Poldrack RA. Human midbrain sensitivity to cognitive feedback and uncertainty during classification learning. J Neurophysiol 2004; 92: 1144-1152.
31. Rorden C, Brett M. Stereotaxic display of brain lesions. Behav Neurol 2000; 12: 191-200.
32. Martinez D, Slifstein M, Broft A, Mawlawi O, Hwang DR, Huang Y et al. Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. J Cereb Blood Flow Metab 2003; 23: 285-300.
33. Fine C, Gardner M, Craigie J, Gold I. Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cogn Neuropsychiatry 2007; 12: 46-77.
34. Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 2001; 30: 619-639.
35. O'Doherty JP, Deichmann R, Critchley HD, Dolan RJ. Neural responses during anticipation of a primary taste reward. Neuron 2002; 33: 815-826.
36. Knutson B, Bjork JM, Fong GW, Hommer D, Mattay VS, Weinberger DR. Amphetamine modulates human incentive processing. Neuron 2004; 43: 261-269.
37. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD et al. Acute effects of cocaine on human brain activity and emotion. Neuron 1997; 19: 591-611.
38. Robbins TW, Everitt BJ. Neurobehavioural mechanisms of reward and motivation. Curr Opin Neurobiol 1996; 6: 228-236.
39. Juckel G, Schlagenhauf F, Koslowski M, Filonov D, Wustenberg T, Villringer A et al. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl) 2006; 187: 222-228.
40. McKenna PJ. Pathology, phenomenology and the dopamine hypothesis of schizophrenia. Br J Psychiatry 1987; 151: 288-301.
41. Beninger RJ. The role of dopamine in locomotor activity and learning. Brain Res 1983; 287: 173-196.
42. Robbins TW. Relationship between reward-enhancing and stereotypical effects of psychomotor stimulant drugs. Nature 1976; 264: 57-59.
43. Robbins TW. Cognitive deficits in schizophrenia and parkinson's disease: neural basis and the role of dopamine. In: Willner P, Scheel-Kruger J (eds). The Mesolimbic Dopamine System: From Motivation to Action. Wiley: Chichester, UK, 1991, pp 497-528.
44. Juckel G, Schlagenhauf F, Koslowski M, Wustenberg T, Villringer A, Knutson B et al. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 2006; 29: 409-416.
45. Jones SH, Gray JA, Hemsley DR. Loss of the Kamin blocking effect in acute but not chronic schizophrenics. Biol Psychiatry 1992; 32: 739-755.
46. Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR et al. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Arch Gen Psychiatry 2006; 63: 611-621.