An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide

Neuroscience Research

Volumn 70, Issue 3, 2011, Pages 294-304

  Huang, Si Fan ^a   Ding, Ying ^a   Ruan, Jing Wen ^b   Zhang, Wei ^a   Wu, Jin Lang ^a   He, Bing ^a   Zhang, Yu Jiao ^a   Li, Yan ^a   Zeng, Yuan Shan ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Behavioural recovery; Governor Vessel electro acupuncture; Neurotrophin 3; Oligodendrocyte precursor cells; Oligodendrocytes; Remyelination

Indexed keywords

APC PROTEIN; ETHIDIUM BROMIDE; MYELIN; NEUROFILAMENT PROTEIN; NEUROTROPHIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; CONVALESCENCE; DEMYELINATING DISEASE; ELECTROACUPUNCTURE; MALE; MULTIPLE SCLEROSIS; NEUROFILAMENT; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REMYELINIZATION; SPINAL CORD; SPINAL CORD INJURY; STEM CELL;

ANIMALS; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; ELECTROACUPUNCTURE; ETHIDIUM; MALE; NERVE REGENERATION; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 79957593088     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2011.03.010     Document Type: Article

References (63)

1. Barres B.A., Raff M.C., Gaese F., Bartke I., Dechant G., Barde Y.A. A crucial role for neurotrophin-3 in oligodendrocyte development. Nature 1994, 367:371-375.
2. Blakemore W.F. Ethidium bromide induced demyelination in the spinal cord of the cat. Neuropathol. Appl. Neurobiol. 1982, 8:365-375.
3. Blakemore W.F., Franklin R.J., Crang A.J. Repair of demyelinated lesions by glial cell transplantation. J. Neurol. 1994, 242:61-63.
4. Bjartmar C., Trapp B.D. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr. Opin. Neurol. 2001, 14:271-278.
5. Caroline M.G. Acupuncture in the treatment of fatigue by Caroline McGuire in a patient with multiple sclerosis. Physiotherapy 2003, 89:637-640.
6. Carroll W.M., Jennings A.R., Ironside L.J. Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination. Brain 1998, 121:293-302.
7. Chen J., Qi J.G., Zhang W., Zhou X., Meng Q.S., Zhang W.M., Wang X.Y., Wang T.H. Electro-acupuncture induced NGF, BDNF and NT-3 expression in spared L6 dorsal root ganglion in cats subjected to removal of adjacent ganglia. Neurosci. Res. 2007, 59:399-405.
8. Chen Y.Y., Zhang W., Chen Y.L., Chen S.J., Dong H.X., Zeng Y.S. Electro-acupuncture improves survival and migration of transplanted neural stem cells in injured spinal cord in rats. Acupunct. Electrother. Res. 2008, 33:19-31.
9. Chiu Y.J., Chi A., Reid I.A. Cardiovascular and endocrine effects of acupuncture in hypertensive patients. Clin. Exp. Hypertens. 1997, 19:1047-1063.
10. Cohen R.I., Marmur R., Norton W.T., Mehler M.F., Kessler J.A. Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J. Neurosci. 1996, 16:6433-6442.
11. Cooper D.M.F., Mons N., Karpan J.W. Adenylyl cyclases and the interaction between calcium and cAMP signaling. Nature 1995, 374:421-424.
12. De Stefano N., Matthews P.M., Fu L., Narayanan S., Stanley J., Francis G.S., Antel J.P., Arnold D.L. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 1998, 121:1469-1477.
13. DiBello I.C., Dawson M.R., Levine J.M., Reynolds R. Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation. J. Neurocytol. 1999, 28:365-381.
14. Ding Y., Yan Q., Ruan J.W., Zhang Y.Q., Li W.J., Zhang Y.J., Li Y., Dong H., Zeng Y.S. Electro-acupuncture promotes survival, differentiation of the bone marrow mesenchymal stem cells as well as functional recovery in the spinal cord-transected rats. BMC Neurosci. 2009, 10:35.
15. Duncan I.D., Brower A., Kondo Y., Curlee J.F., Schultz R.D. Extensive remyelination of the CNS leads to functional recovery. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6832-6836.
16. Ganter P., Prince C., Esiri M.M. Spinal cord axonal loss in multiple sclerosis: a post-mortem study. Neuropathol. Appl. Neurobiol. 1999, 25:459-467.
17. Ghosh A., Carnahan J., Greenberg M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 1994, 263:1618-1623.
18. Gensert J.M., Goldman J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 1998, 19:197-203.
19. Hansen M.R., Zha X.M., Bok J., Green S.H. Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro. J. Neurosci. 2001, 21:2256-2267.
20. Heinrich M., Gorath M., Richter-Landsberg C. Neurotrophin-3 (NT-3) modulates early differentiation of oligodendrocytes in rat brain cortical cultures. Glia 1999, 28:244-255.
21. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 2001, 24:677-736.
22. Iglesias A., Bauer J., Litzenburger T., Schubart A., Linington C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 2001, 36:220-234.
23. Jean I., Lavialle C., Barthelaix-Pouplard A., Fressinaud C. Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS. Brain Res. 2003, 972:110-118.
24. Jeffery N.D., Crang A.J., O'leary M.T., Hodge S.J., Blakemore W.F. Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord. Eur. J. Neurosci. 1999, 11:1508-1514.
25. Johnson J.R., Chu A.K., Sato-Bigbee C. Possible role of CREB in the stimulation of oligodendrocyte precursor cell proliferation by neurotrophin-3. J. Neurochem. 2000, 74:1409-1417.
26. Joos S., Schott C., Zou H., Daniel V., Martin E. Immunomodulatory effects of acupuncture in the treatment of allergic asthma: a randomized controlled study. J. Altern. Complement. Med. 2000, 6:519-525.
27. Kahn M.A., Kumar S., Liebl D., Chang R., Parada L.F., De Vellis J. Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glia cells. Glia 1999, 26:153-165.
28. Keirstead H.S., Levine J.M., Blakemore W.F. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 1998, 22:161-170.
29. Kornek B., Storch M.K., Weissert R., Wallstroem E., Stefferl A., Olsson T., Linington C., Schmidbauer M., Lassmann H. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol. 2000, 157:267-276.
30. Kumar S., de Vellis J. Neurotrophin activates signal transduction in oligodendroglial cells: expression of functional TrkC receptor isoforms. J. Neurosci. Res. 1996, 44:490-498.
31. Kumar S., Kahn M.A., Dinh L., de Vellis J. NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo. J. Neurosci. Res. 1998, 54:754-765.
32. Lee S.K., Kim M.H., Kim H.J., Seo D.S., Yoo K.S., Joo Y.H., Min Y.I., Kim J.H., Min B.I. Electroacupuncture may relax the sphincter of Oddi in humans. Gastrointest. Endosc. 2001, 53:211-216.
33. Levine J.M., Reynolds R. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp. Neurol. 1999, 160:333-347.
34. Linington C., Berger T., Perry L., Weerth S., Hinze-Selch D., Zhang Y., Lu H.C., Lassmann H., Wekerle H. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol. 1993, 23:1364-1372.
35. Liu Y.M., Liu X.J., Bai S.S. The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis. J. Neuroimmunol. 2010, 25:25-33.
36. Li W.J., Pan S.Q., Zeng Y.S., Su B.G., Li S.M., Ding Y., Li Y., Ruan J.W. Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury. Neurosci. Res. 2010, 67:307-316.
37. McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 1998, 18:5354-5365.
38. McTigue D.M., Wei P., Stokes B.T. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J. Neurosci. 2001, 21:3392-3400.
39. Miller R.H. Oligodendrocyte origins. Trends Neurosci. 1996, 19:92-96.
40. Miller R.H., Bai L. Cellular approaches for stimulating CNS remyelination. Regen. Med. 2007, 2:817-829.
41. Owens T. Animal models for multiple sclerosis. Adv. Neurol. 2006, 98:77-89.
42. Patel N., Poo M.M. Orientation of neurite growth by extracellular electric fields. J. Neurosci. 1982, 2:483-496.
43. Patel N., Poo M.M. Perturbation of the direction of neurite growth by pulsed and focal electric fields. J. Neurosci. 1984, 4:2939-2947.
44. Patrikios P., Stadelmann C., Kutzelnigg A., Rauschka H., Schmidbauer M., Laursen H., Sorensen P.S., Bruck W., Lucchinetti C., Lassmann H. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006, 129:3165-3172.
45. Peterson J.W., Bo L., Mork S., Chang A., Trapp B.D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 2001, 50:389-400.
46. Prineas J.W., Barnard R.O., Kwon E.E., Sharer L.R., Cho E.S. Multiple sclerosis: remyelination of nascent lesions. Ann. Neurol. 1993, 33:137-151.
47. Raine C.S., Wu E. Multiple sclerosis: remyelination in acute lesions. J. Neuropathol. Exp. Neurol. 1993, 52:199-204.
48. Rubio N., Rodriguez R., Arevalo M.A. In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene. Glia 2004, 47:78-87.
49. Reynolds R., Dawson M., Papadopoulos D., Polito A., Di Bello I.C., Pham-Dinh D., Levine J. The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS. J. Neurocytol. 2002, 31:523-536.
50. Saini H.S., Gorse K.M., Boxer L.M., Sato-Bigbee C. Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells. J. Neurochem. 2004, 89:951-961.
51. Smith K.J., Blakemore W.F., McDonald W.I. Central remyelination restores secure conduction. Nature 1979, 280:395-396.
52. Storch M.K., Stefferl A., Brehm U., Weissert R., Wallstrom E., Kerschensteiner M., Olsson T., Linington C., Lassmann H. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 1998, 8:681-694.
53. Talbott J.F., Loy D.N., Liu Y., Qiu M.S., Bunge M.B., Rao M.S., Whittemore S.R. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp. Neurol. 2005, 192:11-24.
54. Tjon Eng Soe S.H., Kopsky D.J., Jongen P.J., de Vet H.C., Oei-Tan C.L. Multiple sclerosis patients with bladder dysfunction have decreased symptoms after electro-acupuncture. Mult. Scler. 2009, 15:1376-1377.
55. Trapp B.D., Bo L., Mork S., Chang A. Pathogenesis of tissue injury in MS lesions. J. Neuroimmunol. 1999, 98:49-56.
56. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mörk S., Bö L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 1998, 338:278-285.
57. Tsunoda I., Kuang L.Q., Theil D.J., Fujinami R.S. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol. 2000, 10:402-418.
58. Wang T.H., Wang X.Y., Li X.L., Chen H.M., Wu L.F. Effect of electroacupuncture on neurotrophin expression in cat spinal cord after partial dorsal rhizotomy. Neurochem. Res. 2007, 32:1415-1422.
59. Wang J.M., Zeng Y.S., Liu R.Y., Huang W.L., Xiong Y., Wang Y.H., Chen S.J., Teng Y.D. Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells. Exp. Neurol. 2007, 203:123-127.
60. Watanabe M., Hadzic T., Nishiyama A. Transient up-regulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination. Glia 2004, 46:311-322.
61. Zhang Y.Q., Zeng X., He L.M., Ding Y., Li Y., Zeng Y.S. NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. Anat. Sci. Int. 2010, 85:61-67.
62. Yan H., Wood P.M. NT-3 weakly stimulates proliferation of adult rat O1(-) O4(+) oligodendrocyte-lineage cells and increases oligodendrocyte myelination in vitro. J. Neurosci. Res. 2000, 62:329-335.
63. Yan Q., Ruan J.W., Ding Y., Li W.J., Li Y., Zeng Y.S. Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibres and partial functional recovery after spinal cord injury. Exp. Toxicol. Pathol. 2011, 63:151-156.