Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination

Brain

Volumn 120, Issue 1, 1997, Pages 27-37

  Jeffery, N D ^b,c   Blakemore, W F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

Behaviour; Demyelination; Experimental; Remyelination; Spinal cord

Indexed keywords

ETHIDIUM BROMIDE; GLIOTOXIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; DEMYELINATION; ELECTROPHYSIOLOGY; FEMALE; LOCOMOTION; MOTOR DYSFUNCTION; MULTIPLE SCLEROSIS; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; REMYELINIZATION; SPINAL CORD LESION; X RAY;

ANIMALS; DEMYELINATING DISEASES; ETHIDIUM; FEMALE; LOCOMOTION; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; SPINAL CORD; SPINAL CORD DISEASES;

EID: 0031050183     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/120.1.27     Document Type: Article

References (48)

1. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
2. Bernstein JJ, Goldberg WJ. Grafted fetal astrocyte migration can prevent host neuronal atrophy: comparison of astrocytes from cultures and whole piece donors. Rest Neurol Neurosci 1991; 2: 261-70.
3. Black JA, Felts P, Smith KJ, Kocsis JD, Waxman SG. Distribution of sodium channels in chronically demyelinated spinal cord axons: immuno-ultrastructural localization and electrophysiological observations. Brain Res 1991; 544: 59-70.
4. Blakemore WF. Ethidium bromide induced demyelination in the spinal cord of the cat. Neuropathol Appl Neurobiol 1982; 8: 365-75.
5. Blakemore WF, Patterson RC. Suppression of remyelination in the CNS by X-irradiation. Acta Neuropathol (Berl) 1978; 42: 105-13.
6. Blakemore WF, Crang AJ, Franklin RJM. Transplantation of glial cells. In: Kettenmann H, Ransom BR, editors. Neuroglia. New York: Oxford University Press, 1995: 869-82.
7. Blakemore WF, Franklin RJM, Noble M. Glial cell transplantation and the repair of demyelinating lesions. In: Jessen KR, Richardson WD, editors. Glial cell development: basic principles and clinical relevance. Oxford: BIOS Scientific, 1996: 209-20.
8. Bostock H, Sears TA. Continuous conduction in demyelinated mammalian nerve fibers. Nature 1976; 263: 786-7.
9. Castro AJ. Motor performance in rats. The effects of pyramidal tract section. Brain Res 1972; 44: 313-23.
10. Christie MA, Dalrymple-Alford JC. Behavioural consequences of frontal cortex grafts and enriched environments after sensorimotor cortex lesions. J Neural Transplant Plast 1995; 5: 199-210.
11. Davidoff RA. The dorsal columns [see comments]. [Review]. Neurology 1989; 39: 1377-85. Comment in: Neurology 1990; 40: 1007.
12. Davidoff RA. The dorsal columns [see comments]. [Review]. Neurology 1989; 39: 1377-85. Comment in: Neurology 1990; 40: 1007.
13. Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, et al. A fluid percussion model of experimental brain injury in the rat. J Neurosurg 1987; 67: 110-19.
14. Dubrovsky B, Davelaar E, Garcia-Rill E. The role of dorsal columns in serial order acts. Exp Neurol 1971; 33: 93-102.
15. + channels and node of Ranvier formation in remyelinating axons. J Neurosci 1995; 15: 492-503.
16. Eidelberg E, Woolf B, Kreinick CJ, Davis F. Role of the dorsal funiculi in movement control. Brain Res 1976; 114: 427-38.
17. Feeney DM, Gonzalez A, Law WA. Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 1982; 217: 855-7.
18. Felts PA, Smith KJ. Conduction properties of central nerve fibers remyelinated by Schwann cells. Brain Res 1992; 574: 178-92.
19. Franklin RJM. Reconstructing myelin-deficient environments in the CNS by glial cell transplantation. Semin Neurosci 1993; 5: 443-51.
20. Gale K, Kerasidis H, Wrathall JR. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp Neurol 1985; 88: 123-34.
21. Ganchrow D, Margolin JK, Bernstein JJ. Component analysis of hind limb behavioral alterations after damage to the rat dorsal funiculus. Exp Neurol 1980; 70: 339-55.
22. Glendinning DS, Vierck CJ Jr. Lack of a proprioceptive deficit after dorsal column lesions in monkeys. Neurology 1993; 43: 363-6.
23. Graça DL. Investigation into ethidium bromide induced demyelination in the central nervous system [PhD thesis]. Cambridge: University of Cambridge, 1986.
24. Graça DL, Blakemore WF. Delayed remyelination in rat spinal cord following ethidium bromide injection. Neuropathol Appl Neurobiol 1986; 12: 593-605.
25. Harris RM, Little JW, Goldstein B. Spared descending pathways mediate locomotor recovery after subtotal spinal cord injury. Neurosci Lett 1994; 180: 37-40.
26. Helgren ME, Goldberger ME. The recovery of postural reflexes and locomotion following low thoracic hemisection in adult cats involves compensation by undamaged primary afferent pathways. Exp Neurol 1993; 123: 17-34.
27. Honmou O, Felts PA, Waxman SG, Kocsis JD. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells. J Neurosci 1996; 16: 3199-208.
28. Jeffery ND, Olby NJ, Blakemore WF. Evaluation of behavioural consequences of experimental infarction of the rat dorsal funiculus [abstract]. J Neurotrauma 1995; 12: 446.
29. Kalderon N, Altieri AA, Fuks Z. Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue. Proc Natl Acad Sci USA 1990; 87: 10058-62.
30. Kalil K, Schneider GE. Motor performance following unilateral pyramidal tract lesions in the hamster. Brain Res 1975; 100: 170-4.
31. Kerasidis H, Wrathall JR, Gale K. Behavioral assessment of functional deficit in rats with contusive spinal cord injury. J Neurosci Methods 1987; 20: 167-79.
32. Kunkel-Bagden E, Dai HN, Bregman BS. Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp Neurol 1993; 119: 153-64.
33. Mastaglia FL, McDonald WI, Watson JV, Yogendran K. Effects of x-radiation on the spinal cord: an experimental study of the morphological changes in central nerve fibres. Brain 1976; 99: 101-22.
34. Matthaei I, Polman CH, de Groot CJA, Dijkstra CD, Koetsier JC, Sminia T. Observer agreement in the assessment of clinical signs in experimental allergic encephalomyelitis. J Neuroimmunol 1989; 23: 25-8.
35. Melzack R, Bridges JA. Dorsal column contributions to motor behavior. Exp Neurol 1971; 33: 53-68.
36. Melzack R, Southmayd SE. Dorsal column contributions to anticipatory motor behavior. Exp Neurol 1974; 42: 274-81.
37. Reh T, Kalil K. Functional role of regrowing pyramidal tract fibers. J Comp Neurol 1982; 211: 276-283.
38. Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977; 47: 577-81.
39. Schrimsher GW, Reier PJ. Forelimb motor performance following dorsal column, dorsolateral funiculi, or ventrolateral funiculi lesions of the cervical spinal cord in the rat. Exp Neurol 1993; 120: 264-76.
40. Sims TJ, Gilmore SA. Regeneration of dorsal root axons into experimentally altered glial environments in the rat spinal cord. Exp Brain Res 1994; 99: 25-33.
41. Smith KJ. Conduction properties of central demyelinated and remyelinated axons, and their relation to symptom production in demyelinating disorders. [Review]. Eye 1994; 8: 224-37.
42. Smith KJ, Blakemore WF, McDonald WI. Central remyelination restores secure conduction. Nature 1979; 280: 395-6.
43. Smith KJ, Blakemore WF, McDonald WI. The restoration of conduction by central remyelination. Brain 1981; 104: 383-404.
44. Smith KJ, Bostock H, Hall SM. Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline. J Neurol Sci 1982; 54: 13-31.
45. Utzschneider DA, Archer DR, Kocsis JD, Waxman SG, Duncan ID. Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat. Proc Natl Acad Sci USA 1994; 91: 53-7.
46. Wall PD. The sensory and motor role of impulses travelling in the dorsal columns towards cerebral cortex. Brain 1970; 93: 505-24.
47. Waxman SG. Biophysical mechanisms of impulse conduction in demyelinated axons. In: Waxman SG, editor. Functional recovery in neurological disease. New York: Raven Press, 1988; 185-213.
48. Yezierski RP, Devon RM, Vicedomini JP, Broton JG. Effects of dorsal column demyelination on evoked potentials in nucleus gracilis. J Neurotrauma 1992; 9: 231-44.