Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l

Developmental Neurobiology

Volumn 68, Issue 4, 2008, Pages 521-541

  Llorens, Franc ^a   Gil, Vanesa ^b,c   Iraola, Susana ^a   Carim Todd, Laura ^a,d   Martí, Eulàlia ^a   Estivill, Xavier ^a   Soriano, Eduardo ^b,c   Del Rio, José Antonio ^b,c   Sumoy, Lauro ^a  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Lingo 1; Lrrn6A; Myt1l; NgR1; p75

Indexed keywords

LINGO 1 PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYT 11 PROTEIN; PROTEIN NOGO; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL CULTURE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; NORTHERN BLOTTING; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

EID: 40149100815     PISSN: 19328451     EISSN: 1932846X     Source Type: Journal    
DOI: 10.1002/dneu.20607     Document Type: Article

References (61)

1. Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, et al. 2007. The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics 0: M7000077–MCP200. Epub ahead of print.
2. Barrette B, Vallieres N, Dube M, Lacroix S. 2007. Expression profile of receptors for myelin‐associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system. Mol Cell Neurosci 34: 519–38.
3. Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, et al. 2003. Structure and axon outgrowth inhibitor binding of the Nogo‐66 receptor and related proteins. EMBO J 22: 3291–3302.
4. Bellefroid EJ, Bourguignon C, Hollemann T, Ma Q, Anderson DJ, Kintner C, Pieler T. 1996. X‐MyT1, a Xenopus C2HC‐type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87: 1191–1202.
5. Carim‐Todd L. 2004. Anàlisi transcripcional de 15q24‐q26: Caracterització d'un nou gen expressat al sistema límbic, LRRN6A/LERN1. In: Doctoral Thesis, Departament de Genètica. Barcelona, Spain: Universitat de Barcelona. p 205.
6. Carim‐Todd L, Escarceller M, Estivill X, Sumoy L. 2003. LRRN6A/LERN1 (leucine‐rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Eur J Neurosci 18: 3167–3182.
7. Chao MV. 1994. The p75 neurotrophin receptor. J Neurobiol 25: 1373–1385.
8. Chen Y, Aulia S, Li L, Tang BL. 2006. AMIGO and friends: An emerging family of brain‐enriched, neuronal growth modulating, type I transmembrane proteins with leucine‐rich repeats (LRR) and cell adhesion molecule motifs. Brain Res Rev 51: 265–274.
9. Chivatakarn O, Kaneko S, He Z, Tessier‐Lavigne M, Giger RJ. 2007. The Nogo‐66 receptor NgR1 is required only for the acute growth cone‐collapsing but not the chronic growth‐inhibitory actions of myelin inhibitors. J Neurosci 27: 7117–7124.
10. Eby MT, Jasmin A, Kumar A, Sharma K, Chaudhary PM. 2000. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c‐Jun N‐terminal kinase pathway and mediates caspase‐independent cell death. J Biol Chem 275: 15336–15342.
11. Filbin MT. 1996. The muddle with MAG. Mol Cell Neurosci 8: 84–92.
12. Fournier AE, GrandPre T, Strittmatter SM. 2001. Identification of a receptor mediating Nogo‐66 inhibition of axonal regeneration. Nature 409: 341–346.
13. Gil V, Nicolas O, Mingorance A, Urena JM, Tang BL, Hirata T, Saez‐Valero J, et al. 2006. Nogo‐A expression in the human hippocampus in normal aging and in Alzheimer disease. J Neuropathol Exp Neurol 65: 433–444.
14. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, et al. 1999. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98: 739–755.
15. Hunt D, Coffin RS, Anderson PN. 2002a. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. J Neurocytol 31: 93–120.
16. Hunt D, Mason MR, Campbell G, Coffin R, Anderson PN. 2002b. Nogo receptor mRNA expression in intact and regenerating CNS neurons. Mol Cell Neurosci 20: 537–552.
17. Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass‐Belt P, Sweigard H, et al. 2007. Inhibition of the leucine‐rich repeat protein LINGO‐1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci USA 104: 14430–14435.
18. Ji B, Li M, Wu WT, Yick LW, Lee X, Shao Z, Wang J, et al. 2006. LINGO‐1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. Mol Cell Neurosci 33: 311–320.
19. Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, et al. 2006. The neurite outgrowth inhibitor Nogo‐A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep 7: 1162–1167.
20. Josephson A, Trifunovski A, Scheele C, Widenfalk J, Wahlestedt C, Brene S, Olson L, et al. 2003. Activity‐induced and developmental downregulation of the Nogo receptor. Cell Tissue Res 311: 333–342.
21. Josephson A, Trifunovski A, Widmer HR, Widenfalk J, Olson L, Spenger C. 2002. Nogo‐receptor gene activity: Cellular localization and developmental regulation of mRNA in mice and humans. J Comp Neurol 453: 292–304.
22. Karnezis T, Mandemakers W, McQualter JL, Zheng B, Ho PP, Jordan KA, Murray BM, et al. 2004. The neurite outgrowth inhibitor Nogo A is involved in autoimmune‐mediated demyelination. Nat Neurosci 7: 736–744.
23. Kim JE, Li S, GrandPre T, Qiu D, Strittmatter SM. 2003. Axon regeneration in young adult mice lacking Nogo‐A/B. Neuron 38: 187–199.
24. Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD. 1997. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J Neurosci Res 50: 272–290.
25. Kim JG, Hudson LD. 1992. Novel member of the zinc finger superfamily: A C2‐HC finger that recognizes a glia‐specific gene. Mol Cell Biol 12: 5632–5639.
26. Lauren J, Airaksinen MS, Saarma M, Timmusk T. 2003. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci 24: 581–594.
27. Lee JK, Kim JE, Sivula M, Strittmatter SM. 2004. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci 24: 6209–6217.
28. Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, et al. 2007. NGF regulates the expression of axonal LINGO‐1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci 27: 220–225.
29. McGee AW, Yang Y, Fischer QS, Daw NW, Strittmatter SM. 2005. Experience‐driven plasticity of visual cortex limited by myelin and Nogo receptor. Science 309: 2222–2226.
30. Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, Wong WM, et al. 2007. LINGO‐1 antagonist promotes spinal cord remyelination and axonal integrity in MOG‐induced experimental autoimmune encephalomyelitis. Nat Med 13: 1228–1233.
31. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, et al. 2004. LINGO‐1 is a component of the Nogo‐66 receptor/p75 signaling complex. Nat Neurosci 7: 221–228.
32. Mi S, Miller RH, Lee X, Scott ML, Shulag‐Morskaya S, Shao Z, Chang J, et al. 2005. LINGO‐1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 8: 745–751.
33. Mingorance A, Fontana X, Sole M, Burgaya F, Urena JM, Teng FY, Tang BL, et al. 2004. Regulation of Nogo and Nogo receptor during the development of the entorhino‐hippocampal pathway and after adult hippocampal lesions. Mol Cell Neurosci 26: 34–49.
34. Mingorance A, Fontana X, Soriano E, Del Rio JA. 2005. Overexpression of myelin‐associated glycoprotein after axotomy of the perforant pathway. Mol Cell Neurosci 29: 471–483.
35. Mingorance‐Le Meur A, Zheng B, Soriano E, Del Rio JA. 2007. Involvement of the myelin‐associated inhibitor Nogo‐A in early cortical development and neuronal maturation. Cereb Cortex 17: 2375–2386.
36. Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, et al. 2006. The structure of the Lingo‐1 ectodomain, a module implicated in CNS repair inhibition. J Biol Chem 281: 36378–36390.
37. Nie DY, Ma QH, Law JW, Chia CP, Dhingra NK, Shimoda Y, Yang WL, et al. 2006. Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp. Neuron Glia Biol 2: 151–164.
38. Novak G, Tallerico T. 2006. Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3′‐UTR. Brain Res 1120: 161–171.
39. Okafuji T, Tanaka H. 2005. Expression pattern of LINGO‐1 in the developing nervous system of the chick embryo. Gene Expr Patterns 6: 57–62.
40. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL, Garcia KC, et al. 2005. A TNF receptor family member. TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 45: 345–351.
41. Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH, et al. 2006. Alzheimer precursor protein interaction with the Nogo‐66 receptor reduces amyloid‐beta plaque deposition. J Neurosci 26: 1386–1395.
42. Pignot V, Hein AE, Barske C, Wiessner C, Walmsley AR, Kaupmann K, Mayeur H, et al. 2003. Characterization of two novel proteins. Ng RH1 and Ng RH2, structurally and biochemically homologous to the Nogo‐66 receptor. J Neurochem 85: 717–728.
43. Rossi FM, Sala R, Maffei L. 2002. Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat: Development and regulation by the cholinergic input. J Neurosci 22: 912–919.
44. Rutherford LC, DeWan A, Lauer HM, Turrigiano GG. 1997. Brain‐derived neurotrophic factor mediates the activity‐dependent regulation of inhibition in neocortical cultures. J Neurosci 17: 4527–4535.
45. Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H. 2007. TROY and LINGO‐1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Neuropathol Appl Neurobiol 33: 99–107.
46. Shao Z, Browning JL, Lee X, Scott ML, Shulga‐Morskaya S, Allaire N, Thill G, et al. 2005. TAJ/TROY, an orphan TNF receptor family member, binds Nogo‐66 receptor 1 and regulates axonal regeneration. Neuron 45: 353–359.
47. Simonen M, Pedersen V, Weinmann O, Schnell L, Buss A, Ledermann B, Christ F, et al. 2003. Systemic deletion of the myelin‐associated outgrowth inhibitor Nogo‐A improves regenerative and plastic responses after spinal cord injury. Neuron 38: 201–211.
48. Strittmatter SM. 2002. Modulation of axonal regeneration in neurodegenerative disease: Focus on Nogo. J Mol Neurosci 19: 117–121.
49. Teng FY, Tang BL. 2005. Nogo signaling and non‐physical injury‐induced nervous system pathology. J Neurosci Res 79: 273–278.
50. Trifunovski A, Josephson A, Ringman A, Brene S, Spenger C, Olson L. 2004. Neuronal activity‐induced regulation of Lingo‐1. Neuroreport 15: 2397–2400.
51. Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, et al. 2005. The Nogo‐66 receptor homolog NgR2 is a sialic acid‐dependent receptor selective for myelin‐associated glycoprotein. J Neurosci 25: 808–822.
52. Venkatesh K, Chivatakarn O, Sheu SS, Giger RJ. 2007. Molecular dissection of the myelin‐associated glycoprotein receptor complex reveals cell type‐specific mechanisms for neurite outgrowth inhibition. J Cell Biol 177: 393–399.
53. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. 2006. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124: 573–586.
54. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. 2002. P75 interacts with the Nogo receptor as a co‐receptor for Nogo. MAG and OMgp. Nature 420: 74–78.
55. Weiner JA, Chun J. 1997. Png‐1, a nervous system‐specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J Comp Neurol 381: 130–142.
56. Wong ST, Henley JR, Kanning KC, Huang KH, Bothwell M, Poo MM. 2002. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin‐associated glycoprotein. Nat Neurosci 5: 1302–1308.
57. Wrathall JR, Li W, Hudson LD. 1998. Myelin gene expression after experimental contusive spinal cord injury. J Neurosci 18: 8780–8793.
58. Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F. 2005. Multiple signals regulate axon regeneration through the nogo receptor complex. Mol Neurobiol 32: 105–111.
59. Yamashita T, Tohyama M. 2003. The p75 receptor acts as a displacement factor that releases Rho from Rho‐GDI. Nat Neurosci 6: 461–467.
60. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, et al. 2005. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci USA 102: 1205–1210.
61. Zheng B, Ho C, Li S, Keirstead H, Steward O, Tessier‐Lavigne M. 2003. Lack of enhanced spinal regeneration in Nogo‐deficient mice. Neuron 38: 213–224.