The cognitive neuroscience of schizophrenia

Annual Review of Clinical Psychology

Volumn 1, Issue , 2005, Pages 321-353

  Barch, Deanna M ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Episodic memory; Executive control; Hippocampus; Prefrontal cortex; Working memory

Indexed keywords

BRAIN DYSFUNCTION; BRAIN FUNCTION; BRAIN REGION; COGNITION; COGNITIVE DEFECT; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; NEUROSCIENCE; PHONETICS; REVIEW; SCHIZOPHRENIA; SYMPTOMATOLOGY; VERBAL MEMORY; WORKING MEMORY;

BRAIN; BRAIN MAPPING; COGNITION; HIGHER NERVOUS ACTIVITY; HIPPOCAMPUS; HUMANS; MEMORY; MODELS, NEUROLOGICAL; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 26444477725     PISSN: 15485943     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.clinpsy.1.102803.143959     Document Type: Review

References (140)

1. Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, et al. 2002. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J. Neurosci. 22(9):3708-19
2. Achim AM, Lelpage M. 2003. Is associative recognition more impaired than item recognition memory in schizophrenia? A meta-analysis. Brain Cogn. 53:121-24
3. Aggleton JP, Shaw C. 1996. Amnesia and recognition memory: a re-analysis of psychometric data. Neuropsychologia 34(1):51-62
4. Aleman A, Hij R, de Haan EH, Kahn RS. 1999. Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry 156(9): 1358-66
5. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, et al. 1996. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc. Natl. Acad. Sci. USA 93:9985-90
6. Andreasen NC, Rezai K, Alliger R, Swayze VW, Flaum M, et al. 1992. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia: assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Arch. Gen. Psychiatry 49:943-58
7. Awh E, Jonides J. 2001. Overlapping mechanisms of attention and spatial working memory. Trends Cogn. Sci. 5:119-26
8. Baddeley AD. 1986. Working Memory. New York: Oxford Univ. Press
9. Baddeley AD. 2000. The episodic buffer: a new component of working memory? Trends Cogn. Sci. 4:417-23
10. Barch DM. 2004. Pharmacological manipulation of human working memory. Psychopharmacology 174(1):126-35
11. Barch DM, Carter CS, Braver TS, McDonald A, Sabb FW, et al. 2001. Selective deficits in prefrontal cortex regions in medication naive schizophrenia patients. Arch. Gen. Psychiatry 50:280-88
12. Barch DM, Carter CS, Cohen JD. 2003. Context processing deficit in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms. J. Abnorm. Psychol. 112:132-43
13. Barch DM, Csernansky J, Conturo T, Snyder AZ, Ollinger J. 2002. Working and long-term memory deficits in schizophrenia. Is there a common underlying prefrontal mechanism? J. Abnorm. Psychol. 111:478-94
14. Barch DM, Mitropoulou V, Harvey PD, New AS, Silverman JM, Siever LJ. 2004. Context processing deficits in schizotypal personality disorder. J. Abnorm. Psychol. 113:556-68
15. Benes FM. 2000. Emerging principles of altered neural circuitry in schizophrenia. Brain Res. Rev. 31:251-69
16. Berman KF, Torrey F, Daniel DG, Weinberger DR. 1992. Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Arch. Gen. Psychiatry 49:927-34
17. Berman KF, Zec RF, Weinberger DR. 1986. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II: Role of neuroleptic treatment, attention and mental effort. Arch. Gen. Psychiatry 43:126-35
18. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, et al. 1996. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am. J. Psychiatry 153(12):1554-63
19. Bonner-Jackson A, Haut K, Csernansky JG, Barch DM. 2005. The influence of encoding strategy on episodic memory and cortical activity in schizophrenia. In press
20. Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JC. 2001. Conflict monitoring and cognitive control. Psychol. Rev. 108:624-52
21. Brahmbhatt S, Haut KM, Csernansky JG, Barch DM. 2004. Working memory deficits in individuals with schizophrenia and their high-risk siblings. Presented at Meet. Soc. Neurosci., San Diego
22. Braver TS, Barch DM, Cohen JD. 1999. Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function. Biol. Psychiatry 46:312-28
23. Braver TS, Cohen JD, Barch DM. 2002. The role of the prefrontal cortex in normal and disordered cognitive control: a cognitive neuroscience perspective. In Principles of Frontal Lobe Function, ed. DT Stuss, RT Knight, pp. 428-48. Oxford: Oxford Univ. Press
24. Brebion G, Amador X, Smith MJ, German JM. 1997. Mechanisms underlying memory impairment in schizophrenia. Psychol. Med. 27:383-93
25. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, et al. 2000. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex 10:1078-92
26. Callicott JH, Egan MF, Bertolino A, Mattay VS, Langbein FJP, et al. 1998a. Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biol. Psychiatry 44:941-50
27. Callicott JH, Egan MF, Mattay VS, Bertolino A, Bone AD, et al. 2003a. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am. J. Psychiatry 160(4):709-19
28. Callicott JH, Mattay VS, Bertolino KF, Coppola R, Frank JA, et al. 1999. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb. Cortex 9(20):20-26
29. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. 2003b. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am. J. Psychiatry 160(12):2209-15
30. Callicott JH, Ramsey NF, Tallent K, Bertolino A, Knable MB, et al. 1998b. Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 18(3):186-96
31. Callicott JH, Ramsey NF, Tallent K, Bertolino A, Knable MB, et al. 1996. fMRI brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Washington, DC: NIMH Neurosci. Cent, at St. Elizabeths
32. Cannon TD, van Erp TG, Glahn DC. 2002. Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous system. Schizophr. Res. 54(1-2): 151-56
33. 2O PET study during single-trial Stroop task performance. Am. J. Psychiatry 154(12):1670-75
34. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen J. 1998. Functional hypofrontality and working memory dysfunction in schizophrenia. Am. J. Psychiatry 155(9):1285-87
35. Chein JM, Fiez JA. 2001. Dissociation of verbal working memory system components using a delayed serial recall task. Cereb. Cortex 11(11):1003-14
36. Cohen JD, Barch DM, Carter C, Servan-Schreiber D. 1999. Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. J. Abnorm. Psychol. 108:120-33
37. Cohen JD, Servan-Schreiber D. 1992. Context, cortex and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol. Rev. 99(1):45-77
38. Crespo-Facorro B, Paradiso S, Andreasen NC, O'Leary DS, Watkins GL, et al. 1999. Recalling word lists reveals "cognitive dysmetria" in schizophrenia: a positron emission tomography study. Am. J. Psychiatry 156(3):386-92
39. Curtis CE, Rao VY, D'Esposito M. 2004. Maintenance of spatial and motor codes during oculomotor delayed response tasks. J. Neurosci. 24(16):3944-52
40. Curtis CE, Zald DH, Pardo JV. 2000. Organization of working memory within the human prefrontal cortex: a PET study of self-ordered object working memory. Neuropsychologia 38(11):1503-10
41. Daniel DG, Berman KF, Weinberger DR. 1989. The effect of apomorphine on regional cerebral blood flow in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 1:377-84
42. Danion JM, Rizzo L, Bruant A. 1999. Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Arch. Gen. Psychiatry 56(7):639-44
43. Davidson GS, Neale JM. 1974. The effects of signal-noise similarity on visual information processing of schizophrenics. J. Abnorm. Psychol. 83(6):683-86
44. Docherty NM, Hawkins KA, Hoffman RE, Quinlan DM, Rakfeldt J, Sledge WH. 1996. Working memory, attention, and communication disturbances in schizophrenia. J. Abnorm. Psychol. 105(2):212-19
45. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, et al. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad. Sci. USA 98:6917-22
46. Eichenbaum H, Cohen NJ. 2001. From Conditioning to Conscious Recollection: Memory Systems of the Brain. New York: Oxford Univ. Press
47. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA. 2000. Remembering episodes: a selective role for the hippocampus during retrieval. Nat. Neurosci. 3(11):1149-52
48. Elvevag B, Weinberger DR, Goldberg TE. 2002. The phonological similarity effect in short-term memory serial recall in schizophrenia. Psychiatry Res. 112(1):77-81
49. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT. 2000. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol. Psychiatry 48(2):120-26
50. Fitzgerald D, Lucas S, Redoblado MA, Winter V, Brennan J, et al. 2004. Cognitive functioning in young people with first episode psychosis: relationship to diagnosis and clinical characteristics. Aust. NZ J. Psychiatry 38(7):501-10
51. Fleming K, Goldberg TE, Gold JM, Weinberger DR. 1995. Verbal working memory dysfunction in schizophrenia: use of a Brown-Peterson paradigm. Psychiatry Res. 56(2):155-61
52. Fletcher PC, Frith CD, Grasby PM, Shallice T, Frackowiak RSJ, Dolan RJ. 1995. Brain systems for encoding and retrieval of auditory-verbal memory: an in vivo study in humans. Brain 118:401-16
53. Fletcher PC, McKenna PJ, Frith CD, Grasby PM, Friston KJ, Dolan RJ. 1998. Brain activation in schizophrenia during a graded memory task studied with functional neuroimaging. Arch. Gen. Psychiatry 55:1001-8
54. Glahn DC, Therman S, Manninen M, Huttunen M, Kaprio J, et al. 2003. Spatial working memory as an endophenotype for schizophrenia. Biol. Psychiatry 53(7):624-26
55. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. 1997. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch. Gen. Psychiatry 54(2):159-65
56. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, et al. 2003. Executive subprocesses in working memory: relationship to catechol-O- methyltransferase Val158Met genotype and schizophrenia. Arch. Gen. Psychiatry 60(9):889-96
57. Goldman-Rakic PS, Muly EC, Williams GV. 2000. D1 receptors in prefrontal cells and circuits. Brain Res. Rev. 31:295-301
58. Gooding DC, Tallent KA. 2004. Nonverbal working memory deficits in schizophrenia patients: evidence of a supramodal executive processing deficit. Schizophr. Res. 68:189-201
59. Green MF, Kern RS, Braff DL, Mintz J. 2000. Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"? Schizophr. Bull. Spec. Issue: Psychosoc. Treat. Schizophr. 26(1):119-36
60. Habib R, Nyberg L, Tulving E. 2003. Hemispheric asymmetries of memory: the HERA model revisited. Trends Cogn. Sci. 7(6):241-45
61. Heckers S, Curran T, Goff DC, Rauch SL, Fischman AJ, et al. 2000. Abnormalities in the thalamus and prefrontal cortex during episodic object recognition in schizophrenia. Biol. Psychiatry 48:651-57
62. Heckers S, Rauch SL, Goff D, Savage CR, Schacter DL, et al. 1998. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat. Neurosci. 1(4):318-23
63. Heckers S, Zalesak M, Weiss AP, Ditman T, Titone D. 2004. Hippocampal activation during transitive inference in humans. Hippocampus 14(2):153-62
64. Hofer A, Weiss EM, Golaszweski SM, Siedentopf CM, Brinkhoff C, et al. 2003. An fMRI study of episodic encoding and recognition of words in patients with schizophrenia in remission. Am. J. Psychiatry 160(5):911-18
65. Holroyd CB, Coles MG. 2002. The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol. Rev. 109(4):679-709
66. Honey GD, Bullmore ET, Sharma T. 2002. De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophr. Res. 53:45-56
67. Honey GD, Sharma T, Suckling J, Giampietro V, Soni W, et al. 2003. The functional neuroanatomy of schizophrenic subsyndromes. Psychol. Med. 33(6):1007-18
68. Hugdahl K, Rund BR, Lund A, Asbjornsen A, Egeland J, et al. 2004. Brain activation measured with fMRI during a mental arithmetic task in schizophrenia and major depression. Am. J. Psychiatry 161(2):286-93
69. Jacoby LL. 1991. A process dissociation framework: separating automatic from intentional uses of memory. J. Mem. Lang. 30:513-41
70. Janowsky JS, Shimamura AP, Kritchevsky M, Squire LR. 1989. Cognitive impairment following frontal lobe damage and its relevance to human amnesia. Behav. Neurosci. 103(3):548-60
71. Jansma JM, Ramsey NF, van der Wee NJ, Kahn RS. 2004. Working memory capacity in schizophrenia: a parametric fMRI study. Schizophr. Res. 68(2-3):159-71
72. Javitt DC, Shelley A, Silipo G, Lieberman JA. 2000. Deficits in auditory and visual context-dependent processing in schizophrenia. Arch. Gen. Psychiatry 57:1131-37
73. Jessen F, Scheef L, Germeshausen L, Tawo Y, Kockler M, et al. 2003. Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients. Am. J. Psychiatry 160:1305-12
74. Keshavan MS, Diwadkar VA, Spencer SM, Harenski KA, Luna B, Sweeney JA. 2002. A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Prog. Neuropsychopharmacol. Biol. Psychiatry 26:1143-49
75. Kim J, Glahn DC, Nuechterlein KH, Cannon TD. 2004. Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr. Res. 68(2-3):173-87
76. Kim JJ, Kwon JS, Park HJ, Youn T, Kang DH, et al. 2003. Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: a [15O]H20 PET study. Am. J. Psychiatry 160:919-23
77. Kindermann SS, Brown GG, Zorrilla LE, Olsen RK, Jeste DV. 2004. Spatial working memory among middle-aged and older patients with schizophrenia and volunteers using fMRI. Schizophr. Res. 68:203-16
78. Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF. 2004. Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol. Psychiatry 9(6):609-20, 544
79. Koh SD. 1978. Remembering of verbal material by schizophrenic young adults. In Language and Cognitive in Schizophrenia, ed. S Schwartz, pp. 55-99. Hillsdale, NJ: Erlbaum
80. Kopp B, Rist F. 1994. Error-correcting behavior in schizophrenic patients. Schizophr. Res. 13(1):11-22
81. Laurens KR, Ngan ETC, Bates AT, Kiehl KA, Liddle PF. 2003. Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia. Brain 126:610-22
82. MacDonald AW III, Carter CS. 2003. Event-related fMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia. J. Abnorm. Psychol. 112(4): 689-97
83. MacDonald AW III, Pogue-Geile MF, Johnson MK, Carter CS. 2003. A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Arch. Gen. Psychiatry 60:57-65
84. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, et al. 2000. Schizophrenic subjects show aberrant fMRI activation of dorsolatral prefrontal cortex and basal ganglia during working memory performance. Biol. Psychiatry 48:99-109
85. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, et al. 1999. Schizophrenia subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol. Psychiatry 45(9):1128-37
86. McClelland JL, McNaughton BL, O'Reilly RC. 1995. Why there are complementary learnings systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychol. Rev. 102:419-57
87. Meehl PE. 1962. Schizotaxia, schizotypy, schizophrenia. Am. Psychol. 17:827-38
88. Melinder MR, Barch DM. 2003. The influence of a working memory load manipulation on language production in schizophrenia. Schizophr. Bull. 29(3):473-85
89. Mendrek A, Laurens KR, Kiehl KA, Ngan ET, Stip E, Liddle PF. 2004. Changes in distributed neural circuitry function in patients with first-episode schizophrenia. Br. J. Psychiatry 185:205-14
90. Menon V, Anagnoson RT, Mathalon DH, Glover GH, Pfefferbaum A. 2001. Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms. NeuroImage 13:433-46
91. Meyer-Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, et al. 2002. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat. Neurosci. 5(3):267-71
92. Meyer-Lindenberg A, Poline J, Kohn PD, Holt JL, Egan MF, et al. 2001. Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am. J. Psychiatry 158:1809-17
93. Mitropoulou V, Harvey PD, Maldari LA, Moriarty PJ, New AS, et al. 2002. Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity. Biol. Psychiatry 52(12):1175-82
94. Newcomer JW, Krystal JH. 2001. NMDA receptor regulation of memory and behavior in humans. Hippocampus 11(5):529-42
95. Niendam TA, Bearden CE, Rosso JM, Sanchez LE, Hadley T, et al. 2003. A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am. J. Psychiatry 160(11):2060-62
96. Olney JW, Newcomer JW, Farber NB. 1999. NMDA receptor hypofunction model of schizophrenia. J. Psychiatr. Res. 33(6):523-33
97. Owen AM. 1997. The functional organization of working memory processes within human lateral frontal cortex: the contribution of functional neuroimaging. Eur. J. Neurosci. 9:1329-39
98. Pantelis C, Harvey CA, Plant G, Fossey E, Maruff P, et al. 2004. Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability. Psychol. Med. 34(4):693-703
99. Park S, Holzman PS. 1992. Schizophrenics show spatial working memory deficits. Arch. Gen. Psychiatry 49(12):975-82
100. Perlstein WH, Carter CS, Noll DC, Cohen JD. 2001. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am. J. Psychiatry 158(7):1105-13
101. Perlstein WM, Dixit NK, Carter CS, Noll DC, Cohen JD. 2003. Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biol. Psychiatry 53:25-38
102. Pisella L, Berberovic N, Mattingley JB. 2004. Impaired working memory for location but not for colour or shape in visual neglect: a comparison of parietal and non-parietal lesions. Cortex 40(2):379-90
103. Postle BR, Awh E, Jonides J, Smith EE, D'Esposito M. 2004. The where and how of attention-based rehearsal in spatial working memory. Brain Res. Cogn. Brain Res. 20(2):194-205
104. Quintana J, Wong T, Ortiz-Portillo E, Kovalik E, Davidson T, et al. 2003. Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations. Biol. Psychiatry 53(1):12-24
105. Ragland JD, Gur RC, Glahn DC, Censits DM, Smith RJ, et al. 1998. Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology 12(3):399-413
106. Ragland JD, Gur RC, Raz J, Schroeder L, Kohler CG, et al. 2001. Effect of schizophrenia on frontotemporal activity during word encoding and recognition: a PET cerebral blood flow study. Am. J. Psychiatry 158(7): 1114-25
107. Ragland JD, Gur RC, Valdez J, Turetski BI, Elliott M, et al. 2004. Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia. Am. J. Psychiatry 161:1004-15
108. Ravizza SM, Delgado MR, Chein JM, Becker JT, Fiez JA. 2004. Functional dissociations within the inferior parietal cortex in verbal working memory. NeuroImage 22(2):562-73
109. Reed JM, Squire LR. 1997. Impaired recognition memory in patients with lesions limited to the hippocampal formation. Behav. Neurosci. 111(4):667-75
110. Ryan JD, Cohen NJ. 2004. Processing and short-term retention of relational information in amnesia. Neuropsychologia 42(4):497-511
111. Sabri O, Owega A, Schreckenberger M, Sturz L, Fimm B, et al. 2003. A truly simultaneous combination of functional transcranial Doppler sonography and H(2)(15)O PET adds fundamental new information on differences in cognitive activation between schizophrenics and healthy control subjects. J. Nucl. Med. 44(5):671-81
112. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, et al. 1994. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry 51(2):124-31
113. Schlosser R, Gesierich T, Kaufmann B, Vucurevic G, Hunsche S, et al. 2003. Altered effective connectivity during working memory performance in schizophrenia: a study with fMRI and structural equation modeling. NeumImage 19(3):751-63
114. Scoville WB, Milner B. 1957. Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiatry 20:11-21
115. Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, et al. 2002. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch. Gen. Psychiatry 59(9):839-49
116. Selemon LD, Mrzljak J, Kleinman JE, Herman MM, Goldman-Rakic PS. 2003. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Arch. Gen. Psychiatry 60(1):69-77
117. Shenton ME, Dickey CC, Frumin M, McCarley RW. 2001. A review of MRI findings in schizophrenia. Schizophr. Res. 49:1-52
118. Siever LJ, Koenigsberg HW, Harvey PD, Mitropoulou V, Lamelle M, et al. 2002. Cognitive and brain function in schizotypal personality disorder. Schizophr. Res. 54:157-67
119. Smith EE, Jonides J. 1999. Storage and executive processes in the frontal lobes. Science 283:1657-61
120. Snitz BE, Curtis CE, Zald DH, Katsanis J, Iacono WG. 1999. Neuropsychological and oculomotor correlates of spatial working memory performance in schizophrenia patients and controls. Schizophr. Res. 38(1):37-50
121. Squire LR, Knowlton BJ. 1995. Memory, hippocampus, and brain systems. In The Cognitive Neurosciences, ed. M Gazzaniga, pp. 825-37. Cambridge, MA: MIT Press
122. Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler R. 1998. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch. Gen. Psychiatry 55:1097-103
123. Stratta P, Daneluzzo E, Bustini M, Casacchia M, Rossi A. 1998. Schizophrenic deficits in the processing of context. Arch. Gen. Psychiatry 55:186-87
124. Stratta P, Daneluzzo E, Bustini M, Prosperini P, Rossi A. 2000. Processing of context information in schizophrenia: relation to clinical symptoms and WCST performance. Schizophr. Res. 44:57-67
125. Strauss ME, Reynolds KS, Jayaram G, Tune LE. 1990. Effects of anticholinergic medication on memory in schizophrenia. Schizophr. Res. 3(2):127-29
126. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. 1990. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322(12):789-94
127. Thermenos HW, Seidman LJ, Breiter H, Goldstein JM, Goodman JM, et al. 2004. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biol. Psychiatry 55:490-500
128. Titone D, Ditman T, Holzman PS, Eichenbaum H, Levy DL. 2004. Transitive inference in schizophrenia: impairments in relational memory organization. Schizophr. Res. 68(2-3):235-47
129. Toulopoulou T, Morris RG, Rabe-Hesketh S, Murray RM. 2003. Selectivity of verbal memory deficit in schizophrenic patients and their relatives. Am. J. Med. Genet. 116B(1): 1-7
130. Tulving E. 1985. Memory and consciousness. Can. Psychol. 26:1-12
131. Tuulio-Henriksson A, Arajarvi R, Partonen T, Haukka J, Varilo T, et al. 2003. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol. Psychiatry 54(6):623-28
132. Vallar G, Di Betta AM, Silveri MC. 1997. The phonological short-term store-rehearsal system: patterns of impairment and neural correlates. Neuropsychologia 35(6):795-812
133. Van Erp TG, Saleh PA, Rosso IM, Huttunen M, Lonnqvist J, et al. 2002. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am. J. Psychiatry 159(9):1514-20
134. Wagner AD, Schacter D, Rotte M, Koutstaal W, Maril A, et al. 1998. Building memories: remembering and forgetting of verbal experiences as predicted by brain activity. Science 281(5380):1188-91
135. Walter H, Wunderlich AP, Blankenhorn M, Schafer S, Tomczak R, et al. 2003. No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial working memory in schizophrenia. Schizophr. Res. 61:175-84
136. Weiss AP, Schacter DL, Goff DC, Rauch SL, Alpert NM, et al. 2003. Impaired hippocampal recruitment during normal modulation of memory performance in schizophrenia. Biol. Psychiatry 53:48-55
137. Weiss EM, Golaszewski SM, Mottaghy FM, Hofer A, Hausmann A, et al. 2003. Brain activation patterns during a selective attention test-a functional MRI study in healthy volunteers and patients with schizophrenia. Psychiatry Res. 123:1-15
138. Wexler BE, Donegan N, Stevens AA, Jacob SA. 2002. Deficits in language-mediated mental operations in patients with schizophrenia. Schizophr. Res. 53(3):171-79
139. Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS. 1998. Word and tone working memory deficits in schizophrenia. Arch. Gen. Psychiatry 55:1093-96
140. Wykes T, Brammer M, Mellers J, Bray P, Reeder C, et al. 2002. Effects on the brain of a psychological treatment: cognitive remediation therapy: functional magnetic resonance imaging in schizophrenia. Br. J. Psychiatry 181:144-52