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Volumn 12, Issue 6, 2012, Pages 686-696

Genetics of type 2 diabetes in east asian populations

Author keywords

Disease susceptibility locus; Ethnic populations; Genetic variant; Genetics; Genome wide association (GWA) study; HapMap; Meta Analysis; Type 2 diabetes

Indexed keywords

ARTICLE; BODY MASS; DISEASE PREDISPOSITION; EAST ASIAN; EPIGENETICS; ETHNIC DIFFERENCE; ETHNIC GROUP; EUROPEAN; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PHENOTYPE; POPULATION RESEARCH; PREVALENCE; PROTEIN FUNCTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84870702024     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0326-z     Document Type: Article
Times cited : (51)

References (87)
  • 2
    • 77649336781 scopus 로고    scopus 로고
    • Global healthcare expenditure on diabetes for 2010 and 2030
    • Zhang P, Zhang X, Brown J, et al. Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87 (3):293-301.
    • (2010) Diabetes Res Clin Pract , vol.87 , Issue.3 , pp. 293-301
    • Zhang, P.1    Zhang, X.2    Brown, J.3
  • 3
    • 66149131064 scopus 로고    scopus 로고
    • Diabetes in asia: Epidemiology, risk factors, and pathophysiology. Jama
    • This review rovides a thorough descrition on the eidemiology of tye 2 diabetes in ouations in East Asian ancestry grous
    • Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA: J Am Med Assoc. 2009;301(20):2129-40. This review provides a thorough description on the epidemiology of type 2 diabetes in popuations in East Asian ancestry groups.
    • (2009) J Am Med Assoc , vol.301 , Issue.20 , pp. 2129-2140
    • Chan, J.C.1    Malik, V.2    Jia, W.3
  • 4
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: The role of diet, lifestyle, and genes
    • Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249-57.
    • (2011) Diabetes Care , vol.34 , Issue.6 , pp. 1249-1257
    • Hu, F.B.1
  • 5
    • 79951719256 scopus 로고    scopus 로고
    • Trends in the prevalence of type 2 diabetes in asians versus whites: Results from the united states national health interview survey 1997-2008
    • Lee JW, Brancati FL, Yeh HC. Trends in the prevalence of type 2 diabetes in Asians versus whites: results from the United States national health interview survey, 1997-2008. Diabetes Care. 2011;34(2):353-7.
    • (2011) Diabetes Care , vol.34 , Issue.2 , pp. 353-357
    • Lee, J.W.1    Brancati, F.L.2    Yeh, H.C.3
  • 6
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing C
    • International Human Genome Sequencing C. Finishing the euchromatic sequence of the human genome. Nature. 2004;431 (7011):931-45.
    • (2004) Nature , vol.431 , Issue.7011 , pp. 931-945
  • 7
    • 77953064009 scopus 로고    scopus 로고
    • Detecting undiagnosed type 2 diabetes: Family history as a risk factor and screening tool
    • Valdez R. Detecting undiagnosed type 2 diabetes: family history as a risk factor and screening tool. J Diabetes Sci Technol. 2009;3 (4):722-6.
    • (2009) J Diabetes Sci Technol , vol.3 , Issue.4 , pp. 722-726
    • Valdez, R.1
  • 8
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type ii (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-A population-based twin study
    • Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-A population-based twin study. Diabetologia. 1999;42(2):139-45.
    • (1999) Diabetologia , vol.42 , Issue.2 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 9
    • 0033624575 scopus 로고    scopus 로고
    • The common ppargamma pro12ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 2000;26(1):76-80.
    • (2000) Nat Genet , vol.26 , Issue.1 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 10
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell katp channel subunits kir6.2 (kcnj11) and sur1 (abcc8) confirm that the kcnj11 e23k variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes. 2003;52(2):568-72.
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3
  • 11
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (tcf7l2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38(3):320-3.
    • (2006) Nat Genet , vol.38 , Issue.3 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 12
    • 34547536393 scopus 로고    scopus 로고
    • Common variants in wfs1 confer risk of type 2 diabetes
    • Sandhu MS, Weedon MN, Fawcett KA, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet. 2007;39(8):951-3.
    • (2007) Nat Genet , vol.39 , Issue.8 , pp. 951-953
    • Sandhu, M.S.1    Weedon, M.N.2    Fawcett, K.A.3
  • 13
    • 34547510624 scopus 로고    scopus 로고
    • Two variants on chromosome 17 confer prostate cancer risk, and the one in tcf2 protects against type 2 diabetes
    • Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007;39(8):977-83.
    • (2007) Nat Genet , vol.39 , Issue.8 , pp. 977-983
    • Gudmundsson, J.1    Sulem, P.2    Steinthorsdottir, V.3
  • 14
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International
    • International HapMap C. A haplotype map of the human genome. Nature. 2005;437(7063):1299-320.
    • (2005) Nature , vol.437 , Issue.7063 , pp. 1299-1320
    • HapMap, C.1
  • 15
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of H, Mit LU, Novartis Institutes of BioMedical R, et al
    • Diabetes Genetics Initiative of Broad Institute of H, Mit LU, Novartis Institutes of BioMedical R, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316(5829):1331- 6.
    • (2007) Science , vol.316 , Issue.5829 , pp. 1331-1336
  • 16
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in uk samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316(5829):1336-41.
    • (2007) Science , vol.316 , Issue.5829 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 17
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316(5829):1341-5.
    • (2007) Science , vol.316 , Issue.5829 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 18
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445(7130):881-5.
    • (2007) Nature , vol.445 , Issue.7130 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 19
    • 70349557826 scopus 로고    scopus 로고
    • Genetic variant near irs1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    • Rung J, Cauchi S, Albrechtsen A, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009;41(10):1110-5.
    • (2009) Nat Genet , vol.41 , Issue.10 , pp. 1110-1115
    • Rung, J.1    Cauchi, S.2    Albrechtsen, A.3
  • 20
    • 77954172286 scopus 로고    scopus 로고
    • Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    • Qi L, Cornelis MC, Kraft P, et al. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 2010;19(13):2706-15.
    • (2010) Hum Mol Genet , vol.19 , Issue.13 , pp. 2706-2715
    • Qi, L.1    Cornelis, M.C.2    Kraft, P.3
  • 21
    • 72449122779 scopus 로고    scopus 로고
    • Parental origin of sequence variants associated with complex diseases
    • Kong A, Steinthorsdottir V, Masson G, et al. Parental origin of sequence variants associated with complex diseases. Nature. 2009;462(7275):868-74.
    • (2009) Nature , vol.462 , Issue.7275 , pp. 868-874
    • Kong, A.1    Steinthorsdottir, V.2    Masson, G.3
  • 22
    • 50449085998 scopus 로고    scopus 로고
    • Variants in kcnq1 are associated with susceptibility to type 2 diabetes mellitus
    • This article reorts genome-wide association results for tye 2 diabetes first erformed in East Asian oulations
    • Yasuda K, Miyake K, Horikawa Y, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genet. 2008;40(9):1092-7. This article reports genome-wide association results for type 2 diabetes first performed in East Asian populations.
    • (2008) Nature Genet , vol.40 , Issue.9 , pp. 1092-1097
    • Yasuda, K.1    Miyake, K.2    Horikawa, Y.3
  • 23
    • 50449085212 scopus 로고    scopus 로고
    • Snps in kcnq1 are associated with susceptibility to type 2 diabetes in east asian and european populations
    • This article reorts genome-wide association results for tye 2 diabetes first erformed in East Asian oulations
    • Unoki H, Takahashi A, Kawaguchi T, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genet. 2008;40(9):1098-102. This article reports genome-wide association results for type 2 diabetes first performed in East Asian populations.
    • (2008) Nature Genet , vol.40 , Issue.9 , pp. 1098-1102
    • Unoki, H.1    Takahashi, A.2    Kawaguchi, T.3
  • 24
    • 77957553197 scopus 로고    scopus 로고
    • A genome-wide association study in the japanese population identifies susceptibility loci for type 2 diabetes at ube2e2 and c2cd4a-c2cd4b
    • Yamauchi T, Hara K, Maeda S, et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet. 2010;42(10):864-8.
    • (2010) Nat Genet , vol.42 , Issue.10 , pp. 864-868
    • Yamauchi, T.1    Hara, K.2    Maeda, S.3
  • 25
    • 77649214654 scopus 로고    scopus 로고
    • A genome-wide association study identifies susceptibility variants for type 2 diabetes in han chinese
    • Tsai FJ, Yang CF, Chen CC, et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010;6(2):e1000847.
    • (2010) PLoS Genet , vol.6 , Issue.2
    • Tsai, F.J.1    Yang, C.F.2    Chen, C.C.3
  • 26
    • 78049438674 scopus 로고    scopus 로고
    • Identification of new genetic risk variants for type 2 diabetes
    • Shu XO, Long J, Cai Q, et al. Identification of new genetic risk variants for type 2 diabetes. PLoS genetics. Sep 2010;6(9).
    • (2010) PLoS genetics. Sep , vol.6 , pp. 9
    • Shu, X.O.1    Long, J.2    Cai, Q.3
  • 27
    • 80053385333 scopus 로고    scopus 로고
    • Genome-wide association study in individuals of south asian ancestry identifies six new type 2 diabetes susceptibility loci
    • Kooner JS, Saleheen D, Sim X, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43(10):984-9.
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 984-989
    • Kooner, J.S.1    Saleheen, D.2    Sim, X.3
  • 28
    • 79960905856 scopus 로고    scopus 로고
    • Genome-wide association study of type 2 diabetes in a sample from mexico city and a meta-Analysis of a mexican-American sample from starr county texas
    • Parra EJ, Below JE, Krithika S, et al. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-Analysis of a Mexican-American sample from Starr County, Texas. Diabetologia. 2011;54(8):2038-46.
    • (2011) Diabetologia , vol.54 , Issue.8 , pp. 2038-2046
    • Parra, E.J.1    Below, J.E.2    Krithika, S.3
  • 29
    • 79960923810 scopus 로고    scopus 로고
    • Genome-wide association and meta-Analysis in populations from starr county texas and mexico city identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals
    • Below JE, Gamazon ER, Morrison JV, et al. Genome-wide association and meta-Analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia. 2011;54(8):2047-55.
    • (2011) Diabetologia , vol.54 , Issue.8 , pp. 2047-2055
    • Below, J.E.1    Gamazon, E.R.2    Morrison, J.V.3
  • 30
    • 84855405312 scopus 로고    scopus 로고
    • A genome-wide association search for type 2 diabetes genes in african americans
    • Palmer ND, McDonough CW, Hicks PJ, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012;7(1):e29202.
    • (2012) PLoS One , vol.7 , Issue.1
    • Palmer, N.D.1    McDonough, C.W.2    Hicks, P.J.3
  • 31
    • 42349106044 scopus 로고    scopus 로고
    • Meta-Analysis of genomewide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E, Scott LJ, Saxena R, et al. Meta-Analysis of genomewide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40 (5):638-45.
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3
  • 32
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • Voight BF, Scott LJ, Steinthorsdottir V, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42(7):579-89.
    • (2010) Nat Genet , vol.42 , Issue.7 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 33
    • 84655162045 scopus 로고    scopus 로고
    • Meta-Analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east asians
    • This article provides a number of association results for type 2 diabetes from the largest GWA meta-Analysis in genetic studies that has ever been performed in East Asian popultions
    • Cho YS, Chen CH, Hu C, et al. Meta-Analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nature Genet. 2012;44(1):67-72. This article provides a number of association results for type 2 diabetes from the largest GWA meta-Analysis in genetic studies that has ever been performed in East Asian popultions.
    • (2012) Nature Genet , vol.44 , Issue.1 , pp. 67-72
    • Cho, Y.S.1    Chen, C.H.2    Hu, C.3
  • 34
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42(2):105-16.
    • (2010) Nat Genet , vol.42 , Issue.2 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 36
    • 78649468820 scopus 로고    scopus 로고
    • The genetics of type 2 diabetes: What have we learned from gwas?
    • Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci. 2010;1212:59-77.
    • (2010) Ann N Y Acad Sci , vol.1212 , pp. 59-77
    • Billings, L.K.1    Florez, J.C.2
  • 37
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010;363(24):2339-50.
    • (2010) N Engl J Med , vol.363 , Issue.24 , pp. 2339-2350
    • McCarthy, M.I.1
  • 38
    • 79960016921 scopus 로고    scopus 로고
    • Type 2 diabetes and obesity: Genomics and the clinic
    • Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum Genet. 2011;130(1):41-58.
    • (2011) Hum Genet , vol.130 , Issue.1 , pp. 41-58
    • Travers, M.E.1    McCarthy, M.I.2
  • 39
    • 0029952101 scopus 로고    scopus 로고
    • V LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current
    • Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature. 1996;384(6604):78-80.
    • (1996) Nature , vol.384 , Issue.6604 , pp. 78-80
    • Barhanin, J.1    Lesage, F.2    Guillemare, E.3    Fink, M.4    Lazdunski, M.5    Romey, G.K.6
  • 40
    • 28344448471 scopus 로고    scopus 로고
    • Effects of i(ks) channel inhibitors in insulin-secreting ins-1 cells. Pflugers archiv
    • Ullrich S, Su J, Ranta F, et al. Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Archiv: Eur J Physiol. 2005;451(3):428-36.
    • (2005) Eur J Physiol , vol.451 , Issue.3 , pp. 428-436
    • Ullrich, S.1    Su, J.2    Ranta, F.3
  • 41
    • 0030705226 scopus 로고    scopus 로고
    • Cdna cloning, characterization, and chromosome mapping of ube2e2 encoding a human ubiquitin-conjugating e2 enzyme
    • Kimura M, Hattori T, Matsuda Y, et al. cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. Cytogenet Cell Genet. 1997;78 (2):107-11.
    • (1997) Cytogenet Cell Genet , vol.78 , Issue.2 , pp. 107-111
    • Kimura, M.1    Hattori, T.2    Matsuda, Y.3
  • 42
    • 58249108069 scopus 로고    scopus 로고
    • Emerging roles for the ubiquitinproteasome system and autophagy in pancreatic beta-cells
    • Hartley T, Brumell J, Volchuk A. Emerging roles for the ubiquitinproteasome system and autophagy in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2009;296(1):E1-10.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , Issue.1
    • Hartley, T.1    Brumell, J.2    Volchuk, A.3
  • 43
    • 18144363161 scopus 로고    scopus 로고
    • Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells
    • Kitiphongspattana K, Mathews CE, Leiter EH, Gaskins HR. Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells. J Biol Chem. 2005;280 (16):15727-34.
    • (2005) J Biol Chem , vol.280 , Issue.16 , pp. 15727-15734
    • Kitiphongspattana, K.1    Mathews, C.E.2    Leiter, E.H.3    Gaskins, H.R.4
  • 44
    • 33744965755 scopus 로고    scopus 로고
    • Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion
    • Kawaguchi M, Minami K, Nagashima K, Seino S. Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion. J Biol Chem. 2006;281(19):13015-20.
    • (2006) J Biol Chem , vol.281 , Issue.19 , pp. 13015-13020
    • Kawaguchi, M.1    Minami, K.2    Nagashima, K.3    Seino, S.4
  • 46
    • 7644220322 scopus 로고    scopus 로고
    • A novel gene family induced by acute inflammation in endothelial cells
    • Warton K, Foster NC, Gold WA, Stanley KK. A novel gene family induced by acute inflammation in endothelial cells. Gene. 2004;342(1):85-95.
    • (2004) Gene , vol.342 , Issue.1 , pp. 85-95
    • Warton, K.1    Foster, N.C.2    Gold, W.A.3    Stanley, K.K.4
  • 47
    • 0031594367 scopus 로고    scopus 로고
    • Transgenic mice deficient in the lar protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis
    • Ren JM, Li PM, Zhang WR, et al. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. Diabetes. 1998;47(3):493-7.
    • (1998) Diabetes , vol.47 , Issue.3 , pp. 493-497
    • Ren, J.M.1    Li, P.M.2    Zhang, W.R.3
  • 48
    • 33845423553 scopus 로고    scopus 로고
    • Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma
    • Chagnon MJ, Elchebly M, Uetani N, et al. Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma. Can J Physiol Pharmacol. 2006;84(7):755-63.
    • (2006) Can J Physiol Pharmacol , vol.84 , Issue.7 , pp. 755-763
    • Chagnon, M.J.1    Elchebly, M.2    Uetani, N.3
  • 49
    • 0036137813 scopus 로고    scopus 로고
    • Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigmadeficient mice
    • Batt J, Asa S, Fladd C, Rotin D. Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigmadeficient mice. Mol Endocrinol. 2002;16(1):155-69.
    • (2002) Mol Endocrinol , vol.16 , Issue.1 , pp. 155-169
    • Batt, J.1    Asa, S.2    Fladd, C.3    Rotin, D.4
  • 50
    • 0035942161 scopus 로고    scopus 로고
    • Overexpression of the lar (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance
    • Zabolotny JM, Kim YB, Peroni OD, et al. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A. 2001;98(9):5187-92.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5187-5192
    • Zabolotny, J.M.1    Kim, Y.B.2    Peroni, O.D.3
  • 51
    • 0033582230 scopus 로고    scopus 로고
    • Purification of serine racemase: Biosynthesis of the neuromodulator d-serine
    • Wolosker H, Sheth KN, Takahashi M, et al. Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A. 1999;96(2):721-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.2 , pp. 721-725
    • Wolosker, H.1    Sheth, K.N.2    Takahashi, M.3
  • 52
    • 0028275894 scopus 로고
    • Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line min6
    • Gonoi T, Mizuno N, Inagaki N, et al. Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6. J Biol Chem. 1994;269(25):16989-92.
    • (1994) J Biol Chem , vol.269 , Issue.25 , pp. 16989-16992
    • Gonoi, T.1    Mizuno, N.2    Inagaki, N.3
  • 53
    • 0029078886 scopus 로고
    • Expression and role of ionotropic glutamate receptors in pancreatic islet cells
    • Inagaki N, Kuromi H, Gonoi T, et al. Expression and role of ionotropic glutamate receptors in pancreatic islet cells. FASEB J: Off Publ Fed Am Soc Exp Biol. 1995;9(8):686-91.
    • (1995) FASEB J: Off Publ Fed Am Soc Exp Biol , vol.9 , Issue.8 , pp. 686-691
    • Inagaki, N.1    Kuromi, H.2    Gonoi, T.3
  • 54
    • 41049103244 scopus 로고    scopus 로고
    • Sprouty proteins, masterminds of receptor tyrosine kinase signaling
    • Cabrita MA, Christofori G. Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis. 2008;11(1):53-62.
    • (2008) Angiogenesis , vol.11 , Issue.1 , pp. 53-62
    • Cabrita, M.A.1    Christofori, G.2
  • 55
    • 0036105451 scopus 로고    scopus 로고
    • Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase tesk1
    • Leeksma OC, Van Achterberg TA, Tsumura Y, et al. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Eur J Biochem /FEBS. 2002;269 (10):2546-56.
    • (2002) Eur J Biochem /FEBS , vol.269 , Issue.10 , pp. 2546-2556
    • Leeksma, O.C.1    Van Achterberg, T.A.2    Tsumura, Y.3
  • 56
    • 40949146033 scopus 로고    scopus 로고
    • Modulation of endocrine pancreas development but not beta-cell carcinogenesis by sprouty4
    • Jaggi F, Cabrita MA, Perl AK, Christofori G. Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4. Mol Cancer Res: MCR. 2008;6(3):468-82.
    • (2008) Mol Cancer Res: MCR , vol.6 , Issue.3 , pp. 468-482
    • Jaggi, F.1    Cabrita, M.A.2    Perl, A.K.3    Christofori, G.4
  • 57
    • 7244260481 scopus 로고    scopus 로고
    • Cdc123 and checkpoint forkhead associated with ring proteins control the cell cycle by controlling eif2gamma abundance
    • Bieganowski P, Shilinski K, Tsichlis PN, Brenner C. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. J Biol Chem. 2004;279(43):44656-66.
    • (2004) J Biol Chem , vol.279 , Issue.43 , pp. 44656-44666
    • Bieganowski, P.1    Shilinski, K.2    Tsichlis, P.N.3    Brenner, C.4
  • 58
    • 71949099797 scopus 로고    scopus 로고
    • Transcription factor glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    • Kang HS, Kim YS, ZeRuth G, et al. Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009;29 (24):6366-79.
    • (2009) Mol Cell Biol , vol.29 , Issue.24 , pp. 6366-6379
    • Kang, H.S.1    Kim, Y.S.2    ZeRuth, G.3
  • 59
    • 65849094299 scopus 로고    scopus 로고
    • The kruppel-like zinc finger protein glis3 directly and indirectly activates insulin gene transcription
    • Yang Y, Chang BH, Samson SL, Li MV, Chan L. The Kruppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 2009;37(8):2529-38.
    • (2009) Nucleic Acids Res , vol.37 , Issue.8 , pp. 2529-2538
    • Yang, Y.1    Chang, B.H.2    Samson, S.L.3    Li, M.V.4    Chan, L.5
  • 60
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-Analysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, et al. Genome-wide association study and meta-Analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41(6):703-7.
    • (2009) Nat Genet , vol.41 , Issue.6 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 61
    • 0034811143 scopus 로고    scopus 로고
    • Genomic and functional characteristics of novel human pancreatic 2p domain k(+) channels
    • Girard C, Duprat F, Terrenoire C, et al. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem Biophys Res Commun. 2001;282(1):249-56.
    • (2001) Biochem Biophys Res Commun , vol.282 , Issue.1 , pp. 249-256
    • Girard, C.1    Duprat, F.2    Terrenoire, C.3
  • 62
    • 21744438286 scopus 로고    scopus 로고
    • The trans- golgi network grip-domain proteins form alpha-helical homodimers
    • Luke MR, Houghton F, Perugini MA, Gleeson PA. The trans- Golgi network GRIP-domain proteins form alpha-helical homodimers. Biochem J. 2005;388(Pt 3):835-41.
    • (2005) Biochem J , vol.388 , Issue.PART 3 , pp. 835-841
    • Luke, M.R.1    Houghton, F.2    Perugini, M.A.3    Gleeson, P.A.4
  • 63
    • 79251489130 scopus 로고    scopus 로고
    • A novel pax4 mutation in a japanese patient with maturity-onset diabetes of the young
    • Jo W, Endo M, Ishizu K, Nakamura A, Tajima T. A novel PAX4 mutation in a Japanese patient with maturity-onset diabetes of the young. Tohoku J Exp Med. 2011;223(2):113-8.
    • (2011) Tohoku J Exp Med , vol.223 , Issue.2 , pp. 113-118
    • Jo, W.1    Endo, M.2    Ishizu, K.3    Nakamura, A.4    Tajima, T.5
  • 64
    • 0030485089 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4 alpha gene mutations in japanese non-insulin dependent diabetes mellitus (niddm) patients
    • Nakajima H, Yoshiuchi I, Hamaguchi T, et al. Hepatocyte nuclear factor-4 alpha gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients. Res Commun Mol Pathol Pharmacol. 1996;94(3):327-30.
    • (1996) Res Commun Mol Pathol Pharmacol , vol.94 , Issue.3 , pp. 327-330
    • Nakajima, H.1    Yoshiuchi, I.2    Hamaguchi, T.3
  • 65
    • 57649190746 scopus 로고    scopus 로고
    • Population-specific risk of type 2 diabetes conferred by hnf4a p2 promoter variants: A lesson for replication studies
    • Barroso I, Luan J, Wheeler E, et al. Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes. 2008;57(11):3161-5.
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 3161-3165
    • Barroso, I.1    Luan, J.2    Wheeler, E.3
  • 66
    • 36849037397 scopus 로고    scopus 로고
    • Studies in 3,523 norwegians and meta-Analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (hnf4a) p2 region are associated with type 2 diabetes in scandinavians
    • Johansson S, Raeder H, Eide SA, et al. Studies in 3,523 Norwegians and meta-Analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. Diabetes. 2007;56(12):3112-7.
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3112-3117
    • Johansson, S.1    Raeder, H.2    Eide, S.A.3
  • 67
    • 56349170898 scopus 로고    scopus 로고
    • Common variants in cdkal1, cdkn2a/b, igf2bp2, slc30a8, and hhex/ide genes are associated with type 2 diabetes and impaired fasting glucose in a chinese han population
    • Wu Y, Li H, Loos RJ, et al. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008;57(10):2834-42.
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2834-2842
    • Wu, Y.1    Li, H.2    Loos, R.J.3
  • 68
    • 50449104632 scopus 로고    scopus 로고
    • Implication of genetic variants near tcf7l2, slc30a8, hhex, cdkal1, cdkn2a/b, igf2bp2, and fto in type 2 diabetes and obesity in 6,719 asians
    • Ng MC, Park KS, Oh B, et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes. 2008;57(8):2226-33.
    • (2008) Diabetes , vol.57 , Issue.8 , pp. 2226-2233
    • Ng, M.C.1    Park, K.S.2    Oh, B.3
  • 69
    • 34948845069 scopus 로고    scopus 로고
    • Association study of the genetic polymorphisms of the transcription factor 7-like 2 (tcf7l2) gene and type 2 diabetes in the chinese population
    • Chang YC, Chang TJ, Jiang YD, et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007;56(10):2631-7.
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2631-2637
    • Chang, Y.C.1    Chang, T.J.2    Jiang, Y.D.3
  • 70
    • 44749093346 scopus 로고    scopus 로고
    • Exon sequencing and association analysis of polymorphisms in tcf7l2 with type 2 diabetes in a chinese population
    • Ren Q, Han XY, Wang F, et al. Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. Diabetologia. 2008;51(7):1146-52.
    • (2008) Diabetologia , vol.51 , Issue.7 , pp. 1146-1152
    • Ren, Q.1    Han, X.Y.2    Wang, F.3
  • 71
    • 38949083548 scopus 로고    scopus 로고
    • Association of tcf7l2 polymorphisms with susceptibility to type 2 diabetes in 4,087 japanese subjects
    • Miyake K, Horikawa Y, Hara K, et al. Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet. 2008;53(2):174-80.
    • (2008) J Hum Genet , vol.53 , Issue.2 , pp. 174-180
    • Miyake, K.1    Horikawa, Y.2    Hara, K.3
  • 72
    • 70349566593 scopus 로고
    • Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"?
    • Neel JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet. 1962;14:353-62.
    • (1962) Am J Hum Genet , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 73
    • 0032606068 scopus 로고    scopus 로고
    • Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"? 1962
    • discussion 692-693
    • Neel JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962. Bull World Health Org. 1999;77(8):694-703. discussion 692-693.
    • (1999) Bull World Health Org , vol.77 , Issue.8 , pp. 694-703
    • Neel, J.V.1
  • 74
    • 68449102930 scopus 로고    scopus 로고
    • Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
    • Southam L, Soranzo N, Montgomery SB, et al. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? Diabetologia. 2009;52(9):1846-51.
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1846-1851
    • Southam, L.1    Soranzo, N.2    Montgomery, S.B.3
  • 75
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747-53.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 76
    • 79951481957 scopus 로고    scopus 로고
    • Initial impact of the sequencing of the human genome
    • Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011;470(7333):187-97.
    • (2011) Nature , vol.470 , Issue.7333 , pp. 187-197
    • Lander, E.S.1
  • 78
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of cnvs in 16,000 cases of eight common diseases and 3,000 shared controls
    • Wellcome Trust Case Control C
    • Wellcome Trust Case Control C, Craddock N, Hurles ME, et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464 (7289):713-20.
    • (2010) Nature , vol.464 , Issue.7289 , pp. 713-120
    • Craddock, N.1    Hurles, M.E.2
  • 79
    • 79954442305 scopus 로고    scopus 로고
    • Targeted nextgeneration sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure. Leuk
    • Grossmann V, Kohlmann A, Klein HU, et al. Targeted nextgeneration sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure. Leuk: Off J Leuk Soc Am, Leuk Res Fund, U K. 2011;25(4):671-80.
    • (2011) Off J Leuk Soc Am, Leuk Res Fund, U K , vol.25 , Issue.4 , pp. 671-680
    • Grossmann, V.1    Kohlmann, A.2    Klein, H.U.3
  • 80
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol. 2010;28(10):1057-68.
    • (2010) Nat Biotechnol , vol.28 , Issue.10 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 82
    • 27244452482 scopus 로고    scopus 로고
    • Dietary pattern inflammation and incidence of type 2 diabetes in women
    • quiz 714-675
    • Schulze MB, Hoffmann K, Manson JE, et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr. 2005;82(3):675-84. quiz 714-675.
    • (2005) Am J Clin Nutr , vol.82 , Issue.3 , pp. 675-684
    • Schulze, M.B.1    Hoffmann, K.2    Manson, J.E.3
  • 83
    • 34548459044 scopus 로고    scopus 로고
    • Whole grain, bran, and germ intake and risk of type 2 diabetes: A prospective cohort study and systematic review
    • deMunter JS, Hu FB, Spiegelman D, FranzM, van Dam RM.Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med. 2007;4(8):e261.
    • (2007) PLoS Med , vol.4 , Issue.8
    • DeMunter, J.S.1    Hu, F.B.2    Spiegelman, D.3    Franz, M.4    Van Dam, R.M.5
  • 84
    • 33746075560 scopus 로고    scopus 로고
    • Tcf7l2 polymorphisms and progression to diabetes in the diabetes prevention program
    • Florez JC, Jablonski KA, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med. 2006;355(3):241-50.
    • (2006) N Engl J Med , vol.355 , Issue.3 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3
  • 85
    • 67649427368 scopus 로고    scopus 로고
    • Whole-grain consumption and transcription factor-7-like 2 (tcf7l2) rs7903146: Gene-diet interaction in modulating type 2 diabetes risk
    • Fisher E, Boeing H, Fritsche A, Doering F, Joost HG, Schulze MB. Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br J Nutr. 2009;101(4):478-81.
    • (2009) Br J Nutr , vol.101 , Issue.4 , pp. 478-481
    • Fisher, E.1    Boeing, H.2    Fritsche, A.3    Doering, F.4    Joost, H.G.5    Schulze, M.B.6
  • 86
    • 65549098759 scopus 로고    scopus 로고
    • Genetic predisposition, western dietary pattern, and the risk of type 2 diabetes in men
    • Qi L, Cornelis MC, Zhang C, van Dam RM, Hu FB. Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. Am J Clin Nutr. 2009;89(5):1453-8.
    • (2009) Am J Clin Nutr , vol.89 , Issue.5 , pp. 1453-1458
    • Qi, L.1    Cornelis, M.C.2    Zhang, C.3    Van Dam, R.M.4    Hu, F.B.5
  • 87
    • 27944473261 scopus 로고    scopus 로고
    • The case for strategic international alliances to harness nutritional genomics for public and personal health
    • Kaput J, Ordovas JM, Ferguson L, et al. The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr. 2005;94(5):623-32.
    • (2005) Br J Nutr , vol.94 , Issue.5 , pp. 623-632
    • Kaput, J.1    Ordovas, J.M.2    Ferguson, L.3


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