Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic β-cells

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 15727-15734

  Kitiphongspattana, Kajorn ^a,d   Mathews, Clayton E ^b   Leiter, Edward H ^c   Gaskins, H Rex ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c JACKSON LABORATORY   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); ENZYMES; IMMUNOLOGY; INSULIN; METABOLISM; PROTEINS; RADIOACTIVITY; SYNTHESIS (CHEMICAL);

ENDOPLASMIC RETICULUM; ISLETS; LACTACYSTIN; PROTEOSOME INHIBITION;

GLUCOSE;

CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; GLUCOSE; GLUCOSE REGULATED PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LACTACYSTIN; PROINSULIN; PROTEASOME; PROTEIN DISULFIDE ISOMERASE; TYROSINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; DEGRADATION; ENDOPLASMIC RETICULUM; FEMALE; IMMUNOREACTIVITY; INSULIN METABOLISM; INSULIN RELEASE; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY; STATISTICAL SIGNIFICANCE; STRESS; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE; ISLETS OF LANGERHANS; MICE; MICROSCOPY, CONFOCAL; POLYUBIQUITIN; PROINSULIN; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 18144363161     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410876200     Document Type: Article

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