The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127

Biomaterials

Volumn 34, Issue 6, 2013, Pages 1686-1700

  Wu, Hong Fu ^a,b   Cen, Jing Sheng ^a   Zhong, Qian ^c   Chen, Luming ^d   Wang, Jue ^a   Deng, David Y B ^a   Wan, Yong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d YALE UNIVERSITY   (United States)

Author keywords

Functional recovery; Lingo 1 RNA interference; Nerve regeneration; PF 127 hydrogel; Spinal cord injury

Indexed keywords

CELL APOPTOSIS; CENTRAL NERVOUS SYSTEMS; COGRAFTING; CULTURE IN VITRO; ENDOPLASMIC RETICULUM STRESS; FUNCTIONAL RECOVERY; GENE DELIVERY; GLIAL CELLS; IN-VIVO; LENTIVIRAL VECTOR; MYELINATED AXONS; NEGATIVE REGULATORS; NERVE REGENERATION; NEURITE OUTGROWTH; NEURONAL SURVIVAL; OLIGODENDROCYTES; PLURONIC F-127; RNA INTERFERENCE; SPINAL CORD INJURIES (SCI); SPINAL CORDS; THERAPEUTIC TARGETS; TRANSFECTION EFFICIENCY; VIRAL CONCENTRATION; VIRAL VECTORS;

CELL CULTURE; CELL DEATH; CELL MEMBRANES; ENCODING (SYMBOLS); GENE TRANSFER; NEURONS; PATIENT REHABILITATION; RECOVERY; RNA; VECTORS;

MOLECULAR BIOLOGY;

LENTIVIRUS VECTOR; LINGO 1 PROTEIN; MEMBRANE PROTEIN; POLOXAMER; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CONVALESCENCE; DOWN REGULATION; ENCAPSULATION; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; GENETIC TRANSFECTION; GLIA CELL; HISTOPATHOLOGY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NERVE FIBER GROWTH; NERVE REGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; SYNAPSE;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; EVOKED POTENTIALS; FEMALE; GENETIC VECTORS; LENTIVIRUS; MEMBRANE PROTEINS; NERVE REGENERATION; NERVE TISSUE PROTEINS; POLOXAMER; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA; SPINAL CORD INJURIES;

RATTUS;

EID: 84870854041     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.11.013     Document Type: Article

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